{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:29:42Z","timestamp":1790364582533,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570509"],"award-info":[{"award-number":["81570509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.10.030","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T01:34:33Z","timestamp":1509932073000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["L-ascorbic Acid-2-Glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in Gastric Epithelial cells"],"prefix":"10.1016","volume":"97","author":[{"given":"Xiong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.10.030_bib0005","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/92.23.1881","article-title":"Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy","volume":"92","author":"Correa","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"issue":"Suppl. 6","key":"10.1016\/j.biopha.2017.10.030_bib0010","first-page":"33","article-title":"Assessment of co-existence of Helicobacter pylori and Candida fungi in diseases of the upper gastrointestinal tract","volume":"60","author":"Karczewska","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0015","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1128\/IAI.00172-07","article-title":"Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells","volume":"75","author":"Ding","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2017.10.030_bib0020","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0016-5085(93)90148-6","article-title":"Mechanisms involved in Helicobacter pylori-induced inflammation","volume":"105","author":"Yoshida","year":"1993","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.biopha.2017.10.030_bib0025","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s10495-008-0255-0","article-title":"Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells","volume":"13","author":"Calvino Fern\u00e1ndez","year":"2008","journal-title":"Apoptosis"},{"key":"10.1016\/j.biopha.2017.10.030_bib0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s005350050344","article-title":"Proliferation and apoptosis in gastric antral epithe-lial cells of patients infected with Helicobacter pylori","volume":"35","author":"Jang","year":"2000","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0035","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.38.4.498","article-title":"Induction of gastric epithelial apoptosis by Helicobacter pylori","volume":"38","author":"Moss","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2017.10.030_bib0040","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.69.5.3181-3189.2001","article-title":"Apoptotic signaling pathway activated by Helicobacter pylori infection and increase of apoptosis-inducing activity under serum-starved conditions","volume":"69","author":"Shibayama","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.biopha.2017.10.030_bib0045","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.3748\/wjg.v11.i37.5899","article-title":"Effect of Helicobacter pylori infection on Bax protein expression in patients with gastric precan-cerous lesions","volume":"11","author":"Liu","year":"2005","journal-title":"World J. Gastroenterol."},{"issue":"7","key":"10.1016\/j.biopha.2017.10.030_bib0050","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1440-1746.2007.04959.x","article-title":"Helicobacter pylori infection induces apoptosis in gastric cancer cells through the mitochondrial pathway","volume":"22","author":"Zhang","year":"2007","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0008-6215(92)80054-5","article-title":"The crystal structure and physicochemical properties of L-ascorbic acid 2-glucoside","volume":"232","author":"Mandai","year":"1992","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.biopha.2017.10.030_bib0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/0955300021000038635","article-title":"Radiation induced genomic instability in immortalized haemopoetic stem cells","volume":"79","author":"Mcllrath","year":"2003","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0065","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/jn\/122.4.871","article-title":"Collagen synthesis in human skin fibroblasts is stimulated by a stable form of ascorbate, 2-O-alpha-D-glucopyranosyl-L-ascorbic acid","volume":"122","author":"Yamamoto","year":"1992","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.10.030_bib0070","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3177\/jnsv.38.235","article-title":"Vita min C activity of 2-O-\u03b1-D-glucopyranosyl-L-ascorbic acid in guinea pigs","volume":"38","author":"Wakamiya","year":"1992","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0075","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/biof.5520070115","article-title":"Vitamins E plus C and interacting conutrients required for optimal health: a critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer","volume":"7","author":"Gey","year":"1998","journal-title":"Biofactors"},{"issue":"2-3","key":"10.1016\/j.biopha.2017.10.030_bib0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejphar.2011.11.013","article-title":"Anti-oxidative and anti-aging activities of 2-O-\u03b1-glucopyranosyl-L-ascorbic acid on human dermal fibroblasts","volume":"674","author":"Taniguchi","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.imlet.2009.01.007","article-title":"Promotion of IL-4- and IL-5-dependent differentiation of anti-\u03bc-primed B cells by ascorbic acid 2-glucoside","volume":"122","author":"Ichiyama","year":"2009","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.biopha.2017.10.030_bib0090","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1248\/bpb.19.984","article-title":"Ascorbic acid 2-O-alpha-glucoside, a stable form of ascorbic acid, rescues human keratinocyte cell line, SCC, from cytotoxicity of ultraviolet light B","volume":"19","author":"Miyai","year":"1996","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.030_bib0095","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/mp.56.1.19","article-title":"Effect of Helicobacter pylori on apoptosis and apoptosis related genes in gastric cancer cells","volume":"56","author":"Yang","year":"2003","journal-title":"Mol. Pathol."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.030_bib0100","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2007.10.138","article-title":"LEF-1 activates the transcription of E2F1","volume":"365","author":"Zhou","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.biopha.2017.10.030_bib0105","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.freeradbiomed.2009.02.018","article-title":"Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: implications for the treatment of Alzheimer's disease","volume":"46","author":"Sheng","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2017.10.030_bib0110","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1128\/IAI.69.8.5080-5087.2001","article-title":"Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS","volume":"69","author":"Kuck","year":"2001","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.030_bib0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4321\/S1130-01082010000100006","article-title":"H. Pylori and mitochondrial changes in epithelial cells. The role of oxidative stress","volume":"102","author":"Calvino Fern\u00e1ndez","year":"2010","journal-title":"Rev. Esp. Enferm. Dig."},{"issue":"7","key":"10.1016\/j.biopha.2017.10.030_bib0120","first-page":"631","article-title":"DNA damage and oxidative stress induced by Helicobacter pylori in gastric epithelial cells: protection by vitamin C and sodium selenite","volume":"61","author":"Shi","year":"2006","journal-title":"Pharmazie"},{"key":"10.1016\/j.biopha.2017.10.030_bib0125","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1248\/bpb.20.632","article-title":"Ascorbic acid 2-O-\u03b1-glucoside induced redox modulation in human keratinocyte cell line, SCC: mechanisms of photoprotective effect against ultraviolet light B","volume":"20","author":"Miyai","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2017.10.030_bib0130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-12-385493-3.00004-8","article-title":"Apoptosis and beyond: cytometry in studies of programmed cell death","volume":"103","author":"Wlodkowic","year":"2011","journal-title":"Methods Cell Biol."},{"issue":"7","key":"10.1016\/j.biopha.2017.10.030_bib0135","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2017.10.030_bib0140","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1074\/jbc.M509404200","article-title":"Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation","volume":"281","author":"Yamasaki","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.10.030_bib0145","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1136\/gut.2003.024372","article-title":"Bax translocation and mitochondrial fragmentation induced by Heli-cobacter pylori","volume":"53","author":"Ashktorab","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2017.10.030_bib0150","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2017.10.030_bib0155","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF03044961","article-title":"Morphologic criteria and detection of apoptosis","volume":"24","author":"Saraste","year":"1999","journal-title":"Herz"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217329840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217329840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:27:10Z","timestamp":1780338430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217329840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":31,"alternative-id":["S0753332217329840"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.030","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L-ascorbic Acid-2-Glucoside inhibits Helicobacter pylori-induced apoptosis through mitochondrial pathway in Gastric Epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}