{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:41:56Z","timestamp":1787060516069,"version":"build-2736575974"},"update-to":[{"DOI":"10.1016\/j.biopha.2017.10.068","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000}}],"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Traditional Chinese Medicine Administration","doi-asserted-by":"publisher","award":["2016ZA140"],"award-info":[{"award-number":["2016ZA140"]}],"id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.10.068","type":"journal-article","created":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:17:01Z","timestamp":1510013821000},"page":"886-894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["RETRACTED: Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat"],"prefix":"10.1016","volume":"97","author":[{"given":"Jun-Jun","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Kun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Tao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Zhao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-lun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Long","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biopha.2017.10.068_bib0005","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.joca.2016.07.018","article-title":"Cartilage inflammation and degeneration is enhanced by pro-inflammatory (M1) macrophages in vitro, but not inhibited directly by anti-inflammatory (M2) macrophages","volume":"24","author":"Utomo","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0010","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.068_bib0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.50.2.75","article-title":"In vivo studies of cartilage regeneration after damage induced by catabolin\/interleukin-1","volume":"50","author":"Page Thomas","year":"1991","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0025","first-page":"306","article-title":"Arthritogenic actions of recombinant IL-1 and tumour necrosis factor alpha in the rabbit: evidence for synergistic interactions between cytokines in vivo","volume":"75","author":"Henderson","year":"1989","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.068_bib0030","first-page":"139","article-title":"The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review","volume":"26","author":"Bondeson","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"issue":"3","key":"10.1016\/j.biopha.2017.10.068_bib0035","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0167-4889(90)90145-4","article-title":"Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes","volume":"1052","author":"Lefebvre","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.10.068_bib0040","doi-asserted-by":"crossref","first-page":"202","DOI":"10.22203\/eCM.v021a16","article-title":"Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis","volume":"21","author":"Goldring","year":"2011","journal-title":"Eur. Cell Mater."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0045","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/ar2850","article-title":"Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis","volume":"11","author":"Csaki","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0050","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2017.10.068_bib0055","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/emboj.2013.80","article-title":"Mapping the crossroads of immune activation and cellular stress response pathways","volume":"32","author":"Claudio","year":"2013","journal-title":"EMBO J."},{"issue":"10","key":"10.1016\/j.biopha.2017.10.068_bib0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molmed.2012.06.010","article-title":"ER stress-induced inflammation: does it aid or impede disease progression?","volume":"18","author":"Garg","year":"2012","journal-title":"Trends Mol. Med."},{"issue":"Pt. 2","key":"10.1016\/j.biopha.2017.10.068_bib0065","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1042\/bj2830525","article-title":"Mechanism of inhibition of the calcium pump of sarcoplasmic reticulum by thapsigargin","volume":"283","author":"Wictome","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2017.10.068_bib0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.21.122303.120200","article-title":"Intracellular signaling by the unfolded protein response","volume":"22","author":"Bernales","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"16","key":"10.1016\/j.biopha.2017.10.068_bib0080","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"273","author":"Janicke","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0085","doi-asserted-by":"crossref","first-page":"R218","DOI":"10.1186\/ar4415","article-title":"C\/EBP homologous protein drives pro-catabolic responses in chondrocytes","volume":"15","author":"Husa","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.biopha.2017.10.068_bib0090","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.joca.2012.08.011","article-title":"In vivo reduction or blockade of interleukin-1beta in primary osteoarthritis influences expression of mediators implicated in pathogenesis","volume":"20","author":"Santangelo","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.biopha.2017.10.068_bib0095","first-page":"540","article-title":"Panax quinquefolium saponin attenuates cardiomyocyte apoptosis induced by thapsigargin through inhibition of endoplasmic reticulum stress","volume":"12","author":"Liu","year":"2015","journal-title":"J. Geriatric Cardiol. JGC"},{"issue":"4","key":"10.1016\/j.biopha.2017.10.068_bib0100","first-page":"513","article-title":"Natural health products, modulation of immune function and prevention of chronic diseases evidence-based complementary and alternative medicine","volume":"2","author":"Haddad","year":"2005","journal-title":"eCAM"},{"issue":"26","key":"10.1016\/j.biopha.2017.10.068_bib0105","doi-asserted-by":"crossref","first-page":"41988","DOI":"10.18632\/oncotarget.16716","article-title":"Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway","volume":"8","author":"Xue","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2017.10.068_bib0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biopha.2017.04.093","article-title":"Celastrol reduces IL-1beta induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo","volume":"91","author":"Chen","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"9","key":"10.1016\/j.biopha.2017.10.068_bib0115","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.biopha.2017.10.068_bib0120","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3892\/ijmm.2013.1318","article-title":"Protective effect of lentivirus-mediated siRNA targeting ADAMTS-5 on cartilage degradation in a rat model of osteoarthritis","volume":"31","author":"Chu","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.biopha.2017.10.068_bib0125","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1159\/000366347","article-title":"Panax quinquefolium saponin attenuates cardiomyocyte apoptosis and opening of the mitochondrial permeability transition pore in a rat model of ischemia\/reperfusion","volume":"34","author":"Li","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.068_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2005.08.015","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Moskowitz","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.biopha.2017.10.068_bib0135","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"10.1016\/j.biopha.2017.10.068_bib0140","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/ard.59.12.959","article-title":"Apoptosis in normal and osteoarthritic human articular cartilage","volume":"59","author":"Heraud","year":"2000","journal-title":"Ann. Rheum. Dis."},{"issue":"12","key":"10.1016\/j.biopha.2017.10.068_bib0145","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1136\/ard.59.12.959","article-title":"Apoptosis in normal and osteoarthritic human articular cartilage","volume":"59","author":"Heraud","year":"2000","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/cs1010593","article-title":"Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis","volume":"101","author":"Mazzetti","year":"2001","journal-title":"Clin. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.biopha.2017.10.068_bib0160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3390\/ijms17040436","article-title":"Mechanical and IL-1beta responsive miR-365 contributes to osteoarthritis development by targeting histone deacetylase 4","volume":"17","author":"Yang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"25","key":"10.1016\/j.biopha.2017.10.068_bib0165","doi-asserted-by":"crossref","first-page":"18172","DOI":"10.1074\/jbc.M112.407296","article-title":"Endoplasmic reticulum stress regulates rat mandibular cartilage thinning under compressive mechanical stress","volume":"288","author":"Li","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.068_bib0170","doi-asserted-by":"crossref","DOI":"10.1186\/ar2850","article-title":"Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1 beta-induced NF-kappa B-mediated inflammation and apoptosis","volume":"11","author":"Csaki","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0175","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2174\/138945007779940025","article-title":"Cell death and apoptosis in ostearthritic cartilage","volume":"8","author":"Kim","year":"2007","journal-title":"Curr. Drug Targets"},{"issue":"8","key":"10.1016\/j.biopha.2017.10.068_bib0180","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/jmcc.2002.2045","article-title":"Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes","volume":"34","author":"Uchiyama","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2017.10.068_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jep.2016.07.015","article-title":"Panax quinquefolium saponin combined with dual antiplatelet drugs inhibits platelet adhesion to injured HUVECs via PI3K\/AKT and COX pathways","volume":"192","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.10.068_bib0190","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-016-1070-6","article-title":"The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target","volume":"18","author":"Li","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"6765","key":"10.1016\/j.biopha.2017.10.068_bib0195","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/47513","article-title":"Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta","volume":"403","author":"Nakagawa","year":"2000","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0200","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cellsig.2013.11.018","article-title":"ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage","volume":"26","author":"Guo","year":"2014","journal-title":"Cell. Signal."},{"issue":"7","key":"10.1016\/j.biopha.2017.10.068_bib0205","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.joca.2014.04.025","article-title":"Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C\/EBP homologous protein","volume":"22","author":"Uehara","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.biopha.2017.10.068_bib0210","first-page":"540","article-title":"Panax quinquefolium saponin attenuates cardiomyocyte apoptosis induced by thapsigargin through inhibition of endoplasmic reticulum stress","volume":"12","author":"Liu","year":"2015","journal-title":"J. Geriatric Cardiol."},{"issue":"4","key":"10.1016\/j.biopha.2017.10.068_bib0215","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0b013e3182a3f9e5","article-title":"Panax quinquefolium saponin attenuates ventricular remodeling after acute myocardial infarction by inhibiting chop-mediated apoptosis","volume":"40","author":"Liu","year":"2013","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0220","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/SHK.0b013e31823f15c4","article-title":"Panax quinquefolium saponins reduce myocardial hypoxia-reoxygenation injury by inhibiting excessive endoplasmic reticulum stress","volume":"37","author":"Wang","year":"2012","journal-title":"Shock"},{"issue":"12","key":"10.1016\/j.biopha.2017.10.068_bib0225","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/nm.2543","article-title":"Identification of a central role for complement in osteoarthritis","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.biopha.2017.10.068_bib0230","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"B as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.biopha.2017.10.068_bib0235","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.joca.2007.06.006","article-title":"Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-medated NF-kappa Bp65-specific siRNA","volume":"16","author":"Chen","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.biopha.2017.10.068_bib0240","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jep.2012.03.029","article-title":"Panax quinquefolium saponins inhibited immune maturation of human monocyte-derived dendritic cells via blocking nuclear factor-kappa B pathway","volume":"141","author":"Liu","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"7203","key":"10.1016\/j.biopha.2017.10.068_bib0245","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2017.10.068_bib0250","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1128\/jvi.69.3.1480-1484.1995","article-title":"Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B","volume":"69","author":"Pahl","year":"1995","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.biopha.2017.10.068_bib0255","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/j.1460-2075.1992.tb05369.x","article-title":"B virus transactivator MHBst: activation of NF-kappa B, selective inhibition by antioxidants and integral membrane localization","volume":"11","author":"Meyer","year":"1992","journal-title":"EMBO J."},{"issue":"23","key":"10.1016\/j.biopha.2017.10.068_bib0260","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1128\/MCB.24.23.10161-10168.2004","article-title":"Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2","volume":"24","author":"Deng","year":"2004","journal-title":"Mol. Cell. Biol."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2017.10.068","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000}},{"DOI":"10.1016\/j.biopha.2026.119628","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000}},{"DOI":"10.1016\/j.biopha.2026.119628","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000}}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217345110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217345110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:11:51Z","timestamp":1780337511000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217345110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":52,"alternative-id":["S0753332217345110"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.068","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Panax quinquefolium saponin inhibits endoplasmic reticulum stress-induced apoptosis and the associated inflammatory response in chondrocytes and attenuates the progression of osteoarthritis in rat","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}