{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:25:54Z","timestamp":1780385154130,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573985"],"award-info":[{"award-number":["81573985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.10.070","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T01:38:00Z","timestamp":1509932280000},"page":"248-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Autophagy participates in isoliquiritigenin\u2013induced melanin degradation in human epidermal keratinocytes through PI3K\/AKT\/mTOR signaling"],"prefix":"10.1016","volume":"97","author":[{"given":"Zhibo","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.clindermatol.2004.09.013","article-title":"Genetic disorders of pigmentation","volume":"23","author":"Passeron","year":"2005","journal-title":"Clin. Dermatol."},{"issue":"3","key":"10.1016\/j.biopha.2017.10.070_bib0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-5793(96)00109-3","article-title":"Tyrosinase and related proteins in mammalian pigmentation","volume":"381","author":"del Marmol","year":"1996","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0749.2005.00288.x","article-title":"Tyrosinase maturation through the mammalian secretory pathway: bringing color to life","volume":"19","author":"Wang","year":"2006","journal-title":"Pigment Cell Res."},{"issue":"3","key":"10.1016\/j.biopha.2017.10.070_bib0020","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobiol."},{"issue":"3","key":"10.1016\/j.biopha.2017.10.070_bib0025","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.freeradbiomed.2011.11.019","article-title":"Investigating the role of melanin in UVA\/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells","volume":"52","author":"Swalwell","year":"2012","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.biopha.2017.10.070_bib0030","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1248\/bpb.26.1348","article-title":"Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens","volume":"26","author":"Kim","year":"2003","journal-title":"Biol. Pharm. Bull."},{"issue":"5","key":"10.1016\/j.biopha.2017.10.070_bib0035","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1021\/jf020935u","article-title":"Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots","volume":"51","author":"Nerya","year":"2003","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.070_bib0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF01923509","article-title":"Autophagy and other vacuolar protein degradation mechanisms","volume":"48","author":"Seglen","year":"1992","journal-title":"Experientia"},{"issue":"4","key":"10.1016\/j.biopha.2017.10.070_bib0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.biopha.2017.10.070_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2003.07.023","article-title":"Autophagy: a regulated bulk degradation process inside cells","volume":"313","author":"Yoshimori","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"22","key":"10.1016\/j.biopha.2017.10.070_bib0055","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1101\/gad.1599207","article-title":"Autophagy: process and function","volume":"21","author":"Mizushima","year":"2007","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.biopha.2017.10.070_bib0060","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/jid.2013.165","article-title":"Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes","volume":"133","author":"Murase","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1755-148X.2009.00640.x","article-title":"Keratinocytes in culture accumulate phagocytosed melanosomes in the perinuclear area","volume":"23","author":"Ando","year":"2010","journal-title":"Pigment Cell Melanoma Res."},{"issue":"4","key":"10.1016\/j.biopha.2017.10.070_bib0070","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/jid.2013.432","article-title":"Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo\/endocytosis","volume":"134","author":"Tarafder","year":"2014","journal-title":"J. Invest. Dermatol."},{"issue":"2","key":"10.1016\/j.biopha.2017.10.070_bib0075","first-page":"425","article-title":"Cell cycle arrest and differentiation induction by 5,7-dimethoxycoumarin in melanoma cell lines","volume":"32","author":"Alesiani","year":"2008","journal-title":"Int. J. Oncol."},{"issue":"10","key":"10.1016\/j.biopha.2017.10.070_bib0080","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/jid.2013.165","article-title":"Autophagy has a significant role in determining skin color by regulating melanosome degradation in keratinocytes","volume":"133","author":"Murase","year":"2013","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.biopha.2017.10.070_bib0085","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/pcmr.12287","article-title":"Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k\/Akt and MEK\/ERK signaling pathways in human epidermal keratinocytes","volume":"27","author":"Makino-Okamura","year":"2014","journal-title":"Pigment Cell Melanoma Res."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0090","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1432-1033.1996.0012t.x","article-title":"Tyrosinase, the key enzyme in melanin synthesis, is expressed in murine brain","volume":"241","author":"Tief","year":"1996","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4838(94)00204-T","article-title":"Tyrosinase A review of its mechanism","volume":"1247","author":"S\u00e1nchez-Ferrer","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.biopha.2017.10.070_bib0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.bbrc.2017.02.033","article-title":"Disruption of melanosome transport in melanocytes treated with theophylline causes their degradation by autophagy","volume":"485","author":"Katsuyama","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.biopha.2017.10.070_bib0105","doi-asserted-by":"crossref","first-page":"e1000298","DOI":"10.1371\/journal.pgen.1000298","article-title":"Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells","volume":"4","author":"Ganesan","year":"2008","journal-title":"PLoS Genet."},{"issue":"21","key":"10.1016\/j.biopha.2017.10.070_bib0110","doi-asserted-by":"crossref","first-page":"34565","DOI":"10.18632\/oncotarget.16655","article-title":"Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3beta signaling","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217337800?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217337800?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:21:55Z","timestamp":1780338115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217337800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":22,"alternative-id":["S0753332217337800"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.070","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy participates in isoliquiritigenin\u2013induced melanin degradation in human epidermal keratinocytes through PI3K\/AKT\/mTOR signaling","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.070","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}