{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:41:53Z","timestamp":1790952113606,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.10.120","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T01:37:52Z","timestamp":1509932272000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Hepatoprotective evaluation and isolation of the major secondary metabolites from the ethyl acetate extract of liquid culture filtrate of Chaetomium globosum"],"prefix":"10.1016","volume":"97","author":[{"given":"Nagwa E.","family":"Awad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa A.","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal A.","family":"Hamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal M.","family":"El-Feky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.A.","family":"El-Naggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.10.120_bib0005","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1021\/np050515+","article-title":"Chaetoglobosin U: a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019","volume":"69","author":"Ding","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2017.10.120_bib0010","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.procbio.2010.12.005","article-title":"Adaptation of marine derived fungi, Chaetomium globosum (NIOCC 36), under alkaline stress using antioxidant properties","volume":"46","author":"Ravindran","year":"2011","journal-title":"Process Biochem."},{"key":"10.1016\/j.biopha.2017.10.120_bib0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/hlca.200890002","article-title":"Secondary metabolites from the fungu: Chaetomium brasiliense","volume":"91","author":"Li","year":"2008","journal-title":"Helvetica Chimica Acta"},{"key":"10.1016\/j.biopha.2017.10.120_bib0020","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.bse.2011.06.019","article-title":"Antifungal metabolites from Chaetomium globosum, an endophytic fungus in Ginkgo biloba","volume":"39","author":"Li","year":"2011","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0025","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1016\/j.mycmed.2013.10.005","article-title":"Bioassays guided isolation of compounds from Chaetomium globosum","volume":"24","author":"Awad","year":"2014","journal-title":"J. de Mycologie M\u00e9dicale"},{"key":"10.1016\/j.biopha.2017.10.120_bib0030","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0953-7562(09)80215-3","article-title":"Endophytesfrom herbaceous plants and shrubs: effectiveness of surface sterilization methods","volume":"97","author":"Schulz","year":"1993","journal-title":"Mycol. Res."},{"key":"10.1016\/j.biopha.2017.10.120_bib0035","series-title":"Illustrated Genera of Imperfect Fungi","author":"Barnett","year":"1972"},{"key":"10.1016\/j.biopha.2017.10.120_bib0040","series-title":"Manual and Atlas of the Penicilla","author":"Ramirez","year":"1982"},{"key":"10.1016\/j.biopha.2017.10.120_bib0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-230X-9-3","article-title":"Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease","volume":"9","author":"Marsillach","year":"2009","journal-title":"BMC. Gastroenterol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1515\/JBCPP.2009.20.2.169","article-title":"Hepatoprotective property of Thespesia populnea against carbon tetrachloride induced liver damage in rats","volume":"20","author":"Yuvaraj","year":"2009","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Level of glutathione, glutathione reductase and glutathone-S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.10.120_bib0060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0065","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the action of reduced phenazine methosulphate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2017.10.120_bib0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases","volume":"28","author":"Reitman","year":"1957","journal-title":"Am. J. Clin. Path."},{"key":"10.1016\/j.biopha.2017.10.120_bib0075","first-page":"561","article-title":"Hydrolysis of adenosine monophosphate by acid phosphatase as measured by a continuos spectrophotometric assay","volume":"12","author":"Belfield","year":"1971","journal-title":"Enzyme"},{"key":"10.1016\/j.biopha.2017.10.120_bib0080","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.10.120_bib0085","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1017\/S0031182097001078","article-title":"Induction of protective immunity and modulation of granulaomatous hypersensitivity in mice using PIII: an anionic fraction of Schistosoma mansoni adult worm","volume":"115","author":"Hirsch","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.biopha.2017.10.120_bib0090","series-title":"Dictionary of the Fungi","first-page":"131","author":"Kirk","year":"2011"},{"key":"10.1016\/j.biopha.2017.10.120_bib0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jep.2010.06.038","article-title":"Integral pharmacokinetics of multiple lignan components in normal: cCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers","volume":"131","author":"Xie","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0100","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.etp.2010.02.006","article-title":"Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats","volume":"63","author":"Bilgin","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1743-7075-8-40","article-title":"Zingiber officinale acts as a nutraceutical agent against liver fibrosis","volume":"8","author":"Motawi","year":"2011","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biopha.2017.10.120_bib0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/19390211.2012.760509","article-title":"Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent","volume":"10","author":"El-Gengaihi","year":"2013","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.biopha.2017.10.120_bib0115","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/j.fct.2008.07.010","article-title":"Hepatoprotective and antioxidant effects of Commiphora berryi (Arn) Engl bark extract against CCl4-induced oxidative damage in rats","volume":"46","author":"Gowri Shankar","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2007.05.064","article-title":"Hyperlipidemia induced by a cholesterol-rich diet aggravates necrotizing pancreatitis in rats","volume":"572","author":"Czak\u00f3","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1472-6882-6-33","article-title":"Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders","volume":"6","author":"Manna","year":"2006","journal-title":"BMC. Comp. Alt. Med."},{"key":"10.1016\/j.biopha.2017.10.120_bib0130","first-page":"26","article-title":"Hepatotoxicity studies of sub-chronic administration of aqueous stem bark of Khaya senegalensis in albino rats","volume":"3","author":"Abubakar","year":"2010","journal-title":"Bayero J. Pure Appl. Sci."},{"key":"10.1016\/j.biopha.2017.10.120_bib0135","first-page":"1229","article-title":"Lipid peroxidation products and antioxidants in human disease","volume":"106","author":"Romero","year":"1998","journal-title":"Environ Health Perspectives"},{"key":"10.1016\/j.biopha.2017.10.120_bib0140","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.etp.2010.05.009","article-title":"Hepatoprotective potential of aqueous extract of Butea monosperma against CCl4 induced damage in rats","volume":"63","author":"Sharma","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2017.10.120_bib0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000070030","article-title":"Biological relevance of terpenoids. Overview focusing on mono-: di- and tetraterpenes","volume":"47","author":"Wagner","year":"2003","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.biopha.2017.10.120_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.fct.2014.06.010","article-title":"Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: a mechanistic study","volume":"71","author":"Gross Arya","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"31","key":"10.1016\/j.biopha.2017.10.120_bib0155","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.2174\/092986712803833335","article-title":"Terpene compounds in nature: a review of their potential antioxidant activity","volume":"19","author":"Gonz\u00e1lez-Burgos","year":"2012","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2017.10.120_bib0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jn\/136.1.11","article-title":"Induction of hepatic antioxidant enzymes by phenolic acids in rats is accompanied by increased levels of multidrug resistance-associated protein 3 mRNA expression","volume":"136","author":"Yeh","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2017.10.120_bib0165","series-title":"Butterworths","first-page":"315","article-title":"Chemical microbiology: an introduction to microbial physiology","author":"Rose","year":"2014"},{"issue":"4","key":"10.1016\/j.biopha.2017.10.120_bib0170","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3109\/19390211.2015.1099584","article-title":"Chemical composition of golden berry leaves against hepato-renal fibrosis?","volume":"13","author":"Khalaf-Allah","year":"2016","journal-title":"J. Diet Suppl."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:25:26Z","timestamp":1780338326000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217344542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"alternative-id":["S0753332217344542"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.120","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective evaluation and isolation of the major secondary metabolites from the ethyl acetate extract of liquid culture filtrate of Chaetomium globosum","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.10.120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}