{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:34:28Z","timestamp":1784590468972,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["406733\/2013-9"],"award-info":[{"award-number":["406733\/2013-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["446497\/2014-2"],"award-info":[{"award-number":["446497\/2014-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.11.019","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T01:01:43Z","timestamp":1510362103000},"page":"1147-1154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Antidiarrheal effects of water-soluble proteins from Plumeria pudica latex in mice"],"prefix":"10.1016","volume":"97","author":[{"given":"Lucas de Ara\u00fajo Bastos","family":"Santana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Passos","family":"Arag\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago de Souza Lopes","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Alves de","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan Kelves Miranda de","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Eduardo Silva","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carolina Toledo da Cunha","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Portela","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naylla Veras de Moraes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna da Silva","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca Beatriz Melo","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Viana","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleverson Diniz Teixeira de","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jand-Venes Rolim","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson Soares de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.11.019_bib0005","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1469-8137.2007.02323.x","article-title":"Laticifers and secretory ducts: two other tube systems in plants","volume":"177","author":"Pickard","year":"2007","journal-title":"New Phytol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.plaphy.2007.07.020","article-title":"Enzymatic activities and protein profile of latex from Calotropis procera","volume":"45","author":"Freitas","year":"2007","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.biopha.2017.11.019_bib0015","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.phytochem.2008.01.004","article-title":"Bioactive triterpene derivatives from latex of two Euphorbia species","volume":"69","author":"Mazoir","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.biopha.2017.11.019_bib0020","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11829-010-9084-5","article-title":"The defensive role of latex in plants: detrimental effects on insects","volume":"4","author":"Ramos","year":"2010","journal-title":"Arthropod-Plant Interact."},{"key":"10.1016\/j.biopha.2017.11.019_bib0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jep.2009.07.030","article-title":"Involvement of NO in the inhibitory effect of Calotropis procera latex protein fractions on leukocyte rolling, adhesion and infiltration in rat peritonitis model","volume":"125","author":"Ramos","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0030","first-page":"521","article-title":"Analgesic and antidiarrheal properties of the latex of Calotropis Procera","volume":"2","author":"Das","year":"2011","journal-title":"Int. J. Pharm. Biol. Sci. Arch."},{"key":"10.1016\/j.biopha.2017.11.019_bib0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-8741(01)00219-7","article-title":"Anti-diarrhoeal activity of the latex of Calotropis procera","volume":"76","author":"Kumar","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0040","first-page":"217","article-title":"Phytopharmacological review of Plumeria species","volume":"3","author":"Shinde","year":"2014","journal-title":"SAJP"},{"key":"10.1016\/j.biopha.2017.11.019_bib0045","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bjp.2015.05.003","article-title":"Laticifer proteins from Plumeria pudica inhibit the inflammatory and nociceptive responses by decreasing the action of inflammatory mediators and pro-inflammatory cytokines","volume":"25","author":"Fernandes","year":"2015","journal-title":"Rev. Bras. Farmacogn."},{"key":"10.1016\/j.biopha.2017.11.019_bib0050","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jep.2015.08.020","article-title":"Antidiarrheal activity of cashew GUM: a complex heteropolysaccharide extracted from exudate of Anacardium occidentale L. in rodents","volume":"174","author":"Ara\u00fajo","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0055","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/bcpt.12531","article-title":"Sulfated polysaccharide isolated from the seaweed Gracilaria caudata exerts an antidiarrhoeal effect in rodents","volume":"118","author":"Costa","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0060","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the priciple of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.11.019_bib0065","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/jf00088a071","article-title":"Poor correlation between the levels of proteinase inhibitors found in seeds of different cultivars of cowpea (Vigna unguiculata) and the resistance\/susceptibility to predation by Callosobruchus maculatus","volume":"37","author":"Xavier-Filho","year":"1989","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2017.11.019_bib0070","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/bj3380441","article-title":"A novel class of protein from wheat which inhibits xylanases","volume":"338","author":"Mclauchlan","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2017.11.019_bib0075","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3565(25)38478-8","article-title":"Nitric oxide and castor oil-induced diarrhoea","volume":"268","author":"Mascolo","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2017.11.019_bib0080","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0090-6980(76)90189-1","article-title":"Enteropooling assay: a test for diarrhea produced by prostaglandins","volume":"11","author":"Robert","year":"1976","journal-title":"Prostagladins"},{"key":"10.1016\/j.biopha.2017.11.019_bib0085","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/jphp.12231","article-title":"Sulfated-polysaccharide fraction extracted from red algae Gracilaria birdiae ameliorates trinitrobenzenesulfonic acid-induced colitis in rats","volume":"66","author":"Brito","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/ptr.2650080110","article-title":"Effects of quercetin on gastrointestinal tract in rats and mice","volume":"8","author":"Dicarlo","year":"1994","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2017.11.019_bib0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0378-8741(97)00130-X","article-title":"Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India","volume":"1","author":"Mukherjee","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0002674","article-title":"Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy","volume":"8","author":"Tradtrantip","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2017.11.019_bib0105","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ijbiomac.2016.02.028","article-title":"The efficacy of a sulphated polysaccharide fraction from Hypnea musciformis against diarrhea in rodents","volume":"86","author":"Sousa","year":"2016","journal-title":"\u200eInt. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0110","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.biopha.2016.11.008","article-title":"Role of gastrointestinal motility inhibition and antioxidant properties of myrtle berries (Myrtus communis L.) juice in diarrhea treatment","volume":"84","author":"Jabri","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.11.019_bib0115","first-page":"591","article-title":"Antidiarrhoeal activity of Rhododendron arborium leaves in wistar rats","volume":"3","author":"Semwal","year":"2014","journal-title":"Int. J. Pharm. Res. Bio-Sci."},{"key":"10.1016\/j.biopha.2017.11.019_bib0120","first-page":"50","volume":"vol. 1","author":"Dash","year":"2013"},{"key":"10.1016\/j.biopha.2017.11.019_bib0125","first-page":"23","article-title":"Studies in vivo and in vitro on effects of PGE2 on colonic motility in rabbits","volume":"262","author":"Burakoff","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0130","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1089\/ars.2010.3547","article-title":"Chronic inflammatory disorders and their redox control: from molecular mechanisms to therapeutic opportunities","volume":"15","author":"Chiurchi\u00f9","year":"2011","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.biopha.2017.11.019_bib0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jep.2014.01.015","article-title":"Antidiarrheal and antioxidant activities of chamomile (Matricaria recutita L.) decoction extract in rats","volume":"152","author":"Sebai","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0140","first-page":"598","article-title":"Free radicals antioxidants, and human disease: where are we now?","volume":"119","author":"Halliwell","year":"1992","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.biopha.2017.11.019_bib0145","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1128\/mr.56.4.622-647.1992","article-title":"Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin","volume":"56","author":"Spangler","year":"1992","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.biopha.2017.11.019_bib0150","first-page":"153","article-title":"Cholera toxin \u2013 a foe & a friend","volume":"133","author":"S\u00e1nchez","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.biopha.2017.11.019_bib0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1590\/S1677-04202010000100002","article-title":"Anti-oxidative and proteolytic activities and protein profile of laticifer cells of Cryptostegia grandiflora, Plumeria rubra and Euphorbia tirucalli","volume":"22","author":"Freitas","year":"2010","journal-title":"Braz. J. Plant Physiol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijbiomac.2013.04.001","article-title":"New insights into the complex mixture of latex cysteine peptidases in Calotropis procera","volume":"58","author":"Ramos","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.plaphy.2016.07.028","article-title":"First insights into the diversity and functional properties of chitinases of the latex of Calotropis procera","volume":"108","author":"Freitas","year":"2016","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.biopha.2017.11.019_bib0170","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.tiv.2007.05.007","article-title":"In vitro cytotoxicity against different human cancer cell lines of laticifer proteins of Calotropis procera (Ait.) R. Br","volume":"21","author":"Oliveira","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.biopha.2017.11.019_bib0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00210-012-0733-3","article-title":"Proteins derived from latex of C. procera maintain coagulation homeostasis in septic mice and exhibit thrombin- and plasmin-like activities","volume":"385","author":"Ramos","year":"2012","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0180","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.phymed.2016.03.012","article-title":"Latex protein extracts from Calotropis procera with immunomodulatory properties protect against experimental infections with Listeria monocytogenes","volume":"23","author":"Nascimento","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2017.11.019_bib0185","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1136\/gut.43.2.196","article-title":"Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli","volume":"43","author":"Chandler","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2017.11.019_bib0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3892\/br.2016.720","article-title":"Potential role of bromelain in clinical and therapeutic applications","volume":"5","author":"Rathnavelu","year":"2016","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.biopha.2017.11.019_bib0195","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1042\/bst0300116","article-title":"Novel roles of protease inhibitors in infection and inflammation","volume":"30","author":"Hiemstra","year":"2002","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.biopha.2017.11.019_bib0200","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1136\/gutjnl-2015-309147","article-title":"Protease inhibition as new therapeutic strategy for GI diseases","volume":"65","author":"Vergnolle","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.biopha.2017.11.019_bib0205","first-page":"809","article-title":"Plant chitinases-regulation and function","volume":"8","author":"Kasprzewska","year":"2003","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.biopha.2017.11.019_bib0210","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-physiol-012110-142250","article-title":"Role of chitin and chitinase\/chitinase-like proteins in inflammation tissue remodeling, and injury","volume":"73","author":"Lee","year":"2011","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.biopha.2017.11.019_bib0215","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.imbio.2015.11.014","article-title":"Chitinases and immunity: ancestral molecules with new functions","volume":"221","author":"Di Rosa","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.biopha.2017.11.019_bib0220","first-page":"1","article-title":"Cytotoxicity against tumor cell lines and anti-inflammatory properties of chitinases from Calotropis procera latex","volume":"9","author":"Viana","year":"2017","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:14:40Z","timestamp":1780337680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217344657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":44,"alternative-id":["S0753332217344657"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.019","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antidiarrheal effects of water-soluble proteins from Plumeria pudica latex in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}