{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:53:30Z","timestamp":1792511610371,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.11.030","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T05:19:14Z","timestamp":1510291154000},"page":"1109-1118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models"],"prefix":"10.1016","volume":"97","author":[{"given":"Puthanpura Sasidharan","family":"Sreeja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuppusamy","family":"Arunachalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathyanarayanan","family":"Saikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muniyandi","family":"Kasipandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaraj","family":"Dhivya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajan","family":"Murugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangaraj","family":"Parimelazhagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.11.030_bib0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fct.2012.09.026","article-title":"Ethanolic extract of roots from Arctium lappa L. accelerates the healing of acetic acid-induced gastric ulcer in rats: involvement of the antioxidant system","volume":"51","author":"da Silva","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1053\/j.gastro.2008.05.030","article-title":"Gastric mucosal defense and cytoprotection: bench to bedside","volume":"135","author":"Laine","year":"2008","journal-title":"Gastroenterol"},{"key":"10.1016\/j.biopha.2017.11.030_bib0015","first-page":"5","article-title":"Prostaglandins and ulcer healing","volume":"56","author":"Konturek","year":"2005","journal-title":"J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0020","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.phymed.2003.09.006","article-title":"Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated fromMikania laevigata Schultz Bip","volume":"12","author":"Bighetti","year":"2005","journal-title":"Phytomed"},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4291\/wjgp.v5.i1.40","article-title":"Quality of healing of gastric ulcers: natural products beyond acid suppression","volume":"5","author":"Kangwan","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"22","key":"10.1016\/j.biopha.2017.11.030_bib0030","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.3748\/wjg.v16.i22.2710","article-title":"Spices, herbal xenobiotics and the stomach: friends or foes?","volume":"16","author":"Al Mofleh","year":"2010","journal-title":"World J. Gastroenterol: WJG"},{"key":"10.1016\/j.biopha.2017.11.030_bib0035","unstructured":"http:\/\/www.theplantlist.org\/browse\/A\/Lamiaceae\/Sphenodesme\/. Accessed on June 2017."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0040","first-page":"22","article-title":"Medicinal plants used in the Kutchum district, Yasothon Province, Thailand","volume":"9","author":"Chuakul","year":"2002","journal-title":"Thai J. Phytopharm."},{"issue":"1 & 2","key":"10.1016\/j.biopha.2017.11.030_bib0045","first-page":"1","article-title":"Species diversity and economic importance of the family Verbenaceae in Arunachal Pradesh","volume":"24","author":"Srivastava","year":"2008","journal-title":"Bull. Arunachal For. Res."},{"key":"10.1016\/j.biopha.2017.11.030_bib0050","series-title":"Medicinal plants in Thailand","author":"Saralamp","year":"1996"},{"key":"10.1016\/j.biopha.2017.11.030_bib0055","series-title":"CRC Ethnobotany Desk Reference","author":"Johnson","year":"1999"},{"key":"10.1016\/j.biopha.2017.11.030_bib0060","series-title":"Medicinal plants of the Asia-Pacific: drugs for the future?","author":"Wiart","year":"2006"},{"key":"10.1016\/j.biopha.2017.11.030_bib0065","series-title":"CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, Synonyms, and Etymology","first-page":"3535","author":"Quattrocchi","year":"2012"},{"issue":"2","key":"10.1016\/j.biopha.2017.11.030_bib0070","first-page":"75","article-title":"Antinociceptive activity evaluation of an Indonesian herbal preparation Cleng Marem","volume":"8","author":"Afroz","year":"2014","journal-title":"Adv. Nat. Appl. Sci."},{"key":"10.1016\/j.biopha.2017.11.030_bib0075","first-page":"547","article-title":"Medicinal plants used for treating body pain by the tribals in Pathanamthitta district, Kerala, India","volume":"10","author":"Binu","year":"2011","journal-title":"Indian J. Tradit. Knowl."},{"key":"10.1016\/j.biopha.2017.11.030_bib0080","series-title":"Medicinal Plants of India used in treatment of Neurological Disorders from Pankaj Oudhia\u2019s Medicinal Plant Database","author":"Oudhia","year":"2012"},{"key":"10.1016\/j.biopha.2017.11.030_bib0085","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.biopha.2017.11.030_bib0090","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Rad. Biol. Med."},{"issue":"8","key":"10.1016\/j.biopha.2017.11.030_bib0095","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1021\/jf9913458","article-title":"Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing\/antioxidant power assay","volume":"48","author":"Pulido","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2017.11.030_bib0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/jac\/49.4.601","article-title":"The PHLS Helicobacter Working Group. Helicobacter pylori susceptibility testing by disc diffusion","volume":"49","author":"McNulty","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.biopha.2017.11.030_bib0105","series-title":"Test No. 425: OECD Guidelines for the Testing of Chemicals","first-page":"1","author":"OECD\/OCDE","year":"2008"},{"key":"10.1016\/j.biopha.2017.11.030_bib0110","article-title":"Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents","author":"OECD","year":"2008","journal-title":"Drug Chem. Toxicol."},{"issue":"4","key":"10.1016\/j.biopha.2017.11.030_bib0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0021-5198(19)39795-1","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Jpn. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2017.11.030_bib0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.vascn.2003.10.004","article-title":"Computer-assisted visualization and quantitation of experimental gastric lesions in rats","volume":"49","author":"Khan","year":"2004","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"5","key":"10.1016\/j.biopha.2017.11.030_bib0125","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0021-5198(19)52438-6","article-title":"Effect of polyamines on acidified ethanol-induced gastric lesions in rats","volume":"33","author":"Mizui","year":"1983","journal-title":"Jpn. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2017.11.030_bib0130","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00365521.1969.12562619","article-title":"The production of acute gastric ulceration by indomethacin in the rat","volume":"4","author":"Djahanguiri","year":"1969","journal-title":"Scand. J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.biopha.2017.11.030_bib0135","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(54)80008-4","article-title":"A quantitative method for measuring spontaneous gastric secretion in the rat","volume":"26","author":"Shay","year":"1954","journal-title":"Gastroenterol"},{"key":"10.1016\/j.biopha.2017.11.030_bib0140","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalasein vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2017.11.030_bib0145","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.11.030_bib0150","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: Improved assays and an assay applicable to acrylamide gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem. Rev."},{"key":"10.1016\/j.biopha.2017.11.030_bib0155","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2017.11.030_bib0160","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/497606","article-title":"Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos","volume":"2014","author":"Mujeeb","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0165","first-page":"148","article-title":"GC-MS analysis of phytoconstituents in alcohol extract ofEpiphyllum oxypetalum leaves","volume":"4","author":"Dandekar","year":"2015","journal-title":"J. Pharmacogn. Phytochem."},{"key":"10.1016\/j.biopha.2017.11.030_bib0170","first-page":"818","article-title":"GC-MS analysis of bioactive components ofHugonia mystax L. bark (Linaceae)","volume":"29","author":"Rajeswari","year":"2013","journal-title":"J. Pharm. Biomed. Sci."},{"key":"10.1016\/j.biopha.2017.11.030_bib0175","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1055\/s-2006-957748","article-title":"Anti-inflammatory actions of pentacyclic triterpenes","volume":"63","author":"Safayhi","year":"1997","journal-title":"Planta Med."},{"key":"10.1016\/j.biopha.2017.11.030_bib0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2014.09.013","article-title":"Toxicological evaluation of hydroethanolic extract of Helicteres sacarolha A. St.-Hil","volume":"157","author":"Balogun","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2017.11.030_bib0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3181\/00379727-185-4-RC1","article-title":"Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components: possible role of endogenous sulphydryls","volume":"4","author":"Szabo","year":"1987","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.biopha.2017.11.030_bib0190","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0378-8741(00)00290-7","article-title":"Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats","volume":"73","author":"Tan","year":"2000","journal-title":"J. Ethnopharm."},{"key":"10.1016\/j.biopha.2017.11.030_bib0195","unstructured":"Sherwood Physiologie humaine, 2nd edition of Book, Paris, (2006) 452\u2013462."},{"key":"10.1016\/j.biopha.2017.11.030_bib0200","first-page":"677","article-title":"Current concepts in gastric microcirculatory pathophysiology","volume":"65","author":"Guth","year":"1992","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.biopha.2017.11.030_bib0205","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2036.2009.04086.x","article-title":"Review article : cellular and molecular mechanisms of NSAID induced peptic ulcers","volume":"30","author":"Musumba","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2017.11.030_bib0210","first-page":"378","article-title":"Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves in fusion extract ofCopaifera malmei Harms","volume":"75","author":"Bulus","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1472-6882-12-247","article-title":"Anti-ulcerogenic activity of the root bark extract of the African laburnum \u201cCassia sieberiana\u201d and its effect on the anti-oxidant defence system in rats","volume":"12","author":"Nartey","year":"2012","journal-title":"BMC Complem. Altern. Med."},{"issue":"53","key":"10.1016\/j.biopha.2017.11.030_bib0220","first-page":"1","article-title":"Reactive oxygen species (ROS) and response of antioxidants as ROS-scavengers during environmental stress in plants","volume":"2","author":"Das","year":"2014","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.biopha.2017.11.030_bib0225","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2015.01092","article-title":"ROS regulation during abiotic stress responses in crop plants","volume":"6","author":"You","year":"2015","journal-title":"Front. Plant Sci."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.030_bib0230","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12906-015-0638-z","article-title":"Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves","volume":"15","author":"Zakaria","year":"2015","journal-title":"BMC Complem. Altern. Med."},{"key":"10.1016\/j.biopha.2017.11.030_bib0235","first-page":"218","article-title":"Evaluation of the anti-ulcer activity of NR-ANX-C (a polyherbal formulation) in aspirin & pyloric ligature induced gastric ulcers in albino rats","volume":"132","author":"Vinod","year":"2010","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.biopha.2017.11.030_bib0240","first-page":"155","article-title":"Mitigating effect of Avicenna marina on indomethacin induced gastric ulcer in male albino rats","volume":"3","author":"Magda","year":"2016","journal-title":"Egypt. J. Basic Appl. Sci."},{"key":"10.1016\/j.biopha.2017.11.030_bib0245","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.00102.2004","article-title":"Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin","volume":"288","author":"Allen","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2017.11.030_bib0250","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/10715760410001705168","article-title":"Role of L-arginine in ibuprofen-induced oxidative stress and neutrophil infiltration in gastric mucosa","volume":"38","author":"Jim\u00e8nez","year":"2004","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2017.11.030_bib0255","doi-asserted-by":"crossref","first-page":"501","DOI":"10.33549\/physiolres.930126","article-title":"Protective effect of quercetin on 354 ischemia\/reperfusion induced gastric mucosal injury in rats","volume":"50","author":"Moj\u017ei\u0161","year":"2001","journal-title":"Physiol. Res."},{"key":"10.1016\/j.biopha.2017.11.030_bib0260","first-page":"149","article-title":"Antiulcerogenic effect of gallic acid in rats and its effect on oxidant and antioxidant parameters in stomach tissue","volume":"75","author":"Sen","year":"2013","journal-title":"Indian J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2017.11.030_bib0265","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0891-5849(98)00179-8","article-title":"Modulation of arachidonic acid metabolism by phenols: Relation to their structure and antioxidant\/pro-oxidant properties","volume":"26","author":"Alanko","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2017.11.030_bib0270","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4103\/0975-7406.84437","article-title":"Role of phenolic compounds in peptic ulcer: An overview","volume":"3","author":"Sabiha","year":"2011","journal-title":"J. Pharm. Bioall. Sci."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217344323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:23:26Z","timestamp":1780338206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217344323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":54,"alternative-id":["S0753332217344323"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.030","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastroprotective effect and mode of action of methanol extract of Sphenodesme involucrata var. paniculata (C.B. Clarke) Munir (Lamiaceae) leaves on experimental gastric ulcer models","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}