{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:06:04Z","timestamp":1780340764257,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570996"],"award-info":[{"award-number":["81570996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z131100006813005"],"award-info":[{"award-number":["Z131100006813005"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.biopha.2017.11.038","type":"journal-article","created":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T10:00:48Z","timestamp":1510912848000},"page":"1438-1444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Effects of standardized isopropanolic black cohosh and estrogen on salivary function in ovariectomized rats"],"prefix":"10.1016","volume":"97","author":[{"given":"Shuya","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmeng","family":"Da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenpei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.11.038_bib0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.sdj.2014.12.001","article-title":"Dry mouth \u2013 an overview","volume":"36","author":"Ying","year":"2015","journal-title":"Singapore Dent. J."},{"key":"10.1016\/j.biopha.2017.11.038_bib0010","first-page":"233","article-title":"Evaluation of salivary flow rate, pH and buffer in pre, post & post menopausal women on HRT","volume":"8","author":"Mahesh","year":"2014","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.biopha.2017.11.038_bib0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/adj.12057","article-title":"Assessing the impact of menopause on salivary flow and xerostomia","volume":"58","author":"Minicucci","year":"2013","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.biopha.2017.11.038_bib0020","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1741-2358.2010.00403.x","article-title":"Relationship of stimulated whole saliva cortisol level with the severity of a feeling of dry mouth in menopausal women","volume":"229","author":"Agha-Hosseini","year":"2012","journal-title":"Gerodontology"},{"key":"10.1016\/j.biopha.2017.11.038_bib0025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1741-2358.2011.00580.x","article-title":"Correlation of serum oestrogen with salivary calcium in post-menopausal women with and without oral dryness feeling","volume":"29","author":"Singh","year":"2012","journal-title":"Gerodontology"},{"key":"10.1016\/j.biopha.2017.11.038_bib0030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0003-9969(03)00094-3","article-title":"Minor gland and whole saliva in postmenopausal women using a low potency oestrogen (oestriol)","volume":"48","author":"Eliasson","year":"2003","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0035","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/09513590.2014.959918","article-title":"The influence of hormone replacement therapy on the salivary flow of post-menopausal women","volume":"31","author":"Lago","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0040","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0002-9440(10)63505-5","article-title":"Development of autoimmune exocrinopathy resembling Sjogren's syndrome in estrogen-deficient mice of healthy background","volume":"163","author":"Ishimaru","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0045","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1128\/MCB.26.8.2924-2935.2006","article-title":"Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands","volume":"26","author":"Ishimaru","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000358781","article-title":"Salivary secretion: mechanism and neural regulation","volume":"24","author":"Proctor","year":"2014","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.biopha.2017.11.038_bib0055","doi-asserted-by":"crossref","first-page":"G1106","DOI":"10.1152\/ajpgi.00194.2010","article-title":"Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation","volume":"299","author":"Azlina","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0060","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1126\/science.1192046","article-title":"Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis","volume":"329","author":"Knox","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biopha.2017.11.038_bib0065","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1124\/mol.66.2.260","article-title":"Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice","volume":"66","author":"Gautam","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2006.10.006","article-title":"Regulation of salivary gland function by autonomic nerves","volume":"133","author":"Proctor","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.biopha.2017.11.038_bib0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1034\/j.1601-0825.2002.10815.x","article-title":"Understanding salivary fluid and protein secretion","volume":"8","author":"Turner","year":"2002","journal-title":"Oral Dis."},{"key":"10.1016\/j.biopha.2017.11.038_bib0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10735-010-9308-0","article-title":"Localization of AQP5 during development of the mouse submandibular salivary gland","volume":"42","author":"Larsen","year":"2011","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0085","doi-asserted-by":"crossref","first-page":"23413","DOI":"10.1074\/jbc.M008760200","article-title":"Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation","volume":"276","author":"Krane","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.11.038_bib0090","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1267\/ahc.12018","article-title":"Function of the membrane water channel aquaporin-5 in the salivary gland","volume":"45","author":"Matsuzaki","year":"2012","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.biopha.2017.11.038_bib0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tem.2011.08.002","article-title":"Neuroprotective actions of estradiol revisited","volume":"22","author":"Azcoitia","year":"2011","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.11.038_bib0100","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejphar.2010.02.032","article-title":"Effects of 17\u03b2-estradiol on expression of muscarinic acetylcholine receptor subtypes and estrogen receptor alpha in rat hippocampus","volume":"634","author":"Cardoso","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0105","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.bcp.2008.01.016","article-title":"Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus","volume":"75","author":"Pereira","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0110","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5414\/CPP45143","article-title":"Isopropanolic black cohosh extract and recurrence-free survival after breast cancer","volume":"45","author":"Henneicke-Von Zepelin","year":"2007","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2017.11.038_bib0115","doi-asserted-by":"crossref","first-page":"e121470","DOI":"10.1371\/journal.pone.0121470","article-title":"A comparison of the effects of estrogen and Cimicifuga racemosa on the lacrimal gland and submandibular gland in ovariectomized rats","volume":"10","author":"Da","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.11.038_bib0120","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.acthis.2014.07.010","article-title":"Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats","volume":"116","author":"Wang","year":"2014","journal-title":"Acta Histochemica"},{"key":"10.1016\/j.biopha.2017.11.038_bib0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/rej.2015.1724","article-title":"Black cohosh ameliorates metabolic disorders in female ovariectomized rats","volume":"19","author":"Sun","year":"2016","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.biopha.2017.11.038_bib0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.maturitas.2008.06.001","article-title":"Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats","volume":"60","author":"Racho\u0144","year":"2008","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2017.11.038_bib0135","first-page":"61","article-title":"Cells in the duct system of the rat submandibular gland","volume":"36","author":"Sato","year":"1998","journal-title":"Eur. J. Morphol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0140","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1177\/154405910308201110","article-title":"Blood flow and interstitial fluid pressure in the rat submandibular gland during changes in perfusion","volume":"82","author":"Berggreen","year":"2003","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biopha.2017.11.038_bib0145","series-title":"Dysphagia","first-page":"19","article-title":"Saliva and the control of its secretion","author":"Ekstr\u00f6m","year":"2011"},{"key":"10.1016\/j.biopha.2017.11.038_bib0150","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/01.gme.0000196813.34247.e2","article-title":"First-time proof of endometrial safety of the special black cohosh extract (Actaea or Cimicifuga racemosa extract) CR BNO 1055","volume":"13","author":"Raus","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.biopha.2017.11.038_bib0155","first-page":"36","article-title":"Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis","volume":"16","author":"Shams","year":"2010","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.biopha.2017.11.038_bib0160","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3109\/13697137.2014.966241","article-title":"Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review","volume":"18","author":"Chen","year":"2015","journal-title":"Climacteric: J. Int. Menopause Soc."},{"key":"10.1016\/j.biopha.2017.11.038_bib0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.autneu.2012.03.004","article-title":"Influence of experimental periodontitis on cholinergic stimulation of K\u207arelease in rat parotid glands","volume":"169","author":"Miozza","year":"2012","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.biopha.2017.11.038_bib0170","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1136\/bjophthalmol-2014-305117","article-title":"Obstructive sialadenitis of a transplanted submandibular gland: chronic inflammation secondary to ductal obstruction","volume":"98","author":"Su","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0175","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0022034513519107","article-title":"Hypersensitive mAChRs are involved in the epiphora of transplanted glands","volume":"93","author":"Ding","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biopha.2017.11.038_bib0180","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1113\/jphysiol.2004.064626","article-title":"M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice","volume":"558","author":"Nakamura","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.biopha.2017.11.038_bib0185","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2443.2006.01009.x","article-title":"Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus","volume":"11","author":"Kobayashi","year":"2006","journal-title":"Genes Cells"},{"key":"10.1016\/j.biopha.2017.11.038_bib0190","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1152\/ajpendo.00317.2013","article-title":"Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo","volume":"306","author":"Chen","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.11.038_bib0195","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-94-017-9343-8_14","article-title":"Urea transport mediated by aquaporin water channel proteins","volume":"73","author":"Li","year":"2014","journal-title":"Subcell. Biochem."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217336193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217336193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:27:56Z","timestamp":1780338476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217336193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":39,"alternative-id":["S0753332217336193"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.038","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of standardized isopropanolic black cohosh and estrogen on salivary function in ovariectomized rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}