{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T13:10:49Z","timestamp":1778245849357,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008257","name":"Tarbiat Modares University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008257","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004920","name":"Royan Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.biopha.2017.11.094","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T18:46:16Z","timestamp":1511376376000},"page":"1222-1229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Enhanced neurogenesis in degenerated hippocampi following pretreatment with miR-302\/367 expressing lentiviral vector in mice"],"prefix":"10.1016","volume":"96","author":[{"given":"Maryam","family":"Ghasemi-Kasman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Baharvand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Javan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6807","key":"10.1016\/j.biopha.2017.11.094_bib0005","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/35039559","article-title":"Regenerating the damaged central nervous system","volume":"407","author":"Horner","year":"2000","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biopha.2017.11.094_bib0010","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2796.2009.02157.x","article-title":"Regenerative medicine: a 2009 overview","volume":"266","author":"Andersson","year":"2009","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.biopha.2017.11.094_bib0015","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1056\/NEJMra022361","article-title":"Adult stem cells for tissue repair \u2013 a new therapeutic concept?","volume":"349","author":"Korbling","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2017.11.094_bib0020","doi-asserted-by":"crossref","DOI":"10.1007\/s10571-017-0472-6","article-title":"Attempts to overcome remyelination failure: toward opening new therapeutic avenues for multiple sclerosis","author":"Motavaf","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.biopha.2017.11.094_bib0025","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"7471","key":"10.1016\/j.biopha.2017.11.094_bib0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature12586","article-title":"Reprogramming in vivo produces teratomas and iPS cells with totipotency features","volume":"502","author":"Abad","year":"2013","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.biopha.2017.11.094_bib0035","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nbt.2249","article-title":"Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2017.11.094_bib0040","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nbt.1535","article-title":"Embryonic stem cell-specific microRNAs promote induced pluripotency","volume":"27","author":"Judson","year":"2009","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.094_bib0045","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/cr.2013.156","article-title":"Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells","volume":"24","author":"Zhu","year":"2014","journal-title":"Cell Res."},{"issue":"18","key":"10.1016\/j.biopha.2017.11.094_bib0050","first-page":"4179","article-title":"How microRNAs facilitate reprogramming to pluripotency","volume":"125","author":"Anokye-Danso","year":"2012","journal-title":"J. Cell Sci."},{"issue":"4","key":"10.1016\/j.biopha.2017.11.094_bib0055","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.stem.2011.03.001","article-title":"Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency","volume":"8","author":"Anokye-Danso","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"7359","key":"10.1016\/j.biopha.2017.11.094_bib0060","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature10323","article-title":"MicroRNA-mediated conversion of human fibroblasts to neurons","volume":"476","author":"Yoo","year":"2011","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.biopha.2017.11.094_bib0065","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.yexcr.2012.02.040","article-title":"Direct reprogramming of human astrocytes into neural stem cells and neurons","volume":"318","author":"Corti","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.biopha.2017.11.094_bib0070","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nbt.2561","article-title":"Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells","volume":"31","author":"Najm","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.biopha.2017.11.094_bib0075","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nbt.2564","article-title":"Generation of oligodendroglial cells by direct lineage conversion","volume":"31","author":"Yang","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0080","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.stem.2013.12.001","article-title":"In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model","volume":"14","author":"Guo","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.biopha.2017.11.094_bib0085","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/ncb2843","article-title":"In vivo reprogramming of astrocytes to neuroblasts in the adult brain","volume":"15","author":"Niu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biopha.2017.11.094_bib0090","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1038\/ncomms4338","article-title":"In vivo conversion of astrocytes to neurons in the injured adult spinal cord","volume":"5","author":"Su","year":"2014","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.biopha.2017.11.094_bib0095","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.stemcr.2014.10.007","article-title":"Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral cortex","volume":"3","author":"Heinrich","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.biopha.2017.11.094_bib0100","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lfs.2014.12.007","article-title":"Exogenous Oct4 in combination with valproic acid increased neural progenitor markers: an approach for enhancing the repair potential of the brain","volume":"122","author":"Dehghan","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2017.11.094_bib0105","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2016.01.028","article-title":"Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice","volume":"318","author":"Dehghan","year":"2016","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.biopha.2017.11.094_bib0110","doi-asserted-by":"crossref","first-page":"e0127878","DOI":"10.1371\/journal.pone.0127878","article-title":"MicroRNA-mediated in vitro and in vivo direct conversion of astrocytes to neuroblasts","volume":"10","author":"Ghasemi-Kasman","year":"2015","journal-title":"PloS one"},{"key":"10.1016\/j.biopha.2017.11.094_bib0115","article-title":"In vivo conversion of astrocytes to myelinating cells by miR-302\/367 and valproate to","author":"Ghasemi-Kasman","year":"2017","journal-title":"Enhanc. Myelin Repair J. Tissue Eng. Regen. Med."},{"issue":"12","key":"10.1016\/j.biopha.2017.11.094_bib0120","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/cercor\/bhg081","article-title":"The aging Hippocampus: cognitive, biochemical and structural findings","volume":"13","author":"Driscoll","year":"2003","journal-title":"Cereb. Cortex"},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0125","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1684\/j.1950-6945.2002.tb00479.x","article-title":"Seizure-induced hippocampal damage in the mature and immature brain","volume":"4","author":"Lado","year":"2002","journal-title":"Epileptic Disord.: Int. Epilepsy J. Videotape"},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1399-5618.2002.01144.x","article-title":"Stress and depression: possible links to neuron death in the hippocampus","volume":"4","author":"Lee","year":"2002","journal-title":"Bipolar Disord."},{"issue":"9","key":"10.1016\/j.biopha.2017.11.094_bib0135","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hbm.20934","article-title":"Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease","volume":"31","author":"Mueller","year":"2010","journal-title":"Hum. Brain Mapp."},{"issue":"5","key":"10.1016\/j.biopha.2017.11.094_bib0140","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1523\/JNEUROSCI.09-05-01705.1989","article-title":"Hippocampal damage associated with prolonged and fatal stress in primates","volume":"9","author":"Uno","year":"1989","journal-title":"J. Neurosci."},{"issue":"Pt 4","key":"10.1016\/j.biopha.2017.11.094_bib0145","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/brain\/awn030","article-title":"Regional hippocampal atrophy in multiple sclerosis","volume":"131","author":"Sicotte","year":"2008","journal-title":"Brain : J. Neurol."},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(02)02268-0","article-title":"Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL\/6 mice","volume":"931","author":"Chen","year":"2002","journal-title":"Brain Res."},{"issue":"1-3","key":"10.1016\/j.biopha.2017.11.094_bib0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1385\/MN:31:1-3:003","article-title":"Kainic acid-mediated excitotoxicity as a model for neurodegeneration","volume":"31","author":"Wang","year":"2005","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2017.11.094_bib0160","first-page":"457079","article-title":"Kainic acid-induced neurodegenerative model: potentials and limitations","volume":"2011","author":"Zheng","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0165","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/neu.20099","article-title":"Increased microglial activation and astrogliosis after intranasal administration of kainic acid in C57BL\/6 mice","volume":"62","author":"Chen","year":"2005","journal-title":"J. Neurobiol."},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0170","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuron.2014.10.016","article-title":"Generation of human striatal neurons by MicroRNA-dependent direct conversion of fibroblasts","volume":"84","author":"Victor","year":"2014","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.biopha.2017.11.094_bib0175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.stem.2011.07.002","article-title":"Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions","volume":"9","author":"Ambasudhan","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"23","key":"10.1016\/j.biopha.2017.11.094_bib0180","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1089\/scd.2015.0123","article-title":"MicroRNA 302\/367 cluster effectively facilitates direct reprogramming from human fibroblasts into functional neurons","volume":"24","author":"Zhou","year":"2015","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.094_bib0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbrc.2011.11.058","article-title":"A novel role of miR-302\/367 in reprogramming","volume":"417","author":"Kuo","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2017.11.094_bib0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuroscience.2009.11.073","article-title":"Valproic acid reduces spatial working memory and cell proliferation in the hippocampus","volume":"166","author":"Umka","year":"2010","journal-title":"Neuroscience"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217341835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217341835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:21:12Z","timestamp":1778242872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217341835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":38,"alternative-id":["S0753332217341835"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.094","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced neurogenesis in degenerated hippocampi following pretreatment with miR-302\/367 expressing lentiviral vector in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.11.094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}