{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:57:59Z","timestamp":1780343879519,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2014HM006"],"award-info":[{"award-number":["ZR2014HM006"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.biopha.2017.12.011","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:39:40Z","timestamp":1512646780000},"page":"899-904","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Lipopolysaccharide induces autophagy by targeting the AMPK-mTOR pathway in Human Nasal Epithelial Cells"],"prefix":"10.1016","volume":"96","author":[{"given":"Xue-Hai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.12.011_bib0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1398-9995.2011.02709.x","article-title":"Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe","volume":"67","author":"Jarvis","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.biopha.2017.12.011_bib0010","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2014an underestimated disease. A GA(2)LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.biopha.2017.12.011_bib0015","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: epidemiology and medical management","volume":"128","author":"Hamilos","year":"2011","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.biopha.2017.12.011_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.biopha.2017.12.011_bib0025","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.jaci.2007.08.046","article-title":"Epithelium: at the interface of innate and adaptive immune responses","volume":"120","author":"Schleimer","year":"2007","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.biopha.2017.12.011_bib0030","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nri3151","article-title":"Accessory molecules for Toll-like receptors and their function","volume":"12","author":"Lee","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0035","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/alr.21159","article-title":"The bacteriology of chronic rhinosinusitis and the pre-eminence of Staphylococcus aureus in revision patients","volume":"3","author":"Cleland","year":"2013","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0040","doi-asserted-by":"crossref","first-page":"925164","DOI":"10.1155\/2012\/925164","article-title":"TLR4 and TLR9 expression in different phenotypes of rhinitis","volume":"2012","author":"Lauriello","year":"2012","journal-title":"Int. J. Otolaryngol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0045","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ceb.2016.01.006","article-title":"Lysosomal signaling in control of degradation pathways","volume":"39","author":"Huber","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0050","doi-asserted-by":"crossref","first-page":"e985913","DOI":"10.4161\/23723556.2014.985913","article-title":"Autophagy, cell death, and cancer","volume":"2","author":"Lin","year":"2015","journal-title":"Mol. Cell Oncol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.biopha.2017.12.011_bib0060","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3389\/fimmu.2016.00240","article-title":"The mucosal immune system and its regulation by autophagy","volume":"7","author":"Kabat","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0065","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1074\/jbc.M114.597492","article-title":"Autophagy enhances intestinal epithelial tight junction barrier function by targeting claudin-2 protein degradation","volume":"290","author":"Nighot","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2017.12.011_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12165","article-title":"Autophagy in the immune system","volume":"141","author":"Puleston","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.biopha.2017.12.011_bib0075","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/01902148.2013.845626","article-title":"Participation of autophagy in acute lung injury induced by seawater","volume":"39","author":"Liu","year":"2013","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.biopha.2017.12.011_bib0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/all.12761","article-title":"Autophagy in airway diseases: a new frontier in human asthma?","volume":"71","author":"Zeki","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.biopha.2017.12.011_bib0085","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1513\/pats.200906-052DP","article-title":"United airways concept: what does it teach us about systemic inflammation in airways disease?","volume":"6","author":"Braunstahl","year":"2009","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.biopha.2017.12.011_bib0090","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2017.12.011_bib0095","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.cellsig.2012.01.020","article-title":"Autophagy in regulation of Toll-like receptor signaling","volume":"24","author":"Into","year":"2012","journal-title":"Cell Signal."},{"key":"10.1016\/j.biopha.2017.12.011_bib0100","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.4161\/auto.25570","article-title":"Cutting a fine figure: on the use of thin sections in electron microscopy to quantify autophagy","volume":"9","author":"Lucocq","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.biopha.2017.12.011_bib0105","first-page":"1","article-title":"An overview of the molecular mechanism of autophagy","volume":"335","author":"Yang","year":"2009","journal-title":"Curr. Top. Microbiol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0110","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev-genet-102808-114910","article-title":"Regulation mechanisms and signaling pathways of autophagy","volume":"43","author":"He","year":"2009","journal-title":"Ann. Rev. Genet."},{"key":"10.1016\/j.biopha.2017.12.011_bib0115","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.intimp.2011.05.003","article-title":"The active contribution of Toll-like receptors to allergic airway inflammation","volume":"11","author":"Chen","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaci.2009.04.045","article-title":"Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis","volume":"124","author":"Tieu","year":"2009","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.biopha.2017.12.011_bib0130","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"Xiao","year":"2011","journal-title":"J. Allergy Clin. Immun."},{"key":"10.1016\/j.biopha.2017.12.011_bib0135","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4049\/jimmunol.178.1.463","article-title":"Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages","volume":"178","author":"Thorley","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2017.12.011_bib0140","doi-asserted-by":"crossref","first-page":"7922","DOI":"10.1073\/pnas.0501190102","article-title":"Autophagy promotes MHC class II presentation of peptides from intracellular source proteins","volume":"102","author":"Dengjel","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2017.12.011_bib0145","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1182\/blood-2004-09-3556","article-title":"Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA","volume":"105","author":"Dorfel","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2017.12.011_bib0150","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"Sanjuan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2017.12.011_bib0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.immuni.2007.05.022","article-title":"Toll-like receptor 4 is a sensor for autophagy associated with innate immunity","volume":"27","author":"Xu","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2017.12.011_bib0160","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1513\/pats.200909-103JS","article-title":"Autophagy in innate and adaptive immunity","volume":"7","author":"Xu","year":"2010","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.biopha.2017.12.011_bib0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2017.12.011_bib0170","first-page":"418","article-title":"Toll-like receptor expression and function in airway epithelial cells","volume":"53","author":"Greene","year":"2005","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.biopha.2017.12.011_bib0175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1600-065X.2010.00995.x","article-title":"Autophagy in immunity and cell-autonomous defense against intracellular microbes","volume":"240","author":"Deretic","year":"2011","journal-title":"Immunol. Rev."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217338842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217338842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:15:52Z","timestamp":1778242552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217338842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":35,"alternative-id":["S0753332217338842"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.011","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide induces autophagy by targeting the AMPK-mTOR pathway in Human Nasal Epithelial Cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}