{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:32:15Z","timestamp":1790778735923,"version":"4.1.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.biopha.2017.12.074","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T09:17:29Z","timestamp":1514366249000},"page":"424-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Adipokines in neurovascular diseases"],"prefix":"10.1016","volume":"98","author":[{"given":"Radka","family":"Opatrilova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Caprnda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kubatka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Valentova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Uramova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Nosal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovit","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Zachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Mozos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Petrovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Dragasek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavomira","family":"Filipova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"B\u00fcsselberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Zulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kruzliak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Krasnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.12.074_bib0005","series-title":"Metabolic Syndrome and Cardiovascular Disease","author":"Levine","year":"2006"},{"key":"10.1016\/j.biopha.2017.12.074_bib0010","series-title":"Nutrition and Health: Adipose Tissue and Adipokines in Health and Disease","first-page":"63","article-title":"Vasoactive factors and inflammatory mediators produced in adipose tissue","author":"Fr\u00fchbeck","year":"2007"},{"key":"10.1016\/j.biopha.2017.12.074_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1079\/PNS200194","article-title":"Physiological role of adipose tissue as an endocrine and secretory organ","volume":"60","author":"Trayhurn","year":"2001","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.biopha.2017.12.074_bib0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Horizon in nutritional science. adipokines: in\ufb02ammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.biopha.2017.12.074_bib0025","first-page":"802078","article-title":"The role of adipose tissue and adipokines in obesity-related inflammatory diseases","author":"Balistreri","year":"2010","journal-title":"Mediators Inflamm. 2010"},{"key":"10.1016\/j.biopha.2017.12.074_bib0030","series-title":"Nutrition and Health: Adipose Tissue and Adipokines in Health and Disease","first-page":"91","article-title":"Leptin in autoimmune diseases","author":"Matarese","year":"2007"},{"key":"10.1016\/j.biopha.2017.12.074_bib0035","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1161\/STROKEAHA.107.496588","article-title":"Metabolic syndrome and ischemic stroke risk. Nothern Manhattan study","volume":"39","author":"Boden-Albala","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0040","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2174\/15701611113116660176","article-title":"Metabolic syndrome and cardiometabolic risk factors","volume":"11","author":"Papakonstantinou","year":"2013","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0045","first-page":"159","article-title":"Cytokines, diabetes mellitus and psychopathology: a challenging combination","volume":"35","author":"Kontoangelos","year":"2014","journal-title":"Neuro. Endocrinol. Lett."},{"key":"10.1016\/j.biopha.2017.12.074_bib0050","first-page":"295","article-title":"The association of obesity and cerebrovascular disease in young adults. A pilot study","volume":"48","author":"Bosnar-Pureti\u010d","year":"2009","journal-title":"Acta Clin. Croat."},{"key":"10.1016\/j.biopha.2017.12.074_bib0055","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/01.STR.0000169935.35394.38","article-title":"Components of metabolic syndrome and risk for first-ever acute ischemic non embolic stroke in elderly subjects","volume":"36","author":"Millionis","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0060","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1161\/01.STR.0000075294.98582.2F","article-title":"Northern Manhattan stroke study, abdominal obesity and risk of ischemic stroke: the Northern Manhattan stroke study","volume":"34","author":"Suk","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0065","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1161\/STROKEAHA.108.523001","article-title":"Contribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacks","volume":"39","author":"Winter","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0070","doi-asserted-by":"crossref","first-page":"255762","DOI":"10.1001\/archinte.162.22.2557","article-title":"Body mass index and the risk of stroke in men","volume":"162","author":"Kurth","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/STROKEAHA.112.670331","article-title":"Adiposity, adipokines, and risk of incident stroke in older men","volume":"44","author":"Wannamethee","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0080","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/aje\/kwq311","article-title":"Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women","volume":"173","author":"Kizer","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0085","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/ijs.12016","article-title":"The obesity paradox in stroke: lower mortality and lower risk of readmission for recurrent stroke in obese stroke patients","volume":"10","author":"Andersen","year":"2015","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0090","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1097\/01.hjh.0000179511.93889.e9","article-title":"Obesity is associated with increased arterial stiffness from adolescence until old age","volume":"23","author":"Zebekakis","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.biopha.2017.12.074_bib0095","doi-asserted-by":"crossref","first-page":"E827","DOI":"10.1152\/ajpendo.2001.280.6.E827","article-title":"The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation","volume":"280","author":"Fr\u00fchbeck","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0100","series-title":"Nutrition and Health: Adipose Tissue and aDipokines in Health and Disease","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-59745-370-7_3","article-title":"Leptin","author":"Jackson","year":"2007"},{"key":"10.1016\/j.biopha.2017.12.074_bib0105","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2006-1841","article-title":"Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus","volume":"92","author":"Kos","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0110","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1471-4159.2008.05457.x","article-title":"Leptin neuroprotection in the central nervous system: mechanism and therapeutic potentials","volume":"106","author":"Signore","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2017.12.074_bib0115","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.maturitas.2011.09.002","article-title":"Adipokines and stroke: a review of the literature","volume":"70","author":"Savopoulos","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.biopha.2017.12.074_bib0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2796.2000.00600.x","article-title":"Cortisol axis abnormalities early after stroke - relationships to cytokines and leptin","volume":"247","author":"Johansson","year":"2000","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0125","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2337\/diabetes.48.4.903","article-title":"Pivotal role of nitric oxide in the control of blood pressure following leptin administration","volume":"48","author":"Fr\u00fchbeck","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2017.12.074_bib0130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijcard.2011.07.047","article-title":"The role of adiponectine in human vascular physiology","volume":"155","author":"Vaiopoulos","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fendo.2017.00045","article-title":"Leptin resistance and the neuro-adipose connection","volume":"8","author":"Barateiro","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.biopha.2017.12.074_bib0140","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jacc.2008.05.060","volume":"52","author":"Martin","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0145","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12481","article-title":"Temporal and regional onset of leptin resistance in diet-induced obese mice","author":"Rizwan","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0150","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jne.12131","article-title":"High-fat diet induces leptin resistance in leptin-deficient mice","volume":"26","author":"Koch","year":"2014","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0155","doi-asserted-by":"crossref","DOI":"10.7243\/2050-0866-2-2","article-title":"Blood biomarkers of insulin resistance in acute stroke patients treated with intravenous thrombolysis: temporal profile and prognostic value","author":"Calleja","year":"2013","journal-title":"J. Diabetes. Res. Clin. Metabol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0160","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.amjcard.2007.02.088","article-title":"Relation of increased leptin concentration to history of myocardial infarction and stroke in the US population","volume":"100","author":"Sierra-Johnson","year":"2007","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2265.2009.03627.x","article-title":"Leptinemia and its assotiation with stroke and coronary heart disease in the Jackson heart study","volume":"72","author":"Liu","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fpubh.2013.00016","article-title":"Associations of adiponectin and leptin with incident coronary heart disease and ischemic stroke in African Americans: the Jackson heart study","volume":"1","author":"Bidulescu","year":"2013","journal-title":"Front. Public. Health"},{"key":"10.1016\/j.biopha.2017.12.074_bib0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2796.2004.01351.x","article-title":"Leptin, but not adiponectin, predicts stroke in males","volume":"256","author":"S\u00f6derberg","year":"2004","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0180","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/STROKEAHA.110.607853","article-title":"Resistin, but not adiponectin and leptin, is associated with the risk of ischemic stroke among postmenopausal women: results rrom the women's health initiative","volume":"42","author":"Rajpathak","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0185","first-page":"716","article-title":"Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke","volume":"32","author":"Kantorova","year":"2011","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.biopha.2017.12.074_bib0190","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ajh.2010.8","article-title":"Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness","volume":"23","author":"Windham","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.biopha.2017.12.074_bib0195","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/STROKEAHA.107.485540","article-title":"Leptin: adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery","volume":"38","author":"Norata","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0200","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/STROKEAHA.111.641761","article-title":"Adiponectin and carotid intima-media thickness in the Northern Manhattan study","volume":"43","author":"Gardener","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0205","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1161\/STROKEAHA.107.482786","article-title":"Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia","volume":"38","author":"Zhang","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0210","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI0215693","article-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","volume":"110","author":"Farooqi","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2017.12.074_bib0215","first-page":"174341","article-title":"Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells","author":"Anfossi","year":"2010","journal-title":"Mediators Inflamm. 2010"},{"key":"10.1016\/j.biopha.2017.12.074_bib0220","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0953-6205(03)90001-X","article-title":"Fenofibrate treatment is associated with better glycemic control and lower serum leptin and insulin leveles in type 2 diabetic patients wih hyper TAG","volume":"14","author":"Damci","year":"2003","journal-title":"Eur. J. Intern. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0225","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1161\/CIRCULATIONAHA.107.725044","article-title":"Adiponectin prevents cerebral ischemic injury through endotelial nitric oxide synthase-dependent mechanisms","volume":"117","author":"Nishimura","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2017.12.074_bib0230","series-title":"Nutrition and Health: Adipose Tissue and Adipokines in Health and Disease","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-59745-370-7_4","article-title":"Adiponectine","author":"Xu","year":"2007"},{"key":"10.1016\/j.biopha.2017.12.074_bib0235","doi-asserted-by":"crossref","first-page":"e1321","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2017.12.074_bib0240","doi-asserted-by":"crossref","first-page":"E965","DOI":"10.1152\/ajpendo.00119.2007","article-title":"Detection of adiponetin in cerebrospinal fluid in humans","volume":"239","author":"Neumeier","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0245","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2337\/diabetes.55.01.06.db05-1077","article-title":"Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells","volume":"55","author":"Spranger","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2017.12.074_bib0250","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1212\/01.wnl.0000263186.20988.9f","article-title":"Adiponectin levels in patients with intracranial atherosclerosis","volume":"68","author":"Bang","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.biopha.2017.12.074_bib0255","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1210\/jc.2005-2775","article-title":"Effects of obesity, body composition, and adiponectin on carotid intima-media thickness in healthy women","volume":"91","author":"Lo","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0260","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.10.045","article-title":"Adiponectin gene polymorphism and ischemic stroke subtypes in a Chinese Population","volume":"26","author":"Li","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.biopha.2017.12.074_bib0265","doi-asserted-by":"crossref","first-page":"31945","DOI":"10.1038\/srep31945","article-title":"Association of adiponectin polymorphism with metabolic syndrome risk and adiponectin level with stroke risk: a meta-analysis","volume":"6","author":"Yuan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2017.12.074_bib0270","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/STROKEAHA.109.576546","article-title":"High-molecular-weight adiponectin and incident ischemic stroke in postmenopausal women a women\u2019s health initiative study","volume":"41","author":"Ogorodnikova","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0275","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/1354750X.2016.1201539","article-title":"Ratios of leptin to insulin and adiponectin to endothelin are sex-dependently associated with extent of coronary atherosclerosis","volume":"22","author":"Gumanova","year":"2017","journal-title":"Biomarkers"},{"key":"10.1016\/j.biopha.2017.12.074_bib0280","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.metabol.2017.01.002","article-title":"Circulating adiponectin levels in relation to carotid atherosclerotic plaque presence, ischemic stroke risk, and mortality: a systematic review and meta-analyses","volume":"69","author":"Gorgui","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.biopha.2017.12.074_bib0285","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/ije\/dyn215","article-title":"Adipocytokines and risk of stroke in older people: a nested case-case control study","volume":"38","author":"Stott","year":"2008","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0290","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1161\/01.STR.0000177874.29849.f0","article-title":"Plasma adiponectin levels and five-year survival after first-ever ischemic stroke","volume":"35","author":"Efstathiou","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0295","first-page":"908901","article-title":"Total adiponectin is inversely associated with platelet activation and CHA2-DS2-VASc-score in anticoagulated patients with atrial fibrillation","author":"Carnevale","year":"2014","journal-title":"Mediators Inflamm. 2014"},{"key":"10.1016\/j.biopha.2017.12.074_bib0300","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/dom.12180","article-title":"Observational follow-up of the PROactive study: a 6-year update","volume":"16","author":"Erdmann","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0305","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1506930","article-title":"IRIS trial investigators. Pioglitazone after ischemic stroke or transient ischemic attack","volume":"374","author":"Kernan","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0310","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MOL.0000000000000431","article-title":"Adiponectin, lipids and atherosclerosis","volume":"28","author":"Katsiki","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"issue":"304","key":"10.1016\/j.biopha.2017.12.074_bib0315","article-title":"Adipokines, diabetes and atherosclerosis: an inflammatory association","volume":"6","author":"Freitas Lima","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0320","doi-asserted-by":"crossref","first-page":"e6622","DOI":"10.1097\/MD.0000000000006622","article-title":"Serum resistin positively correlates with serum lipids, but not with insulin resistance, in first-degree relatives of type-2 diabetes patients: an observational study in China","volume":"96","author":"Niu","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.biopha.2017.12.074_bib0325","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3904\/kjim.2016.229","article-title":"Linking resistin, inflammation, and cardiometabolic diseases","volume":"32","author":"Park","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0330","doi-asserted-by":"crossref","first-page":"41529","DOI":"10.18632\/oncotarget.17561","article-title":"Association between serum resistin concentration and hypertension: a systematic review and meta-analysis","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2017.12.074_bib0335","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/1354750X.2016.1252953","article-title":"Resistin may be an independent predictor of subclinical atherosclerosis formale smokers","volume":"22","author":"He","year":"2017","journal-title":"Biomarkers"},{"key":"10.1016\/j.biopha.2017.12.074_bib0340","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2017.02.021","article-title":"PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages","volume":"259","author":"Zuniga","year":"2017","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.biopha.2017.12.074_bib0345","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2016.08.015","article-title":"PKC\u03b5 mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia","volume":"253","author":"Raghuraman","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2017.12.074_bib0350","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0355","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s12035-016-9751-3","article-title":"Serum resistin levels may contribute to an increased risk of acute cerebral infarction","volume":"54","author":"Dong","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0360","first-page":"603","article-title":"Resistin levels in women with ischemic stroke","volume":"33","author":"Kochanowski","year":"2012","journal-title":"Neuroendocrinol. Lett."},{"key":"10.1016\/j.biopha.2017.12.074_bib0365","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.bbadis.2016.11.007","article-title":"Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases","volume":"1863","author":"Zhong","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2017.12.074_bib0370","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2014.03.037","article-title":"Apelin-13 protects the brain against ischemia\/reperfusion injury through activating PI3K\/Akt and ERK1\/2 signaling pathways","volume":"568","author":"Yang","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2017.12.074_bib0375","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.peptides.2015.11.002","article-title":"Apelin-13 protects against apoptosis by activating AMP-activated protein kinase pathway in ischemia stroke","volume":"75","author":"Yang","year":"2016","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2017.12.074_bib0380","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/abbs\/gmx038","article-title":"Apelin-13 inhibits lipoprotein lipase expression via the APJ\/PKC\u03b1\/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells","volume":"49","author":"Zhang","year":"2017","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.biopha.2017.12.074_bib0385","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ncprheum0674","article-title":"Adipokines as emerging mediators of immune response and inflammation","volume":"12","author":"Lago","year":"2007","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0390","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biocel.2015.10.015","article-title":"Apelin induces vascular smooth muscle cells migration via a PI3K\/Akt\/FoxO3a\/MMP-2 pathway","volume":"69","author":"Wang","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0395","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.atherosclerosis.2016.11.024","article-title":"Apelin concentrations are associated with altered atherosclerotic plaque stability mediator levels and atherosclerosis in rheumatoid arthritis","volume":"256","author":"Gunter","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2017.12.074_bib0400","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/cen.12404","article-title":"Circulating apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control","volume":"81","author":"Habchi","year":"2014","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.biopha.2017.12.074_bib0405","first-page":"99","article-title":"Relationship of vaspin and apelin levels with insulin resistance and atherosclerosis in metabolic syndrome","volume":"39","author":"Karbek","year":"2014","journal-title":"Minerva. Endocrinol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0410","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/HYPERTENSIONAHA.116.08916","article-title":"Beneficial effects of apelin on vascular function in patients with central obesity","volume":"69","author":"Schinzari","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.biopha.2017.12.074_bib0415","doi-asserted-by":"crossref","first-page":"e57231","DOI":"10.1371\/journal.pone.0057231","article-title":"Apelin ameliorates TNF-\u03b1-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ","volume":"8","author":"Chu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2017.12.074_bib0420","first-page":"70","article-title":"Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease","volume":"22","author":"Montazerifar","year":"2017","journal-title":"J. Res. Med. Sci."},{"key":"10.1016\/j.biopha.2017.12.074_bib0425","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.peptides.2014.04.008","article-title":"Serum level of novel adipokines in patients with ischemic stroke: potential contribution to diagnosis and prognosis","volume":"57","author":"Kadoglou","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2017.12.074_bib0430","doi-asserted-by":"crossref","first-page":"e2705","DOI":"10.1038\/cddis.2017.132","article-title":"Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2017.12.074_bib0435","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.tips.2015.08.012","article-title":"NAMPT as a therapeutic target against stroke","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2017.12.074_bib0440","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2017.tb00757.x","article-title":"Regulation and function of extracellular nicotinamide phosphoribosyltransferase\/visfatin","volume":"7","author":"Carbone","year":"2017","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.biopha.2017.12.074_bib0445","first-page":"001","article-title":"Is there a relationship between visfatin level and type 2 diabetes mellitus in obese and non obese patients?","volume":"S11","author":"El-Shafey","year":"2012","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0450","first-page":"4965","article-title":"Nicotinamide phosphoribosyltransferase enhances beta cell expansion during pregnancy","volume":"20","author":"Feng","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2017.12.074_bib0455","doi-asserted-by":"crossref","first-page":"23427","DOI":"10.18632\/oncotarget.15080","article-title":"Elevated serum visfatin levels are associated with poor prognosis of hepatocellular carcinoma","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2017.12.074_bib0460","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00774-015-0728-5","article-title":"Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia","volume":"35","author":"Siviero-Miachon","year":"2017","journal-title":"J. Bone Min.. Metab."},{"key":"10.1016\/j.biopha.2017.12.074_bib0465","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/00365513.2016.1230884","article-title":"The relationship between circulating visfatin\/nicotinamide phosphoribosyltransferase, obesity, inflammation and lipids profile in elderly population, determined by structural equation modelling","volume":"76","author":"Owczarek","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.biopha.2017.12.074_bib0470","first-page":"688","article-title":"Elevated serum visfatin levels in patients with acute myocardial infarction","volume":"15","author":"Mazaherioun","year":"2012","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.biopha.2017.12.074_bib0475","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.peptides.2013.01.005","article-title":"Prognostic significance of plasma visfatin level in acute ischemic stroke","volume":"42","author":"Yin","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2017.12.074_bib0480","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1161\/STROKEAHA.115.009216","article-title":"Regenerative neurogenesis after ischemic stroke promoted by nicotinamide phosphoribosyltransferase-nicotinamide adenine dinucleotide cascade","volume":"46","author":"Zhao","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2017.12.074_bib0485","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/cns.12576","article-title":"Neuroprotective efficacy of an aminopropyl carbazole derivative P7C3-A20 in ischemic stroke","volume":"22","author":"Wang","year":"2016","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.biopha.2017.12.074_bib0490","doi-asserted-by":"crossref","first-page":"32416","DOI":"10.1038\/srep32416","article-title":"Pre-B-cell colony-enhancing factor protects against apoptotic neuronal death and mitochondrial damage in ischemia","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2017.12.074_bib0495","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/cns.12388","article-title":"Nicotinamide phosphoribosyltransferase facilitates post-stroke angiogenesis","volume":"21","author":"Wang","year":"2015","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.biopha.2017.12.074_bib0500","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.2174\/1568026615666150610142234","article-title":"The role of nicotinamide phosphoribosyltransferase in cerebral ischemia","volume":"15","author":"Chen","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.biopha.2017.12.074_bib0505","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cyto.2016.12.027","article-title":"The role of Visfatin in atherosclerotic peripheral arterial obstructive disease","volume":"91","author":"Pitoulias","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.biopha.2017.12.074_bib0510","doi-asserted-by":"crossref","first-page":"748","DOI":"10.3945\/an.115.008292","article-title":"Retinol binding protein 4 in relation to diet, inflammation, immunity, and cardiovascular diseases","volume":"6","author":"Zabetian-Targhi","year":"2015","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.biopha.2017.12.074_bib0515","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1038\/nutd.2015.33","article-title":"Omentin-1 plasma levels and cholesterol metabolism in obese patients with diabetes mellitus type 1: impact of weight reduction","volume":"5","author":"Lesn\u00e1","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.biopha.2017.12.074_bib0520","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.atherosclerosis.2016.06.003","article-title":"Omentin-1 and risk of myocardial infarction and stroke: results from the EPIC-Potsdam cohort study","volume":"251","author":"Menzel","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biopha.2017.12.074_bib0525","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.atherosclerosis.2014.05.957","article-title":"The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability","volume":"235","author":"Kadoglou","year":"2014","journal-title":"Atherosclerosis"},{"issue":"July (14)","key":"10.1016\/j.biopha.2017.12.074_bib0530","article-title":"Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients","author":"Xu","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"issue":"17","key":"10.1016\/j.biopha.2017.12.074_bib0535","first-page":"30413","article-title":"Plasma retinol-binding protein 4 levels and the risk of ischemic stroke among women","volume":"S1052\u2013S3057","author":"Rist","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.biopha.2017.12.074_bib0540","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/jnc.13419","article-title":"Plasmatic retinol-binding protein 4 and glial fibrillary acidic protein as biomarkers to differentiate ischemic stroke and intracerebral hemorrhage","volume":"136","author":"Llombart","year":"2016","journal-title":"J. Neurochem."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217342415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217342415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:23:45Z","timestamp":1760095425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217342415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":108,"alternative-id":["S0753332217342415"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.074","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adipokines in neurovascular diseases","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}