{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T19:30:07Z","timestamp":1776972607231,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008410","name":"Shanghai Municipal Population and Family Planning Commission","doi-asserted-by":"publisher","award":["201540078"],"award-info":[{"award-number":["201540078"]}],"id":[{"id":"10.13039\/501100008410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010842","name":"Guangzhou Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","award":["ME201202"],"award-info":[{"award-number":["ME201202"]}],"id":[{"id":"10.13039\/501100010842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81100048"],"award-info":[{"award-number":["81100048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201829"],"award-info":[{"award-number":["81201829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.biopha.2017.12.100","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T14:22:23Z","timestamp":1515075743000},"page":"754-761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Curcumin ameliorated ventilator-induced lung injury in rats"],"prefix":"10.1016","volume":"98","author":[{"given":"Xun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxue","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2017.12.100_bib0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.biopha.2016.05.025","article-title":"Tetrahydroberberrubine attenuates lipopolysaccharide-induced acute lung injury by down-regulating MAPK, AKT, and NF-kappaB signaling pathways","volume":"82","author":"Yu","year":"2016","journal-title":"Biomed. Pharmacother.=Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2017.12.100_bib0010","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1213\/ANE.0b013e31824762f0","article-title":"The volatile anesthetic isoflurane prevents ventilator-induced lung injury via phosphoinositide 3-kinase\/Akt signaling in mice","volume":"114","author":"Faller","year":"2012","journal-title":"Anesthesia & Analgesia"},{"key":"10.1016\/j.biopha.2017.12.100_bib0015","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/CCM.0b013e3181d56fae","article-title":"Use of intensive care, mechanical ventilation, both, or neither by patients with acute lung injury","volume":"38","author":"Cely","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.biopha.2017.12.100_bib0020","doi-asserted-by":"crossref","first-page":"L847","DOI":"10.1152\/ajplung.00193.2015","article-title":"Exposure to mechanical ventilation promotes tolerance to ventilator-induced lung injury by Ccl3 downregulation","volume":"309","author":"Blazquez-Prieto","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0025","doi-asserted-by":"crossref","first-page":"L259","DOI":"10.1152\/ajplung.00323.2014","article-title":"Differential and opposing effects of imatinib on LPS- and ventilator-induced lung injury","volume":"308","author":"Letsiou","year":"2015","journal-title":"Am. J. Physiol Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0030","doi-asserted-by":"crossref","first-page":"e57374","DOI":"10.1371\/journal.pone.0057374","article-title":"Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a Murine model of ventilator\u2013induced lung injury","volume":"8","author":"Hegeman","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2017.12.100_bib0035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bpa.2015.08.004","article-title":"Mechanisms of ventilator-induced lung injury in healthy lungs","volume":"29","author":"Silva","year":"2015","journal-title":"Best Pract. Res. Clin.Anaesthesiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0040","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.chest.2016.07.019","article-title":"Biotrauma and ventilator-induced lung injury: clinical implications","volume":"150","author":"Curley","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.biopha.2017.12.100_bib0045","first-page":"23","article-title":"Organ crosstalk during acute lung injury, acute respiratory distress syndrome, and mechanical ventilation","volume":"18","author":"Quilez","year":"2012","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.biopha.2017.12.100_bib0050","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12931-015-0275-6","article-title":"Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury","volume":"16","author":"Li","year":"2015","journal-title":"Respir. Res."},{"key":"10.1016\/j.biopha.2017.12.100_bib0055","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1165\/rcmb.2006-0131OC","article-title":"EGFR-activated signaling and actin remodeling regulate cyclic stretch\u2013induced NRF2-ARE activation","volume":"36","author":"Papaiahgari","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0060","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.injury.2011.12.026","article-title":"N-acetylcysteine attenuates ventilator-induced lung injury in an isolated and perfused rat lung model","volume":"43","author":"Chiang","year":"2012","journal-title":"Injury"},{"key":"10.1016\/j.biopha.2017.12.100_bib0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejmech.2014.01.041","article-title":"Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents","volume":"75","author":"Samaan","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2017.12.100_bib0070","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/0748233711430984","article-title":"Protective effect of curcumin on acute lung injury induced by intestinal ischaemia\/reperfusion","volume":"29","author":"Guzel","year":"2013","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.biopha.2017.12.100_bib0075","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1183\/09031936.00142407","article-title":"Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats","volume":"33","author":"Sun","year":"2009","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.biopha.2017.12.100_bib0080","doi-asserted-by":"crossref","first-page":"e93820","DOI":"10.1371\/journal.pone.0093820","article-title":"Study to evaluate molecular mechanics behind synergistic chemo-preventive effects of curcumin and resveratrol during lung carcinogenesis","volume":"9","author":"Malhotra","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.biopha.2017.12.100_bib0085","first-page":"969","article-title":"A study on the role of apoptotic human umbilical cord mesenchymal stem cells in bleomycin-induced acute lung injury in rat models","volume":"20","author":"Liu","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2017.12.100_bib0090","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/CCM.0b013e31816a06fc","article-title":"Preventive effects of curcumin and dexamethasone on lung transplantation-associated lung injury in rats","volume":"36","author":"Sun","year":"2008","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.biopha.2017.12.100_bib0095","first-page":"147","article-title":"Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade","volume":"63","author":"Frank","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.biopha.2017.12.100_bib0100","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s10439-010-0237-6","article-title":"Quantifying the roles of tidal volume and PEEP in the pathogenesis of ventilator-induced lung injury","volume":"39","author":"Seah","year":"2011","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.biopha.2017.12.100_bib0105","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1164\/ajrccm.163.5.2006053","article-title":"Production of inflammatory cytokines in ventilator-induced lung injury: a reappraisal","volume":"163","author":"Ricard","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biopha.2017.12.100_bib0110","doi-asserted-by":"crossref","first-page":"R234","DOI":"10.1186\/cc9389","article-title":"Hydrogen inhalation ameliorates ventilator-induced lung injury","volume":"14","author":"Huang","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.biopha.2017.12.100_bib0115","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1164\/rccm.200210-1216OC","article-title":"Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury","volume":"167","author":"Choi","year":"2003","journal-title":"Am. J. Resp. Crit. Care Med."},{"key":"10.1016\/j.biopha.2017.12.100_bib0120","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.4049\/jimmunol.1301589","article-title":"Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation","volume":"192","author":"Yoo","year":"2014","journal-title":"J. Immunol. (Baltim. Md. : 1950)"},{"key":"10.1016\/j.biopha.2017.12.100_bib0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/imr.12308","article-title":"Roles of linear ubiquitinylation, a crucial regulator of NF-kappaB and cell death, in the immune system","volume":"266","author":"Sasaki","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biopha.2017.12.100_bib0130","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1378\/chest.10-3100","article-title":"Pre-B-cell colony-enhancing factor and its clinical correlates with acute lung injury and sepsis","volume":"140","author":"Lee","year":"2011","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.biopha.2017.12.100_bib0135","doi-asserted-by":"crossref","first-page":"L297","DOI":"10.1152\/ajplung.00305.2016","article-title":"Dysregulated Nox4 ubiquitination contributes to redox imbalance and age-related severity of acute lung injury","volume":"312","author":"Palumbo","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0140","doi-asserted-by":"crossref","first-page":"L345","DOI":"10.1152\/ajplung.00453.2005","article-title":"Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways","volume":"291","author":"Abdulnour","year":"2006","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0145","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1043-6618(02)00123-8","article-title":"Protective effects of curcumin against \/reperfusion insult in rat forebrain","volume":"46","author":"Ghoneim","year":"2002","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2017.12.100_bib0150","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.4049\/jimmunol.153.4.1789","article-title":"Xanthine dehydrogenase and xanthine oxidase activity and gene expression in renal epithelial cells. Cytokine and steroid regulation","volume":"153","author":"Pfeffer","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0155","doi-asserted-by":"crossref","first-page":"L616","DOI":"10.1152\/ajplung.00002.2009","article-title":"Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury","volume":"298","author":"Smith","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biopha.2017.12.100_bib0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1043-6618(02)00130-5","article-title":"The effects of dexamethasone on lipid peroxidation and nitric oxide levels on the healing of tracheal anastomoses: an experimental study in rats","volume":"46","author":"Talas","year":"2002","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2017.12.100_bib0165","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/01.CCM.0000205663.92384.E7","article-title":"Ventilation-induced lung injury in rats is associated with organ injury and systemic inflammation that is attenuated by dexamethasone","volume":"34","author":"Nin","year":"2006","journal-title":"Crit. Care Med."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217351466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217351466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:32:07Z","timestamp":1760095927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217351466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":33,"alternative-id":["S0753332217351466"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.100","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin ameliorated ventilator-induced lung injury in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2017.12.100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}