{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:58:35Z","timestamp":1778731115984,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T00:00:00Z","timestamp":1546646400000},"content-version":"am","delay-in-days":338,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201549"],"award-info":[{"award-number":["81201549"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["XJTU1AF-CRF-2015-011"],"award-info":[{"award-number":["XJTU1AF-CRF-2015-011"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2016qngz05"],"award-info":[{"award-number":["2016qngz05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","award":["2017QN-13"],"award-info":[{"award-number":["2017QN-13"]}],"id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2017JM8039"],"award-info":[{"award-number":["2017JM8039"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.biopha.2018.01.013","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:26:32Z","timestamp":1515111992000},"page":"783-792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma"],"prefix":"10.1016","volume":"98","author":[{"given":"Benji","family":"Lv","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianhai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runchen","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunbin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biopha.2018.01.013_bib0005","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/mpo.10171","article-title":"Hepatoblastoma: assessment of criteria for histologic classification","volume":"39","author":"Rowland","year":"2002","journal-title":"Med. Pediatr. Oncol."},{"issue":"2","key":"10.1016\/j.biopha.2018.01.013_bib0010","first-page":"136","article-title":"Hepatoblastoma","volume":"11","author":"Stocker","year":"1994","journal-title":"Semin. Diagn. Pathol."},{"issue":"10","key":"10.1016\/j.biopha.2018.01.013_bib0015","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.ejca.2011.12.011","article-title":"Prognostic stratification for children with hepatoblastoma: the SIOPEL experience","volume":"48","author":"Maibach","year":"2012","journal-title":"Eur. J. Cancer"},{"issue":"6","key":"10.1016\/j.biopha.2018.01.013_bib0020","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1200\/JCO.2005.07.145","article-title":"Predictive value of the pretreatment extent of disease system in hepatoblastoma: results from the international society of pediatric oncology liver tumor study group SIOPEL-1 study","volume":"23","author":"Aronson","year":"2005","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.013_bib0025","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccr.2008.11.002","article-title":"Hepatic stem-like phenotype and interplay of Wnt\/beta-catenin and Myc signaling in aggressive childhood liver cancer","volume":"14","author":"Cairo","year":"2008","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.28888","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","volume":"65","author":"Sumazin","year":"2017","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.biopha.2018.01.013_bib0035","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-017-0572-9","article-title":"An immune-related six-lncRNA signature to improve prognosis prediction of glioblastoma multiforme","author":"Zhou","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12943-017-0580-4","article-title":"Discovery and validation of immune-associated long non-coding RNA biomarkers associated with clinically molecular subtype and prognosis in diffuse large B cell lymphoma","volume":"16","author":"Zhou","year":"2017","journal-title":"Mol. Cancer"},{"issue":"35","key":"10.1016\/j.biopha.2018.01.013_bib0045","doi-asserted-by":"crossref","first-page":"56383","DOI":"10.18632\/oncotarget.10891","article-title":"Construction and analysis of dysregulated lncRNA-associated ceRNA network identified novel lncRNA biomarkers for early diagnosis of human pancreatic cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"issue":"22","key":"10.1016\/j.biopha.2018.01.013_bib0050","doi-asserted-by":"crossref","first-page":"32433","DOI":"10.18632\/oncotarget.8653","article-title":"Comprehensive analysis of lncRNA expression profiles reveals a novel lncRNA signature to discriminate nonequivalent outcomes in patients with ovarian cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biopha.2018.01.013_bib0055","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.3192","article-title":"The landscape of long noncoding RNAs in the human transcriptome","volume":"47","author":"Iyer","year":"2015","journal-title":"Nat. Genet."},{"issue":"28","key":"10.1016\/j.biopha.2018.01.013_bib0060","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.01.013_bib0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"issue":"5","key":"10.1016\/j.biopha.2018.01.013_bib0070","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4161\/epi.6.5.15221","article-title":"RNA templating the epigenome: long noncoding RNAs as molecular scaffolds","volume":"6","author":"Spitale","year":"2011","journal-title":"Epigenetics"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2012.06.004","article-title":"Long non-coding RNA expression profiles predict clinical phenotypes in glioma","volume":"48","author":"Zhang","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.biopha.2018.01.013_bib0080","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11684-016-0440-4","article-title":"Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis","volume":"10","author":"Xu","year":"2016","journal-title":"Front. Med."},{"issue":"10","key":"10.1016\/j.biopha.2018.01.013_bib0085","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/cgt.2014.49","article-title":"Screening genes crucial for pediatric pilocytic astrocytoma using weighted gene coexpression network analysis combined with methylation data analysis","volume":"21","author":"Zhao","year":"2014","journal-title":"Cancer Gene Ther."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0090","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.canlet.2015.08.004","article-title":"Toll-like receptor-4 is a target for suppression of proliferation and chemoresistance in HepG2 hepatoblastoma cells","volume":"368","author":"Hsiao","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.canlet.2012.12.008","article-title":"Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma","volume":"331","author":"Qu","year":"2013","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.biopha.2018.01.013_bib0100","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/pbc.24214","article-title":"Current issues and controversies in the classification of pediatric hepatocellular tumors","volume":"59","author":"Lopez-Terrada","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"issue":"5","key":"10.1016\/j.biopha.2018.01.013_bib0105","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.013_bib0110","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"issue":"15","key":"10.1016\/j.biopha.2018.01.013_bib0115","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1158\/0008-5472.CAN-16-2634","article-title":"Long noncoding RNA and cancer: a new paradigm","volume":"77","author":"Bhan","year":"2017","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.013_bib0120","doi-asserted-by":"crossref","first-page":"e2278","DOI":"10.1038\/cddis.2016.143","article-title":"Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma","volume":"7","author":"Dong","year":"2016","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0125","doi-asserted-by":"crossref","first-page":"e85599","DOI":"10.1371\/journal.pone.0085599","article-title":"Genome-wide analysis of long noncoding RNA (lncRNA) expression in hepatoblastoma tissues","volume":"9","author":"Dong","year":"2014","journal-title":"PloS one"},{"issue":"26","key":"10.1016\/j.biopha.2018.01.013_bib0130","doi-asserted-by":"crossref","first-page":"42087","DOI":"10.18632\/oncotarget.14992","article-title":"Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma","volume":"8","author":"Dong","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.biopha.2018.01.013_bib0135","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.celrep.2016.12.066","article-title":"Primary cell culture of live neurosurgically resected aged adult human brain cells and single cell transcriptomics","volume":"18","author":"Spaethling","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.013_bib0140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/jnc.13255","article-title":"Identification of long noncoding RNAs dysregulated in the midbrain of human cocaine abusers","volume":"135","author":"Bannon","year":"2015","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.biopha.2018.01.013_bib0145","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.gene.2016.07.002","article-title":"Co-expression networks revealed potential core lncRNAs in the triple-negative breast cancer","volume":"591","author":"Yang","year":"2016","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.biopha.2018.01.013_bib0150","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/j.gastro.2014.05.004","article-title":"Activation of beta-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice","volume":"147","author":"Tao","year":"2014","journal-title":"Gastroenterology"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217351247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217351247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:32:35Z","timestamp":1760095955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217351247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":30,"alternative-id":["S0753332217351247"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.013","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}