{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:03:08Z","timestamp":1783641788398,"version":"3.55.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.biopha.2018.01.042","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T05:29:39Z","timestamp":1515475779000},"page":"96-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia"],"prefix":"10.1016","volume":"99","author":[{"given":"Kunpeng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyong","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.01.042_bib0005","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1182\/blood-2011-07-363333","article-title":"Lack of clarity in the definition of treatment-related mortality: pediatric acute leukemia and adult acute promyelocytic leukemia as examples","volume":"118","author":"Ethier","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.01.042_bib0010","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biopha.2017.10.100","article-title":"Immunotherapy for acute myeloid leukemia (AML): a potent alternative therapy","volume":"97","author":"Acheampong","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.01.042_bib0015","first-page":"16","article-title":"In vitro antiproliferative activity of saffron extracts against human acute lymphoblastic T-cell human leukemia","volume":"15","author":"Makhlouf","year":"2016","journal-title":"Indian J. Trad. Knowl."},{"key":"10.1016\/j.biopha.2018.01.042_bib0020","first-page":"675","article-title":"DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from Kashmiri Saffron in a human pancreatic cancer cell line, Asian Pac","volume":"11","author":"Bakshi","year":"2010","journal-title":"J. Cancer Prev."},{"key":"10.1016\/j.biopha.2018.01.042_bib0025","doi-asserted-by":"crossref","first-page":"690164","DOI":"10.1155\/2013\/690164","article-title":"Crocin exhibits antitumor effects on human Leukemia HL-60 cells in vitro and in vivo","volume":"2013","author":"Sun","year":"2013","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.01.042_bib0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.biopha.2017.03.072","article-title":"Antioxidant and selective anticancer activities of two Euphorbia species in human acute myeloid leukemia","volume":"90","author":"Ben Jannet","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.01.042_bib0035","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.biopha.2017.05.109","article-title":"Cafestol, a diterpene molecule found in coffee, induces leukemia cell death","volume":"92","author":"Lima","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.01.042_bib0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1191\/0960327106ht589oa","article-title":"Protective effect of saffron (Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice","volume":"25","author":"Premkumar","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biopha.2018.01.042_bib0045","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/ars.2007.1740","article-title":"Cancer chemoprevention through dietary antioxidants: progress and promise","volume":"10","author":"Khan","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2018.01.042_bib0050","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantization of low levels of DNA damage in individual cells","volume":"175","author":"Singh","year":"1998","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.biopha.2018.01.042_bib0055","first-page":"1731","article-title":"Intracellular metabolism of Ara-C and resulting DNA fragmentation and apoptosis of human AML HL-60 cells possessing disparate levels of Bcl-2 protein","volume":"10","author":"Bullock","year":"1996","journal-title":"Leukemia"},{"key":"10.1016\/j.biopha.2018.01.042_bib0060","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0748233711420471","article-title":"The protective role of ascorbic acid on imazalil-induced genetic damage assessed by the cytogenetic tests","volume":"28","author":"T\u00fcrkez","year":"2012","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.biopha.2018.01.042_bib0065","first-page":"51","article-title":"Effect of saffron on thymocyte proliferation, intracellular glutathione levels and its antitumor activity","volume":"4","author":"Nair","year":"1992","journal-title":"Biofactors"},{"key":"10.1016\/j.biopha.2018.01.042_bib0070","first-page":"419","article-title":"Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents, crocin and safranal","volume":"5","author":"Hosseinzadeh","year":"2009","journal-title":"Pharmacogn. Mag."},{"key":"10.1016\/j.biopha.2018.01.042_bib0075","first-page":"71","article-title":"Crocin improves damage induced by nicotine on A number of reproductive parameters in male mice","volume":"10","author":"Salahshoor","year":"2016","journal-title":"Int. J. Fertil. Steril."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221736626X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221736626X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:17:32Z","timestamp":1781590652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221736626X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":15,"alternative-id":["S075333221736626X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.042","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}