{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:54:09Z","timestamp":1781592849697,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.biopha.2018.01.101","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T10:33:33Z","timestamp":1519382013000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Centaurea albonitens extract enhances the therapeutic effects of Vincristine in leukemic cells by inducing apoptosis"],"prefix":"10.1016","volume":"99","author":[{"given":"Forouzan","family":"Bahmani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Esmaeili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davood","family":"Bashash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Dehghan-Nayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pargol","family":"Mashati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Gharehbaghian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.01.101_bib0005","series-title":"Seminars in Oncology Nursing","first-page":"6","article-title":"Paclitaxel (TAXOL\u00ae): side effects and patient education issues","author":"Walker","year":"1993"},{"issue":"5","key":"10.1016\/j.biopha.2018.01.101_bib0010","first-page":"341","article-title":"Therapeutic results and toxic side effects of the combination cytostasan, adriamycin and vincristine as second-line therapy of metastatic breast cancer","volume":"59","author":"Brockmann","year":"1989","journal-title":"Archiv fur Geschwulstforschung"},{"issue":"9","key":"10.1016\/j.biopha.2018.01.101_bib0015","first-page":"637","article-title":"Comparison of side effects caused by intra-arterial and intravenous infusion of M-VAC (methotrexate, vinblastine, adriamycin and cisplatin) for urothelial cancer, Hinyokika kiyo","volume":"43","author":"Uchida","year":"1997","journal-title":"Acta Urologica Japonica"},{"issue":"33","key":"10.1016\/j.biopha.2018.01.101_bib0020","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1200\/JCO.2004.00.6817","article-title":"Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma","volume":"23","author":"Au","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.101_bib0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/00365599.2011.560577","article-title":"Side-effects of post-treatment biopsies in prostate cancer patients treated with endocrine therapy alone or combined with radical radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial","volume":"45","author":"Solberg","year":"2011","journal-title":"Scand. J. Urol. Nephrol."},{"key":"10.1016\/j.biopha.2018.01.101_bib0030","first-page":"411","article-title":"Side effects of radiotherapy in lung cancer and their treatment, Nihon rinsho","volume":"60","author":"Naka","year":"2002","journal-title":"Jpn. J. Clin. Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.01.101_bib0035","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/030089161209800308","article-title":"Long-term side effects and cosmetic outcome in a pool of breast cancer patients treated with intraoperative radiotherapy with electrons as sole treatment","volume":"98","author":"Leonardi","year":"2011","journal-title":"Tumori"},{"issue":"20","key":"10.1016\/j.biopha.2018.01.101_bib0040","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1158\/1078-0432.CCR-06-1465","article-title":"Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells","volume":"12","author":"Kaur","year":"2006","journal-title":"Clin. Cancer Res."},{"issue":"7","key":"10.1016\/j.biopha.2018.01.101_bib0045","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1158\/1078-0432.CCR-06-0948","article-title":"Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect","volume":"13","author":"Widodo","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.biopha.2018.01.101_bib0050","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nrc1189","article-title":"Cancer chemoprevention with dietary phytochemicals","volume":"3","author":"Surh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.101_bib0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3181\/00379727-208-43843","article-title":"Neonatal genistein chemoprevents mammary cancer","volume":"208","author":"Lamartiniere","year":"1995","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"5297","key":"10.1016\/j.biopha.2018.01.101_bib0060","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","volume":"275","author":"Jang","year":"1997","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.101_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3835(98)00084-6","article-title":"Induction of apoptosis in prostate cancer cell lines by the green tea component,(\u2212)-epigallocatechin-3-gallate","volume":"130","author":"Paschka","year":"1998","journal-title":"Cancer Lett."},{"issue":"9","key":"10.1016\/j.biopha.2018.01.101_bib0070","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1158\/1078-0432.CCR-09-2937","article-title":"Sulforaphane, a dietary component of broccoli\/broccoli sprouts, inhibits breast cancer stem cells","volume":"16","author":"Li","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2018.01.101_bib0075","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fitote.2013.10.010","article-title":"Synergy effects of herb extracts: pharmacokinetics and pharmacodynamic basis","volume":"92","author":"Yang","year":"2014","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.biopha.2018.01.101_bib0080","first-page":"178","article-title":"The chemistry and biological activity the the genus Centaurea","volume":"67","author":"Kaij-a-Kamb","year":"1992","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.biopha.2018.01.101_bib0085","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201700099","article-title":"Qualitative HPLC\u2010DAD\u2010ESI\u2010TOF\u2010MS analysis, cytotoxic and apoptotic effects of Croatian endemic Centaurea ragusina L. aqueous extracts","author":"Radan","year":"2017","journal-title":"Chem. Biodivers."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.101_bib0090","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.apjtm.2016.04.016","article-title":"Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire","volume":"9","author":"Zater","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"9","key":"10.1016\/j.biopha.2018.01.101_bib0095","first-page":"583","article-title":"Cytotoxic potential of Centaurea bruguierana ssp. belangerana: the MTT assay","volume":"54","author":"Ostad","year":"2016","journal-title":"Acta Medica Iranica"},{"key":"10.1016\/j.biopha.2018.01.101_bib0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2017.05.016","article-title":"Antiproliferative activity against leukemia cells of sesquiterpene lactones from the Turkish endemic plant Centaurea drabifolia subsp. detonsa","author":"Formisano","year":"2017","journal-title":"Fitoterapia"},{"issue":"17","key":"10.1016\/j.biopha.2018.01.101_bib0105","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/j.carres.2010.09.002","article-title":"Phenolic glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei","volume":"345","author":"G\u00fclcemal","year":"2010","journal-title":"Carbohydr. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.01.101_bib0110","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jep.2008.10.041","article-title":"Screening of antiplasmodial properties among some traditionally used Iranian plants","volume":"121","author":"Esmaeili","year":"2009","journal-title":"J. Ethnopharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2018.01.101_bib0115","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1016\/j.ejmech.2011.03.011","article-title":"Anti-proliferative activity of aguerin B and a new rare nor-guaianolide lactone isolated from the aerial parts of Centaurea deflexa","volume":"46","author":"Chicca","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"38","key":"10.1016\/j.biopha.2018.01.101_bib0120","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.1016\/j.tet.2005.07.047","article-title":"Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii","volume":"61","author":"Shoeb","year":"2005","journal-title":"Tetrahedron"},{"issue":"2","key":"10.1016\/j.biopha.2018.01.101_bib0125","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s11418-006-0117-4","article-title":"Anti-colon cancer potential of phenolic compounds from the aerial parts of Centaurea gigantea (Asteraceae)","volume":"61","author":"Shoeb","year":"2007","journal-title":"J. Nat. Med."},{"issue":"11","key":"10.1016\/j.biopha.2018.01.101_bib0130","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/ptr.3187","article-title":"Bioactivity\u2010guided isolation of antiproliferative compounds from Centaurea arenaria","volume":"24","author":"Csapi","year":"2010","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.101_bib0135","first-page":"841","article-title":"Purified salograviolide A isolated from Centaurea ainetensis causes growth inhibition and apoptosis in neoplastic epidermal cells","volume":"32","author":"Ghantous","year":"2008","journal-title":"Int. J. Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.101_bib0140","first-page":"897","article-title":"Anti-colon cancer effects of salograviolide A isolated from Centaurea ainetensis","volume":"19","author":"El-Najjar","year":"2008","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.101_bib0145","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","article-title":"Natural products: a continuing source of novel drug leads","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA) Gen. Subj."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.101_bib0150","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2005.05.011","article-title":"Plants as a source of anti-cancer agents","volume":"100","author":"Cragg","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.01.101_bib0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jep.2015.03.039","article-title":"Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53\/p21 and mitochondrial signalling pathway","volume":"166","author":"Foo","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.01.101_bib0160","first-page":"1","article-title":"Screening of several biological activities induced by different sesquiterpene lactones isolated from Centaurea behen L. and Rhaponticum repens (L.) Hidalgo","author":"Shakeri","year":"2017","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.101_bib0165","first-page":"1552","article-title":"Screening for antitumor activity of various plant extracts on HeLa and C 4-I cell lines","volume":"21","author":"Ozcan","year":"2016","journal-title":"J. BUON"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217345572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217345572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:21:55Z","timestamp":1781590915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217345572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":33,"alternative-id":["S0753332217345572"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.101","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Centaurea albonitens extract enhances the therapeutic effects of Vincristine in leukemic cells by inducing apoptosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.101","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}