{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:53:39Z","timestamp":1781592819316,"version":"3.54.5"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.biopha.2018.01.133","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T11:54:11Z","timestamp":1519127651000},"page":"986-996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Polygala japonica Houtt. reverses depression-like behavior and restores reduced hippocampal neurogenesis in chronic stress mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.biopha.2018.01.133_bib0005","first-page":"1517","article-title":"Depression is the leading cause of disability around the world","volume":"317","author":"Friedrich","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/npp.2014.230","article-title":"Adult neurogenesis and mental illness","volume":"40","author":"Schoenfeld","year":"2015","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.biopha.2018.01.133_bib0015","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.biopha.2018.01.133_bib0020","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1007\/s00125-010-1874-x","article-title":"Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis","volume":"53","author":"Nouwen","year":"2010","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.biopha.2018.01.133_bib0025","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.biopha.2018.01.133_bib0030","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2147\/PPA.S29716","article-title":"Treatment-resistant depression: therapeutic trends, challenges, and future directions","volume":"6","author":"Al-Harbi","year":"2012","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.biopha.2018.01.133_bib0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fncir.2014.00107","article-title":"Structure, function, and plasticity of hippocampal dentate gyrus microcircuits","volume":"8","author":"Jonas","year":"2014","journal-title":"Front. Neural Circuits"},{"issue":"13","key":"10.1016\/j.biopha.2018.01.133_bib0040","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1038\/npp.2011.220","article-title":"Depression, antidepressants, and neurogenesis: a critical reappraisal","volume":"36","author":"Hanson","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"7361","key":"10.1016\/j.biopha.2018.01.133_bib0045","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.01.133_bib0050","series-title":"WHO Guidelines on Safety Monitoring of Herbal Medicines in Pharmacovigilance Systems","author":"WHO","year":"2004"},{"key":"10.1016\/j.biopha.2018.01.133_bib0055","series-title":"Chinese Pharmacopoeia","author":"C.P. Committee","year":"2015"},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0060","first-page":"266","article-title":"[The isolation and structure of a sapogenin from Gua Zi Jin (Polygala japonica Houtt)]","volume":"18","author":"Fang","year":"1983","journal-title":"Yao xue xue bao = Acta Pharm. Sin."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.01.133_bib0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/10286020500381951","article-title":"Three new xanthones from the roots of Polygala japonica Houtt","volume":"8","author":"Fu","year":"2006","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0070","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/14756360802051362","article-title":"Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro","volume":"24","author":"Kim","year":"2009","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"7","key":"10.1016\/j.biopha.2018.01.133_bib0075","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.fitote.2012.07.002","article-title":"Three triterpenoid saponins from the roots of Polygala japonica Houtt","volume":"83","author":"Li","year":"2012","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.biopha.2018.01.133_bib0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/10286020500172558","article-title":"New flavonol glycosides and new xanthone from Polygala japonica","volume":"8","author":"Li","year":"2006","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0085","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.jpba.2006.11.012","article-title":"Quality evaluation of Polygala japonica through simultaneous determination of six bioactive triterpenoid saponins by HPLC-ELSD","volume":"43","author":"Wang","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.biopha.2018.01.133_bib0090","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/10286020902835547","article-title":"Three new xanthones from the roots of Polygala japonica Houtt","volume":"11","author":"Xue","year":"2009","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.133_bib0095","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1248\/cpb.43.966","article-title":"Studies on the constituents of Polygala japonica HOUTT. II. Structures of polygalasaponins XI-XIX","volume":"43","author":"Zhang","year":"1995","journal-title":"Chem. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0100","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1248\/cpb.43.115","article-title":"Studies on the constituents of Polygala japonica Houtt. I. Structures Polygalasaponins I-X","volume":"43","author":"Zhang","year":"1995","journal-title":"Chem. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0105","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1248\/cpb.44.810","article-title":"Five new triterpene saponins, polygalasaponins XXVIII-XXXII from the root of Polygala japonica Houtt","volume":"44","author":"Zhang","year":"1996","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.01.133_bib0110","series-title":"The Medicine Application of Polygala japonica Houtt.","author":"Zhang","year":"2007"},{"issue":"3","key":"10.1016\/j.biopha.2018.01.133_bib0115","first-page":"333","article-title":"Inhibitory effect of Polygalasaponin F on the apoptosis of PC12 cells induced by sodium dithionite-caused oxygen-glucose deprivation and reperfusion","volume":"29","author":"Shi","year":"2013","journal-title":"Chin. Pharm. Bull."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0120","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1021\/np050439a","article-title":"Saponins from Polygala japonica and their effects on a forced swimming test in mice","volume":"69","author":"Li","year":"2006","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.biopha.2018.01.133_bib0125","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biopha.2018.01.133_bib0130","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fnbeh.2014.00136","article-title":"Learning and memory impairments in a neuroendocrine mouse model of anxiety\/depression","volume":"8","author":"Darcet","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"33","key":"10.1016\/j.biopha.2018.01.133_bib0135","article-title":"Dissection of hippocampal dentate gyrus from adult mouse","author":"Hagihara","year":"2009","journal-title":"J. Vis. Exp. JoVE"},{"issue":"7","key":"10.1016\/j.biopha.2018.01.133_bib0140","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.cell.2011.05.024","article-title":"In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics","volume":"145","author":"Bonaguidi","year":"2011","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2018.01.133_bib0145","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In animal models, psychosocial stress-induced (neuro)inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression","volume":"35","author":"Kubera","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2018.01.133_bib0150","first-page":"75","article-title":"The Bcl-2 gene family and apoptosis","volume":"62","author":"Bruckheimer","year":"1998","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"issue":"6","key":"10.1016\/j.biopha.2018.01.133_bib0155","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00406-015-0588-y","article-title":"Inhibition of MAPK\/ERK signaling blocks hippocampal neurogenesis and impairs cognitive performance in prenatally infected neonatal rats","volume":"265","author":"Jiang","year":"2015","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"8","key":"10.1016\/j.biopha.2018.01.133_bib0160","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/j.1460-9568.2005.04377.x","article-title":"Increased generation of granule cells in adult Bcl-2-overexpressing mice: a role for cell death during continued hippocampal neurogenesis","volume":"22","author":"Kuhn","year":"2005","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.expneurol.2011.04.003","article-title":"Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1\/2 and phosphatidylinositol-3-kinase\/Akt\/glycogen synthase kinase-3beta pathways","volume":"230","author":"Lim","year":"2011","journal-title":"Exp. Neurol."},{"issue":"11","key":"10.1016\/j.biopha.2018.01.133_bib0170","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/nm.4218","article-title":"Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis","volume":"22","author":"Yun","year":"2016","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.biopha.2018.01.133_bib0175","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/dgd.12393","article-title":"Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions","volume":"59","author":"Blume","year":"2017","journal-title":"Dev. Growth Differ."},{"issue":"11","key":"10.1016\/j.biopha.2018.01.133_bib0180","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/3305","article-title":"Neurogenesis in the adult human hippocampus","volume":"4","author":"Eriksson","year":"1998","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.biopha.2018.01.133_bib0185","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019026","article-title":"Adult neurogenesis and Psychiatric Disorders","volume":"8","author":"Kang","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"9","key":"10.1016\/j.biopha.2018.01.133_bib0190","doi-asserted-by":"crossref","first-page":"e0185129","DOI":"10.1371\/journal.pone.0185129","article-title":"Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress","volume":"12","author":"Hu","year":"2017","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.biopha.2018.01.133_bib0195","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/npp.2013.5","article-title":"Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression","volume":"38","author":"Boldrini","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"10.1016\/j.biopha.2018.01.133_bib0200","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.biopsych.2012.04.024","article-title":"Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression","volume":"72","author":"Boldrini","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"7215","key":"10.1016\/j.biopha.2018.01.133_bib0205","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.biopha.2018.01.133_bib0210","doi-asserted-by":"crossref","first-page":"12796","DOI":"10.1073\/pnas.211427898","article-title":"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine","volume":"98","author":"Czeh","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.biopha.2018.01.133_bib0215","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021303","article-title":"Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation","volume":"7","author":"Lucassen","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2018.01.133_bib0220","article-title":"Control of cell survival in adult mammalian neurogenesis","volume":"7","author":"Kuhn","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0225","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"Ming","year":"2011","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0230","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrd.2016.253","article-title":"From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors","volume":"16","author":"Ashkenazi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"49","key":"10.1016\/j.biopha.2018.01.133_bib0235","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1523\/JNEUROSCI.1436-04.2004","article-title":"Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax","volume":"24","author":"Sun","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2018.01.133_bib0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.advenzreg.2006.12.013","article-title":"Targeting the RAF\/ MEK\/ ERK, PI3K\/AKT and p53 pathways in hematopoietic drug resistance","volume":"47","author":"McCubrey","year":"2007","journal-title":"Adv. Enzyme Regul."},{"issue":"5","key":"10.1016\/j.biopha.2018.01.133_bib0245","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1586\/17474086.2013.827415","article-title":"The Bcl-2\/Bax and Ras\/Raf\/MEK\/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches","volume":"6","author":"Vitagliano","year":"2013","journal-title":"Expert Rev. Hematol."},{"issue":"11","key":"10.1016\/j.biopha.2018.01.133_bib0250","doi-asserted-by":"crossref","first-page":"H231","DOI":"10.1111\/j.1750-3841.2012.02934.x","article-title":"Comparison of quercetin pharmacokinetics following oral supplementation in humans","volume":"77","author":"Kaushik","year":"2012","journal-title":"J. Food Sci."},{"issue":"66","key":"10.1016\/j.biopha.2018.01.133_bib0255","doi-asserted-by":"crossref","first-page":"110708","DOI":"10.18632\/oncotarget.22800","article-title":"Antioxidant agents against trichothecenes: new hints for oxidative stress treatment","volume":"8","author":"Wu","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0260","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","article-title":"A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention","volume":"138","author":"Chen","year":"2013","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0265","doi-asserted-by":"crossref","DOI":"10.3390\/nu9010041","article-title":"Hederagenin supplementation alleviates the pro-inflammatory and apoptotic response to alcohol in rats","volume":"9","author":"Kim","year":"2017","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.biopha.2018.01.133_bib0270","first-page":"470","article-title":"Study on chemical constituents of medicinal herb Polygala japonica from polygalaceae","volume":"27","author":"WANG","year":"2011","journal-title":"J. Nanjing TCM Univ."},{"issue":"3","key":"10.1016\/j.biopha.2018.01.133_bib0275","first-page":"1","article-title":"A study on chemical constituents of Polygala japonica","volume":"8","author":"Li","year":"1996","journal-title":"Tianran Chanwu Yanjiu Yu Kai fa"},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0280","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fitote.2006.03.018","article-title":"A new cerebroside from Polygala japonica","volume":"77","author":"Zhang","year":"2006","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0285","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1248\/cpb.44.173","article-title":"Studies on the constituents of Polygala japonica Houtt III structures of polygalasaponins XX-XXVII","volume":"44","author":"Zhang","year":"1996","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.01.133_bib0290","series-title":"Shen Yang Pharmaceutical University Doctorel Thesis","article-title":"Studies on the chemieal constituents and biologieal activities from two medieinal plants of Polygala","author":"Wu","year":"2007"},{"issue":"1","key":"10.1016\/j.biopha.2018.01.133_bib0295","first-page":"9","article-title":"Flavonoids from the leaves of Polygala japonica","volume":"23","author":"Do","year":"1992","journal-title":"Saengyak Hakhoechi"},{"issue":"4","key":"10.1016\/j.biopha.2018.01.133_bib0300","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0031-9422(00)90747-7","article-title":"Kaempferol 3-O-[62\u2033-O-(3-hydroxy-3-methylglutaroyl) glucoside] from leaves of Polygala japonica","volume":"34","author":"Jung","year":"1993","journal-title":"Phytochemistry"},{"issue":"12","key":"10.1016\/j.biopha.2018.01.133_bib0305","first-page":"1767","article-title":"Chemical constituents from roots of Polygala japonica","volume":"36","author":"ZHANG","year":"2005","journal-title":"Chin. Tradit. Herb. Drugs"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217359772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217359772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:14:28Z","timestamp":1781590468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217359772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":61,"alternative-id":["S0753332217359772"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.133","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polygala japonica Houtt. reverses depression-like behavior and restores reduced hippocampal neurogenesis in chronic stress mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.01.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}