{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:36:37Z","timestamp":1769168197195,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Pro. Shunji Hattori, Nippi Research Institute of Biomatrix"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.biopha.2018.03.133","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T01:25:02Z","timestamp":1522977902000},"page":"782-791","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Concentration-dependent dual effects of silibinin on kanamycin-induced cells death in Staphylococcus aureus"],"prefix":"10.1016","volume":"102","author":[{"given":"Jia-Yi","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Na","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikuji","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Tashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Onodera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.03.133_bib0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nrmicro.2017.28","article-title":"Next-generation approaches to understand and combat the antibiotic resistome","volume":"15","author":"Crofts","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpeds.2013.08.072","article-title":"Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S aureus skin and soft tissue infections","volume":"164","author":"Rodriguez","year":"2014","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.biopha.2018.03.133_bib0015","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1086\/675838","article-title":"Correlation between methicillin-resistant Staphylococcus aureus nasal sampling and S. aureus pneumonia in the medical intensive care unit","volume":"35","author":"Rimawi","year":"2014","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"6","key":"10.1016\/j.biopha.2018.03.133_bib0020","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00109-014-1246-y","article-title":"Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis","volume":"93","author":"Peng","year":"2015","journal-title":"J. Mol. Med. (Berl)"},{"issue":"9","key":"10.1016\/j.biopha.2018.03.133_bib0025","doi-asserted-by":"crossref","first-page":"625e1","DOI":"10.1016\/j.eimc.2015.03.015","article-title":"Diagnosis and treatment of bacteremia and endocarditis due to Staphylococcus aureus. A clinical guideline from the Spanish society of clinical microbiology and infectious diseases (SEIMC)","volume":"33","author":"Gudiol","year":"2015","journal-title":"Enfermedades Infecciosas Microbiol. Clin."},{"issue":"12","key":"10.1016\/j.biopha.2018.03.133_bib0030","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1517\/14656566.2013.806486","article-title":"Aminoglycoside therapy in infectious diseases","volume":"14","author":"Poulikakos","year":"2013","journal-title":"Expert Opin. Pharmacother."},{"issue":"214","key":"10.1016\/j.biopha.2018.03.133_bib0035","first-page":"225","article-title":"How to safely and effectively administer aminoglycoside antibiotics","volume":"36","author":"Gomolka","year":"2014","journal-title":"Polski Merkur. Lekarski"},{"issue":"4","key":"10.1016\/j.biopha.2018.03.133_bib0040","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1128\/AAC.04379-14","article-title":"Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii","volume":"59","author":"Yadav","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"7","key":"10.1016\/j.biopha.2018.03.133_bib0045","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1128\/AAC.43.7.1747","article-title":"Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin","volume":"43","author":"Climo","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.biopha.2018.03.133_bib0050","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0196-9781(03)00172-4","article-title":"In vitro and in vivo activity of an antibacterial peptide analog against uropathogens","volume":"24","author":"Cudic","year":"2003","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/1573406411666151030110530","article-title":"Antioxidant, antimicrobial activity and medicinal properties of Grewia asiatica L","volume":"12","author":"Shukla","year":"2016","journal-title":"Med. Chem."},{"key":"10.1016\/j.biopha.2018.03.133_bib0060","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.micpath.2017.04.020","article-title":"Novel properties of Hippophae rhamnoides L. twig and leaf extracts - anti-virulence action and synergy with antifungals studied in vitro on Candida spp. model","volume":"107","author":"Sadowska","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.biopha.2018.03.133_bib0065","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/1873-3468.12629","article-title":"A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry","volume":"591","author":"Bose","year":"2017","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0070","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/s12906-016-1465-6","article-title":"Antibacterial and antifungal potentials of the solvents extracts from Eryngium caeruleum, Notholirion thomsonianum and Allium consanguineum","volume":"16","author":"Sadiq","year":"2016","journal-title":"BMC Complement Altern. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0075","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jep.2003.11.017","article-title":"Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus","volume":"91","author":"Kim","year":"2004","journal-title":"J. Ethnopharm."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0080","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1248\/bpb.29.443","article-title":"Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE)","volume":"29","author":"Nagoshi","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.03.133_bib0085","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fmicb.2017.00422","article-title":"The potential of systems biology to discover antibacterial mechanisms of plant Phenolics","volume":"8","author":"Rempe","year":"2017","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.biopha.2018.03.133_bib0090","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3109\/13880201003770150","article-title":"Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus","volume":"48","author":"Lee","year":"2010","journal-title":"Pharm. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2018.03.133_bib0095","first-page":"2309","article-title":"Identification of different varieties of Rhei Radix et Rhizoma based on chemical analysis","volume":"40","author":"Ge","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.biopha.2018.03.133_bib0100","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fphar.2016.00247","article-title":"A comprehensive and system review for the pharmacological mechanism of action of Rhein, an active Anthraquinone Ingredient","volume":"7","author":"Sun","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.133_bib0105","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3892\/etm.2012.459","article-title":"Synergistic effect of rhein in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus","volume":"3","author":"Joung","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.03.133_bib0110","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jphotobiol.2017.03.015","article-title":"Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatory effects on skin damage UVB radiation-induced in mice","volume":"170","author":"Marchiori","year":"2017","journal-title":"J. Photochem. Photobiol. B"},{"issue":"26","key":"10.1016\/j.biopha.2018.03.133_bib0115","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v22.i26.6016","article-title":"Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells","volume":"22","author":"Vecchione","year":"2016","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0120","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.etap.2012.07.004","article-title":"Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats","volume":"34","author":"Ezhilarasan","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.03.133_bib0125","doi-asserted-by":"crossref","first-page":"618081","DOI":"10.1155\/2012\/618081","article-title":"Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria","volume":"2012","author":"Lee","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.biopha.2018.03.133_bib0130","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2147\/DDDT.S133806","article-title":"Haseeb, Fabrication, characterization and in vitro evaluation of silibinin nanoparticles: an attempt to enhance its oral bioavailability","volume":"11","author":"Sahibzada","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.133_bib0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2\u2019,7\u2019-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2018.03.133_bib0140","first-page":"292797","article-title":"In vitro antimicrobial and modulatory activity of the natural products silymarin and silibinin","volume":"2015","author":"de Oliveira","year":"2015","journal-title":"Biomed. Res. Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.133_bib0145","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2008.09.038","article-title":"Mistranslation of membrane proteins and two-component system activation trigger antibiotic-mediated cell death","volume":"135","author":"Kohanski","year":"2008","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.biopha.2018.03.133_bib0150","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biopha.2018.03.133_bib0155","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3109\/10715762.2012.688964","article-title":"P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells","volume":"46","author":"Fan","year":"2012","journal-title":"Free Radic. Res."},{"issue":"11\u201312","key":"10.1016\/j.biopha.2018.03.133_bib0160","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3109\/10715762.2011.618186","article-title":"Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells","volume":"45","author":"Fan","year":"2011","journal-title":"Free Radic. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.133_bib0165","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/aps.2016.117","article-title":"Crosstalk of ROS\/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro","volume":"38","author":"Zheng","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2018.03.133_bib0170","doi-asserted-by":"crossref","first-page":"33194","DOI":"10.1039\/C7RA03981F","article-title":"Silibinin protects Staphylococcus aureus from UVC-induced bactericide via enhanced generation of reactive oxygen species","volume":"7","author":"Cai","year":"2017","journal-title":"RSC Adv."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.133_bib0175","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/10715762.2013.765951","article-title":"Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women","volume":"47","author":"Cristofalo","year":"2013","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0180","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12012-013-9227-x","article-title":"Silibinin potentially attenuates arsenic-induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats","volume":"14","author":"Muthumani","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"issue":"19","key":"10.1016\/j.biopha.2018.03.133_bib0185","doi-asserted-by":"crossref","first-page":"19002","DOI":"10.1007\/s11356-016-7309-6","article-title":"Catalase and ascorbate peroxidase-representative H2O2-detoxifying heme enzymes in plants","volume":"23","author":"Anjum","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"10","key":"10.1016\/j.biopha.2018.03.133_bib0190","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.tplants.2004.08.009","article-title":"Reactive oxygen gene network of plants","volume":"9","author":"Mittler","year":"2004","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.biopha.2018.03.133_bib0195","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.freeradbiomed.2015.06.017","article-title":"Regulation of catalase expression in healthy and cancerous cells","volume":"87","author":"Glorieux","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.03.133_bib0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exger.2016.02.017","article-title":"Photo-protective activity of pogostone against UV-induced skin premature aging in mice","volume":"77","author":"Wang","year":"2016","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.biopha.2018.03.133_bib0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ecoenv.2016.06.014","article-title":"Antioxidant enzyme activities as biomarkers of fluvial biofilm to ZnO NPs ecotoxicity and the integrated biomarker responses (IBR) assessment","volume":"133","author":"Hou","year":"2016","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.133_bib0210","first-page":"627","article-title":"In-vitro and in-vivo evaluation of Silymarin Nanoliposomes against isolated methicillin-resistant Staphylococcus aureus","volume":"14","author":"Faezizadeh","year":"2015","journal-title":"Iran. J. Pharm. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.133_bib0215","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1055\/s-0032-1328068","article-title":"Silibinin in vitro protects A549 cells from Staphylococcus aureus-mediated injury and in vivo alleviates the lung injury of staphylococcal pneumonia","volume":"79","author":"Wang","year":"2013","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0220","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS signaling in organismal homeostasis","volume":"163","author":"Shadel","year":"2015","journal-title":"Cell"},{"issue":"Pt 4","key":"10.1016\/j.biopha.2018.03.133_bib0225","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1242\/jcs.099234","article-title":"Mitochondria and cell signalling","volume":"125","author":"Tait","year":"2012","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.biopha.2018.03.133_bib0230","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2016.10.011","article-title":"Mitochondrial H2O2 signaling is controlled by the concerted action of peroxiredoxin III and sulfiredoxin: Linking mitochondrial function to circadian rhythm","volume":"100","author":"Rhee","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2018.03.133_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2006.06.016","article-title":"Involvement of calcium-mediated apoptotic signals in H2O2-induced MIN6N8a cell death","volume":"547","author":"Choi","year":"2006","journal-title":"Eur. J. Pharmacol."},{"issue":"38","key":"10.1016\/j.biopha.2018.03.133_bib0240","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0506390102","article-title":"Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2007.03.016","article-title":"Hydrogen peroxide sensing and signaling","volume":"26","author":"Veal","year":"2007","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0250","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1091\/mbc.01-06-0288","article-title":"Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe","volume":"13","author":"Quinn","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"1\u20133","key":"10.1016\/j.biopha.2018.03.133_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.03.059","article-title":"The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: a comparison with desferrioxamine","volume":"589","author":"Gharagozloo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2018.03.133_bib0260","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF02976707","article-title":"Gram-positive bacteria specific properties of silybin derived from Silybum marianum","volume":"26","author":"Lee","year":"2003","journal-title":"Arch. Pharm. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0265","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/mutage\/gep064","article-title":"Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2)","volume":"25","author":"Angeli","year":"2010","journal-title":"Mutagenesis"},{"issue":"1","key":"10.1016\/j.biopha.2018.03.133_bib0270","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms4010014","article-title":"Bacterial multidrug efflux pumps: much more than antibiotic resistance determinants","volume":"4","author":"Blanco","year":"2016","journal-title":"Microorganisms"},{"issue":"6","key":"10.1016\/j.biopha.2018.03.133_bib0275","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.tim.2014.02.001","article-title":"Molecular mechanisms of antimicrobial tolerance and resistance in bacterial and fungal biofilms","volume":"22","author":"Van Acker","year":"2014","journal-title":"Trends Microbiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.133_bib0280","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.phrs.2010.04.004","article-title":"Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?","volume":"62","author":"Balakumar","year":"2010","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.03.133_bib0285","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1365-2885.2008.00982.x","article-title":"Pharmacokinetics of erythromycin after the administration of intravenous and various oral dosage forms to dogs","volume":"31","author":"Albarellos","year":"2008","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.03.133_bib0290","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.12659\/MSM.898014","article-title":"Prophylactic administration of Silybin Ameliorates L-Arginine-induced acute pancreatitis","volume":"22","author":"Ucmak","year":"2016","journal-title":"Med. Sci. Monit."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217367082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217367082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T16:02:05Z","timestamp":1731427325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217367082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":58,"alternative-id":["S0753332217367082"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.133","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concentration-dependent dual effects of silibinin on kanamycin-induced cells death in Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}