{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:49:41Z","timestamp":1790264981512,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07273-2"],"award-info":[{"award-number":["2013\/07273-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/14267-1"],"award-info":[{"award-number":["2014\/14267-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/18528-7"],"award-info":[{"award-number":["2015\/18528-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/07519-0"],"award-info":[{"award-number":["2016\/07519-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/09392-7"],"award-info":[{"award-number":["2016\/09392-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/01265-9"],"award-info":[{"award-number":["2017\/01265-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.03.135","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T18:11:59Z","timestamp":1524593519000},"page":"18-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Phosphoethanolamine induces caspase-independent cell death by reducing the expression of C-RAF and inhibits tumor growth in human melanoma model"],"prefix":"10.1016","volume":"103","author":[{"given":"Lisley I.","family":"Mambelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e3o D.","family":"Jorge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Meneguelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.M.","family":"Barbuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson K.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.03.135_bib0005","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.2147\/IJN.S90850","article-title":"Potential antitumor activity of novel DODAC\/PHO-S liposomes","volume":"11","author":"de Lima Luna","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.biopha.2018.03.135_bib0010","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.biopha.2013.01.012","article-title":"Synthetic phosphoethanolamine induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells through the mitochondrial pathway","volume":"67","author":"Ferreira","year":"2013","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.biopha.2018.03.135_bib0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.biopha.2012.04.008","article-title":"Synthetic phosphoethanolamine a precursor of membrane phospholipids reduce tumor growth in mice bearing melanoma B16-F10 and in vitro induce apoptosis and arrest in G2\/M phase","volume":"66","author":"Ferreira","year":"2012","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.03.135_bib0020","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.freeradbiomed.2016.03.011","article-title":"Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines","volume":"95","author":"Annibal","year":"2016","journal-title":"Free Radical Biol. Med."},{"issue":"11","key":"10.1016\/j.biopha.2018.03.135_bib0025","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1038\/bjc.2013.510","article-title":"Synthetic phosphoethanolamine has in vitro and in vivo anti-leukemia effects","volume":"109","author":"Ferreira","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2018.03.135_bib0030","doi-asserted-by":"crossref","first-page":"e57937","DOI":"10.1371\/journal.pone.0057937","article-title":"Anti-angiogenic and anti-metastatic activity of synthetic phosphoethanolamine","volume":"8","author":"Ferreira","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.biopha.2018.03.135_bib0035","first-page":"753","article-title":"Dacarbazine causes transcriptional up-regulation of interleukin 8 and vascular endothelial growth factor in melanoma cells: a possible escape mechanism from chemotherapy1","volume":"2","author":"Lev","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.biopha.2018.03.135_bib0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.biopha.2018.03.135_bib0045","article-title":"Vemurafenib in combination with cobimetinib in relapsed and refractory extramedullary multiple myeloma harboring the BRAF V600E mutation","author":"Mey","year":"2016","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.biopha.2018.03.135_bib0050","series-title":"AACR","article-title":"A first-in-human phase 1 study to evaluate the MEK1\/2 inhibitor GDC-0973 administered daily in patients with advanced solid tumors","author":"Rosen","year":"2011"},{"issue":"2","key":"10.1016\/j.biopha.2018.03.135_bib0055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/CCO.0000000000000050","article-title":"The role of MEK inhibitors in the treatment of metastatic melanoma","volume":"26","author":"Grimaldi","year":"2014","journal-title":"Curr. Opin. Oncol."},{"issue":"14","key":"10.1016\/j.biopha.2018.03.135_bib0060","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/onc.2013.131","article-title":"MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines","volume":"33","author":"Vultur","year":"2014","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/j.biopha.2018.03.135_bib0065","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/carcin\/bgh115","article-title":"Evidence of STAT1 phosphorylation modulated by MAPKs, MEK1 and MSK1","volume":"25","author":"Zhang","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.biopha.2018.03.135_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/srep14310","article-title":"A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo","volume":"5","author":"Figueiredo","year":"2015","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.135_bib0075","first-page":"95","article-title":"Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: an experimental study","volume":"32","author":"Ferreira","year":"2012","journal-title":"Anticancer Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.135_bib0080","first-page":"53","article-title":"Synthetic phosphoethanolamine induces apoptosis through caspase-3 pathway by decreasing expression of Bax\/Bad protein and changes cell cycle in melanoma","volume":"3","author":"Ferreira","year":"2011","journal-title":"J. Cancer Sci. Ther."},{"key":"10.1016\/j.biopha.2018.03.135_bib0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2018.03.135_bib0090","doi-asserted-by":"crossref","first-page":"e1004142","DOI":"10.1371\/journal.pcbi.1004142","article-title":"Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy","volume":"11","author":"Fu","year":"2015","journal-title":"PLoS Comput. Biol."},{"issue":"1S","key":"10.1016\/j.biopha.2018.03.135_bib0095","first-page":"S37","article-title":"Hormesis: a revolution in toxicology, risk assessment and medicine","volume":"5","author":"Calabrese","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biopha.2018.03.135_bib0100","first-page":"1","article-title":"The comparsion of silybin and silybin-phosphatidylcholine effects on viability, ESR1 and ESR2 expression in human breast cancer T47D cell line","volume":"16","author":"Mahmoodi","year":"2015","journal-title":"Cell. J."},{"issue":"12","key":"10.1016\/j.biopha.2018.03.135_bib0105","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/sj.cdd.4401130","article-title":"Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe","volume":"9","author":"Castedo","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2018.03.135_bib0110","series-title":"Cell Adhesion Assay","author":"Chen","year":"2012"},{"key":"10.1016\/j.biopha.2018.03.135_bib0115","series-title":"Cancer Invasion and Metastasis: Molecular and Cellular Perspective","author":"Martin","year":"2013"},{"issue":"5","key":"10.1016\/j.biopha.2018.03.135_bib0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.biopha.2018.03.135_bib0125","doi-asserted-by":"crossref","first-page":"e27637","DOI":"10.1371\/journal.pone.0027637","article-title":"p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112","volume":"6","author":"Diana","year":"2011","journal-title":"PloS One"},{"issue":"24","key":"10.1016\/j.biopha.2018.03.135_bib0130","doi-asserted-by":"crossref","first-page":"21004","DOI":"10.1074\/jbc.M007592200","article-title":"Regulation of Stat3 activation by MEK kinase 1","volume":"276","author":"Lim","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.135_bib0135","doi-asserted-by":"crossref","first-page":"e22882","DOI":"10.4161\/jkst.22882","article-title":"STAT3 inhibitors for cancer therapy: Have all roads been explored?","volume":"2","author":"Fagard","year":"2013","journal-title":"Jak-Stat"},{"issue":"6","key":"10.1016\/j.biopha.2018.03.135_bib0140","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00001813-200507000-00002","article-title":"Targeting Stat3 in cancer therapy","volume":"16","author":"Jing","year":"2005","journal-title":"Anti-Cancer Drugs"},{"issue":"7287","key":"10.1016\/j.biopha.2018.03.135_bib0145","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/464358a","article-title":"Drug discovery: inhibitors that activate","volume":"464","author":"Cichowski","year":"2010","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.biopha.2018.03.135_bib0150","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1038\/sj.jid.5701246","article-title":"Cucurbitacin I inhibits Stat3 and induces apoptosis in Sezary cells","volume":"128","author":"Van Kester","year":"2008","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.biopha.2018.03.135_bib0155","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/icb.2008.27","article-title":"Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model","volume":"86","author":"Molavi","year":"2008","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.biopha.2018.03.135_bib0160","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature08833","article-title":"RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth","volume":"464","author":"Hatzivassiliou","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biopha.2018.03.135_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.135_bib0170","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/comjnl\/7.4.308","article-title":"A simplex method for function minimization","volume":"7","author":"Nelder","year":"1965","journal-title":"Comput. J."},{"issue":"1","key":"10.1016\/j.biopha.2018.03.135_bib0175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/ci800298z","article-title":"Empirical scoring functions for advanced protein- ligand docking with plants","volume":"49","author":"Korb","year":"2009","journal-title":"J. Chem. Inf. Model."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217364582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217364582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:28:02Z","timestamp":1720661282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217364582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":35,"alternative-id":["S0753332217364582"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.135","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phosphoethanolamine induces caspase-independent cell death by reducing the expression of C-RAF and inhibits tumor growth in human melanoma model","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}