{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:34:24Z","timestamp":1785411264434,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Scientific Research Project for Traditional Chinese medicine of Henan Province","award":["2013ZY02004"],"award-info":[{"award-number":["2013ZY02004"]}]},{"name":"Scientific Research Project for Traditional Chinese medicine of Henan Province","award":["2013ZY04058"],"award-info":[{"award-number":["2013ZY04058"]}]},{"name":"National Health and Medical Research Council (NHMRC Australia) Senior Research Fellowship","award":["1042105"],"award-info":[{"award-number":["1042105"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.biopha.2018.03.166","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T01:24:22Z","timestamp":1522977862000},"page":"1015-1024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K\/Akt axis"],"prefix":"10.1016","volume":"102","author":[{"given":"Yuankun","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory J.","family":"Xian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.biopha.2018.03.166_bib0005","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/jbmr.2882","article-title":"Anti- osteoporosis medication prescriptions And incidence of subsequent fracture among primary hip fracture patients in England and Wales: an interrupted time-series analysis","volume":"31","author":"Hawley","year":"2016","journal-title":"J. Bone Min. Res."},{"issue":"10","key":"10.1016\/j.biopha.2018.03.166_bib0010","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1007\/s00198-016-3631-6","article-title":"The current economic burden of illness of osteoporosis in Canada","volume":"27","author":"Hopkins","year":"2016","journal-title":"Osteoporos Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.166_bib0015","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jebdp.2016.05.007","article-title":"Bisphosphonates, osteoporosis, and osteonecrosis of the jaw: a critical review of a large nested case-control study","volume":"16","author":"Zavras","year":"2016","journal-title":"J. Evid. Based Dent. Pract."},{"issue":"5","key":"10.1016\/j.biopha.2018.03.166_bib0020","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/iub.320","article-title":"Parathyroid hormone (PTH) peptides through the regulation of hyaluronan metabolism affect osteosarcoma cell migration","volume":"62","author":"Berdiaki","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2018.03.166_bib0025","doi-asserted-by":"crossref","first-page":"627631","DOI":"10.1155\/2015\/627631","article-title":"Denosumab for elderly men with osteoporosis: a cost-effectiveness analysis from the US payer perspective","volume":"2015","author":"Silverman","year":"2015","journal-title":"J. Osteoporos"},{"key":"10.1016\/j.biopha.2018.03.166_bib0030","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.maturitas.2016.05.013","article-title":"Hormone replacement therapy and the risk of endometrial cancer: a systematic review","volume":"91","author":"Sjogren","year":"2016","journal-title":"Maturitas"},{"issue":"9","key":"10.1016\/j.biopha.2018.03.166_bib0035","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3109\/13880209.2014.884606","article-title":"Chinese herbal medicine for bone health","volume":"52","author":"Mukwaya","year":"2014","journal-title":"Pharm. Biol."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.166_bib0040","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/1381612822666151112145907","article-title":"An ancient Chinese herbal medicine in the prevention and treatment of osteoporosis","volume":"22","author":"Wang","year":"2016","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.166_bib0045","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1142\/S0192415X07005168","article-title":"Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats","volume":"35","author":"Tsai","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biopha.2018.03.166_bib0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mce.2015.09.025","article-title":"Positive skeletal effect of two ingredients of Psoralea corylifolia L. On estrogen deficiency-induced osteoporosis and the possible mechanisms of action","volume":"417","author":"Weng","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"issue":"7","key":"10.1016\/j.biopha.2018.03.166_bib0055","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1017\/S0007114508066750","article-title":"Ethanol extract of Psoralea corylifolia L. And its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats","volume":"101","author":"Lim","year":"2009","journal-title":"Br. J. Nutr."},{"issue":"Suppl. 2","key":"10.1016\/j.biopha.2018.03.166_bib0060","first-page":"S155","article-title":"Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation","volume":"24","author":"Wong","year":"2010","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.03.166_bib0065","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/jphp.12166","article-title":"Suppression of mast cell activity contributes to the osteoprotective effect of an herbal formula containing Herba Epimedii, Fructus Ligustri Lucidi and Fructus Psoraleae","volume":"66","author":"Chan","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.03.166_bib0070","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/ptr.4743","article-title":"The effects of an antiosteoporosis herbal formula containing epimedii herba, ligustri lucidi fructus and psoraleae fructus on density and structure of rat long bones under tail-suspension, and its mechanisms of action","volume":"27","author":"Siu","year":"2013","journal-title":"Phytother. Res."},{"issue":"10","key":"10.1016\/j.biopha.2018.03.166_bib0075","first-page":"1156","article-title":"The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells","volume":"19","author":"Yang","year":"2012","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.biopha.2018.03.166_bib0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbrc.2011.01.021","article-title":"Psoralen stimulates osteoblast differentiation through activation of BMP signaling","volume":"405","author":"Tang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.biopha.2018.03.166_bib0085","first-page":"1816","article-title":"Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism","volume":"38","author":"Li","year":"2013","journal-title":"Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China J. Chin. Mater. Med."},{"key":"10.1016\/j.biopha.2018.03.166_bib0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejphar.2017.03.001","article-title":"Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts","volume":"801","author":"Zhai","year":"2017","journal-title":"Eur. J Pharmacol."},{"issue":"10","key":"10.1016\/j.biopha.2018.03.166_bib0095","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3945\/jn.113.176818","article-title":"Prenylation enhances quercetin uptake and reduces efflux in Caco-2 cells and enhances tissue accumulation in mice fed long-term","volume":"143","author":"Mukai","year":"2013","journal-title":"J. Nutr."},{"issue":"9","key":"10.1016\/j.biopha.2018.03.166_bib0100","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.phymed.2016.05.008","article-title":"Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells","volume":"23","author":"Ren","year":"2016","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2018.03.166_bib0105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jchromb.2016.06.031","article-title":"Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes","volume":"1029\u20131030","author":"Shi","year":"2016","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.166_bib0110","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.pnpbp.2007.10.005","article-title":"Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea corylifolia in the forced swimming test in mice","volume":"32","author":"Yi","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.biopha.2018.03.166_bib0115","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.bcp.2011.05.027","article-title":"Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation","volume":"82","author":"Yang","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.03.166_bib0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2017.07.003","article-title":"Psoralidin suppresses osteoclastogenesis in BMMs and attenuates lps-mediated osteolysis by inhibiting inflammatory cytokines","volume":"51","author":"Kong","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.biopha.2018.03.166_bib0125","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s12272-009-1712-1","article-title":"Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells","volume":"32","author":"Lee","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2018.03.166_bib0130","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.fitote.2016.03.013","article-title":"Monotropein isolated from the roots of morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice","volume":"110","author":"Zhang","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.biopha.2018.03.166_bib0135","doi-asserted-by":"crossref","first-page":"921954","DOI":"10.1155\/2014\/921954","article-title":"The importance of the prenyl group in the activities of osthole in enhancing bone formation and inhibiting bone resorption in vitro","volume":"2014","author":"Zhai","year":"2014","journal-title":"Int. J. Endocrinol."},{"issue":"9","key":"10.1016\/j.biopha.2018.03.166_bib0140","doi-asserted-by":"crossref","first-page":"e44693","DOI":"10.1371\/journal.pone.0044693","article-title":"Isolation and characterization of canine amniotic membrane-derived multipotent stem cells","volume":"7","author":"Park","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biopha.2018.03.166_bib0145","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.ophtha.2016.02.009","article-title":"Correlation of histologic features with in vivo imaging of reticular pseudodrusen","volume":"123","author":"Greferath","year":"2016","journal-title":"Ophthalmology"},{"issue":"17","key":"10.1016\/j.biopha.2018.03.166_bib0150","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.biopha.2018.03.166_bib0155","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.ejmech.2008.05.032","article-title":"Synthesis of (+\/-)abyssinone I and related compounds: their anti-oxidant and cytotoxic activities","volume":"44","author":"Rao","year":"2009","journal-title":"Eur. J. Med. Chem."},{"issue":"14","key":"10.1016\/j.biopha.2018.03.166_bib0160","first-page":"84","article-title":"Study on quercetin isopentenyl modification and free radical scavenging activity","volume":"35","author":"Li","year":"2014","journal-title":"Sci. Technol. Food Ind."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.03.166_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsbmb.2009.08.005","article-title":"Prenylation has a compound specific effect on the estrogenicity of naringenin and genistein","volume":"118","author":"Kretzschmar","year":"2010","journal-title":"J. Steroid Biochem Mol. Biol."},{"issue":"2","key":"10.1016\/j.biopha.2018.03.166_bib0170","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/jbm.b.31326","article-title":"Coumestrol promotes proliferation and osteoblastic differentiation in rat bone marrow stromal cells","volume":"90","author":"Wu","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.biopha.2018.03.166_bib0175","doi-asserted-by":"crossref","first-page":"6027402","DOI":"10.1155\/2017\/6027402","article-title":"Mechanical stress regulates osteogenesis and adipogenesis of rat mesenchymal stem cells through PI3K\/Akt\/GSK-3beta\/beta-catenin signaling pathway","volume":"2017","author":"Song","year":"2017","journal-title":"Biomed. Res. Int"},{"key":"10.1016\/j.biopha.2018.03.166_bib0180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fendo.2012.00088","article-title":"A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?","volume":"3","author":"McGonnell","year":"2012","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.biopha.2018.03.166_bib0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bcp.2017.04.010","article-title":"Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K\/Akt\/GSK3beta\/beta-catenin integrated signaling pathway","volume":"136","author":"Hu","year":"2017","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.biopha.2018.03.166_bib0190","doi-asserted-by":"crossref","first-page":"e0163634","DOI":"10.1371\/journal.pone.0163634","article-title":"agmatine reduces lipopolysaccharide-mediated oxidant response via activating PI3K\/Akt pathway and up-regulating Nrf2 and HO-1 expression in macrophages","volume":"11","author":"Chai","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.biopha.2018.03.166_bib0195","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/jbm.a.35841","article-title":"The effect of mesoporous bioglass on osteogenesis and adipogenesis of osteoporotic BMSCs","volume":"104","author":"Wu","year":"2016","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.biopha.2018.03.166_bib0200","doi-asserted-by":"crossref","first-page":"30186","DOI":"10.1038\/srep30186","article-title":"Mesenchymal progenitors in osteopenias of diverse pathologies: differential characteristics in the common shift from osteoblastogenesis to adipogenesis","volume":"6","author":"Sui","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T16:01:57Z","timestamp":1731427317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217366830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":40,"alternative-id":["S0753332217366830"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.166","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K\/Akt axis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}