{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:03:53Z","timestamp":1792065833797,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.011","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T18:15:03Z","timestamp":1524593703000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation"],"prefix":"10.1016","volume":"103","author":[{"given":"Luigino","family":"Calzetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Rogliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Facciolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Matera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.04.011_bib0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1586\/17476348.2016.1121105","article-title":"Oxidation pathway and exacerbations in COPD: the role of NAC","volume":"10","author":"Matera","year":"2016","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.biopha.2018.04.011_bib0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/thx.2004.027946","article-title":"Oxidative stress and airway inflammation in severe exacerbations of COPD","volume":"60","author":"Drost","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.biopha.2018.04.011_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj2120039","article-title":"The effect of cysteine oxidation on isolated hepatocytes","volume":"212","author":"Vina","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.biopha.2018.04.011_bib0020","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2013.09.006","article-title":"Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits","volume":"141","author":"Rushworth","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.04.011_bib0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biopha.2018.04.011_bib0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1378\/chest.12-2357","article-title":"High-dose N-acetylcysteine in stable COPD: the 1-year, double-blind, randomized, placebo-controlled HIACE study","volume":"144","author":"Tse","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.biopha.2018.04.011_bib0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S2213-2600(13)70286-8","article-title":"Twice daily N-acetylcysteine 600\u202fmg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial","volume":"2","author":"Zheng","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.biopha.2018.04.011_bib0040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1183\/16000617.00002215","article-title":"Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis","volume":"24","author":"Cazzola","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.biopha.2018.04.011_bib0045","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1080\/15412555.2017.1347918","article-title":"Impact of mucolytic agents on COPD exacerbations: a pair-wise and network meta-analysis","volume":"14","author":"Cazzola","year":"2017","journal-title":"COPD"},{"key":"10.1016\/j.biopha.2018.04.011_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pupt.2005.12.007","article-title":"Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: discordant in vitro and in vivo dose-effects: a review","volume":"20","author":"Sadowska","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.04.011_bib0055","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1165\/ajrcmb.26.1.4652","article-title":"Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology","volume":"26","author":"Vernooy","year":"2002","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0060","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12931-016-0500-y","article-title":"Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation","volume":"18","author":"Cazzola","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.biopha.2018.04.011_bib0065","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2015.03.023","article-title":"Contribution of sensory nerves to LPS-induced hyperresponsiveness of human isolated bronchi","volume":"131","author":"Calzetta","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.04.011_bib0070","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejphar.2015.09.007","article-title":"Propofol protects against opioid-induced hyperresponsiveness of airway smooth muscle in a horse model of target-controlled infusion anaesthesia","volume":"765","author":"Calzetta","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1124\/jpet.106.110635","article-title":"Novel rho kinase inhibitors with anti-inflammatory and vasodilatory activities","volume":"320","author":"Doe","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.04.011_bib0080","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1165\/rcmb.2010-0306OC","article-title":"Protein prenylation contributes to the effects of LPS on EFS-induced responses in human isolated bronchi","volume":"45","author":"Cazzola","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0085","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1182\/blood.V95.10.3044","article-title":"Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells","volume":"95","author":"Hippenstiel","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.04.011_bib0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1054\/npep.1999.0027","article-title":"NK(2)-receptor mediated contraction in monkey, guinea-pig and human airway smooth muscle","volume":"33","author":"Rizzo","year":"1999","journal-title":"Neuropeptides"},{"key":"10.1016\/j.biopha.2018.04.011_bib0095","series-title":"Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting","author":"Motulsky","year":"2004"},{"key":"10.1016\/j.biopha.2018.04.011_bib0100","series-title":"The Visual Display of Quantitative Information","author":"Mulrow","year":"2002"},{"key":"10.1016\/j.biopha.2018.04.011_bib0105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1021\/cb4007584","article-title":"Colloidal drug formulations can explain \u201cbell-shaped\u201d concentration\u2013response curves","volume":"9","author":"Owen","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0110","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0165-6147(00)01996-9","article-title":"Modelling the consequences of receptor-G-protein promiscuity","volume":"23","author":"Tucek","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.04.011_bib0115","first-page":"799","article-title":"High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial","volume":"11","author":"Johnson","year":"2016","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.biopha.2018.04.011_bib0120","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1080\/10715760500250257","article-title":"Oxygen therapy at low flow causes oxidative stress in chronic obstructive pulmonary disease: prevention by N-acetyl cysteine","volume":"39","author":"Foschino Barbaro","year":"2005","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biopha.2018.04.011_bib0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0022034511400225","article-title":"LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons","volume":"90","author":"Diogenes","year":"2011","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.biopha.2018.04.011_bib0130","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1398-9995.2004.00665.x","article-title":"Neurogenic mechanisms in bronchial inflammatory diseases","volume":"59","author":"Groneberg","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.biopha.2018.04.011_bib0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0167-0115(02)00258-6","article-title":"Effects of lipopolysaccharide on neurokinin A content and release in the hypothalamic-pituitary axis","volume":"111","author":"De Laurentiis","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biopha.2018.04.011_bib0140","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1471-4892(03)00048-1","article-title":"Airway sensory innervation as a target for novel therapies: an outdated concept?","volume":"3","author":"Belvisi","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1094-5539(02)00180-3","article-title":"Sensory nerves and airway inflammation: role of A delta and C-fibres","volume":"16","author":"Belvisi","year":"2003","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.biopha.2018.04.011_bib0150","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1164\/ajrccm.153.6.8665034","article-title":"The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics","volume":"153","author":"Joos","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biopha.2018.04.011_bib0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2222.2001.00975.x","article-title":"The NK\u20102 receptor antagonist SR 48968C does not improve adenosine hyperresponsiveness and airway obstruction in allergic asthma","volume":"31","author":"Kraan","year":"2001","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.biopha.2018.04.011_bib0160","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/sj.bjp.0707168","article-title":"Capsaicin-induced mucus secretion in rat airways assessed in vivo and non-invasively by magnetic resonance imaging","volume":"150","author":"Karmouty-Quintana","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.011_bib0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000334900","article-title":"IL-6 and IL-13 in induced sputum of COPD and asthma patients: correlation with respiratory tests","volume":"84","author":"Grubek-Jaworska","year":"2012","journal-title":"Respiration"},{"key":"10.1016\/j.biopha.2018.04.011_bib0170","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.rmed.2003.07.008","article-title":"High levels of interleukin-6 in the exhaled breath condensate of patients with COPD","volume":"97","author":"Bucchioni","year":"2003","journal-title":"Respir. Med."},{"key":"10.1016\/j.biopha.2018.04.011_bib0175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/thorax.55.2.114","article-title":"Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations","volume":"55","author":"Bhowmik","year":"2000","journal-title":"Thorax"},{"key":"10.1016\/j.biopha.2018.04.011_bib0180","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1164\/rccm.201509-1722PP","article-title":"Plasma fibrinogen qualification as a drug development tool in chronic obstructive pulmonary disease. Perspective of the chronic obstructive pulmonary disease biomarker qualification consortium","volume":"193","author":"Miller","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biopha.2018.04.011_bib0185","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2147\/COPD.S132132","article-title":"Serum inflammatory biomarkers and clinical outcomes of COPD exacerbation caused by different pathogens","volume":"12","author":"Kawamatawong","year":"2017","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.biopha.2018.04.011_bib0190","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1378\/chest.129.2.317","article-title":"Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD","volume":"129","author":"Wilkinson","year":"2006","journal-title":"Chest J."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218310709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218310709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:46:18Z","timestamp":1720662378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218310709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":38,"alternative-id":["S0753332218310709"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.011","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-Acetylcysteine protects human bronchi by modulating the release of neurokinin A in an ex vivo model of COPD exacerbation","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}