{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:10:21Z","timestamp":1784214621127,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0104100"],"award-info":[{"award-number":["2017YFA0104100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2013CB967500"],"award-info":[{"award-number":["2013CB967500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.038","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T14:12:27Z","timestamp":1524579147000},"page":"517-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-\u03baB-mediated NLRP3 inflammasome"],"prefix":"10.1016","volume":"103","author":[{"given":"Xiying","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.04.038_bib0005","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(12)60282-7","article-title":"Age-related macular degeneration","volume":"379","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.04.038_bib0010","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3934\/molsci.2016.2.196","article-title":"Oxidative stress, innate immunity, and age-related macular degeneration","volume":"3","author":"Shaw","year":"2016","journal-title":"AIMS Mol. Sci."},{"key":"10.1016\/j.biopha.2018.04.038_bib0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/jcm4010172","article-title":"NLRP3 inflammasome and pathobiology in AMD","volume":"4","author":"Celkova","year":"2015","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.biopha.2018.04.038_bib0020","doi-asserted-by":"crossref","first-page":"930671","DOI":"10.1155\/2014\/930671","article-title":"Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation)","volume":"2014","author":"Nita","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.biopha.2018.04.038_bib0025","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.preteyeres.2007.02.002","article-title":"Transplantation of the RPE in AMD","volume":"26","author":"Binder","year":"2007","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.biopha.2018.04.038_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4252\/wjsc.v6.i2.111","article-title":"Progress of mesenchymal stem cell therapy for neural and retinal diseases","volume":"6","author":"Ng","year":"2014","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.biopha.2018.04.038_bib0035","doi-asserted-by":"crossref","first-page":"14456","DOI":"10.3390\/ijms150814456","article-title":"Recent advances of stem cell therapy for retinitis pigmentosa","volume":"15","author":"He","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"December 1","key":"10.1016\/j.biopha.2018.04.038_bib0040","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13287-016-0432-y","article-title":"Subretinal adipose tissue-derived mesenchymal stem cell implantation in advanced stage retinitis pigmentosa: a phase I clinical safety study","volume":"7","author":"Oner","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2018.04.038_bib0045","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. Immun."},{"issue":"August","key":"10.1016\/j.biopha.2018.04.038_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exer.2014.04.015","article-title":"Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration","volume":"125","author":"Zhang","year":"2014","journal-title":"Exp. Eye Res."},{"issue":"October 1","key":"10.1016\/j.biopha.2018.04.038_bib0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.20689","article-title":"The p53 tumor suppressor participates in multiple cell cycle checkpoints","volume":"209","author":"Giono","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2018.04.038_bib0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2018.04.038_bib0065","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1073\/pnas.1403814111","article-title":"DICER1\/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.04.038_bib0070","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/cdd.2016.14","article-title":"NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis","volume":"23","author":"Chung","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biopha.2018.04.038_bib0075","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2012.03.036","article-title":"DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88","volume":"149","author":"Tarallo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.04.038_bib0080","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1167\/iovs.12-10849","article-title":"Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration","volume":"54","author":"Liu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biopha.2018.04.038_bib0085","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.celrep.2013.08.002","article-title":"NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration","volume":"4","author":"Marneros","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.biopha.2018.04.038_bib0090","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm.2717","article-title":"NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components","volume":"18","author":"Doyle","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2018.04.038_bib0095","doi-asserted-by":"crossref","first-page":"e67263","DOI":"10.1371\/journal.pone.0067263","article-title":"A2E induces IL-1ss production in retinal pigment epithelial cells via the NLRP3 inflammasome","volume":"8","author":"Anderson","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.04.038_bib0100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"May 10","key":"10.1016\/j.biopha.2018.04.038_bib0105","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:21:34Z","timestamp":1778631694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217366696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":21,"alternative-id":["S0753332217366696"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.038","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-\u03baB-mediated NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}