{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:02:55Z","timestamp":1774047775298,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Science and Technology Project of Xiamen, China","award":["3502Z20159018"],"award-info":[{"award-number":["3502Z20159018"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.135","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T12:30:11Z","timestamp":1525696211000},"page":"1384-1391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Vernonia amygdalina Delile extract inhibits the hepatic gluconeogenesis through the activation of adenosine-5\u2019monophosph kinase"],"prefix":"10.1016","volume":"103","author":[{"given":"Xiu-mi","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Chao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.04.135_bib0005","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.04.135_bib0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4239\/wjd.v1.i3.68","article-title":"Molecular mechanisms of insulin resistance in type 2 diabetes mellitus","volume":"1","author":"Saini","year":"2010","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.biopha.2018.04.135_bib0015","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2337\/diabetes.49.8.1367","article-title":"Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study","volume":"49","author":"Gastaldelli","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2018.04.135_bib0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biopha.2018.04.135_bib0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1748-1716.2009.01970.x","article-title":"AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives","volume":"196","author":"Viollet","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.biopha.2018.04.135_bib0030","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2018.04.135_bib0035","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/nature03967","article-title":"The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism","volume":"437","author":"Koo","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.04.135_bib0040","first-page":"1","article-title":"WHO expert committee on diabetes mellitus second report","volume":"646","author":"Committee","year":"1980","journal-title":"World Health Organiz. Tech. Rep. Ser."},{"key":"10.1016\/j.biopha.2018.04.135_bib0045","first-page":"91","article-title":"Amelioration of carbon tetrachloride-induced hepatotoxicity by terpenoid extract from leaves of Vernonia amydgalina","volume":"30","author":"Babalola","year":"2001","journal-title":"Afr. J. Med. Med. Sci."},{"key":"10.1016\/j.biopha.2018.04.135_bib0050","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0031-9384(94)90368-9","article-title":"Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents","volume":"56","author":"Koshimizu","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.biopha.2018.04.135_bib0055","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ptr.2650060318","article-title":"Blood sugar lowering effect of Vernonia amygdalina Del, in an experimental rabbit model","volume":"6","author":"Akah","year":"1992","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.04.135_bib0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3923\/ajb.2007.193.197","article-title":"Studies on some biochemical effects of Vernonia amygdalina in rats","volume":"2","author":"Ekpo","year":"2007","journal-title":"Asian J. Biochem."},{"key":"10.1016\/j.biopha.2018.04.135_bib0065","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/13880200802436927","article-title":"Effect of leaf extracts of Vernonia amygdalina on glucose utilization in chang-liver, C2C12 muscle and 3T3-L1 cells","volume":"47","author":"Erasto","year":"2009","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.biopha.2018.04.135_bib0070","series-title":"Glucose Enzymatic Modulation by Vernonia amygdalina in Streptozotocin-Diabetic Wistar Rats","author":"Ojieh","year":"2016"},{"key":"10.1016\/j.biopha.2018.04.135_bib0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/1472-6882-14-426","article-title":"Vernonia amygdalina simultaneously suppresses gluconeogenesis and potentiates glucose oxidation via the pentose phosphate pathway in streptozotocin-induced diabetic rats","volume":"14","author":"Atangwho","year":"2014","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.04.135_bib0080","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1542\/pir.29.11.374","article-title":"Type 1 diabetes mellitus in pediatrics","volume":"29","author":"Cooke","year":"2008","journal-title":"Pediatr. Rev."},{"key":"10.1016\/j.biopha.2018.04.135_bib0085","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2337\/diacare.26.4.1277","article-title":"Systematic review of herbs and dietary supplements for glycemic control in diabetes","volume":"26","author":"Yeh","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.04.135_bib0090","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jep.2010.10.046","article-title":"Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats","volume":"133","author":"Ong","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.04.135_bib0095","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jep.2010.10.046","article-title":"Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats","volume":"133","author":"Ong","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.04.135_bib0100","doi-asserted-by":"crossref","first-page":"8252741","DOI":"10.1155\/2016\/8252741","article-title":"Antidiabetic effect of Young and Old ethanolic leaf extracts of Vernonia amygdalina: a comparative study","volume":"2016","author":"Asante","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.04.135_bib0105","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/B:REMD.0000021431.90494.0c","article-title":"The role of the liver in type 2 diabetes","volume":"5","author":"Staehr","year":"2004","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.biopha.2018.04.135_bib0110","doi-asserted-by":"crossref","first-page":"E685","DOI":"10.1152\/ajpendo.00253.2003","article-title":"Novel concepts in insulin regulation of hepatic gluconeogenesis","volume":"285","author":"Barthel","year":"2003","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.04.135_bib0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/B:REMD.0000021431.90494.0c","article-title":"The role of the liver in type 2 diabetes","volume":"5","author":"Staehr","year":"2004","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.biopha.2018.04.135_bib0120","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.2337\/diacare.27.10.2569-a","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030: response to Rathman and Giani","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.04.135_bib0125","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2337\/diabetes.49.6.896","article-title":"5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase","volume":"49","author":"Lochhead","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2018.04.135_bib0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2011.06.043","article-title":"Compound c independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo","volume":"219","author":"Kim","year":"2011","journal-title":"Atherosclerosis"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218307728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218307728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:36:14Z","timestamp":1720661774000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218307728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":26,"alternative-id":["S0753332218307728"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.135","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vernonia amygdalina Delile extract inhibits the hepatic gluconeogenesis through the activation of adenosine-5\u2019monophosph kinase","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}