{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:02:23Z","timestamp":1777611743996,"version":"3.51.4"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Technology Bureau of Huzhou, Zhejiang Province","award":["2016GYB33"],"award-info":[{"award-number":["2016GYB33"]}]},{"name":"Technology Bureau of Huzhou, Zhejiang Province","award":["2016GYB44"],"award-info":[{"award-number":["2016GYB44"]}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.141","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T12:29:26Z","timestamp":1525696166000},"page":"1217-1222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["PTEN signaling inhibitor VO-OHpic improves cardiac myocyte survival by mediating apoptosis resistance in vitro"],"prefix":"10.1016","volume":"103","author":[{"given":"Zhang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenfeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Haifeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10065","key":"10.1016\/j.biopha.2018.04.141_bib0005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"issue":"42","key":"10.1016\/j.biopha.2018.04.141_bib0010","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/eurheartj\/ehu299","article-title":"Cardiovascular disease in Europe 2014: epidemiological update","volume":"35","author":"Nichols","year":"2014","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.biopha.2018.04.141_bib0015","doi-asserted-by":"crossref","first-page":"e95622","DOI":"10.1371\/journal.pone.0095622","article-title":"TAT-protein blockade during ischemia\/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2018.04.141_bib0020","first-page":"352","article-title":"How does hypothermia protect cardiomyocytes during cardioplegic ischemia?","volume":"40","author":"Drescher","year":"2011","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"4","key":"10.1016\/j.biopha.2018.04.141_bib0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12154-010-0041-7","article-title":"Characterisation of the PTEN inhibitor VO-OHpic","volume":"3","author":"Mak","year":"2010","journal-title":"J. Chem. Biol."},{"issue":"12","key":"10.1016\/j.biopha.2018.04.141_bib0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/cb600352f","article-title":"A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)","volume":"1","author":"Rosivatz","year":"2006","journal-title":"ACS Chem. Biol."},{"issue":"11","key":"10.1016\/j.biopha.2018.04.141_bib0035","doi-asserted-by":"crossref","first-page":"H1414","DOI":"10.1152\/ajpheart.00748.2014","article-title":"A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac arrest","volume":"308","author":"Li","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2018.04.141_bib0040","doi-asserted-by":"crossref","first-page":"H2164","DOI":"10.1152\/ajpheart.00994.2009","article-title":"Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants","volume":"298","author":"Shao","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2018.04.141_bib0045","doi-asserted-by":"crossref","first-page":"H1761","DOI":"10.1152\/ajpheart.00187.2010","article-title":"Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest","volume":"298","author":"Beiser","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.biopha.2018.04.141_bib0050","doi-asserted-by":"crossref","first-page":"H1307","DOI":"10.1152\/ajpheart.00851.2001","article-title":"Adenosine A(3) receptor activation protects the myocardium from reperfusion\/reoxygenation injury","volume":"283","author":"Maddock","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6 Pt 2","key":"10.1016\/j.biopha.2018.04.141_bib0055","first-page":"H1743","article-title":"NADH measurements in adult rat myocytes during simulated ischemia","volume":"260","author":"Esumi","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2018.04.141_bib0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ctrv.2003.07.007","article-title":"PI3K\/Akt signalling pathway and cancer","volume":"30","author":"Fresno Vara","year":"2004","journal-title":"Cancer Treat. Rev."},{"issue":"7","key":"10.1016\/j.biopha.2018.04.141_bib0065","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/ni.2047","article-title":"The sphingosine 1-phosphate receptor S1P(2) maintains the homeostasis of germinal center B cells and promotes niche confinement","volume":"12","author":"Green","year":"2011","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.biopha.2018.04.141_bib0070","doi-asserted-by":"crossref","first-page":"H1806","DOI":"10.1152\/ajpheart.00929.2011","article-title":"Regulation of phosphatase and tensin homolog on chromosome 10 in response to hypoxia","volume":"302","author":"Qian","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"12","key":"10.1016\/j.biopha.2018.04.141_bib0075","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/jcbfm.2009.102","article-title":"Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia","volume":"29","author":"Li","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.biopha.2018.04.141_bib0080","doi-asserted-by":"crossref","first-page":"H1198","DOI":"10.1152\/ajpheart.00915.2009","article-title":"Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction","volume":"298","author":"Keyes","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218303081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218303081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:32:47Z","timestamp":1720661567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218303081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":16,"alternative-id":["S0753332218303081"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.141","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PTEN signaling inhibitor VO-OHpic improves cardiac myocyte survival by mediating apoptosis resistance in vitro","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}