{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:58:36Z","timestamp":1791367116283,"version":"4.3.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.154","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T12:30:22Z","timestamp":1525696222000},"page":"1436-1445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability"],"prefix":"10.1016","volume":"103","author":[{"given":"Mohammad Javad","family":"Khodayar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heibatollah","family":"Kalantari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layasadat","family":"Khorsandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rashno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Zeidooni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.04.154_bib0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.intimp.2012.09.013","article-title":"Protective effects of nicotinamide against acetaminophen-induced acute liver injury","volume":"14","author":"Shi","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0010","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/jps.21505","article-title":"Biochemical mechanism of acetaminophen (APAP) induced toxicity in melanoma cell lines","volume":"98","author":"Vad","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.04.154_bib0015","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biopha.2018.04.154_bib0020","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.taap.2006.04.010","article-title":"Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity","volume":"216","author":"Cover","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mam.2008.08.009","article-title":"Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase","volume":"30","author":"Franklin","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.biopha.2018.04.154_bib0030","doi-asserted-by":"crossref","first-page":"49075","DOI":"10.18632\/oncotarget.8682","article-title":"Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.04.154_bib0035","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/019262338701500407","article-title":"Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study","volume":"15","author":"Placke","year":"1987","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0040","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ejmech.2012.12.062","article-title":"Recent advances in natural products from plants for treatment of liver diseases","volume":"63","author":"Zhang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.04.154_bib0045","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/ajcn\/80.3.539","article-title":"Betaine in human nutrition","volume":"80","author":"Craig","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.biopha.2018.04.154_bib0050","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.clinbiochem.2010.03.009","article-title":"The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism","volume":"43","author":"Lever","year":"2010","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.biopha.2018.04.154_bib0055","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.3390\/nu5093481","article-title":"The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway","volume":"5","author":"Obeid","year":"2013","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2018.04.154_bib0060","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cbi.2008.09.021","article-title":"Alleviation of dimethylnitrosamine-induced liver injury and fibrosis by betaine supplementation in rats","volume":"177","author":"Kim","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.04.154_bib0065","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/jn\/133.9.2845","article-title":"Betaine lowers elevated S-adenosylhomocysteine levels in hepatocytes from ethanol-fed rats","volume":"133","author":"Barak","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.biopha.2018.04.154_bib0070","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.acthis.2014.05.004","article-title":"Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl4-induced hepatic damage in rats","volume":"116","author":"Ahn","year":"2014","journal-title":"Acta Histochem."},{"key":"10.1016\/j.biopha.2018.04.154_bib0075","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0278-6915(98)00024-6","article-title":"Effects of singly administered betaine on hepatotoxicity of chloroform in mice","volume":"36","author":"Kim","year":"1998","journal-title":"Food Chem.l Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0080","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0278-6915(01)00102-8","article-title":"Attenuation of bacterial lipopolysaccharide-induced hepatotoxicity by betaine or taurine in rats","volume":"40","author":"Kim","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jphs.2014.12.010","article-title":"Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways","volume":"127","author":"Lin","year":"2015","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.04.154_bib0090","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1046\/j.1471-4159.1999.0731127.x","article-title":"Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria","volume":"73","author":"Berman","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2018.04.154_bib0095","first-page":"1297","article-title":"Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: an in vitro study","volume":"20","author":"Ahangarpour","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.biopha.2018.04.154_bib0100","first-page":"825","article-title":"Study of the effects of ATP suppliers and thiol reductants on toxicity of pioglitazone in isolated rat liver mitochondria","volume":"14","author":"Mehrabadi","year":"2015","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.biopha.2018.04.154_bib0105","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1177\/0960327115618247","article-title":"Ellagic acid protects against arsenic toxicity in isolated rat mitochondria possibly through the maintaining of complex II","volume":"35","author":"Keshtzar","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0110","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jplph.2013.09.016","article-title":"Reduced mitochondrial and ascorbate\u2013glutathione activity after artificial ageing in soybean seed","volume":"171","author":"Xin","year":"2014","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0115","first-page":"329","article-title":"Grape seed proanthocyanidin extract improved some of biochemical parameters and antioxidant disturbances of red blood cells in diabetic rats","volume":"14","author":"Mansouri","year":"2015","journal-title":"Iran. J. Pharm. Res."},{"key":"10.1016\/j.biopha.2018.04.154_bib0120","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2018.04.154_bib0125","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.redox.2016.10.001","article-title":"Oxidative stress during acetaminophen hepatotoxicity: sources, pathophysiological role and therapeutic potential","volume":"10","author":"Du","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0130","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/00042737-200509000-00006","article-title":"The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats","volume":"17","author":"Balkan","year":"2005","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3177\/jnsv.44.249","article-title":"The recovering effect of betaine on carbon tetrachloride-induced liver injury","volume":"44","author":"Murakami","year":"1998","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0140","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.etp.2014.11.001","article-title":"Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative\/nitrosative stress and suppression of inflammation and apoptosis in rats","volume":"67","author":"Hagar","year":"2015","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0145","doi-asserted-by":"crossref","first-page":"G634","DOI":"10.1152\/ajpgi.00249.2009","article-title":"Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease","volume":"298","author":"Wang","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s11064-007-9472-0","article-title":"Effects of chronic ethanol consumption on brain synaptosomes and protective role of betaine","volume":"33","author":"Kanbak","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2018.04.154_bib0155","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s12192-009-0111-3","article-title":"Protective effect of betaine on changes in the levels of lysosomal enzyme activities in heart tissue in isoprenaline-induced myocardial infarction in Wistar rats","volume":"14","author":"Ganesan","year":"2009","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.biopha.2018.04.154_bib0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.taap.2015.09.022","article-title":"Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes","volume":"289","author":"Xie","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0165","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/hep.27385","article-title":"Targeting mitochondria with methylene blue protects mice against acetaminophen\u2010induced liver injury","volume":"61","author":"Lee","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2018.04.154_bib0170","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0003-9861(89)90504-3","article-title":"In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria","volume":"273","author":"Ramsay","year":"1989","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2018.04.154_bib0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s002040000179","article-title":"Preventive effect of betaine on ethanol-induced membrane lipid composition and membrane ATPases","volume":"75","author":"Kanbak","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0180","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1104\/pp.126.3.1266","article-title":"Mitochondrial adaptations to NaCl. Complex I is protected by anti-oxidants and small heat shock proteins, whereas complex II is protected by proline and betaine","volume":"126","author":"Hamilton","year":"2001","journal-title":"Plant Physiol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0185","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1016\/S0021-9258(19)67754-9","article-title":"Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes","volume":"266","author":"Burcham","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.04.154_bib0190","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/0006-2952(89)90481-4","article-title":"Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI)","volume":"38","author":"Esterline","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s002040050043","article-title":"Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity","volume":"68","author":"Donnelly","year":"1994","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0200","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0041-008X(96)80036-6","article-title":"Identification of a 54-kDa mitochondrial acetaminophen-binding protein as aldehyde dehydrogenase","volume":"141","author":"Landin","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0205","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1021\/tx1004198","article-title":"Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting","volume":"24","author":"Stamper","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0210","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/978-1-4684-5877-0_73","article-title":"Acetaminophen and protein thiol modification","volume":"283","author":"Nelson","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0215","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.toxlet.2015.05.001","article-title":"Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1\u2013p53 signaling pathways","volume":"236","author":"Wang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biopha.2018.04.154_bib0220","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jep.2009.10.002","article-title":"Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. Against acetaminophen-induced toxicity in mice","volume":"127","author":"Yuan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0225","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0041-008X(86)90051-7","article-title":"Potential role of activated macrophages in acetaminophen hepatotoxicity: I. Isolation and characterization of activated macrophages from rat liver","volume":"86","author":"Laskin","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0230","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/j.1478-3231.2010.02284.x","article-title":"Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice","volume":"30","author":"Williams","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.biopha.2018.04.154_bib0235","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/hep.1840210424","article-title":"Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen","volume":"21","author":"Laskin","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2018.04.154_bib0240","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/hep.510300104","article-title":"Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species","volume":"30","author":"Michael","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2018.04.154_bib0245","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/0006-2952(83)90426-4","article-title":"Acetaminophen hepatotoxicity: an alternative mechanism","volume":"32","author":"Rosen","year":"1983","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0250","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0006-2952(87)90710-6","article-title":"Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen","volume":"36","author":"Van de Straat","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0255","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2014.04.020","article-title":"Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique","volume":"570","author":"Weiduschat","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2018.04.154_bib0260","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/0006-2952(81)90102-7","article-title":"Protective role of the glutathione redox cycle against adriamycin-mediated toxicity in isolated hepatocytes","volume":"30","author":"Babson","year":"1981","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0265","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00204-014-1432-2","article-title":"Acetaminophen hepatotoxicity: an updated review","volume":"89","author":"Lancaste","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2018.04.154_bib0270","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1248\/bpb.30.2244","article-title":"Betaine modulates age-related NF-\u03baB by thiol-enhancing action","volume":"30","author":"Go","year":"2007","journal-title":"Biol. Pharm. Bull."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218308229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218308229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:45:07Z","timestamp":1720662307000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218308229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":54,"alternative-id":["S0753332218308229"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.154","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Betaine protects mice against acetaminophen hepatotoxicity possibly via mitochondrial complex II and glutathione availability","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}