{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:41:14Z","timestamp":1793288474998,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373788"],"award-info":[{"award-number":["81373788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.04.171","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T12:28:47Z","timestamp":1525696127000},"page":"1415-1428","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance"],"prefix":"10.1016","volume":"103","author":[{"given":"Ke-Ke","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Man","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Dong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.04.171_bib0005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jad.2016.12.024","article-title":"The association between depression and mortality\u2013a comparison of survey-and register-based measures of depression","volume":"210","author":"Christensen","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"12","key":"10.1016\/j.biopha.2018.04.171_bib0010","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.2337\/dc08-0985","article-title":"Depression and type 2 diabetes over the lifespan: a meta-analysis","volume":"31","author":"Mezuk","year":"2008","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Alcocer-G\u00f3mez","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: from evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/13651501.2013.859708","article-title":"The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals","volume":"18","author":"Hajebrahimi","year":"2014","journal-title":"Int. J. Psychiatry Clin. Pract."},{"issue":"6","key":"10.1016\/j.biopha.2018.04.171_bib0030","doi-asserted-by":"crossref","first-page":"e0157185","DOI":"10.1371\/journal.pone.0157185","article-title":"Positive correlation between enhanced expression of TLR4\/MyD88\/NF-kappaB with insulin resistance in placentae of gestational diabetes mellitus","volume":"11","author":"Feng","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0035","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2018.04.171_bib0040","doi-asserted-by":"crossref","first-page":"e33201","DOI":"10.1371\/journal.pone.0033201","article-title":"MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects","volume":"7","author":"Smalheiser","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.04.171_bib0045","doi-asserted-by":"crossref","first-page":"e682","DOI":"10.1038\/tp.2015.175","article-title":"Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology","volume":"5","author":"Dwivedi","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.biopha.2018.04.171_bib0050","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1055\/s-0033-1341516","article-title":"Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes","volume":"121","author":"Corral-Fernandez","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"10","key":"10.1016\/j.biopha.2018.04.171_bib0055","doi-asserted-by":"crossref","first-page":"e1006308","DOI":"10.1371\/journal.pgen.1006308","article-title":"MiR-155 enhances insulin sensitivity by coordinated regulation of multiple genes in mice","volume":"12","author":"Lin","year":"2016","journal-title":"PLoS Genet."},{"issue":"8","key":"10.1016\/j.biopha.2018.04.171_bib0060","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.febslet.2010.02.063","article-title":"Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation","volume":"584","author":"Tang","year":"2010","journal-title":"FEBS Lett."},{"issue":"10","key":"10.1016\/j.biopha.2018.04.171_bib0065","doi-asserted-by":"crossref","first-page":"e109525","DOI":"10.1371\/journal.pone.0109525","article-title":"Differential expression of microRNAs in Francisella tularensis-infected human macrophages: miR-155-dependent downregulation of MyD88 inhibits the inflammatory response","volume":"9","author":"Bandyopadhyay","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.04.171_bib0070","doi-asserted-by":"crossref","first-page":"23441","DOI":"10.1038\/srep23441","article-title":"Chronic unpredictive mild stress leads to altered hepatic metabolic profile and gene expression","volume":"6","author":"Jia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.04.171_bib0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jchromb.2017.08.003","article-title":"Chaihu-Shu-Gan-San regulates phospholipids and bile acid metabolism against hepatic injury induced by chronic unpredictable stress in rat","volume":"1064","author":"Jia","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.biopha.2018.04.171_bib0080","doi-asserted-by":"crossref","first-page":"34402","DOI":"10.1038\/srep34402","article-title":"The significance of routine biochemical markers in patients with major depressive disorder","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0085","doi-asserted-by":"crossref","first-page":"G749","DOI":"10.1152\/ajpgi.00184.2011","article-title":"Liver-brain inflammation axis","volume":"301","author":"D\u2019Mello","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0090","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2013.10.009","article-title":"Liver-brain interactions in inflammatory liver diseases: implications for fatigue and mood disorders","volume":"35","author":"D\u2019Mello","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0095","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.psyneuen.2012.05.007","article-title":"Impaired hypothalamic insulin signaling in CUMS rats: restored by icariin and fluoxetine through inhibiting CRF system","volume":"38","author":"Pan","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.biopha.2018.04.171_bib0100","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jep.2017.08.004","article-title":"Banxia-houpu decoction restores glucose intolerance in CUMS rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain","volume":"209","author":"Jia","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0105","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/iub.1496","article-title":"Umbelliferone attenuates unpredictable chronic mild stress induced-insulin resistance in rats","volume":"68","author":"Su","year":"2016","journal-title":"IUBMB Life"},{"issue":"4","key":"10.1016\/j.biopha.2018.04.171_bib0110","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s11011-017-0017-1","article-title":"Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress","volume":"32","author":"Shen","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.biopha.2018.04.171_bib0115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2017.02.007","article-title":"Ferulic acid inhibits neuro-inflammation in mice exposed to chronic unpredictable mild stress","volume":"45","author":"Liu","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats","volume":"41","author":"Pan","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.biopha.2018.04.171_bib0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.intimp.2017.04.019","article-title":"Baicalin ameliorates chronic unpredictable mild stress-induced depressive behavior: involving the inhibition of NLRP3 inflammasome activation in rat prefrontal cortex","volume":"48","author":"Liu","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0130","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbr.2016.05.057","article-title":"Quantitative proteomics analysis of the liver reveals immune regulation and lipid metabolism dysregulation in a mouse model of depression","volume":"311","author":"Wu","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.04.171_bib0135","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jep.2011.08.079","article-title":"Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula Chaihu-Shugan-San in depression","volume":"141","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.biopha.2018.04.171_bib0140","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.lfs.2004.10.022","article-title":"Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression","volume":"76","author":"Kim","year":"2005","journal-title":"Life Sci."},{"issue":"3\u20134","key":"10.1016\/j.biopha.2018.04.171_bib0145","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.brainresbull.2011.07.002","article-title":"Ferulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology","volume":"86","author":"Zhang","year":"2011","journal-title":"Brain Res. Bull."},{"issue":"8","key":"10.1016\/j.biopha.2018.04.171_bib0150","doi-asserted-by":"crossref","first-page":"e72428","DOI":"10.1371\/journal.pone.0072428","article-title":"Chaihu-Shugan-San administration ameliorates perimenopausal anxiety and depression in rats","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"Suppl. 1","key":"10.1016\/j.biopha.2018.04.171_bib0155","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.4103\/0973-1296.127342","article-title":"Antidepressant-like activity of Chaihu-Shugan-San aqueous extract in rats and its possible mechanism","volume":"10","author":"Wang","year":"2014","journal-title":"Pharmacogn. Mag."},{"issue":"4","key":"10.1016\/j.biopha.2018.04.171_bib0160","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3892\/etm.2013.1229","article-title":"Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San","volume":"6","author":"Xie","year":"2013","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0165","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3892\/etm.2015.2867","article-title":"Effect of Chaihu-Shugan-San on the mRNA expression of the 5-HT1A receptor and cellular proliferation in the hippocampus of epileptic rats with depression","volume":"11","author":"Yang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.04.171_bib0170","first-page":"1","article-title":"Protective effects of Chaihu Shugan San on nonalcoholic fatty liver disease in rats with insulin resistance","volume":"2016","author":"Jiang","year":"2016","journal-title":"Chin. J. Integr. Med."},{"issue":"9","key":"10.1016\/j.biopha.2018.04.171_bib0175","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrgastro.2013.99","article-title":"The liver-brain axis in liver failure: neuroinflammation and encephalopathy","volume":"10","author":"Butterworth","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"12","key":"10.1016\/j.biopha.2018.04.171_bib0180","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1017\/S0033291713000500","article-title":"Elevated alanine aminotransferase independently predicts new onset of depression in employees undergoing health screening examinations","volume":"43","author":"Zelber-Sagi","year":"2013","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.04.171_bib0185","doi-asserted-by":"crossref","first-page":"e0121975","DOI":"10.1371\/journal.pone.0121975","article-title":"Identification of differential microRNAs in cerebrospinal fluid and serum of patients with major depressive disorder","volume":"10","author":"Wan","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biopha.2018.04.171_bib0190","first-page":"1022","article-title":"MicroRNA-155 modulates the expression of pro-inflammatory cytokines in natural killer cells of rats exposed to chronic mild stress by regulation of ERK1\/2 signaling pathway","volume":"9","author":"Yang","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0195","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pnpbp.2015.09.004","article-title":"miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats","volume":"65","author":"Li","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0200","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O\u2019Connell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.biopha.2018.04.171_bib0205","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpba.2010.05.014","article-title":"Online identification of the antioxidant constituents of traditional Chinese medicine formula Chaihu-Shu-Gan-San by LC-LTQ-Orbitrap mass spectrometry and microplate spectrophotometer","volume":"53","author":"Su","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.biopha.2018.04.171_bib0210","doi-asserted-by":"crossref","first-page":"607584","DOI":"10.1155\/2012\/607584","article-title":"Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application","volume":"2012","author":"Fan","year":"2012","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.04.171_bib0215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jchromb.2015.10.007","article-title":"Role of Bai-Shao towards the antidepressant effect of Chaihu-Shu-Gan-San using metabonomics integrated with chemical fingerprinting","volume":"1006","author":"Chang","year":"2015","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.biopha.2018.04.171_bib0220","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jchromb.2017.03.029","article-title":"Chemometrics-enhanced one-dimensional\/comprehensive two-dimensional gas chromatographic analysis for bioactive terpenoids and phthalides in Chaihu Shugan San essential oils","volume":"1052","author":"He","year":"2017","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.04.171_bib0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jep.2011.05.009","article-title":"Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia","volume":"137","author":"Qiu","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0230","doi-asserted-by":"crossref","first-page":"354326","DOI":"10.1155\/2015\/354326","article-title":"Naringin attenuates autophagic stress and neuroinflammation in kainic acid-treated hippocampus in vivo","volume":"2015","author":"Jeong","year":"2015","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.biopha.2018.04.171_bib0235","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jff.2014.11.020","article-title":"Naringin prevents carbon tetrachloride-induced acute liver injury in mice","volume":"12","author":"Dong","year":"2015","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2018.04.171_bib0240","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainres.2011.08.047","article-title":"Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke","volume":"1420","author":"Raza","year":"2011","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0245","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s10753-016-0402-7","article-title":"Hesperidin alleviates lipopolysaccharide-induced neuroinflammation in mice by promoting the miRNA-132 pathway","volume":"39","author":"Li","year":"2016","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.biopha.2018.04.171_bib0250","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.intimp.2015.09.003","article-title":"Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice","volume":"29","author":"Shi","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.biopha.2018.04.171_bib0255","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.brainresbull.2012.04.010","article-title":"Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons","volume":"88","author":"Shen","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2018.04.171_bib0260","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.ejphar.2014.06.010","article-title":"Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway","volume":"740","author":"Mahmoud","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.04.171_bib0265","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuroscience.2013.09.044","article-title":"Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats","volume":"255","author":"Rinwa","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.04.171_bib0270","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2014.06.014","article-title":"Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)","volume":"71","author":"Ho","year":"2014","journal-title":"Food Chem. Toxicol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217366180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T01:28:13Z","timestamp":1720661293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217366180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":54,"alternative-id":["S0753332217366180"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.171","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.04.171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}