{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:35:18Z","timestamp":1789443318813,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/24908-4"],"award-info":[{"award-number":["2014\/24908-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["LIM-49-HC-FMUSP"],"award-info":[{"award-number":["LIM-49-HC-FMUSP"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["142839\/2005-1"],"award-info":[{"award-number":["142839\/2005-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["201308\/2008-8"],"award-info":[{"award-number":["201308\/2008-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["457099\/2014-3"],"award-info":[{"award-number":["457099\/2014-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.biopha.2018.05.004","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T12:28:36Z","timestamp":1525696116000},"page":"1609-1616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model: A candidate formulation for visceral leishmaniasis"],"prefix":"10.1016","volume":"103","author":[{"given":"Samanta Etel Treiger","family":"Borborema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Alberto","family":"Osso Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre Gustavo","family":"Tempone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Franco","family":"de Andrade Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanci","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.05.004_bib0005","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1469-0691.2011.03635.x","article-title":"Leishmaniasis impact and treatment access","volume":"17","author":"den Boer","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.biopha.2018.05.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.05.004_bib0015","first-page":"1","article-title":"Chemotherapy of leishmaniasis: present challenges","author":"Uliana","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.biopha.2018.05.004_bib0020","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0024-3205(78)90270-9","article-title":"Improved therapy of experimental leishmaniasis by use of a liposome-encapsulated antimonial drug","volume":"22","author":"Alving","year":"1978","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.05.004_bib0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/00034983.1984.11811817","article-title":"Liposomes in leishmaniasis: effects of parasite virulence on treatment of experimental leishmaniasis in hamsters","volume":"78","author":"Alving","year":"1984","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0169-4758(86)90039-6","article-title":"Liposomes as drug carriers in leishmaniasis and malaria","volume":"2","author":"Alving","year":"1986","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.biopha.2018.05.004_bib0035","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.2042-7158.1989.tb06399.x","article-title":"Visceral Leishmaniasis: drug carrier system characteristics and the ability to clear parasites from the liver, spleen and bone marrow in Leishmania donovani infected BALB\/c mice","volume":"41","author":"Carter","year":"1989","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.2042-7158.1988.tb05210.x","article-title":"Vesicular systems (niosomes and liposomes) for delivery of sodium stibogluconate in experimental murine visceral leishmaniasis","volume":"40","author":"Hunter","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0045","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.3390\/molecules14072317","article-title":"Pentavalent antimonials: new perspectives for old drugs","volume":"14","author":"Fr\u00e9zard","year":"2009","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2018.05.004_bib0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0005-2736(84)90521-2","article-title":"The effects of charge and size on the interaction of unilamellar liposomes with macrophages","volume":"772","author":"Schwendener","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.05.004_bib0055","doi-asserted-by":"crossref","first-page":"e02297","DOI":"10.1128\/AAC.02297-16","article-title":"Nanoliposomal buparvaquone immunomodulates Leishmania infantum-infected macrophages and is highly effective in a murine model","volume":"61","author":"da Costa-Silva","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2018.05.004_bib0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijantimicag.2010.04.006","article-title":"Therapeutic evaluation of free and liposome-loaded furazolidone in experimental visceral leishmaniasis","volume":"36","author":"Tempone","year":"2010","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.biopha.2018.05.004_bib0065","doi-asserted-by":"crossref","first-page":"131","DOI":"10.53393\/rial.2008.67.32780","article-title":"Nanoformulations of pentavalent antimony entrapped in phosphatidylserine-liposomes demonstrate highest efficacy against experimental visceral leishmaniasis","volume":"67","author":"Tempone","year":"2008","journal-title":"Rev. Inst. Adolfo Lutz."},{"key":"10.1016\/j.biopha.2018.05.004_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2014.00174","article-title":"Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research","volume":"5","author":"Tuntland","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0075","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0076-6879(04)87016-2","article-title":"Biodistribution and uptake of liposomes in vivo","author":"Kamps","year":"2004","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0080","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1590\/0074-0276108052013014","article-title":"Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB\/c mice","volume":"108","author":"Borborema","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz."},{"key":"10.1016\/j.biopha.2018.05.004_bib0085","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijantimicag.2011.05.012","article-title":"Uptake and antileishmanial activity of meglumine antimoniate-containing liposomes in Leishmania (Leishmania) major-infected macrophages","volume":"38","author":"Treiger Borborema","year":"2011","journal-title":"Int. J. Antimicrob. Agents."},{"key":"10.1016\/j.biopha.2018.05.004_bib0090","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1590\/0037-8682-0041-2016","article-title":"Antimonial drugs entrapped into phosphatidylserine liposomes: physicochemical evaluation and antileishmanial activity","volume":"49","author":"Borborema","year":"2016","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.biopha.2018.05.004_bib0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpharm.2006.01.048","article-title":"Improved targeting of antimony to the bone marrow of dogs using liposomes of reduced size","volume":"315","author":"Schettini","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2018.05.004_bib0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0003-2697(80)90269-9","article-title":"Colorimetric determination of phospholipids with ammonium ferrothiocyanate","volume":"104","author":"Stewart","year":"1980","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2018.05.004_bib0105","doi-asserted-by":"crossref","first-page":"e105127","DOI":"10.1371\/journal.pone.0105127","article-title":"Potential of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones against Leishmania (L.) infantum: biological activity and structure-activity relationships","volume":"9","author":"Pinto","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.05.004_bib0110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0169-409X(88)90006-3","article-title":"Targeting of immunomodulators to mononuclear phagocytes for therapy of cancer","volume":"2","author":"Fidler","year":"1988","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biopha.2018.05.004_bib0115","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/jac\/dkh281","article-title":"Targeting Leishmania (L.) chagasi amastigotes through macrophage scavenger receptors: the use of drugs entrapped in liposomes containing phosphatidylserine","volume":"54","author":"Tempone","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.biopha.2018.05.004_bib0120","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1517\/17425247.2010.529897","article-title":"New delivery strategies for the old pentavalent antimonial drugs","volume":"7","author":"Fr\u00e9zard","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.biopha.2018.05.004_bib0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2009.10.024","article-title":"An overview of liposome lyophilization and its future potential","volume":"142","author":"Chen","year":"2010","journal-title":"J. Control. Release."},{"key":"10.1016\/j.biopha.2018.05.004_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/15287394.2012.624826","article-title":"Disposition of antimony in rhesus monkeys infected with Leishmania braziliensis and treated with meglumine antimoniate","volume":"75","author":"Friedrich","year":"2012","journal-title":"J. Toxicol. Environ. Heal. Part A."},{"key":"10.1016\/j.biopha.2018.05.004_bib0135","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0022-3565(25)05912-9","article-title":"The correlation between distribution of antimony in tissues and chemotherapeutic effect in experimental leishmaniasis","volume":"88","author":"Gellhorn","year":"1946","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.05.004_bib0140","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.2042-7158.1988.tb05271.x","article-title":"The therapeutic effect of sodium stibogluconate in BALB\/c mice infected with Leishmania donovani is organ-dependent","volume":"40","author":"Carter","year":"1988","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0145","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/00034983.1992.11812628","article-title":"Visceral leishmaniasis in the BALB\/c mouse: antimony tissue disposition and parasite suppression after the administration of free stibogluconate","volume":"86","author":"Collins","year":"1992","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0150","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0163-7827(00)00020-5","article-title":"The role of hepatocytes in the clearance of liposomes from the blood circulation","volume":"40","author":"Scherphof","year":"2001","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.biopha.2018.05.004_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbamem.2004.10.013","article-title":"Uptake of phosphatidylserine-containing liposomes by liver sinusoidal endothelial cells in the serum-free perfused rat liver","volume":"1668","author":"Rothkopf","year":"2005","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.biopha.2018.05.004_bib0160","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1073\/pnas.75.6.2959","article-title":"Therapy of leishmaniasis: superior efficacies of liposome-encapsulated drugs","volume":"75","author":"Alving","year":"1978","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biopha.2018.05.004_bib0165","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/0035-9203(77)90155-9","article-title":"The use of Pentostam liposomes in the chemotherapy of experimental leishmaniasis","volume":"71","author":"Black","year":"1977","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2018.05.004_bib0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/272055a0","article-title":"Antileishmanial activity of antimonials entrapped in liposomes","volume":"272","author":"New","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.05.004_bib0175","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/0024-3205(80)90207-6","article-title":"Liposomes in leishmaniasis: therapeutic effects of antimonial drugs, 8-aminoquinolines, and tetracycline","volume":"26","author":"Alving","year":"1980","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.05.004_bib0180","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1128\/AAC.39.6.1234","article-title":"In vitro antileishmanial properties of tri- and pentavalent antimonial preparations","volume":"39","author":"Roberts","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2018.05.004_bib0185","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(80)90120-8","article-title":"Renal clearance of pentavalent antimony (sodium stibogluconate)","author":"Rees","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.biopha.2018.05.004_bib0190","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0035-9203(88)90267-2","article-title":"Pharmacokinetics of antimony during treatment of visceral leishmaniasis with sodium stibogluconate or meglumine antimoniate","volume":"82","author":"Chulay","year":"1988","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2018.05.004_bib0195","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0022-3565(25)05977-4","article-title":"The tissue-distribution and excretion of four organic antimonials after single or repeated administration to normal hamster","volume":"87","author":"Gellhorn","year":"1946","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.05.004_bib0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4269\/ajtmh.1997.57.403","article-title":"Pharmacokinetics of liposome-encapsulated meglumine antimonate after intramuscular and subcutaneous administration in dogs","volume":"57","author":"Valladares","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2018.05.004_bib0205","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0304-4017(01)00389-2","article-title":"Long term improvement in the treatment of canine leishmaniosis using an antimony liposomal formulation","volume":"97","author":"Valladares","year":"2001","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.biopha.2018.05.004_bib0210","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4269\/ajtmh.1988.39.41","article-title":"Pharmacokinetics of pentavalent antimony (Pentostam) in hamster","volume":"39","author":"Berman","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.biopha.2018.05.004_bib0215","doi-asserted-by":"crossref","first-page":"e0003889","DOI":"10.1371\/journal.pntd.0003889","article-title":"The current in vivo models for the discovery and utility of new anti-leishmanial drugs targeting cutaneous Leishmaniasis","volume":"9","author":"Mears","year":"2015","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217363503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332217363503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:23:48Z","timestamp":1751617428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332217363503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":43,"alternative-id":["S0753332217363503"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.004","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacokinetic of meglumine antimoniate encapsulated in phosphatidylserine-liposomes in mice model: A candidate formulation for visceral leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}