{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:14:30Z","timestamp":1787933670106,"version":"build-2784847793"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.biopha.2018.05.028","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T09:17:51Z","timestamp":1526375871000},"page":"211-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and A\u03b2 expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer\u2019s disease: A pilot study"],"prefix":"10.1016","volume":"104","author":[{"given":"Vinothkumar","family":"G.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnakumar","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sureshkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivashekar","family":"G.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreedhar","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Preethikrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"S.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundaram","family":"A.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakrishnan","family":"D.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Riya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataraman","family":"P.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.05.028_bib0005","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ki.2013.437","article-title":"Cognitive impairment in CKD: keep vascular disease in mind: commentary for kidney international on \u2018cognitive impairment in chronic kidney disease: prevalence, severity and association with HbA1c and fibrinogen\u2019","volume":"85","author":"Drew","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.05.028_bib0010","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5935\/0101-2800.20140035","article-title":"Cognitive alterations in chronic kidney disease: an update","volume":"36","author":"Matta","year":"2014","journal-title":"J. Bras. Nefrol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0015","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.freeradbiomed.2007.05.037","article-title":"Roles of amyloid \u03b2-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer\u2019s disease and mild cognitive impairment","volume":"43","author":"Butterfield","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.05.028_bib0020","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neurobiolaging.2006.11.003","article-title":"Platelet \u03b2-secretase activity is increased in Alzheimer\u2019s disease","volume":"29","author":"Johnston","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.biopha.2018.05.028_bib0025","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1212\/01.WNL.0000106953.49802.9C","article-title":"ADAM 10 and BACE alterations in the early stages of Alzheimer disease","volume":"62","author":"Colciaghi","year":"2004","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.028_bib0030","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00213-007-0748-5","article-title":"Abnormal APP processing in platelets of patients with Alzheimer\u2019s disease: correlations with membrane fluidity and cognitive decline","volume":"192","author":"Zainaghi","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.biopha.2018.05.028_bib0035","first-page":"3","article-title":"Peripheral biomarkers in dementia and Alzheimer\u2019s disease. The handbook of neuropsychiatric biomarkers","author":"Humpel","year":"2009","journal-title":"Endophenotypes Genes"},{"key":"10.1016\/j.biopha.2018.05.028_bib0040","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.bbadis.2011.07.004","article-title":"Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets","volume":"1812","author":"Kokjohn","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.05.028_bib0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jns.2005.09.002","article-title":"Platelet amyloid precursor protein processing: a bio-marker for Alzheimer\u2019s disease","volume":"240","author":"Tang","year":"2006","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.biopha.2018.05.028_bib0050","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00702-012-0807-x","article-title":"Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer\u2019s disease","volume":"119","author":"Zainaghi","year":"2012","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.biopha.2018.05.028_bib0055","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s11064-013-1039-7","article-title":"Processing of the platelet amyloid precursor protein in the mild cognitive impairment (MCI)","volume":"38","author":"Bermejo-Besc\u00f3s","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2018.05.028_bib0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2009.08.004","article-title":"Blood cell markers in Alzheimer disease: amyloid precursor protein form ratio in platelets","volume":"45","author":"Borroni","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/09537100802334434","article-title":"Platelet \u03b1-and \u03b2-secretase activities: a preliminary study in normal human subjects","volume":"20","author":"Smith","year":"2009","journal-title":"Platelets"},{"key":"10.1016\/j.biopha.2018.05.028_bib0070","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/ki.2008.516","article-title":"Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease","volume":"74","author":"Cachofeiro","year":"2008","journal-title":"Kidney Int. Suppl."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.028_bib0075","first-page":"165","article-title":"Oxidative stress in chronic kidney disease","volume":"9","author":"Modaresi","year":"2015","journal-title":"Iran. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2018.05.028_bib0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1021\/tx960130e","article-title":"\u03b2-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer\u2019s disease","volume":"10","author":"Butterfield","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0085","doi-asserted-by":"crossref","first-page":"35789","DOI":"10.1074\/jbc.C500238200","article-title":"Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia","volume":"280","author":"Tabner","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.05.028_bib0090","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1471-4159.2007.05072.x","article-title":"Oxidative stress activates a positive feedback between the \u03b3\u2010and \u03b2\u2010secretase cleavages of the \u03b2\u2010amyloid precursor protein","volume":"104","author":"Tamagno","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2018.05.028_bib0095","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2011111078","article-title":"Mechanisms of anemia in CKD","volume":"23","author":"Babitt","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0100","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ki.1989.18","article-title":"The anemia of chronic renal failure: pathophysiology and effects of recombinant erythropoietin","volume":"35","author":"Eschbach","year":"1989","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.05.028_bib0105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biopha.2016.04.041","article-title":"Assessment of erythropoietin for treatment of anemia in chronic kidney failure - ESRD patients","volume":"82","author":"Srinivasan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.05.028_bib0110","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0272-6386(99)70150-2","article-title":"Normalizing hematocrit in dialysis patients improves brain function","volume":"33","author":"Pickett","year":"1999","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2018.05.028_bib0115","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.neuro.2005.01.016","article-title":"Erythropoietin: a novel neuroprotective cytokine","volume":"26","author":"Bartesaghi","year":"2005","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2018.05.028_bib0120","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.brainres.2009.07.015","article-title":"Erythropoietin prevents zinc accumulation and neuronal death after traumatic brain injury in rat hippocampus: in vitro and in vivo studies","volume":"1289","author":"Zhu","year":"2009","journal-title":"Brain. Res."},{"key":"10.1016\/j.biopha.2018.05.028_bib0125","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2009.07.077","article-title":"Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit","volume":"1294","author":"Zhang","year":"2009","journal-title":"Brain. Res."},{"key":"10.1016\/j.biopha.2018.05.028_bib0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000090184","article-title":"Oxidative stress in renal anemia of hemodialysis patients is mitigated by epoetin treatment","volume":"28","author":"Siems","year":"2005","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.biopha.2018.05.028_bib0135","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/sj.ki.5002482","article-title":"Antioxidative effects of erythropoietin","volume":"72","author":"Katavetin","year":"2007","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.028_bib0140","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2215\/CJN.05671207","article-title":"Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis","volume":"3","author":"McGowan","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0145","first-page":"193","article-title":"Recombinant human erythropoietin in the management of anaemia in chronic kidney disease patients\u2013an Indian multicentre experience","volume":"7","author":"Agarwal","year":"2006","journal-title":"JIACM"},{"key":"10.1016\/j.biopha.2018.05.028_bib0150","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.2215\/CJN.03470509","article-title":"A randomized controlled study of weekly and biweekly dosing of epoetin alfa in CKD patients with anemia","volume":"4","author":"Pergola","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0155","first-page":"689","article-title":"Mini mental state examination (MMSE)","volume":"24","author":"Cockrell","year":"1988","journal-title":"Psychopharmacol. Bull."},{"key":"10.1016\/j.biopha.2018.05.028_bib0160","series-title":"Wechsler Memory Scale-Revised Manual","author":"Wechsler","year":"1987"},{"key":"10.1016\/j.biopha.2018.05.028_bib0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.acn.2003.09.001","article-title":"The tower of London and neuropsychological assessment of ADHD in adults","volume":"19","author":"Riccio","year":"2004","journal-title":"Arch. Neuropsychol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0170","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1123\/jsep.33.6.847","article-title":"Effects of acute exercise on executive function: a study with a tower of London task","volume":"33","author":"Chang","year":"2011","journal-title":"J. Sport Exercise Psychol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0175","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin-phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.05.028_bib0180","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0006-291X(87)91297-6","article-title":"Decreased lipid peroxidation in the rat kidney during gestation","volume":"145","author":"Devasagayam","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.05.028_bib0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-510X(95)00226-7","article-title":"Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment","volume":"134","author":"Fazekas","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.biopha.2018.05.028_bib0190","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0272-6386(97)90563-1","article-title":"Prevalence, recognition, and implications of mental impairment among hemodialysis patients","volume":"30","author":"Sehgal","year":"1997","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2018.05.028_bib0195","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/bbrc.1995.2103","article-title":"Platelets are the primary source of amyloid \u03b2-peptide in human blood","volume":"213","author":"Chen","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.05.028_bib0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cca.2005.06.015","article-title":"Circulating biomarkers of cognitive decline and dementia","volume":"364","author":"Solfrizzi","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.biopha.2018.05.028_bib0205","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","article-title":"The precursor of Alzheimer\u2019s disease amyloid A4 protein resembles a cell-surface receptor","volume":"325","author":"Kang","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.05.028_bib0210","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.tips.2013.01.008","article-title":"\u03b2-Secretase: its biology as a therapeutic target in diseases","volume":"34","author":"Wang","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.05.028_bib0215","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/10408360903335821","article-title":"The structure and function of Alzheimer\u2019s gamma secretase enzyme complex","volume":"46","author":"Krishnaswamy","year":"2009","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.biopha.2018.05.028_bib0220","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/glia.20638","article-title":"Increased expression of the \u03b3\u2010secretase components presenilin\u20101 and nicastrin in activated astrocytes and microglia following traumatic brain injury","volume":"56","author":"Nadler","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.biopha.2018.05.028_bib0225","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bbacli.2017.06.001","article-title":"Abnormal amyloid \u03b242 expression and increased oxidative stress in plasma of CKD patients with cognitive dysfunction: a small scale case control study comparison with Alzheimer\u2019s disease","volume":"8","author":"Vinothkumar","year":"2017","journal-title":"BBA Clin."},{"key":"10.1016\/j.biopha.2018.05.028_bib0230","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/ndt\/gfg074","article-title":"Oxidative stress in end\u2010stage renal disease: an emerging threat to patient outcome","volume":"18","author":"Locatelli","year":"2003","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.biopha.2018.05.028_bib0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2009.11.033","article-title":"Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"469","author":"Padurariu","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2018.05.028_bib0240","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1471-4159.2008.05603.x","article-title":"Lipid peroxidation up\u2010regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer\u2019s disease","volume":"107","author":"Chen","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2018.05.028_bib0245","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12640-011-9283-6","article-title":"Amyloid-\u03b2 production: major link between oxidative stress and BACE1","volume":"22","author":"Tamagno","year":"2012","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.biopha.2018.05.028_bib0250","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35088074","article-title":"Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-\u03baB signalling cascades","volume":"412","author":"Digicaylioglu","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.05.028_bib0255","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.neuropharm.2009.02.006","article-title":"Erythropoietin protects PC12 cells from \u03b2-amyloid 25\u201335-induced apoptosis via PI3K\/Akt signaling pathway","volume":"56","author":"Ma","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2018.05.028_bib0260","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bcp.2011.06.045","article-title":"Erythropoietin, erythropoiesis and beyond","volume":"82","author":"Chateauvieux","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.05.028_bib0265","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.biopha.2016.12.115","article-title":"Neuroprotective effects of erythropoietin against sevoflurane-induced neuronal apoptosis in primary rat cortical neurons involving the EPOR-Erk1\/2-Nrf2\/Bach1 signal pathway","volume":"87","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.05.028_bib0270","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuropharm.2014.04.009","article-title":"Neurodegenerative changes are prevented by erythropoietin in the pmn model of motoneuron degeneration","volume":"83","author":"Ruiz","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2018.05.028_bib0275","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1542-4758.2006.00107.x","article-title":"Effect of improvement in anemia on electroneurophysiological markers (P300) of cognitive dysfunction in chronic kidney disease","volume":"10","author":"Singh","year":"2006","journal-title":"Hemodial. Int."},{"key":"10.1016\/j.biopha.2018.05.028_bib0280","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1038\/s41598-017-03137-6","article-title":"Erythropoietin ameliorates diabetes-associated cognitive dysfunction in vitro and in vivo","volume":"1","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.05.028_bib0285","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(02)00041-1","article-title":"Erythropoietin restores glutathione peroxidase activity in 1-methyl-4-phenyl-1, 2, 5, 6-tetrahydropyridine-induced neurotoxicity in C57BL mice and stimulates murine astroglial glutathione peroxidase production in vitro","volume":"321","author":"Genc","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2018.05.028_bib0290","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000074958","article-title":"Selective inhibition of nitric oxide in hypoxic-ischemic brain model in newborn rats: is it an explanation for the protective role of erythropoietin?","volume":"85","author":"Kumral","year":"2004","journal-title":"Neonatology"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218321565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218321565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:27:48Z","timestamp":1760095668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218321565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":58,"alternative-id":["S0753332218321565"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.028","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic impact of rHuEPO on abnormal platelet APP, BACE 1, presenilin 1, ADAM 10 and A\u03b2 expressions in chronic kidney disease patients with cognitive dysfunction like Alzheimer\u2019s disease: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}