{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T05:46:49Z","timestamp":1776923209777,"version":"3.51.2"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.biopha.2018.05.050","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T04:01:41Z","timestamp":1527220901000},"page":"280-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis"],"prefix":"10.1016","volume":"104","author":[{"given":"Sanam","family":"Dolati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faroogh","family":"Marofi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Babaloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leili","family":"Aghebati-Maleki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Roshangar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Rikhtegar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.05.050_bib0005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.biopha.2016.12.010","article-title":"Multiple sclerosis: Therapeutic applications of advancing drug delivery systems","volume":"86","author":"Dolati","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.biopha.2018.05.050_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-pathol-011811-132443","article-title":"Pathology of demyelinating diseases","volume":"7","author":"Popescu","year":"2012","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"key":"10.1016\/j.biopha.2018.05.050_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","author":"Dendrou","year":"2015","journal-title":"Nature Reviews Immunology"},{"issue":"11","key":"10.1016\/j.biopha.2018.05.050_bib0020","doi-asserted-by":"crossref","first-page":"898","DOI":"10.5692\/clinicalneurol.53.898","article-title":"Immunology for understanding the pathogenesis of multiple sclerosis","volume":"53","author":"Matsui","year":"2012","journal-title":"Rinsho shinkeigaku= Clinical neurology"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0025","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/brain\/aws012","article-title":"NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury","volume":"135","author":"Fischer","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.biopha.2018.05.050_bib0030","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.biopha.2016.12.072","article-title":"Epigenetic modifications and epigenetic based medication implementations of autoimmune diseases","volume":"87","author":"Ahmadi","year":"2017","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0035","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7150\/ijms.8647","article-title":"Expression, regulation and function of microRNAs in multiple sclerosis","volume":"11","author":"Ma","year":"2014","journal-title":"International journal of medical sciences"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12017-016-8422-x","article-title":"Epigenetic modifications and therapy in multiple sclerosis","volume":"19","author":"Aslani","year":"2017","journal-title":"Neuromolecular medicine"},{"key":"10.1016\/j.biopha.2018.05.050_bib0045","doi-asserted-by":"crossref","DOI":"10.1177\/1352458515578771","article-title":"miRNA in multiple sclerosis: search for novel biomarkers","author":"Gandhi","year":"2015","journal-title":"Multiple Sclerosis Journal"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1261\/rna.1972910","article-title":"Sorting of Drosophila small silencing RNAs partitions microRNA* strands into the RNA interference pathway","volume":"16","author":"Ghildiyal","year":"2010","journal-title":"Rna"},{"key":"10.1016\/j.biopha.2018.05.050_bib0055","first-page":"311","article-title":"MicroRNA dysregulation in multiple sclerosis","volume":"3","author":"Moore","year":"2013","journal-title":"Frontiers in genetics"},{"issue":"7","key":"10.1016\/j.biopha.2018.05.050_bib0060","doi-asserted-by":"crossref","first-page":"e6309","DOI":"10.1371\/journal.pone.0006309","article-title":"Differential micro RNA expression in PBMC from multiple sclerosis patients","volume":"4","author":"Otaegui","year":"2009","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12017-014-8298-6","article-title":"Epigenetics of multiple sclerosis: an updated review","volume":"17","author":"K\u00fc\u00e7\u00fckali","year":"2015","journal-title":"Neuromolecular medicine"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/acn3.152","article-title":"Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR\u201020b","volume":"2","author":"Ingwersen","year":"2015","journal-title":"Annals of clinical and translational neurology"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0075","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.bbrc.2015.03.088","article-title":"miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2","volume":"460","author":"Li","year":"2015","journal-title":"Biochemical and biophysical research communications"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0080","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1093\/brain\/awr262","article-title":"Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity","volume":"134","author":"Guerau-de-Arellano","year":"2011","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0085","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/eji.200940032","article-title":"Altered expression of miR\u201017\u20105p in CD4+ lymphocytes of relapsing\u2013remitting multiple sclerosis patients","volume":"40","author":"Lindberg","year":"2010","journal-title":"European journal of immunology"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0090","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/bmt.2014.277","article-title":"Autologous hematopoietic SCT normalizes miR-16,-155 and-142-3p expression in multiple sclerosis patients","volume":"50","author":"Arruda","year":"2015","journal-title":"Bone marrow transplantation"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0095","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3109\/00207454.2012.678444","article-title":"miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients","volume":"122","author":"Lorenzi","year":"2012","journal-title":"International Journal of Neuroscience"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0100","first-page":"6442","article-title":"MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells","volume":"8","author":"Tian","year":"2015","journal-title":"International journal of clinical and experimental pathology"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0105","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.canlet.2014.10.003","article-title":"MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5","volume":"356","author":"Renjie","year":"2015","journal-title":"Cancer letters"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.050_bib0110","first-page":"15999","article-title":"MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cells","volume":"8","author":"Zubillaga-Guerrero","year":"2015","journal-title":"International journal of clinical and experimental medicine"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-015-0323-3","article-title":"Targeting of YAP1 by microRNA-15a and microRNA-16-1 exerts tumor suppressor function in gastric adenocarcinoma","volume":"14","author":"Kang","year":"2015","journal-title":"Molecular cancer"},{"key":"10.1016\/j.biopha.2018.05.050_bib0120","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jneuroim.2016.04.014","article-title":"MicroRNAs associated with the pathogenesis of multiple sclerosis","volume":"295","author":"Huang","year":"2016","journal-title":"Journal of neuroimmunology"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.050_bib0125","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.4049\/jimmunol.1103171","article-title":"miR-29ab1 deficiency identifies a negative feedback loop controlling Th1 bias that is dysregulated in multiple sclerosis","volume":"189","author":"Smith","year":"2012","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.biopha.2018.05.050_bib0130","first-page":"awr262","article-title":"Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity","author":"Guerau-de-Arellano","year":"2011","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0135","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3892\/or.2015.4500","article-title":"miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition","volume":"35","author":"Yao","year":"2016","journal-title":"Oncology reports"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0140","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI88415","article-title":"Excessive expression of miR-27 impairs Treg-mediated immunological tolerance","volume":"127","author":"Cruz","year":"2017","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1084\/jem.20150990","article-title":"miR-23\u223c 27\u223c 24 clusters control effector T cell differentiation and function","volume":"213","author":"Cho","year":"2016","journal-title":"Journal of Experimental Medicine"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.050_bib0150","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.joms.2015.09.038","article-title":"MicroRNA-340 mediates metabolic shift in oral squamous cell carcinoma by targeting glucose transporter-1","volume":"74","author":"Xu","year":"2016","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0155","first-page":"127","article-title":"Identification of miR-24 and miR-137 as novel candidate multiple sclerosis miRNA biomarkers using multi-staged data analysis protocol","volume":"6","author":"Ehya","year":"2017","journal-title":"Molecular biology research communications"},{"key":"10.1016\/j.biopha.2018.05.050_bib0160","article-title":"MicroRNAs and multiple sclerosis","author":"Tufekci","year":"2010","journal-title":"Autoimmune diseases"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0165","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jneuroim.2010.06.009","article-title":"Altered miRNA expression in T regulatory cells in course of multiple sclerosis","volume":"226","author":"De Santis","year":"2010","journal-title":"Journal of neuroimmunology"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0170","doi-asserted-by":"crossref","first-page":"e0124555","DOI":"10.1371\/journal.pone.0124555","article-title":"miR-141 and miR-200a, revelation of new possible players in modulation of Th17\/Treg differentiation and pathogenesis of multiple sclerosis","volume":"10","author":"Naghavian","year":"2015","journal-title":"PloS one"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0175","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/brain\/aww084","article-title":"MicroRNAs targeting TGF\u03b2 signalling underlie the regulatory T cell defect in multiple sclerosis","volume":"139","author":"Severin","year":"2016","journal-title":"Brain"},{"issue":"46","key":"10.1016\/j.biopha.2018.05.050_bib0180","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-\u03baB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0185","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/blood-2009-06-225987","article-title":"An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes","volume":"115","author":"Curtale","year":"2010","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.050_bib0190","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.4049\/jimmunol.0903021","article-title":"miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation","volume":"184","author":"Jurkin","year":"2010","journal-title":"The Journal of Immunology"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.050_bib0195","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-3083.2010.02383.x","article-title":"MicroRNA\u2010146a and Human Disease","volume":"71","author":"Li","year":"2010","journal-title":"Scandinavian journal of immunology"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0200","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.4049\/jimmunol.1303488","article-title":"miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR\u03b3t and STAT3","volume":"192","author":"Zhu","year":"2014","journal-title":"The Journal of Immunology"},{"issue":"50","key":"10.1016\/j.biopha.2018.05.050_bib0205","doi-asserted-by":"crossref","first-page":"16504","DOI":"10.1523\/JNEUROSCI.2830-15.2015","article-title":"miR-155-3p drives the development of autoimmune demyelination by regulation of heat shock protein 40","volume":"35","author":"Mycko","year":"2015","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.biopha.2018.05.050_bib0210","article-title":"Nanocurcumin restores aberrant miRNA expression profile in multiple sclerosis, randomized, double\u2010blind, placebo\u2010controlled trial","author":"Dolati","year":"2017","journal-title":"Journal of cellular physiology"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0215","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/ni.1798","article-title":"MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis","volume":"10","author":"Du","year":"2009","journal-title":"Nature immunology"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0220","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jneuroim.2012.02.012","article-title":"MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions","volume":"246","author":"Lescher","year":"2012","journal-title":"Journal of neuroimmunology"},{"issue":"7","key":"10.1016\/j.biopha.2018.05.050_bib0225","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-[alpha]","volume":"18","author":"Zhu","year":"2012","journal-title":"Nature medicine"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0230","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.gene.2014.04.069","article-title":"miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing\u2013remitting multiple sclerosis","volume":"544","author":"Honardoost","year":"2014","journal-title":"Gene"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0235","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbrc.2017.03.115","article-title":"MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2)","volume":"486","author":"Wu","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7","key":"10.1016\/j.biopha.2018.05.050_bib0240","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.4049\/jimmunol.1601727","article-title":"MicroRNA-15b suppresses Th17 differentiation and is associated with pathogenesis of multiple sclerosis by targeting O-GlcNAc transferase","volume":"198","author":"Liu","year":"2017","journal-title":"The Journal of Immunology"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0245","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clim.2012.04.002","article-title":"Altered microRNA expression in B lymphocytes in multiple sclerosis: towards a better understanding of treatment effects","volume":"144","author":"Sievers","year":"2012","journal-title":"Clinical immunology"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0250","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17\u223c 92 family of miRNA clusters","volume":"132","author":"Ventura","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.05.050_bib0255","article-title":"Decreased Dicer expression is linked to increased expression of co-stimulatory molecule CD80 on B cells in multiple sclerosis","author":"Aung","year":"2014","journal-title":"Multiple Sclerosis Journal"},{"key":"10.1016\/j.biopha.2018.05.050_bib0260","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2014.11.004","article-title":"MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a","volume":"278","author":"Aung","year":"2015","journal-title":"Journal of neuroimmunology"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0265","doi-asserted-by":"crossref","first-page":"e105421","DOI":"10.1371\/journal.pone.0105421","article-title":"A novel microRNA-132-surtuin-1 axis underlies aberrant B-cell cytokine regulation in patients with relapsing-remitting multiple sclerosis","volume":"9","author":"Miyazaki","year":"2014","journal-title":"PloS one"},{"key":"10.1016\/j.biopha.2018.05.050_bib0270","first-page":"1","article-title":"Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3","author":"Yao","year":"2015","journal-title":"Molecular Neurobiology"},{"issue":"20","key":"10.1016\/j.biopha.2018.05.050_bib0275","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1016\/j.febslet.2014.08.021","article-title":"MicroRNA\u2010320a inhibits cell proliferation, migration and invasion by targeting BMI\u20101 in nasopharyngeal carcinoma","volume":"588","author":"Qi","year":"2014","journal-title":"FEBS letters"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12943-015-0344-y","article-title":"MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3","volume":"14","author":"Sun","year":"2015","journal-title":"Molecular cancer"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.050_bib0285","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1158\/1538-7445.AM2015-2719","article-title":"MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A","volume":"5","author":"Wang","year":"2015","journal-title":"American journal of cancer research"},{"issue":"7","key":"10.1016\/j.biopha.2018.05.050_bib0290","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ncb1613","article-title":"MicroRNAs 17-5p\u201320a\u2013106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation","volume":"9","author":"Fontana","year":"2007","journal-title":"Nature cell biology"},{"issue":"10","key":"10.1016\/j.biopha.2018.05.050_bib0295","doi-asserted-by":"crossref","first-page":"e0139233*","DOI":"10.1371\/journal.pone.0139233","article-title":"Plasma exosomal miRNAs in persons with and without Alzheimer disease: altered expression and prospects for biomarkers","volume":"10","author":"Lugli","year":"2015","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0300","doi-asserted-by":"crossref","first-page":"14293","DOI":"10.1038\/s41598-017-14301-3","article-title":"Exosomal microRNA signatures in multiple sclerosis reflect disease status","volume":"7","author":"Ebrahimkhani","year":"2017","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0305","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12031-014-0476-3","article-title":"Selected extracellular microRNA as potential biomarkers of multiple sclerosis activity\u2014preliminary study","volume":"56","author":"Kacperska","year":"2015","journal-title":"Journal of Molecular Neuroscience"},{"issue":"14","key":"10.1016\/j.biopha.2018.05.050_bib0310","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1177\/1352458513490542","article-title":"Differential microRNA expression in blood in multiple sclerosis","volume":"19","author":"S\u00f8ndergaard","year":"2013","journal-title":"Multiple Sclerosis Journal"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0315","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.23880","article-title":"Circulating microRNAs as biomarkers for disease staging in multiple sclerosis","volume":"73","author":"Gandhi","year":"2013","journal-title":"Annals of neurology"},{"issue":"10","key":"10.1016\/j.biopha.2018.05.050_bib0320","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.3390\/ijms131013227","article-title":"MicroRNAs as active players in the pathogenesis of multiple sclerosis","volume":"13","author":"Fenoglio","year":"2012","journal-title":"International journal of molecular sciences"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0325","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neulet.2008.02.040","article-title":"Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients","volume":"435","author":"Sarchielli","year":"2008","journal-title":"Neuroscience letters"},{"key":"10.1016\/j.biopha.2018.05.050_bib0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2016.04.003","article-title":"The emerging role of miR-223 as novel potential diagnostic and therapeutic target for inflammatory disorders","volume":"303","author":"Aziz","year":"2016","journal-title":"Cellular immunology"},{"issue":"14","key":"10.1016\/j.biopha.2018.05.050_bib0335","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1177\/1352458513485654","article-title":"Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis","volume":"19","author":"Fenoglio","year":"2013","journal-title":"Multiple Sclerosis Journal"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0340","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1177\/1352458516651141","article-title":"Circulating microRNAs as biomarkers in progressive multiple sclerosis","volume":"23","author":"Vistbakka","year":"2017","journal-title":"Multiple Sclerosis Journal"},{"issue":"22","key":"10.1016\/j.biopha.2018.05.050_bib0345","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1212\/WNL.0b013e3182759621","article-title":"Regulated microRNAs in the CSF of patients with multiple sclerosis A case-control study","volume":"79","author":"Haghikia","year":"2012","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0350","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0355","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s12974-017-1006-3","article-title":"Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS","volume":"14","author":"Bruinsma","year":"2017","journal-title":"Journal of neuroinflammation"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.050_bib0360","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1093\/brain\/awr200","article-title":"Impaired neurosteroid synthesis in multiple sclerosis","volume":"134","author":"Noorbakhsh","year":"2011","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0365","doi-asserted-by":"crossref","first-page":"e0145237","DOI":"10.1371\/journal.pone.0145237","article-title":"Protoporphyrin treatment modulates susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice","volume":"10","author":"Zhang","year":"2015","journal-title":"PloS one"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0370","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1096\/fj.13-248880","article-title":"MicroRNA-155 negatively affects blood\u2013brain barrier function during neuroinflammation","volume":"28","author":"Lopez-Ramirez","year":"2014","journal-title":"The FASEB Journal"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0375","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.4049\/jimmunol.1003952","article-title":"Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis","volume":"187","author":"Murugaiyan","year":"2011","journal-title":"The Journal of Immunology"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0380","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ana.23967","article-title":"miR\u2010155 as a multiple sclerosis\u2013relevant regulator of myeloid cell polarization","volume":"74","author":"Moore","year":"2013","journal-title":"Annals of neurology"},{"key":"10.1016\/j.biopha.2018.05.050_bib0385","series-title":"miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis, Regulation of Inflammatory Signaling in Health and Disease","first-page":"111","author":"McCoy","year":"2017"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0390","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jneuroim.2010.05.014","article-title":"Orchestrating innate immune responses in multiple sclerosis: molecular players","volume":"225","author":"Fern\u00e1ndez","year":"2010","journal-title":"Journal of neuroimmunology"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0395","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/jcbfm.2014.207","article-title":"Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-\u03baB activation","volume":"35","author":"Wu","year":"2015","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"12","key":"10.1016\/j.biopha.2018.05.050_bib0400","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.4049\/jimmunol.1101196","article-title":"Differential regulation of the Let-7 family of microRNAs in CD4+ T cells alters IL-10 expression","volume":"188","author":"Swaminathan","year":"2012","journal-title":"The Journal of Immunology"},{"issue":"38","key":"10.1016\/j.biopha.2018.05.050_bib0405","doi-asserted-by":"crossref","first-page":"13882","DOI":"10.1073\/pnas.1411674111","article-title":"PreImplantation factor promotes neuroprotection by targeting microRNA let-7","volume":"111","author":"Mueller","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0410","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ni.3146","article-title":"Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function","volume":"16","author":"Pobezinsky","year":"2015","journal-title":"Nature immunology"},{"issue":"16","key":"10.1016\/j.biopha.2018.05.050_bib0415","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1016\/j.febslet.2013.05.065","article-title":"Let7a inhibits the growth of endometrial carcinoma cells by targeting Aurora\u2010B","volume":"587","author":"Liu","year":"2013","journal-title":"FEBS letters"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0420","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.chom.2015.01.007","article-title":"MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-\u03baB Pathway","volume":"17","author":"Kumar","year":"2015","journal-title":"Cell host & microbe"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.050_bib0425","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.bbadis.2015.12.004","article-title":"A cardiac myocyte-restricted Lin28\/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1","volume":"1862","author":"Joshi","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0430","doi-asserted-by":"crossref","first-page":"e1005408","DOI":"10.1371\/journal.pgen.1005408","article-title":"Let-7 represses carcinogenesis and a stem cell phenotype in the intestine via regulation of Hmga2","volume":"11","author":"Madison","year":"2015","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0435","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/cei.12954","article-title":"The identification of up\u2010regulated ebv\u2010miR\u2010BHRF1\u20102\u20105p targeting MALT1 and ebv\u2010miR\u2010BHRF1\u20103 in the circulation of patients with multiple sclerosis","volume":"189","author":"Wang","year":"2017","journal-title":"Clinical & Experimental Immunology"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0440","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1158\/0008-5472.CAN-07-5126","article-title":"EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3","volume":"68","author":"Xia","year":"2008","journal-title":"Cancer research"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.050_bib0445","doi-asserted-by":"crossref","first-page":"e1003220","DOI":"10.1371\/journal.ppat.1003220","article-title":"Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis","volume":"9","author":"Angelini","year":"2013","journal-title":"PLoS pathogens"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0450","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s40291-016-0221-4","article-title":"Specific miRNA disease biomarkers in blood, serum and plasma: challenges and prospects","volume":"20","author":"Backes","year":"2016","journal-title":"Molecular diagnosis & therapy"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.050_bib0455","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.050_bib0460","first-page":"160","article-title":"Extracellular vesicles round off communication in the nervous system, Nature reviews","volume":"17","author":"Budnik","year":"2016","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.050_bib0465","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.24931","article-title":"Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis","volume":"81","author":"Selmaj","year":"2017","journal-title":"Annals of Neurology"},{"issue":"20","key":"10.1016\/j.biopha.2018.05.050_bib0470","doi-asserted-by":"crossref","first-page":"E1248","DOI":"10.1073\/pnas.1114325109","article-title":"MicroRNA-301a regulation of a T-helper 17 immune response controls autoimmune demyelination","volume":"109","author":"Mycko","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.050_bib0475","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/ajt.13595","article-title":"B Cell\u2013Activating Transcription Factor Plays a Critical Role in the Pathogenesis of Anti\u2013Major Histocompatibility Complex\u2013Induced Obliterative Airway Disease","volume":"16","author":"Xu","year":"2016","journal-title":"American Journal of Transplantation"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0480","doi-asserted-by":"crossref","first-page":"16087","DOI":"10.3390\/ijms140816087","article-title":"MicroRNA expression changes during interferon-beta treatment in the peripheral blood of multiple sclerosis patients","volume":"14","author":"Hecker","year":"2013","journal-title":"International journal of molecular sciences"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0485","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41467-017-02406-2","article-title":"Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis","volume":"9","author":"Kimura","year":"2018","journal-title":"Nature communications"},{"key":"10.1016\/j.biopha.2018.05.050_bib0490","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/897249","article-title":"Unraveling Natalizumab Effects on Deregulated miR-17 Expression in CD4","author":"Meira","year":"2014","journal-title":"Journal of immunology research"},{"issue":"13","key":"10.1016\/j.biopha.2018.05.050_bib0495","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s40265-013-0102-7","article-title":"Natalizumab: a review of its use in the management of relapsing-remitting multiple sclerosis","volume":"73","author":"McCormack","year":"2013","journal-title":"Drugs"},{"issue":"14","key":"10.1016\/j.biopha.2018.05.050_bib0500","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1177\/1352458514534513","article-title":"Blood miRNA expression pattern is a possible risk marker for natalizumab-associated progressive multifocal leukoencephalopathy in multiple sclerosis patients","volume":"20","author":"Mu\u00f1oz-Culla","year":"2014","journal-title":"Multiple Sclerosis Journal"},{"issue":"10","key":"10.1016\/j.biopha.2018.05.050_bib0505","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1177\/1352458514524998","article-title":"MiR-126: a novel route for natalizumab action?","volume":"20","author":"Meira","year":"2014","journal-title":"Multiple Sclerosis Journal"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.050_bib0510","doi-asserted-by":"crossref","first-page":"e24604","DOI":"10.1371\/journal.pone.0024604","article-title":"Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis","volume":"6","author":"Waschbisch","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1755-8794-7-26","article-title":"Small non-coding RNA signature in multiple sclerosis patients after treatment with interferon-\u03b2","volume":"7","author":"De Felice","year":"2014","journal-title":"BMC medical genomics"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0520","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbadis.2017.09.024","article-title":"Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis","volume":"1864","author":"Potenza","year":"2018","journal-title":"Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease"},{"issue":"8","key":"10.1016\/j.biopha.2018.05.050_bib0525","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.4049\/jimmunol.1601532","article-title":"Dimethyl fumarate selectively reduces memory T cells and shifts the balance between Th1\/Th17 and Th2 in multiple sclerosis patients","volume":"198","author":"Wu","year":"2017","journal-title":"The Journal of Immunology"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.050_bib0530","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/acn3.270","article-title":"Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis","volume":"3","author":"Michell-Robinson","year":"2016","journal-title":"Annals of clinical and translational neurology"},{"key":"10.1016\/j.biopha.2018.05.050_bib0535","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biopha.2016.03.004","article-title":"Utilization of nanoparticle technology in rheumatoid arthritis treatment","volume":"80","author":"Dolati","year":"2016","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.biopha.2018.05.050_bib0540","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.biopha.2016.08.020","article-title":"Application of nanoparticle technology in the treatment of systemic lupus erythematous","volume":"83","author":"Rostamzadeh","year":"2016","journal-title":"Biomedicine & Pharmacotherapy"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218322364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218322364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:29:15Z","timestamp":1760095755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218322364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":108,"alternative-id":["S0753332218322364"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.050","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated Network of miRNAs Involved in the Pathogenesis of Multiple Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}