{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:25:58Z","timestamp":1789413958075,"version":"build-2803163510"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.biopha.2018.05.067","type":"journal-article","created":{"date-parts":[[2018,5,25]],"date-time":"2018-05-25T04:01:28Z","timestamp":1527220888000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":197,"special_numbering":"C","title":["Nano strategies for berberine delivery, a natural alkaloid of Berberis"],"prefix":"10.1016","volume":"104","author":[{"given":"Elaheh","family":"Mirhadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizhan","family":"Malaekeh-Nikouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1517\/13543776.2013.746314","article-title":"Berberine and its derivatives: a patent review (2009\u20132012)","volume":"23","author":"Singh","year":"2013","journal-title":"Expert Opin. Ther. Pat."},{"issue":"5","key":"10.1016\/j.biopha.2018.05.067_bib0010","first-page":"557","article-title":"A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome","volume":"20","author":"Tabeshpour","year":"2017","journal-title":"Iran J. Basic Med. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2018.05.067_bib0015","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/ptr.2399","article-title":"Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine","volume":"22","author":"Imanshahidi","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.05.067_bib0020","first-page":"1687","article-title":"Development and evaluation of vitamin E D-\u03b1-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical","volume":"11","author":"Shen","year":"2016","journal-title":"Int. J. Nanomed."},{"issue":"9","key":"10.1016\/j.biopha.2018.05.067_bib0025","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1139\/m69-190","article-title":"Berberine sulfate: antimicrobial activity, bioassay, and mode of action","volume":"15","author":"Amin","year":"1969","journal-title":"Can. J. Microbiol."},{"issue":"6","key":"10.1016\/j.biopha.2018.05.067_bib0030","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.bmcl.2006.12.085","article-title":"Antiviral activity of berberine and related compounds against human cytomegalovirus","volume":"17","author":"Hayashi","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0035","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1254\/fpj.102.101","article-title":"Pharmacological studies on antidiarrheal effects of berberine and geranii herba, Nihon yakurigaku zasshi","volume":"102","author":"Takase","year":"1993","journal-title":"Folia Pharmacol. Jpn."},{"issue":"6","key":"10.1016\/j.biopha.2018.05.067_bib0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0024-3205(02)02200-2","article-title":"A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species","volume":"72","author":"K\u00fcpeli","year":"2002","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2003.09.002","article-title":"The anti-inflammatory potential of berberine in vitro and in vivo","volume":"203","author":"Kuo","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2018.05.067_bib0050","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/187354","article-title":"Encapsulation of berberine in nano-sized PLGA synthesized by emulsification method","volume":"2012","author":"Khemani","year":"2012","journal-title":"ISRN Nanotechnol."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0055","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2217\/nnm.14.76","article-title":"Berberine-loaded targeted nanoparticles as specific Helicobacter pylori eradication therapy: in vitro and in vivo study","volume":"10","author":"Lin","year":"2015","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biopha.2018.05.067_bib0060","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.2147\/IJN.S84565","article-title":"Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db\/db mice","volume":"10","author":"Xue","year":"2015","journal-title":"Int. J. Nanomed."},{"issue":"8","key":"10.1016\/j.biopha.2018.05.067_bib0065","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0070","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/cbdd.12866","article-title":"Berberine\u2010loaded Janus nanocarriers for magnetic field\u2010enhanced therapy against hepatocellular carcinoma","volume":"89","author":"Wang","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"issue":"6","key":"10.1016\/j.biopha.2018.05.067_bib0075","doi-asserted-by":"crossref","first-page":"794","DOI":"10.7150\/ijbs.18969","article-title":"Berberine reverses hypoxia-induced chemoresistance in breast cancer through the inhibition of AMPK-HIF-1\u03b1","volume":"13","author":"Pan","year":"2017","journal-title":"Int. J. Biol Sci."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0080","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.3892\/ijo.2012.1588","article-title":"Arachidonic acid metabolism in human prostate cancer","volume":"41","author":"Yang","year":"2012","journal-title":"Int. J. Oncol."},{"issue":"7533","key":"10.1016\/j.biopha.2018.05.067_bib0085","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature14034","article-title":"Blocking PGE 2-induced tumour repopulation abrogates bladder cancer chemoresistance","volume":"517","author":"Kurtova","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0090","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.3892\/mmr.2015.3926","article-title":"Berberine induces apoptosis by suppressing the arachidonic acid metabolic pathway in hepatocellular carcinoma","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0095","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bbrc.2012.08.091","article-title":"Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin \u03b21 signaling","volume":"426","author":"Park","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.canlet.2009.01.033","article-title":"Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-\u03baB, u-PA and MMP-2 and-9","volume":"279","author":"Ho","year":"2009","journal-title":"Cancer Lett."},{"issue":"6","key":"10.1016\/j.biopha.2018.05.067_bib0105","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12393","article-title":"Berberine inhibits the chemotherapy\u2010induced repopulation by suppressing the arachidonic acid metabolic pathway and phosphorylation of FAK in ovarian cancer","volume":"50","author":"Zhao","year":"2017","journal-title":"Cell Prolif."},{"issue":"12","key":"10.1016\/j.biopha.2018.05.067_bib0110","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1124\/dmd.106.011361","article-title":"Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography ion trap mass spectrometry","volume":"34","author":"Zuo","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.biopha.2018.05.067_bib0115","series-title":"1st World Meeting APGI\/APV","first-page":"491","article-title":"Nanosuspensions-a novel formulation for the iv administration of poorly soluble drugs","author":"M\u00fcller","year":"1995"},{"key":"10.1016\/j.biopha.2018.05.067_bib0120","first-page":"574","article-title":"Nanosuspensions for the iv administration of poorly soluble drugs-stability during sterilization and long-term storage","author":"M\u00fcller","year":"1995","journal-title":"Proc. Int. Symp. Control Rel. Bioact. Mater."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0125","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s11051-012-0757-0","article-title":"Preparation of nanoparticles of poorly water-soluble antioxidant curcumin by antisolvent precipitation methods","volume":"14","author":"Kakran","year":"2012","journal-title":"J. Nanopart Res."},{"key":"10.1016\/j.biopha.2018.05.067_bib0130","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/DDDT.S156123","article-title":"Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity","volume":"12","author":"Sahibzada","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"10.1016\/j.biopha.2018.05.067_bib0135","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/03639040600975147","article-title":"Preparation of azithromycin nanosuspensions by high pressure homogenization and its physicochemical characteristics studies","volume":"33","author":"Zhang","year":"2007","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.biopha.2018.05.067_bib0140","article-title":"Berberine nanosuspension enhances hypoglycemic efficacy on streptozotocin induced diabetic C57BL\/6 mice","volume":"2015","author":"Wang","year":"2015","journal-title":"Evid-Based Compl. Alt."},{"issue":"12","key":"10.1016\/j.biopha.2018.05.067_bib0145","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/ki.2008.156","article-title":"Ischemia\u2013reperfusion treatment: opportunities point to modulation of the inflammatory response","volume":"73","author":"Rouschop","year":"2008","journal-title":"Kidney Int."},{"issue":"15","key":"10.1016\/j.biopha.2018.05.067_bib0150","doi-asserted-by":"crossref","first-page":"24154","DOI":"10.18632\/oncotarget.16530","article-title":"Berberine nanoparticles protects tubular epithelial cells from renal ischemia-reperfusion injury","volume":"8","author":"Xie","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0155","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1367-5931(00)00227-1","article-title":"Polymers in drug delivery","volume":"5","author":"Pillai","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.biopha.2018.05.067_bib0160","series-title":"D-Glucosamine and N-Acetyl D-Glucosamine: Their Potential Use as Regenerative Medicine, Chitin and Chitosan for Regenerative Medicine","first-page":"279","author":"Jain","year":"2016"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0165","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/jbm.a.32199","article-title":"Antibiotic delivery system using nano\u2010hydroxyapatite\/chitosan bone cement consisting of berberine","volume":"89","author":"Zou","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"11","key":"10.1016\/j.biopha.2018.05.067_bib0170","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.3390\/md12115677","article-title":"Delivery of berberine using chitosan\/fucoidan-taurine conjugate nanoparticles for treatment of defective intestinal epithelial tight junction barrier","volume":"12","author":"Wu","year":"2014","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0175","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.intimp.2015.05.014","article-title":"In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis","volume":"28","author":"Zhou","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.05.067_bib0180","series-title":"AIP Conference Proceedings","doi-asserted-by":"crossref","DOI":"10.1063\/1.4945180","article-title":"Synthesis of berberine loaded polymeric nanoparticles by central composite design","author":"Mehra","year":"2016"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.067_bib0185","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1177\/0885328213509503","article-title":"Development of poly (N-isopropylacrylamide)\/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment","volume":"28","author":"Xu","year":"2014","journal-title":"J. Biomater. Appl."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089124","article-title":"O-hexadecyl-dextran entrapped berberine nanoparticles abrogate high glucose stress induced apoptosis in primary rat hepatocytes","volume":"9","author":"Kapoor","year":"2014","journal-title":"Plos One"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0195","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1080\/10717544.2017.1321062","article-title":"PEG\u2013lipid\u2013PLGA hybrid nanoparticles loaded with berberine\u2013phospholipid complex to facilitate the oral delivery efficiency","volume":"24","author":"Yu","year":"2017","journal-title":"Drug Delivery"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1146\/annurev.bioeng.2.1.9","article-title":"Physicochemical foundations and structural design of hydrogels in medicine and biology","volume":"2","author":"Peppas","year":"2000","journal-title":"Ann. Rev. Biomed. Eng."},{"issue":"38","key":"10.1016\/j.biopha.2018.05.067_bib0205","doi-asserted-by":"crossref","first-page":"7885","DOI":"10.1039\/C7TB02262J","article-title":"Enhanced antimicrobial effect of berberine in nanogel carriers with cationic surface functionality","volume":"5","author":"Al-Awady","year":"2017","journal-title":"J. Mater. Chem. B"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0210","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/cbdd.12866","article-title":"Berberine\u2010loaded Janus nanocarriers for magnetic field\u2010enhanced therapy against hepatocellular carcinoma","volume":"89","author":"Wang","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.biopha.2018.05.067_bib0215","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/801820","article-title":"Lipid-based drug delivery systems","volume":"2014","author":"Shrestha","year":"2014","journal-title":"J. Pharmaceutics."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0220","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1208\/s12249-010-9563-0","article-title":"Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery","volume":"12","author":"Das","year":"2011","journal-title":"Aaps PharmSciTech"},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0225","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1208\/s12249-014-0112-0","article-title":"Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation","volume":"15","author":"Wang","year":"2014","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0230","doi-asserted-by":"crossref","DOI":"10.4155\/fsoa-2016-0030","article-title":"Nanostructured lipid carriers: versatile oral delivery vehicle","volume":"2","author":"Poonia","year":"2016","journal-title":"Future Sci. OA"},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0235","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ijpharm.2011.05.044","article-title":"Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake","volume":"415","author":"Tiwari","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2018.05.067_bib0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0959-8049(01)00267-2","article-title":"Cancer burden in the year 2000","volume":"37","author":"Parkin","year":"2001","journal-title":"Global Pict. Eur J. Cancer"},{"key":"10.1016\/j.biopha.2018.05.067_bib0245","series-title":"Proc. SPIE","article-title":"In vitro and in vivo antitumor efficacy of berberine-nanostructured lipid carriers against H22 tumor","author":"Wang","year":"2015"},{"key":"10.1016\/j.biopha.2018.05.067_bib0250","series-title":"Anti-Hepatocarcinoma Effects of Berberine-Nanostructured Lipid Carriers Against Human HepG2, Huh7, and EC9706 Cancer Cell Lines","author":"Meng","year":"2016"},{"key":"10.1016\/j.biopha.2018.05.067_bib0255","doi-asserted-by":"crossref","first-page":"8671","DOI":"10.2147\/IJN.S144615","article-title":"Selenium-coated nanostructured lipid carriers used for oral delivery of berberine to accomplish a synergic hypoglycemic effect","volume":"12","author":"Yin","year":"2017","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0260","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejps.2011.06.015","article-title":"Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine","volume":"44","author":"Wang","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0265","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-2836(65)80093-6","article-title":"Diffusion of univalent ions across the lamellae of swollen phospholipids","volume":"13","author":"Bangham","year":"1965","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0270","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/0005-2736(73)90408-2","article-title":"Single bilayer liposomes prepared without sonication","volume":"298","author":"Batzri","year":"1973","journal-title":"BBA)-Biomembranes"},{"issue":"5","key":"10.1016\/j.biopha.2018.05.067_bib0275","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1096\/fj.10-0503","article-title":"From \u201cbanghasomes\u201d to liposomes: a memoir of Alec Bangham, 1921\u20132010","volume":"24","author":"Deamer","year":"2010","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.biopha.2018.05.067_bib0280","doi-asserted-by":"crossref","DOI":"10.1042\/bj1240058P","article-title":"Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases","volume":"124","author":"Gregoriadis","year":"1971","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0285","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0014-5793(73)80394-1","article-title":"Drug entrapment in liposomes","volume":"36","author":"Gregoriadis","year":"1973","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0290","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0295","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ijpharm.2012.11.017","article-title":"Optimizing manufacture of liposomal berberine with evaluation of its antihepatoma effects in a murine xenograft model","volume":"441","author":"Lin","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0300","first-page":"261","article-title":"Preparation of berberine hydrochloride long-circulating liposomes by ionophore A23187-mediated ZnSO4 gradient method","volume":"8","author":"Luo","year":"2013","journal-title":"Asian J. Pharm."},{"issue":"41","key":"10.1016\/j.biopha.2018.05.067_bib0305","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1039\/C4TB00876F","article-title":"Chitosan-coated nano-liposomes for the oral delivery of berberine hydrochloride","volume":"2","author":"Nguyen","year":"2014","journal-title":"J. Mater. Chem. B"},{"issue":"7","key":"10.1016\/j.biopha.2018.05.067_bib0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7324\/JAPS.2015.50704","article-title":"Formulation and in vitro evaluation of berberine containing liposome optimized by 32 full factorial designs","volume":"5","author":"Sailor","year":"2015","journal-title":"J. App. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.05.067_bib0315","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00261","article-title":"Impact of dendrimers on solubility of hydrophobic drug molecules","volume":"8","author":"Choudhary","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.05.067_bib0320","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpharm.2017.04.073","article-title":"Dendrimer encapsulated and conjugated delivery of berberine: a novel approach mitigating toxicity and improving in vivo pharmacokinetics","volume":"528","author":"Gupta","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biopha.2018.05.067_bib0325","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nmat1849","article-title":"The rise of graphene","volume":"6","author":"Novoselov","year":"2007","journal-title":"Nat. Mater."},{"issue":"12","key":"10.1016\/j.biopha.2018.05.067_bib0330","doi-asserted-by":"crossref","first-page":"9243","DOI":"10.1016\/j.actbio.2013.08.016","article-title":"Graphene and graphene oxide as new nanocarriers for drug delivery applications","volume":"9","author":"Liu","year":"2013","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0335","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1039\/C2CS35342C","article-title":"Nano-graphene in biomedicine: theranostic applications","volume":"42","author":"Yang","year":"2013","journal-title":"Chem. Soc. Rev."},{"issue":"11","key":"10.1016\/j.biopha.2018.05.067_bib0340","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1517\/17425247.2012.729575","article-title":"The application of graphene oxide in drug delivery","volume":"9","author":"Pan","year":"2012","journal-title":"Expert Opin. Drug. Del."},{"issue":"01","key":"10.1016\/j.biopha.2018.05.067_bib0345","doi-asserted-by":"crossref","DOI":"10.1142\/S179398441100030X","article-title":"Recent advances in graphene-based nanomaterials for biomedical applications","volume":"2","author":"BAO","year":"2012","journal-title":"Nano Life."},{"issue":"22","key":"10.1016\/j.biopha.2018.05.067_bib0350","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.2174\/1381612821666150531170832","article-title":"Graphene oxide-based nanocarriers for cancer imaging and drug delivery","volume":"21","author":"You","year":"2015","journal-title":"Curr. Pharm. Des."},{"issue":"8","key":"10.1016\/j.biopha.2018.05.067_bib0355","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/jps.24491","article-title":"The structure\u2010dependent electric release and enhanced oxidation of drug in graphene oxide\u2010based nanocarrier loaded with anticancer herbal drug Berberine","volume":"104","author":"Yu","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.05.067_bib0360","first-page":"145","article-title":"The Bakerian lecture: experimental relations of gold (and other metals) to light","volume":"147","author":"Faraday","year":"1857","journal-title":"Philos. Trans. Soc. Lond."},{"issue":"1010","key":"10.1016\/j.biopha.2018.05.067_bib0365","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1259\/bjr\/59448833","article-title":"Gold nanoparticles as novel agents for cancer therapy","volume":"85","author":"Jain","year":"2012","journal-title":"Br. J. Radiol."},{"issue":"01","key":"10.1016\/j.biopha.2018.05.067_bib0370","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4236\/jbnb.2015.61006","article-title":"Gold nanoparticle and berberine entrapped into hydrogel matrix as drug delivery system","volume":"6","author":"Souza","year":"2015","journal-title":"J. Biomater. Nanobiotechnol."},{"issue":"7","key":"10.1016\/j.biopha.2018.05.067_bib0375","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1016\/j.msec.2013.05.007","article-title":"Biogenic gold nanoparticles as fotillas to fire berberine hydrochloride using folic acid as molecular road map","volume":"33","author":"Pandey","year":"2013","journal-title":"Mater. Sci. Eng. C"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.067_bib0380","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.3390\/ijms17091534","article-title":"Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches","volume":"17","author":"Zhang","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0385","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/molecules21030365","article-title":"Silver nanoparticles exhibit the dose-dependent anti-proliferative effect against human squamous carcinoma cells attenuated in the presence of Berberine","volume":"21","author":"Dziedzic","year":"2016","journal-title":"Molecules"},{"issue":"23","key":"10.1016\/j.biopha.2018.05.067_bib0390","doi-asserted-by":"crossref","first-page":"14466","DOI":"10.1039\/C7NJ02531A","article-title":"Bioformulation of silver nanoparticles as berberine carrier cum anticancer agent against breast cancer","volume":"41","author":"Bhanumathi","year":"2017","journal-title":"New J. Chem."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0395","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejps.2013.02.006","article-title":"The applications of vitamin E TPGS in drug delivery","volume":"49","author":"Guo","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.05.067_bib0400","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/951942","article-title":"Investigations on agglomeration and haemocompatibility of vitamin E TPGS surface modified berberine chloride nanoparticles","volume":"2014","author":"Vuddanda","year":"2014","journal-title":"Biomed. Res. Int."},{"issue":"1-2","key":"10.1016\/j.biopha.2018.05.067_bib0405","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijpharm.2014.01.023","article-title":"Solid dispersion of berberine\u2013phospholipid complex\/TPGS 1000\/SiO2: preparation, characterization and in vivo studies","volume":"465","author":"Zhang","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0410","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ijpharm.2016.04.048","article-title":"Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite","volume":"506","author":"Djebbi","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0415","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ijpharm.2016.09.089","article-title":"Delivery system for berberine chloride based on the nanocarrier ZnAl-layered double hydroxide: physicochemical characterization, release behavior and evaluation of anti-bacterial potential","volume":"515","author":"Djebbi","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0420","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12274-014-0644-3","article-title":"The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective","volume":"8","author":"Zhu","year":"2015","journal-title":"Nano Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.05.067_bib0425","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.nantod.2014.09.004","article-title":"Carbon dots\u2014Emerging light emitters for bioimaging, cancer therapy and optoelectronics","volume":"9","author":"Hola","year":"2014","journal-title":"Nano Today"},{"issue":"2","key":"10.1016\/j.biopha.2018.05.067_bib0430","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.nantod.2015.09.002","article-title":"Beyond bottom-up carbon nanodots: citric-acid derived organic molecules","volume":"11","author":"Zhu","year":"2016","journal-title":"Nano Today"},{"issue":"111","key":"10.1016\/j.biopha.2018.05.067_bib0435","doi-asserted-by":"crossref","first-page":"91398","DOI":"10.1039\/C5RA18391J","article-title":"Single and repeated dose toxicity of citric acid-based carbon dots and a derivative in mice","volume":"5","author":"Zheng","year":"2015","journal-title":"RSC Adv."},{"issue":"30","key":"10.1016\/j.biopha.2018.05.067_bib0440","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1039\/C6TB01259K","article-title":"Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo","volume":"4","author":"Zeng","year":"2016","journal-title":"J. Mater. Chem. B"},{"issue":"9","key":"10.1016\/j.biopha.2018.05.067_bib0445","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1039\/C7BM00358G","article-title":"Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells","volume":"5","author":"Shao","year":"2017","journal-title":"Biomater Sci."},{"issue":"52","key":"10.1016\/j.biopha.2018.05.067_bib0450","doi-asserted-by":"crossref","first-page":"27184","DOI":"10.1039\/c3ra47994c","article-title":"Bioimaging based on fluorescent carbon dots","volume":"4","author":"Song","year":"2014","journal-title":"Rsc Adv."},{"issue":"22","key":"10.1016\/j.biopha.2018.05.067_bib0455","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1002\/ange.201700757","article-title":"Piezochromic carbon dots with two\u2010photon fluorescence","volume":"129","author":"Lu","year":"2017","journal-title":"Angew. Chem."},{"issue":"23","key":"10.1016\/j.biopha.2018.05.067_bib0460","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1039\/C4RA00012A","article-title":"A facile, green, and solvent-free route to nitrogen\u2013sulfur-codoped fluorescent carbon nanoparticles for cellular imaging","volume":"4","author":"Huang","year":"2014","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.biopha.2018.05.067_bib0465","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1039\/C3AN02098C","article-title":"Facile synthesis of water-soluble and biocompatible fluorescent nitrogen-doped carbon dots for cell imaging","volume":"139","author":"Wang","year":"2014","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0470","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1021\/nn500368m","article-title":"Common origin of green luminescence in carbon nanodots and graphene quantum dots","volume":"8","author":"Wang","year":"2014","journal-title":"ACS Nano"},{"issue":"43","key":"10.1016\/j.biopha.2018.05.067_bib0475","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1039\/c3cc38815h","article-title":"Bottom-up fabrication of photoluminescent carbon dots with uniform morphology via a soft\u2013hard template approach","volume":"49","author":"Yang","year":"2013","journal-title":"Chem. Commun."},{"issue":"1","key":"10.1016\/j.biopha.2018.05.067_bib0480","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1039\/C4CS00269E","article-title":"Carbon quantum dots and their applications","volume":"44","author":"Lim","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biopha.2018.05.067_bib0485","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mtchem.2017.09.001","article-title":"The polymeric characteristics and photoluminescence mechanism in polymer carbon dots: a review","volume":"6","author":"Tao","year":"2017","journal-title":"Mater. Today Chem."},{"issue":"4","key":"10.1016\/j.biopha.2018.05.067_bib0490","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.1021\/acsnano.6b00043","article-title":"Charge-convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency","volume":"10","author":"Feng","year":"2016","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.biopha.2018.05.067_bib0495","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/adhm.201500720","article-title":"Carbon dots with intrinsic theranostic properties for bioimaging, red\u2010light\u2010triggered photodynamic\/photothermal simultaneous therapy in vitro and in vivo","volume":"5","author":"Ge","year":"2016","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0500","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1039\/C7RA12069A","article-title":"Berberine-based carbon dots for selective and safe cancer theranostics","volume":"8","author":"Zhang","year":"2018","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.biopha.2018.05.067_bib0505","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.phymed.2013.09.013","article-title":"Improvement of anti-inflammatory and anti-angiogenic activity of berberine by novel rapid dissolving nanoemulsifying technique","volume":"21","author":"Pund","year":"2014","journal-title":"Phytomedicine"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218317384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218317384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:33:12Z","timestamp":1760095992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218317384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":101,"alternative-id":["S0753332218317384"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.067","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nano strategies for berberine delivery, a natural alkaloid of Berberis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.05.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}