{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:23:36Z","timestamp":1790274216718,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.biopha.2018.06.004","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T07:49:36Z","timestamp":1529653776000},"page":"1248-1253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients"],"prefix":"10.1016","volume":"105","author":[{"given":"Massimo","family":"Nabissi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatrice","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Nicotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romilde","family":"Iannarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"Amantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Santoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.06.004_bib0005","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5455\/msm.2012.24.100-105","article-title":"Asthma and chronic obstructive pulmonary disease (COPD) \u2013 differences and similarities","volume":"24","author":"Cukic","year":"2012","journal-title":"Mater. Soc.-Med."},{"issue":"4","key":"10.1016\/j.biopha.2018.06.004_bib0010","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.3390\/cells5040040","article-title":"Airway epithelial cell cilia and obstructive lung disease","volume":"5","author":"Yaghi","year":"2016","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.biopha.2018.06.004_bib0015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1164\/rccm.200612-1772OC","article-title":"Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology","volume":"176","author":"Hogg","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biopha.2018.06.004_bib0020","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.1016\/S1995-7645(14)60259-5","article-title":"Traditional effects of medicinal plants in the treatment of respiratory diseases and disorders: an ethnobotanical study in the Urmia","volume":"7","author":"Asadbeigi","year":"2014","journal-title":"Asian Pac. J. Trop. Med."},{"issue":"4","key":"10.1016\/j.biopha.2018.06.004_bib0025","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.phrs.2010.04.005","article-title":"The activity of medicinal plants and secondary metabolites on eosinophilic inflammation","volume":"62","author":"Rogerio","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2018.06.004_bib0030","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2016.06.024","article-title":"Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line","volume":"256","author":"Marinelli","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.004_bib0035","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2007.12.003","article-title":"Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts","volume":"116","author":"Al-Bayati","year":"2008","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.004_bib0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/J157v04n01_07","article-title":"Thyme (Thymus vulgaris L.), thymol","volume":"4","author":"Basch","year":"2004","journal-title":"J. Herb. Pharmacother."},{"issue":"51","key":"10.1016\/j.biopha.2018.06.004_bib0045","doi-asserted-by":"crossref","first-page":"7972","DOI":"10.1016\/j.chroma.2010.07.042","article-title":"Determination of polyphenolic compounds by liquid chromatography\u2013mass spectrometry in Thymus species","volume":"1217","author":"European Medicine Agency (EMA), An agency of the European Union","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.biopha.2018.06.004_bib0050","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.foodchem.2007.11.035","article-title":"Determination of polyphenolic compounds in commercial herbal drugs and spices from Lamiaceae: thyme, wild thyme and sweet marjoram by chromatographic techniques","volume":"108","author":"Fecka","year":"2008","journal-title":"Food Chem."},{"issue":"2-3","key":"10.1016\/j.biopha.2018.06.004_bib0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1078\/094471103321659807","article-title":"Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension","volume":"10","author":"Somova","year":"2003","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2018.06.004_bib0060","first-page":"491","article-title":"Involvement in immunity and infectious diseases","volume":"5","author":"Duque","year":"2014","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.004_bib0065","doi-asserted-by":"crossref","first-page":"L546","DOI":"10.1152\/ajplung.00107.2004","article-title":"Both cAMP and cGMP are require for maximal ciliary beat stimulation in a cell-free model of bovine ciliary axonemes","volume":"288","author":"Wyatt","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"98","key":"10.1016\/j.biopha.2018.06.004_bib0070","article-title":"Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cells","volume":"13","author":"Seagrave","year":"2012","journal-title":"Respir. Res."},{"issue":"Pt 3","key":"10.1016\/j.biopha.2018.06.004_bib0075","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1113\/jphysiol.2003.041707","article-title":"The role of cGMP in the regulation of rabbit airway ciliary beat frequency","volume":"551","author":"Zhang","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.biopha.2018.06.004_bib0080","first-page":"F597","article-title":"Role of the extracellular cyclic AMP-adenosine pathway in renal physiology","volume":"281","author":"Jackson","year":"2001","journal-title":"Am. J. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.004_bib0085","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1476-5381.1994.tb13100.x","article-title":"Effect of salmeterol on human nasal epithelial cell ciliary beating: inhibition of the ciliotoxin, pyocyanin","volume":"112","author":"Kanthakumar","year":"1994","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.biopha.2018.06.004_bib0090","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2165\/00002512-200118060-00006","article-title":"Inhaled salmeterol: a review of its efficacy in chronic obstructive pulmonary disease","volume":"18","author":"Jarvis","year":"2001","journal-title":"Drugs Aging"},{"issue":"8","key":"10.1016\/j.biopha.2018.06.004_bib0095","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.rmed.2012.04.001","article-title":"Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects","volume":"106","author":"Yaghi","year":"2012","journal-title":"Respir. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.004_bib0100","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/bcpt.12135","article-title":"TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells","volume":"114","author":"Alenmyr","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.004_bib0105","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1113\/EP086681","article-title":"[Ca(2+)](i) modulation of cAMP-stimulated ciliary beat frequency via PDE1 in airway ciliary cells of mice","volume":"103","author":"Kogiso","year":"2018","journal-title":"Exp. Physiol."},{"issue":"6","key":"10.1016\/j.biopha.2018.06.004_bib0110","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.1067\/mai.2002.129412","article-title":"Effects of \u03b2-agonists on airway epithelial cells","volume":"110","author":"Salathe","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2018.06.004_bib0115","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1085\/jgp.200409153","article-title":"Intracellular Ca2+ regulates the phosphorylation and the dephosphorylation of ciliary proteins via the NO pathway","volume":"124","author":"Gertsberg","year":"2004","journal-title":"J. Gen. Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.004_bib0120","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1113\/jphysiol.2002.028704","article-title":"Oscillations in ciliary beat frequency and intracellular calcium concentration in rabbit tracheal epithelial cells induced by ATP","volume":"546","author":"Zhang","year":"2003","journal-title":"J. Physiol."},{"issue":"34","key":"10.1016\/j.biopha.2018.06.004_bib0125","doi-asserted-by":"crossref","first-page":"12611","DOI":"10.1073\/pnas.0803970105","article-title":"TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells","volume":"105","author":"Lorenzo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.06.004_bib0130","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41467-017-01201-3","article-title":"TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells","volume":"8","author":"Alpizar","year":"2017","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.004_bib0135","doi-asserted-by":"crossref","first-page":"L99","DOI":"10.1152\/ajplung.00024.2015","article-title":"Continuous mucociliary transport by primary human airway epithelial cells in vitro","volume":"309","author":"Sears","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"04","key":"10.1016\/j.biopha.2018.06.004_bib0140","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1055\/s-0029-1186179","article-title":"Impact of thymol in thyme extracts on their antispasmodic action and ciliary clearance","volume":"76","author":"Begrow","year":"2010","journal-title":"Planta Med."},{"issue":"07","key":"10.1016\/j.biopha.2018.06.004_bib0145","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1055\/s-2007-981535","article-title":"The effect of thyme extract on \u03b22-receptors and mucociliary clearance","volume":"73","author":"Wienk\u00f6tter","year":"2007","journal-title":"Planta Med."},{"issue":"141","key":"10.1016\/j.biopha.2018.06.004_bib0150","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.jep.2012.03.025","article-title":"Bioassay-guided fractionation of a thymol-deprived hydrophilic thyme extract and its antispasmodic effect","volume":"14","author":"Engelbertz","year":"2012","journal-title":"J. Ethnopharmacol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218323072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218323072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T21:41:33Z","timestamp":1731447693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218323072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":30,"alternative-id":["S0753332218323072"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.004","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}