{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:02:30Z","timestamp":1791910950821,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.biopha.2018.06.051","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T10:21:35Z","timestamp":1529576495000},"page":"1192-1204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Umbilical cord blood-mesenchymal stem cells and carvedilol reduce doxorubicin- induced cardiotoxicity: Possible role of insulin-like growth factor-1"],"prefix":"10.1016","volume":"105","author":[{"given":"Hanaa S.E.","family":"Mousa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-8657","authenticated-orcid":false,"given":"Sara M.","family":"Abdel Aal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha A.T.","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/15216540500079093","article-title":"The power and potential of doxorubicin\u2010DNA adducts","volume":"57","author":"Cutts","year":"2005","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0010","first-page":"8","article-title":"Chemotherapy induced cardiomyopathy: pathogenesis, monitoring cardiomyopathy: pathogenesis, monitoring and management","volume":"1","author":"Shakir","year":"2009","journal-title":"J. Clin. Med. Res."},{"key":"10.1016\/j.biopha.2018.06.051_bib0015","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM199809243391307","article-title":"Doxorubicin-induced cardiomyopathy","volume":"339","author":"Singal","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCULATIONAHA.109.895771","article-title":"Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function","volume":"121","author":"De Angelis","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.06.051_bib0025","series-title":"50th Annual Scientific Sessions of the American College of Cardiology","article-title":"Carvedilol post-infarct survival controlled evaluation (CAPRICORN): a multinational, randomized, double blind study on the effects of carvedilol on mortality and morbidity in patients with left ventricular dysfunction after MI","author":"Dargie","year":"2001"},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0030","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40267-016-0370-x","article-title":"Carvedilol: a review of its use in the management of heart failure","volume":"33","author":"Prajapati","year":"2017","journal-title":"Drugs Ther. Perspect."},{"key":"10.1016\/j.biopha.2018.06.051_bib0035","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1634\/stemcells.2007-0381","article-title":"Multipotent stem cell from umbilical cord: cord is richer than blood","volume":"26","author":"Secco","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.biopha.2018.06.051_bib0040","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3727\/096368910X532855","article-title":"The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood-derived stem cells","volume":"20","author":"Sanberg","year":"2011","journal-title":"Cell Transpl."},{"key":"10.1016\/j.biopha.2018.06.051_bib0045","first-page":"547","article-title":"Potential of human umbilical cord blood mesenchymal stem cells to heal damaged corneal endothelium","volume":"18","author":"Joyce","year":"2012","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biopha.2018.06.051_bib0050","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11886-013-0369-z","article-title":"Stem cell therapy for pediatric dilated cardiomyopathy","volume":"15","author":"Selem","year":"2013","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.biopha.2018.06.051_bib0055","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.RES.83.5.516","article-title":"Regulation of cardiomyocyte apoptotic signaling by insulin like growth factor I","volume":"83","author":"Wang","year":"1998","journal-title":"Cir. Res."},{"key":"10.1016\/j.biopha.2018.06.051_bib0060","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.taap.2004.04.005","article-title":"Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity","volume":"200","author":"Oliveira","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.051_bib0065","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1161\/CIRCULATIONAHA.106.662577","article-title":"Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model","volume":"115","author":"Fukushima","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.06.051_bib0070","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3109\/14653249.2011.574118","article-title":"Intramyocardial and intracoronary autologous bone marrow-derived mesenchymal stromal cell treatment in chronic severe dilated cardiomyopathy","volume":"13","author":"Chin","year":"2011","journal-title":"Cytotherpay"},{"issue":"6","key":"10.1016\/j.biopha.2018.06.051_bib0075","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3109\/15376516.2012.678406","article-title":"Cardioprotective effects of rosuvastatin and carvedilol on delayed cardiotoxicity of doxorubicin in rats","volume":"22","author":"Kim","year":"2012","journal-title":"Toxicol. Mech. Methods"},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0080","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1634\/stemcells.22-4-625","article-title":"Critical parameters for the isolation of mesenchymal stem cells from umbilical cord blood","volume":"22","author":"Bieback","year":"2004","journal-title":"Stem Cells"},{"issue":"11","key":"10.1016\/j.biopha.2018.06.051_bib0085","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.exphem.2005.07.003","article-title":"Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood","volume":"33","author":"Wagner","year":"2005","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.biopha.2018.06.051_bib0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.aanat.2016.12.002","article-title":"Efficacy of human umbilical cord derived-mesenchymal stem cells in treatment of rat bone marrow exposed to gamma irradiation","volume":"210","author":"Mousa","year":"2017","journal-title":"Ann. Anat. Anatomischer Anzeiger"},{"key":"10.1016\/j.biopha.2018.06.051_bib0095","series-title":"Theory and Practice of Histology Techniques","first-page":"83","author":"Bancroft","year":"2013"},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0100","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/iub.1608","article-title":"Effect of human umbilical cord blood mesenchymal stem cells administered by intravenous or intravitreal routes on cryo\u2010induced retinal injury","volume":"69","author":"Mohamed","year":"2017","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1439-0272.2009.01018.x","article-title":"Immunohistochemical expression of cyclin a in testicular biopsies of fertile and infertile men: correlation with the morphometry of seminiferous tubules","volume":"43","author":"Abdou","year":"2011","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0110","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bcp.2011.05.013","article-title":"Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells","volume":"82","author":"Wei","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1432-1033.1990.tb15595.x","article-title":"Insulin-like growth factors I and II","volume":"190","author":"Humbel","year":"1990","journal-title":"Eur. J. Biochem."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0120","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1124\/jpet.111.185892","article-title":"Oxidative stress and myocardial gene alterations associated with doxorubicin-induced cardiotoxicity in rats persist for 2 months after treatment cessation","volume":"339","author":"Richard","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0125","doi-asserted-by":"crossref","first-page":"BR110","DOI":"10.12659\/MSM.881711","article-title":"Protective effect of bilberry (VacciniumMyrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats","volume":"17","author":"Ashour","year":"2011","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0971-6580.103656","article-title":"A study on the toxic effects of doxorubicin on the histology of certain organs","volume":"19","author":"Shivakumar","year":"2012","journal-title":"Toxicol. Int."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0135","article-title":"Cardioprotective effect of simvastatin on doxorubicin-induced oxidative cardiotoxicity in rats","volume":"6","author":"Elbaky","year":"2010","journal-title":"J. Basic Appl. Sci."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0140","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1124\/jpet.115.225375","article-title":"Early administration of carvedilol protected against doxorubicin-induced cardiomyopathy","volume":"355","author":"Chen","year":"2015","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0145","first-page":"27","article-title":"The role of HUCB derived stem cells therapy in repair of renal damage and improvement of renal function in cisplatin-induced acute renal failure in rats","volume":"1","author":"Taddesse","year":"2013","journal-title":"J. Afr. Assoc. Physiol. Sci."},{"issue":"28","key":"10.1016\/j.biopha.2018.06.051_bib0150","doi-asserted-by":"crossref","first-page":"29670","DOI":"10.1074\/jbc.M313408200","article-title":"Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy","volume":"279","author":"Sadlier","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0155","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.taap.2012.04.012","article-title":"New therapeutic aspect for carvedilol: antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage","volume":"261","author":"Hamdy","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0160","first-page":"142","article-title":"Effect of mesenchymal stem cells on doxorubicin-induced fibrosis","volume":"14","author":"Gorji","year":"2012","journal-title":"Cell J. (Yakhteh)"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0165","doi-asserted-by":"crossref","first-page":"e00181","DOI":"10.1128\/MCB.00181-17","article-title":"Protein kinase A\/CREB signaling prevents adriamycin-induced podocyte apoptosis via upregulation of mitochondrial respiratory Chain complexes","volume":"38","author":"Xie","year":"2018","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0170","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s13105-014-0339-y","article-title":"Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats","volume":"70","author":"Arafa","year":"2014","journal-title":"J. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.051_bib0175","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bcp.2015.02.006","article-title":"Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: a mechanistic study","volume":"95","author":"Saeed","year":"2015","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0180","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s12012-007-0008-2","article-title":"Adriamycin-induced interference with cardiac mitochondrial calcium homeostasis","volume":"7","author":"Wallace","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.biopha.2018.06.051_bib0185","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00005-009-0051-8","article-title":"Cardiomyocytes death in doxorubicin-induced cardiotoxicity","volume":"57","author":"Zhang","year":"2009","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.biopha.2018.06.051_bib0190","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10529-010-0207-y","article-title":"Mesenchymal stem cell derived from human umbilical cord ameliorate ischemia\/reperfusion-induced acute renal failure in rats","volume":"32","author":"Cao","year":"2010","journal-title":"Biotechnol. Lett."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0195","first-page":"200","article-title":"Carvedilol protects against iron-induced microparticle generation and apoptosis of endothelial cells","volume":"132","author":"Chan","year":"2014","journal-title":"Actahaematologica"},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0200","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.yjmcc.2004.05.024","article-title":"Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro","volume":"37","author":"Spallarossa","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0205","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2261-12-63","article-title":"Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response","volume":"12","author":"Hadi","year":"2012","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.biopha.2018.06.051_bib0210","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13287-017-0472-y","article-title":"Intramuscular injection of human umbilical cord-derived mesenchymal stem cells improves cardiac function in dilated cardiomyopathy rats","volume":"8","author":"Mao","year":"2017","journal-title":"Stem Cell Res. Ther."},{"issue":"1-2","key":"10.1016\/j.biopha.2018.06.051_bib0215","first-page":"19","article-title":"Early changes in myocardial antioxidant enzymes in rats treated with adriamycin","volume":"232","author":"Li","year":"2002","journal-title":"Mol. Cell Cardiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0220","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0300-483X(02)00383-9","article-title":"Antioxidant nutrients and adriamycin toxicity","volume":"180","author":"Quiles","year":"2002","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0225","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S1734-1140(09)70018-0","article-title":"Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron","volume":"61","author":"Simunek","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biopha.2018.06.051_bib0230","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1534735414564425","article-title":"Efficacy of antioxidants as a complementary and alternative medicine (CAM) in combination with chemotherapeutic agents doxorubicin","volume":"14","author":"Sheu","year":"2015","journal-title":"Integr. Cancer Ther."},{"issue":"12","key":"10.1016\/j.biopha.2018.06.051_bib0235","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/14653249.2011.613927","article-title":"Original article: antioxidant pathways are stimulated by mesenchymal stromal cells in renal repair after ischemic injury","volume":"14","author":"Liu","year":"2012","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0240","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/mpo.1155","article-title":"Plasma levels of natriuretic peptides in relation to doxorubicin-induced cardiotoxicity and cardiac function in children with cancer","volume":"37","author":"Hayakawa","year":"2001","journal-title":"Med. Pediatry Oncol."},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0245","doi-asserted-by":"crossref","first-page":"882","DOI":"10.4103\/0973-1482.144636","article-title":"Cardiac troponin-I, brain natriuretic peptide and endothelin-1 levels in a rat model of doxorubicin-induced cardiac injury","volume":"11","author":"Atas","year":"2015","journal-title":"J. Cancer Res. Ther."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0250","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1124\/mol.63.2.368","article-title":"Anthracycline-induced suppression of GATA-4 transcription factor: implication in the regulation of cardiac myocyte apoptosis","volume":"63","author":"Kim","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"18","key":"10.1016\/j.biopha.2018.06.051_bib0255","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.0401833101","article-title":"Essential role of GATA-4 in cell survival and drug induced cardiotoxicity","volume":"101","author":"Aries","year":"2004","journal-title":"Proc. Nat. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.051_bib0260","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1074\/jbc.M109.070037","article-title":"Transcription factor GATA-4 inhibits doxorubicin-induced autophagy and cardiomyocyte death","volume":"285","author":"Kobayashi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2018.06.051_bib0265","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1161\/CIRCULATIONAHA.105.568402","article-title":"Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy","volume":"113","author":"Li","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.06.051_bib0270","doi-asserted-by":"crossref","first-page":"10428","DOI":"10.1158\/0008-5472.CAN-07-1344","article-title":"The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy","volume":"67","author":"Bien","year":"2007","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.06.051_bib0275","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1089\/scd.2008.0292","article-title":"Cardiac differentiation is driven by Nk X2.5 and GATA-4 nuclear translocation is tissue-specific mesenchymal stem cells","volume":"8","author":"Arminan","year":"2009","journal-title":"Stem Cell Dev."},{"key":"10.1016\/j.biopha.2018.06.051_bib0280","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1089\/hgtb.2012.032","article-title":"Controlled angiogenesis in the heart by cell-based expression of specific vascular endothelial growth factor levels","volume":"23","author":"Melly","year":"2012","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.biopha.2018.06.051_bib0285","first-page":"1128","article-title":"Transplantation of mesenchymal stem cells improved cardiac function in a rat model of dilated","volume":"112","author":"Nagaya","year":"2005","journal-title":"Cardiomyopathy"},{"key":"10.1016\/j.biopha.2018.06.051_bib0290","first-page":"1","article-title":"Growth hormone and the cardiovascular function","volume":"30","author":"Svensson","year":"2005","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.biopha.2018.06.051_bib0295","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.CIR.101.6.660","article-title":"Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart","volume":"101","author":"Fujio","year":"2000","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.biopha.2018.06.051_bib0300","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1161\/CIRCRESAHA.108.186742","article-title":"IGF-1 over-expressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1 (alpha\/CXCR4) signaling to promote myocardial repair","volume":"103","author":"Haider","year":"2008","journal-title":"Cir. Res."},{"key":"10.1016\/j.biopha.2018.06.051_bib0305","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1073\/pnas.92.17.8031","article-title":"Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion","volume":"92","author":"Buerke","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.06.051_bib0310","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.RES.88.6.609","article-title":"Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts over-expressing insulin-like growth factor-1","volume":"88","author":"Yamashita","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2018.06.051_bib0315","doi-asserted-by":"crossref","first-page":"H1191","DOI":"10.1152\/ajpheart.2001.280.3.H1191","article-title":"IGF-1 differentially regulates BCl-XL and bax and confers myocardial protection in the rat heart","volume":"280","author":"Yamamura","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.051_bib0320","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1161\/01.RES.0000051885.70159.12","article-title":"Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium","volume":"92","author":"Von Lewinski","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2018.06.051_bib0325","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0303-7207(03)00200-4","article-title":"Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI3 kinase\/Akt pathway","volume":"205","author":"Lai","year":"2003","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.biopha.2018.06.051_bib0330","doi-asserted-by":"crossref","first-page":"R176","DOI":"10.1186\/cc2375","article-title":"Insulin like growth factor-1 protects ischemic murine myocardium from ischemia\/reperfusion associated injury","volume":"7","author":"Davani","year":"2003","journal-title":"Crit. Care"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221832585X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075333221832585X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T21:42:13Z","timestamp":1731447733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075333221832585X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":66,"alternative-id":["S075333221832585X"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.051","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Umbilical cord blood-mesenchymal stem cells and carvedilol reduce doxorubicin- induced cardiotoxicity: Possible role of insulin-like growth factor-1","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}