{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:02:31Z","timestamp":1793703751831,"version":"4.5.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603585"],"award-info":[{"award-number":["81603585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.biopha.2018.06.060","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T22:13:57Z","timestamp":1530051237000},"page":"125-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway"],"prefix":"10.1016","volume":"106","author":[{"given":"Miao","family":"Sui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biopha.2018.06.060_bib0005","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tack","year":"2015","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0010","doi-asserted-by":"crossref","first-page":"610","DOI":"10.7150\/thno.22237","article-title":"Ligand activation of PPAR\u03b3 by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1\u03b1","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.biopha.2018.06.060_bib0015","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1159\/000470650","article-title":"Indole-3-carbinol induces apoptosis of hepatic stellate cells through K63 de-ubiquitination of RIP1 in rats","volume":"41","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0020","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.diff.2016.07.001","article-title":"The characteristics of activated portal fibroblasts\/myofibroblasts in liver fibrosis","volume":"92","author":"Karin","year":"2016","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.060_bib0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jhep.2014.09.023","article-title":"Acid sphingomyelinase-ceramide system in steatohepatitis: a novel target regulating multiple pathways","volume":"62","author":"Garcia-Ruiz","year":"2015","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0030","first-page":"167","article-title":"Liver, blood microdialysate and plasma pharmacokinetics of matrine following transdermal or intravenous administration","volume":"72","author":"Tang","year":"2017","journal-title":"Pharmazie"},{"key":"10.1016\/j.biopha.2018.06.060_bib0035","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.biopha.2018.02.091","article-title":"Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12\/CXCR4 biological axis in liver fibrosis study in vitro and in vivo","volume":"101","author":"Qin","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.06.060_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2014.09.035","article-title":"Artesunate ameliorates hepatic fibrosis induced by bovine serum albumin in rats through regulating matrix metalloproteinases","volume":"744","author":"Xu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.060_bib0045","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.biopha.2017.10.158","article-title":"The exposure-effect-toxicity correlation of docetaxel and magnesium isoglycyrrhizinate in non-small cell lung tumor-bearing mice","volume":"97","author":"Li","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0050","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.3892\/mmr.2017.6993","article-title":"Magnesium isoglycyrrhizinate protects against renal ischemia reperfusion injury in a rat model via ant inflammation, autoxidation and ant apoptosis","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.biopha.2018.06.060_bib0055","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of no apoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"8\u20139","key":"10.1016\/j.biopha.2018.06.060_bib0060","first-page":"779","article-title":"Ferroptosis, a new form of cell death relevant to the medical treatment of cancer","volume":"30","author":"Lachaier","year":"2014","journal-title":"Med. Sci."},{"issue":"11\u201312","key":"10.1016\/j.biopha.2018.06.060_bib0065","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1007\/s00018-016-2194-1","article-title":"Mechanisms of ferroptosis","volume":"73","author":"Cao","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"2","key":"10.1016\/j.biopha.2018.06.060_bib0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0075","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"issue":"7682","key":"10.1016\/j.biopha.2018.06.060_bib0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nature24637","article-title":"NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis","volume":"551","author":"Alvarez","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biopha.2018.06.060_bib0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biopha.2018.06.060_bib0090","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2018.02.010","article-title":"Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis","volume":"117","author":"Meng","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.biopha.2018.06.060_bib0095","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1159\/000480362","article-title":"The Nrf2\/HO-1 pathway mediates the antagonist effect of L-arginine on renal ischemia\/reperfusion injury in rats","volume":"42","author":"Tong","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.biopha.2018.06.060_bib0100","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.lfs.2018.03.017","article-title":"Heme oxygenase-1 protects liver against ischemia\/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control","volume":"200","author":"Hong","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.06.060_bib0105","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jss.2017.06.062","article-title":"Thioredoxin-1 attenuates sepsis-induced cardiomyopathy after cecal ligation and puncture in mice","volume":"220","author":"Wilson","year":"2017","journal-title":"J. Surg. Res."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.06.060_bib0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-010-0563-x","article-title":"Metals, oxidative stress and neurodegenerative disorders","volume":"345","author":"Jomova","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biopha.2018.06.060_bib0115","doi-asserted-by":"crossref","first-page":"24393","DOI":"10.18632\/oncotarget.5162","article-title":"Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death","volume":"6","author":"Kwon","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.06.060_bib0120","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.canlet.2017.12.025","article-title":"Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis","volume":"416","author":"Chang","year":"2018","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.biopha.2018.06.060_bib0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s13167-017-0115-5","article-title":"High regenerative capacity of the liver and irreversible injury of male reproductive system in carbon tetrachloride-induced liver fibrosis rat model","volume":"9","author":"Bubnov","year":"2018","journal-title":"EPMA J."},{"key":"10.1016\/j.biopha.2018.06.060_bib0130","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1053\/j.gastro.2017.12.022","article-title":"Hedgehog-YAP signaling pathway regulates glutaminolysis to control hepatic stellate cell activation","volume":"154","author":"Du","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2018.06.060_bib0135","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2741\/gressner","article-title":"Roles of TGF-beta in hepatic fibrosis","volume":"7","author":"Gressner","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biopha.2018.06.060_bib0140","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ebiom.2016.03.042","article-title":"Targeting the PDGF-B\/PDGFR-\u03b2 interface with Destruxin A5 to selectively block PDGF-BB\/PDGFR-\u03b2\u03b2 signaling and attenuate liver fibrosis","volume":"7","author":"Wang","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biopha.2018.06.060_bib0145","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbrc.2013.05.097","article-title":"Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice","volume":"437","author":"Takemura","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.06.060_bib0150","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/hep.25567","article-title":"Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis","volume":"55","author":"Pellicoro","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.biopha.2018.06.060_bib0155","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2015","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.biopha.2018.06.060_bib0160","first-page":"4755","article-title":"Magnesium isoglycyrrhizinate protects hepatic LO2 cells from ischemia\/reperfusion induced injury","volume":"7","author":"Huang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biopha.2018.06.060_bib0165","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/iub.1639","article-title":"Blockade of hedgehog pathway is required for the protective effects of magnesium isoglycyrrhizinate against ethanol-induced hepatocyte steatosis and apoptosis","volume":"69","author":"Lu","year":"2017","journal-title":"IUBMB Life"},{"key":"10.1016\/j.biopha.2018.06.060_bib0170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.biopha.2016.12.033","article-title":"Magnesium isoglycyrrhizinate attenuates lipopolysaccharide-induced depressive-like behavior in mice","volume":"86","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.biopha.2018.06.060_bib0175","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/biof.1390","article-title":"Magnesium isoglycyrrhizinate promotes the activated hepatic stellate cells apoptosis via endoplasmic reticulum stress and ameliorates fibrogenesis in vitro and in vivo","volume":"43","author":"Bian","year":"2017","journal-title":"Biofactors"},{"issue":"1","key":"10.1016\/j.biopha.2018.06.060_bib0180","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/hep.28251","article-title":"Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells","volume":"63","author":"Sun","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biopha.2018.06.060_bib0185","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/hep.28574","article-title":"Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis","volume":"64","author":"Sun","year":"2016","journal-title":"Hepatology"},{"issue":"45","key":"10.1016\/j.biopha.2018.06.060_bib0190","doi-asserted-by":"crossref","first-page":"5617","DOI":"10.1038\/onc.2015.32","article-title":"HSPB1 as a novel regulator of ferroptotic cancer cell death","volume":"34","author":"Sun","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2018.06.060_bib0195","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.canlet.2014.11.014","article-title":"The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells","volume":"356","author":"Louandre","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biopha.2018.06.060_bib0200","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biopha.2018.06.060_bib0205","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis","volume":"14","author":"Masaldan","year":"2018","journal-title":"Redox. Biol."},{"key":"10.1016\/j.biopha.2018.06.060_bib0210","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1080\/15384101.2016.1215390","article-title":"The African-specific S47 polymorphism of p53 alters chemosensitivity","volume":"15","author":"Basu","year":"2016","journal-title":"Cell Cycle"}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218322546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218322546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T19:31:44Z","timestamp":1750879904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218322546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":42,"alternative-id":["S0753332218322546"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.060","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}