{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:56:33Z","timestamp":1788494193540,"version":"build-2803163510"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Acharya Nagarjuna University"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.biopha.2018.06.079","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T10:39:31Z","timestamp":1529663971000},"page":"1254-1268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"special_numbering":"C","title":["Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington\u2019s disease-like symptoms in rats"],"prefix":"10.1016","volume":"105","author":[{"given":"Ravi Chandra Sekhara Reddy","family":"Danduga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subba Reddy","family":"Dondapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phani Kumar","family":"Kola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilly","family":"Grace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahil Vandana Bisky","family":"Tadigiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Kishore","family":"Kanakaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.06.079_bib0005","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1399-0004.2007.00800.x","article-title":"Mitochondrial deafness","volume":"71","author":"Kokotas","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.biopha.2018.06.079_bib0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1092852900024901","article-title":"Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer\u2019s disease","volume":"14","author":"Reddy","year":"2009","journal-title":"CNS. Spectrums."},{"key":"10.1016\/j.biopha.2018.06.079_bib0015","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tox.2007.11.003","article-title":"Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity","volume":"244","author":"Ahuja","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0025","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuroscience.2014.09.035","article-title":"Profilin-2 increased expression and its altered interaction with \u03b2-actin in the striatum of 3-nitropropionic acid-induced Huntington\u2019s disease in rats","volume":"281","author":"Chakraborty","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.06.079_bib0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/mds.21971","article-title":"The current clinical management of Huntington\u2019s disease","volume":"23","author":"Phillips","year":"2008","journal-title":"Mov. Disord."},{"key":"10.1016\/j.biopha.2018.06.079_bib0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.expneurol.2011.05.024","article-title":"Bioenergetic dysfunction in Huntington's disease human cybrids","volume":"231","author":"Ferreira","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0040","first-page":"128","article-title":"The paradigm of Huntington\u2019s disease: therapeutic opportunities in neurodegeneration","volume":"1","author":"Leegwater-Kim","year":"2004","journal-title":"J. Am. Soc. Exp. Neurother."},{"key":"10.1016\/j.biopha.2018.06.079_bib0045","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ilar.48.4.356","article-title":"Animal models of Huntington\u2019s disease","volume":"48","author":"Ramaswamy","year":"2007","journal-title":"Ilar. J."},{"key":"10.1016\/j.biopha.2018.06.079_bib0050","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbadis.2009.07.012","article-title":"Mitochondria in Huntington\u2019s disease","volume":"1802","author":"Damiano","year":"2010","journal-title":"BBA-Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2018.06.079_bib0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2478\/s13380-011-0008-3","article-title":"Influence of aging and neurodegeneration on dendritic spine morphology","volume":"2","author":"Bloss","year":"2011","journal-title":"Transl. Neurosci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.06741.x","article-title":"Nature and cause of mitochondrial dysfunction in Huntington\u2019s disease: focusing on huntingtin and the striatum","volume":"114","author":"Oliveira","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2018.06.079_bib0065","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/mds.26014","article-title":"Current therapeutic options for Huntington\u2019s disease: Good clinical practice versus evidence\u2010based approaches?","volume":"29","author":"Killoran","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.biopha.2018.06.079_bib0070","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4140\/TCP.n.2009.524","article-title":"Treatment of chorea associated with Huntington\u2019s disease: focus on tetrabenazine","volume":"24","author":"Setter","year":"2009","journal-title":"Consul. Pharm."},{"key":"10.1016\/j.biopha.2018.06.079_bib0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s13311-013-0244-z","article-title":"Treatment of Huntington\u2019s disease","volume":"11","author":"Frank","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.biopha.2018.06.079_bib0080","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.expneurol.2013.04.010","article-title":"Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats","volume":"247","author":"Kao","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuint.2005.10.008","article-title":"Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats","volume":"48","author":"Kao","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2018.06.079_bib0090","doi-asserted-by":"crossref","first-page":"350","DOI":"10.7150\/ijbs.8366","article-title":"Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson\u2019s disease induced by MPTP","volume":"10","author":"Lu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0095","doi-asserted-by":"crossref","first-page":"326","DOI":"10.4236\/jbbs.2012.23037","article-title":"Protective effects of tetramethylpyrazine on glutamate-induced neurotoxicity in mice","volume":"2","author":"Zhang","year":"2012","journal-title":"J. Behav. Brain. Sci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0100","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4236\/nm.2011.22020","article-title":"Antidepressant-like effect of tetramethylpyrazine in mice and rats","volume":"2","author":"Yu","year":"2011","journal-title":"Neurosci. Med."},{"key":"10.1016\/j.biopha.2018.06.079_bib0105","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4236\/pp.2012.31008","article-title":"Antidepressant-like activity of tetramethylpyrazine measured by chronic experimental method in rat model of depression","author":"Yu","year":"2012","journal-title":"Pharmacol. Pharm."},{"key":"10.1016\/j.biopha.2018.06.079_bib0110","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbr.2013.07.052","article-title":"Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP\/PKA\/CREB pathway","volume":"253","author":"Wua","year":"2013","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.biopha.2018.06.079_bib0115","first-page":"180","article-title":"Protective effect of tetramethylpyrazineon learning and memory function in d-galactose-lesioned mice","volume":"19","author":"Zhang","year":"2004","journal-title":"Chin. Med. Sci. J."},{"key":"10.1016\/j.biopha.2018.06.079_bib0120","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1745-7254.2005.00141.x","article-title":"Tetramethylpyrazine protected photoreceptor cells of rats by modulating nuclear translocation of NF-\u03baB","volume":"26","author":"Yang","year":"2005","journal-title":"Acta. Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2018.06.079_bib0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3109\/01480541003642050","article-title":"Possible nitric oxide modulation in protective effect of FK-506 against 3-nitropropionic acid-induced behavioral, oxidative, neurochemical, and mitochondrial alterations in rat brain","volume":"33","author":"Kumar","year":"2010","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0130","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1017\/S0317167100032212","article-title":"3-nitropropionic acid-exogenous animal neurotoxin and possible human striatal toxin","volume":"18","author":"Ludolph","year":"1991","journal-title":"Can. J. Neurolo. Sci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0135","series-title":"Hand Book of Experimental Pharmacology","author":"Kulkarni","year":"1999"},{"key":"10.1016\/j.biopha.2018.06.079_bib0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuroscience.2006.01.045","article-title":"Histamine improves rat rota-rod and balance beam performances through H 2 receptors in the cerebellar interpositus nucleus","volume":"140","author":"Song","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.06.079_bib0145","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0028-3908(99)00262-2","article-title":"Functional assessments in mice and rats after focal stroke","volume":"39","author":"Hunter","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0150","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1365-2990.1999.00212.x","article-title":"3-nitropropionic acid induces a spectrum of Huntington\u2019s disease-like neuropathology in rat striatum","volume":"25","author":"Vis","year":"1999","journal-title":"Neuropath. Appl. Neuro."},{"key":"10.1016\/j.biopha.2018.06.079_bib0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jns.2013.12.033","article-title":"Docosahexaenoic acid confers enduring neuroprotection in experimental stroke","volume":"338","author":"Hong","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1358\/mf.2007.29.1.1063492","article-title":"Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity","volume":"29","author":"Kumar","year":"2007","journal-title":"Method. Find. Exp. Clin."},{"key":"10.1016\/j.biopha.2018.06.079_bib0165","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1007\/s11064-016-1881-5","article-title":"Protective effect of silibinin on learning and memory impairment in LPS-treated rats via ROS\u2013BDNF\u2013TrkB pathway","volume":"41","author":"Song","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2018.06.079_bib0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0175","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.neuint.2010.07.005","article-title":"Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system","volume":"57","author":"Sandhir","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2018.06.079_bib0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay of lipid peroxidesin animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2018.06.079_bib0185","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/0960327108094608","article-title":"Effect of thioperamide on oxidative stress markers in middle cerebral artery occlusion model of focal cerebral ischemia in rats","volume":"27","author":"Akhtar","year":"2008","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0190","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2018.06.079_bib0195","first-page":"657","article-title":"Neuroprotective activity of pongamia pinnata in monosodium glutamate-induced neurotoxicity in rats","volume":"75","author":"Swamy","year":"2013","journal-title":"Indian. J. Pharm. Sci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0200","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4067\/S0716-97602009000100006","article-title":"Superoxide dismutase and catalase: tissue activities and relation with age in the long-lived species Margaritifera Margaritifera","volume":"42","author":"Fernandez","year":"2009","journal-title":"Biol. Res."},{"key":"10.1016\/j.biopha.2018.06.079_bib0205","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.biopha.2018.06.079_bib0210","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/0076-6879(67)10061-X","article-title":"Preparation of succinate dehydrogenase and reconstitution of succinate oxidase","volume":"10","author":"King","year":"1967","journal-title":"Method. Enzymol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yebeh.2017.07.011","article-title":"Protective effect of naringin on pentylenetetrazole (PTZ)-induced kindling; possible mechanisms of antikindling, memory improvement, and neuroprotection","volume":"75","author":"Kola","year":"2017","journal-title":"Epilepsy Behavi."},{"key":"10.1016\/j.biopha.2018.06.079_bib0225","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/01.STR.17.6.1304","article-title":"Evaluation of 2, 3, 5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats","volume":"17","author":"Bederson","year":"1986","journal-title":"Stroke"},{"key":"10.1016\/j.biopha.2018.06.079_bib0230","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/bja\/aet009","article-title":"Combined treatment with celecoxib and sevoflurane after global cerebral ischaemia has no additive neuroprotective effects in rats","volume":"110","author":"Seo","year":"2013","journal-title":"Brit. J. Anaesth."},{"key":"10.1016\/j.biopha.2018.06.079_bib0235","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1111\/j.1471-4159.2005.03515.x","article-title":"3\u2010Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington\u2019s disease","volume":"95","author":"Brouillet","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.biopha.2018.06.079_bib0240","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993","article-title":"Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid","volume":"13","author":"Beal","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0245","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuint.2011.05.009","article-title":"Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats","volume":"59","author":"Mu","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2018.06.079_bib0250","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neures.2009.01.005","article-title":"Neuroprotective effect of cyclosporine and FK506 against 3-nitropropionic acid induced cognitive dysfunction and glutathione redox in rat: possible role of nitric oxide","volume":"63","author":"Kumar","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.biopha.2018.06.079_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.03.018","article-title":"Mitochondrial diseases of the brain","volume":"63","author":"Chaturvedi","year":"2013","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.06.079_bib0260","doi-asserted-by":"crossref","first-page":"6956","DOI":"10.1523\/JNEUROSCI.23-17-06956.2003","article-title":"Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington\u2019s disease","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0265","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0306-4522(97)00192-9","article-title":"Riluzole protects from motor deficits and striatal degeneration produced by systemic 3-nitropropionic acid intoxication in rats","volume":"81","author":"Guyot","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.06.079_bib0270","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2007-971176","article-title":"Huntington's disease","volume":"27","author":"Walker","year":"2007","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0275","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3390\/molecules15020878","article-title":"3-Nitropropionic acid as a tool to study the mechanisms involved in Huntington\u2019s disease: past, present and future","volume":"15","author":"T\u00fanez","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2018.06.079_bib0280","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/exnr.2001.7755","article-title":"A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington\u2019s disease","volume":"171","author":"Keene","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0285","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1097\/00001756-200006260-00007","article-title":"Creatine reduces 3\u2010nitropropionic\u2010acid\u2010induced cognitive and motor abnormalities in rats","volume":"11","author":"Shear","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.biopha.2018.06.079_bib0290","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0361-9230(94)00242-S","article-title":"Systemic 3-nitropropionic acid: behavioral deficits and striatal damage in adult rats","volume":"36","author":"Borlongan","year":"1995","journal-title":"Brain. Res. Bull."},{"key":"10.1016\/j.biopha.2018.06.079_bib0295","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/00207450490475959","article-title":"Antioxidant effects of taurine, vitamin C, and vitamin E on oxidative damage in hippocampus caused by the administration of 3-nitropropionic acid in rats","volume":"114","author":"Rodr\u00edguez-Mart\u00ednez","year":"2004","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0300","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1007\/s12035-016-0028-7","article-title":"Tetramethylpyrazine ameliorates rotenone-induced Parkinson\u2019s disease in rats: involvement of its anti-inflammatory and anti-apoptotic actions","volume":"54","author":"Michel","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0305","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neulet.2004.09.013","article-title":"Tetramethylpyrazine reduces ischemic brain injury in rats","volume":"372","author":"Liao","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2018.06.079_bib0310","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000354722","article-title":"Tetramethylpyrazine analogue CXC195 protects against cerebral ischemia\/reperfusion injury in the rat by an antioxidant action via inhibition of NADPH oxidase and iNOS expression","volume":"92","author":"Liu","year":"2013","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0315","doi-asserted-by":"crossref","first-page":"37148","DOI":"10.1038\/srep37148","article-title":"Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.06.079_bib0320","first-page":"359","article-title":"Huntington\u2019s disease: pathogenesis, diagnosis and treatment","volume":"19","author":"Purdon","year":"1994","journal-title":"J. Psychiatry. Neurosci."},{"key":"10.1016\/j.biopha.2018.06.079_bib0325","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1254\/jjp.67.137","article-title":"Tetramethylpyrazine improves spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries or scopolamine in rats","volume":"67","author":"Ni","year":"1995","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0330","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/abbs\/gmx059","article-title":"Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3\u03b2","volume":"49","author":"Lu","year":"2017","journal-title":"Acta. Bioch. Bioph. Sin."},{"key":"10.1016\/j.biopha.2018.06.079_bib0335","first-page":"219","article-title":"Behavioral changes in Huntington disease","volume":"14","author":"Craufurd","year":"2001","journal-title":"Cogn. Behav. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0340","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1007\/s12035-015-9214-2","article-title":"Neuroanatomical visualization of the impaired striatal connectivity in Huntington\u2019s disease mouse model","volume":"53","author":"Kim","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0345","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5455\/jice.20140903012921","article-title":"Combination of lycopene, quercetin and poloxamer 188 alleviates anxiety and depression in 3-nitropropionic acid-induced Huntington\u2019s disease in rats","volume":"3","author":"Jain","year":"2014","journal-title":"J. Intercult. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0350","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/mp.2016.144","article-title":"Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression","volume":"22","author":"Bouvier","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.biopha.2018.06.079_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ijnp\/pyv010","article-title":"Tetramethylpyrazine produces antidepressant-like effects in mice through promotion of BDNF signaling pathway","volume":"18","author":"Jiang","year":"2015","journal-title":"Int. J. Neuropsychoph."},{"key":"10.1016\/j.biopha.2018.06.079_bib0360","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1742-7843.2005.pto_140.x","article-title":"Effect of thioperamide on modified forced swimming test\u2010induced oxidative stress in mice","volume":"97","author":"Akhtar","year":"2005","journal-title":"Basic. Clin. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0365","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuint.2011.05.007","article-title":"Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress","volume":"59","author":"Rojas","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.biopha.2018.06.079_bib0370","first-page":"244","article-title":"Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production","volume":"29","author":"Villar\u00e1n","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0375","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biopha.2015.11.009","article-title":"Effect of embelin against 3-nitropropionic acid-induced Huntington\u2019s disease in rats","volume":"77","author":"Dhadde","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.06.079_bib0380","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ejphar.2013.06.035","article-title":"Neuroprotective role of PDE4 and PDE5 inhibitors in 3-nitropropionic acid induced behavioral and biochemical toxicities in rats","volume":"714","author":"Thakur","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0385","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4103\/2231-0738.95947","article-title":"Neuroprotective effect of cow colostrum and tetramethylpyrazine against global cerebral ischemia reperfusion injury","volume":"2","author":"Undale","year":"2012","journal-title":"Int. J. Nutr. Pharmacol. Neurol. Dis."},{"key":"10.1016\/j.biopha.2018.06.079_bib0390","first-page":"1","article-title":"Mechanisms and clinical application of tetramethylpyrazine (an interesting natural compound isolated from Ligusticum wallichii): current Status and perspective","author":"Zhao","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2018.06.079_bib0395","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pnpbp.2015.02.005","article-title":"ADIOL protects against 3-NP-induced neurotoxicity in rats: possible impact of its anti-oxidant, anti-inflammatory and anti-apoptotic actions","volume":"60","author":"Hanna","year":"2015","journal-title":"Prog. Neuro-Psychoph."},{"key":"10.1016\/j.biopha.2018.06.079_bib0400","first-page":"905","article-title":"Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats, N-S arch","volume":"390","author":"Wahdan","year":"2017","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0405","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3109\/01480545.2013.776583","article-title":"Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington's disease in rats","volume":"36","author":"Shivasharan","year":"2013","journal-title":"Drug. Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0410","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.biopha.2016.09.070","article-title":"Chrysin exerts neuroprotective effects against 3-nitropropionic acid induced behavioral despair\u2014Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax\u2014Bad genes in male wistar rats","volume":"84","author":"Thangarajan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.06.079_bib0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2006.09.015","article-title":"Transcriptional repression of PGC-1\u03b1 by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration","volume":"127","author":"Cui","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.06.079_bib0420","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2014.10.004","article-title":"Potential of protease inhibitor in 3-nitropropionic acid induced Huntington\u2019s disease like symptoms: mitochondrial dysfunction and neuro degeneration","volume":"45","author":"Hariharan","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0425","doi-asserted-by":"crossref","first-page":"e88243","DOI":"10.1371\/journal.pone.0088243","article-title":"Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.06.079_bib0430","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.neuropharm.2012.05.019","article-title":"Activating mitochondrial regulator PGC-1\u03b1 expression by astrocytic NGF is a therapeutic strategy for Huntington\u2019s disease","volume":"63","author":"Chen","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biopha.2018.06.079_bib0435","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbadis.2012.11.018","article-title":"Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: implications in Huntington\u2019s disease","volume":"1832","author":"Sandhir","year":"2013","journal-title":"BBA-Mol. Basis Dis."},{"key":"10.1016\/j.biopha.2018.06.079_bib0440","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00314742","article-title":"Cerebrospinal fluid acetylcholinesterase and choline measurements in Huntington\u2019s disease","volume":"237","author":"Manyam","year":"1990","journal-title":"J. Neurol."},{"key":"10.1016\/j.biopha.2018.06.079_bib0445","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.physbeh.2015.12.015","article-title":"Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: possible role of oxidative stress, neuroinflammation, and neurotransmitters","volume":"155","author":"Jamwal","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.biopha.2018.06.079_bib0450","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopha.2016.11.111","article-title":"Effect of praeruptorin C on 3-nitropropionic acid induced Huntington\u2019s disease-like symptoms in mice","volume":"86","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.06.079_bib0455","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.bbr.2014.01.048","article-title":"Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington\u2019s disease","volume":"264","author":"Chakraborty","year":"2014","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.biopha.2018.06.079_bib0460","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(99)00763-6","article-title":"Expression and distribution of redox regulatory protein, thioredoxin after metabolic impairment by 3-nitropropionic acid in rat brain","volume":"275","author":"Sugino","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biopha.2018.06.079_bib0465","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12177-009-9024-8","article-title":"Neural protection by naturopathic compounds\u2014an example of tetramethylpyrazine from retina to brain","volume":"2","author":"Tan","year":"2009","journal-title":"J. Ocul. Biol. Dis. Inf."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218312356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218312356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T21:38:57Z","timestamp":1731447537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218312356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":93,"alternative-id":["S0753332218312356"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.079","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington\u2019s disease-like symptoms in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.079","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}