{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:42:35Z","timestamp":1787740955421,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003715","name":"Korea Research Institute of Bioscience and Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003715","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002476","name":"Eulji University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2017R1D1A1B03027968"],"award-info":[{"award-number":["NRF-2017R1D1A1B03027968"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.biopha.2018.06.164","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T21:33:26Z","timestamp":1531344806000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells"],"prefix":"10.1016","volume":"106","author":[{"given":"Jung-Il","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong-Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongmany","family":"Sydara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-5804","authenticated-orcid":false,"given":"Sang Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Ae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.06.164_bib0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.critrevonc.2010.05.002","article-title":"Shooting the messenger: targeting signal transduction pathways in leukemia and related disorders","volume":"78","author":"Noor","year":"2011","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0010","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.06.164_bib0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1749-6632.2009.05124.x","article-title":"New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression","volume":"1183","author":"Steward-Tharp","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2018.06.164_bib0020","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.021908.132706","article-title":"T cell activation","volume":"27","author":"Smith-Garvin","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.immuni.2010.08.004","article-title":"Interleukin-2 receptor signaling: at the interface between tolerance and immunity","volume":"33","author":"Malek","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.biopha.2018.06.164_bib0030","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"Dong","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0035","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1146\/annurev.bi.63.070194.005145","article-title":"Signal transmission between the plasma membrane and nucleus of T lymphocytes","volume":"63","author":"Crabtree","year":"1994","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biopha.2018.06.164_bib0040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0955-0674(99)80030-1","article-title":"Multiple signals converging on NF-kappaB","volume":"11","author":"Mercurio","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0045","first-page":"2360","article-title":"Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells","volume":"93","author":"Mori","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.06.164_bib0050","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11655-016-2501-6","article-title":"Research of Brucea javanica against cancer","volume":"23","author":"Yan","year":"2017","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.biopha.2018.06.164_bib0055","first-page":"819","article-title":"Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway","volume":"6","author":"Zhang","year":"2016","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.biopha.2018.06.164_bib0060","doi-asserted-by":"crossref","first-page":"965016","DOI":"10.1155\/2011\/965016","article-title":"Seed oil of Brucea javanica induces apoptotic death of acute myeloid leukemia cells via both the death receptors and the mitochondrial-related pathways","volume":"2011","author":"Zhang","year":"2011","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.biopha.2018.06.164_bib0065","first-page":"3295","article-title":"NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species","volume":"30","author":"Kim","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2018.06.164_bib0070","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0031-9422(96)00258-0","article-title":"A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells","volume":"43","author":"Luyengi","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.biopha.2018.06.164_bib0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/cbdv.200700409","article-title":"Chemical constituents of plants from the genus Brucea","volume":"6","author":"Liu","year":"2009","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.biopha.2018.06.164_bib0080","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1021\/np50033a030","article-title":"Antitumor agents, 65. Brusatol and cleomiscosin-A, antileukemic principles from Brucea javanica","volume":"47","author":"Lee","year":"1984","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2018.06.164_bib0085","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jep.2013.03.034","article-title":"Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica","volume":"147","author":"Yang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0090","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.7314\/APJCP.2013.14.8.4791","article-title":"Phase II study on Javanica oil emulsion injection (Yadanzi\u00ae) combined with chemotherapy in treating patients with advanced lung adenocarcinoma","volume":"14","author":"Lu","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biopha.2018.06.164_bib0095","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.7314\/APJCP.2013.14.3.2009","article-title":"Phase II study on safety and efficacy of Yadanzi\u00ae (Javanica oil emulsion injection) combined with chemotherapy for patients with gastric cancer","volume":"14","author":"Liu","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biopha.2018.06.164_bib0100","doi-asserted-by":"crossref","first-page":"41091","DOI":"10.18632\/oncotarget.17056","article-title":"Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells","volume":"8","author":"Lee","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.06.164_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.biopha.2018.06.164_bib0110","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0065-2571(84)90007-4","article-title":"Quantitative analysis of dose-effect relatioships: the combined effects of multiple drugs or enzyme inhibitors","volume":"22","author":"Chou","year":"1984","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.biopha.2018.06.164_bib0115","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1158\/1078-0432.CCR-04-1087","article-title":"Evaluation of combination chemotherapy: integration of nonlinear regression, curve shift, isobologram, and combination index analyses","volume":"10","author":"Zhao","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2018.06.164_bib0120","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/leu.2011.385","article-title":"Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways","volume":"26","author":"Piazza","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.biopha.2018.06.164_bib0125","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1182\/blood-2005-11-013672","article-title":"Multiple myeloma cell survival relies on high activity of protein kinase CK2","volume":"108","author":"Piazza","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.06.164_bib0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1078-0432.CCR-06-1602","article-title":"Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia","volume":"13","author":"Kim","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biopha.2018.06.164_bib0135","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1182\/blood-2010-04-277947","article-title":"Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia","volume":"15","author":"Martins","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.06.164_bib0140","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.biopha.2017.12.078","article-title":"Synergistic therapeutic effect of diethylstilbestrol and CX-4945 in human acute T-lymphocytic leukemia cells","volume":"98","author":"Jung","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.06.164_bib0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphar.2015.00070","article-title":"The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies","volume":"6","author":"Chon","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2018.06.164_bib0150","doi-asserted-by":"crossref","first-page":"18204","DOI":"10.18632\/oncotarget.7569","article-title":"Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies","volume":"7","author":"Salizzato","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.06.164_bib0155","doi-asserted-by":"crossref","first-page":"440","DOI":"10.2174\/18715206113136660336","article-title":"Phytochemical and biological activities of an anticancer plant medicine: Brucea javanica","volume":"14","author":"Zhao","year":"2014","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.biopha.2018.06.164_bib0160","first-page":"2003","article-title":"The aqueous extract of Chinese medicinal herb Brucea javanica suppresses the growth of human liver cancer and the derived stem-like cells by apoptosis","volume":"10","author":"Chen","year":"2016","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.biopha.2018.06.164_bib0165","first-page":"1","article-title":"Liver toxicity mechanisms of herbs commonly used in Latin America","volume":"4","author":"L\u00f3pez-Gil","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.biopha.2018.06.164_bib0170","article-title":"Application of combination high-throughput phenotypic screening and target identification methods for the discovery of natural product-based combination drugs","volume":"16","author":"Isgut","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.biopha.2018.06.164_bib0175","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"Ashburn","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2018.06.164_bib0180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/448645a","article-title":"New uses for old drugs","volume":"448","author":"Chong","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.06.164_bib0185","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10059-013-0184-9","article-title":"The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro","volume":"36","author":"Son","year":"2013","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2018.06.164_bib0190","doi-asserted-by":"crossref","first-page":"389","DOI":"10.14348\/molcells.2016.2300","article-title":"A receptor tyrosine kinase inhibitor, dovitinib (TKI-258), enhances BMP-2-induced osteoblast differentiation in vitro","volume":"39","author":"Lee","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biopha.2018.06.164_bib0195","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.18632\/oncotarget.6361","article-title":"Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP\/Grp78 and turning on the pro-apoptotic NF-\u03baB","volume":"7","author":"Buontempo","year":"2016","journal-title":"Oncotarget"},{"issue":"April","key":"10.1016\/j.biopha.2018.06.164_bib0200","article-title":"CX-4945, a selective inhibitor of casein kinase 2, synergizes with B cell receptor signaling inhibitors in inducing diffuse large B cell lymphoma cell death","volume":"26","author":"Mandato","year":"2017","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.biopha.2018.06.164_bib0205","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1006\/cyto.1996.0070","article-title":"Expression of the immunoglobulin J chain in a murine B lymphoma is driven by autocrine production of interleukin 2","volume":"8","author":"Gaffen","year":"1996","journal-title":"Cytokine"},{"key":"10.1016\/j.biopha.2018.06.164_bib0210","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4292\/wjgpt.v7.i3.353","article-title":"Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases","volume":"7","author":"Soufli","year":"2016","journal-title":"World J. Gastrointest. Pharmacol. Ther."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218308266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218308266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:52:22Z","timestamp":1762311142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218308266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":42,"alternative-id":["S0753332218308266"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.164","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.06.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}