{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:33:23Z","timestamp":1785890003119,"version":"3.56.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81241003"],"award-info":[{"award-number":["81241003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.biopha.2018.07.025","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T09:35:04Z","timestamp":1532424904000},"page":"1448-1453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Histamine H1 type receptor antagonist loratadine ameliorates oxidized LDL induced endothelial dysfunction"],"prefix":"10.1016","volume":"106","author":[{"given":"Yuyang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianen","family":"Fa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.biopha.2018.07.025_bib0005","first-page":"915","article-title":"Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity","volume":"320","author":"Steinberg","year":"1989","journal-title":"N Engl. J. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0010","doi-asserted-by":"crossref","first-page":"e55188","DOI":"10.1371\/journal.pone.0055188","article-title":"Localization of oxidized low-density lipoprotein and its relation to plaque morphology in human coronary artery","volume":"8","author":"Uchida","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.07.025_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2016.05.013","article-title":"Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis","volume":"84","author":"Di Pietro","year":"2016","journal-title":"Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0020","first-page":"89","article-title":"Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease","volume":"3","author":"Gao","year":"2017","journal-title":"Chronic Dis. Transl. Med."},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2018.07.025_bib0025","first-page":"13","article-title":"Effect of H1 antihistamines upon the cardiovascular system","volume":"16","author":"D\u00e1vila","year":"2006","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"issue":"18","key":"10.1016\/j.biopha.2018.07.025_bib0030","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1161\/01.CIR.0000066697.19571.AF","article-title":"Circulation. Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells","volume":"107","author":"Li","year":"2003","journal-title":"Circulation"},{"issue":"4 Suppl","key":"10.1016\/j.biopha.2018.07.025_bib0035","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/S0091-6749(03)01878-5","article-title":"H1-receptors: localization and role in airway physiology and in immune functions","volume":"112","author":"Togias","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.biopha.2018.07.025_bib0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/1389200033489523","article-title":"Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird\u2019s eye view","volume":"4","author":"Sharma","year":"2003","journal-title":"Curr. Drug. Metab."},{"issue":"October (4)","key":"10.1016\/j.biopha.2018.07.025_bib0045","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.3892\/ol.2017.6815","article-title":"Combining thioridazine and loratadine for the treatment of gastrointestinal tumor","volume":"14","author":"Chen","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biopha.2018.07.025_bib0050","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/all.12904","article-title":"Combined blockade of the histamine H1 and H4 receptor suppresses peanut-induced by regulating dendritic cell function","volume":"11","author":"Wang","year":"2016","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1067\/mai.2001.116861","article-title":"Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells","volume":"108","author":"Papi","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"issue":"Suppl 3","key":"10.1016\/j.biopha.2018.07.025_bib0060","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1186\/ar576","article-title":"Endothelial activation: intracellular signaling pathways","volume":"4","author":"Pober","year":"2002","journal-title":"Arthritis Res."},{"key":"10.1016\/j.biopha.2018.07.025_bib0065","doi-asserted-by":"crossref","first-page":"951316","DOI":"10.1155\/2012\/951316","article-title":"Localization and upregulation of the nasal histamine H1 receptor in perennial allergic rhinitis","volume":"2012","author":"Shirasaki","year":"2012","journal-title":"Mediators Inflamm."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0014-2999(88)90560-2","article-title":"Histamine H1-receptor in endothelial and smooth muscle cells of guinea-pig aorta","volume":"148","author":"Hide","year":"1988","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00493469","article-title":"Histamine H1-receptor of vascular endothelial cells cultured from guinea pig skin","volume":"282","author":"Noso","year":"1990","journal-title":"Arch. Dermatol. Res."},{"issue":"11","key":"10.1016\/j.biopha.2018.07.025_bib0080","first-page":"3041","article-title":"Histamine H1 receptor-mediated Ca2+ signaling in cultured bovine corneal endothelial cells","volume":"33","author":"Crawford","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"44","key":"10.1016\/j.biopha.2018.07.025_bib0085","doi-asserted-by":"crossref","first-page":"18967","DOI":"10.1073\/pnas.1008816107","article-title":"Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis","volume":"107","author":"Lu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.025_bib0090","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/micc.12189","article-title":"Involvement of the H1 histamine receptor, p38 MAP kinase, myosin light chains kinase, and Rho\/ROCK in histamine-induced endothelial barrier dysfunction","volume":"22","author":"Adderley","year":"2015","journal-title":"Microcirculation"},{"issue":"40","key":"10.1016\/j.biopha.2018.07.025_bib0095","doi-asserted-by":"crossref","first-page":"26928","DOI":"10.1074\/jbc.M803071200","article-title":"Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase C delta-dependent ERK activation pathway","volume":"283","author":"Hao","year":"2008","journal-title":"J. Biol Chem."},{"issue":"18","key":"10.1016\/j.biopha.2018.07.025_bib0100","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1161\/01.CIR.0000066697.19571.AF","article-title":"Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells","volume":"107","author":"Li","year":"2003","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.biopha.2018.07.025_bib0105","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1182\/blood-2010-02-266338","article-title":"Filippini A.NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells","volume":"117","author":"Esposito","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.biopha.2018.07.025_bib0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.02.016","article-title":"Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells","volume":"754","author":"Jie","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.025_bib0115","first-page":"981","article-title":"Expression of the histamine H1 receptor gene in relation to atherosclerosis","volume":"146","author":"Takagishi","year":"1995","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/pin.12246","article-title":"Novel function of histamine signaling in hyperlipidemia-induced atherosclerosis: histamine H1 receptors protect and H2 receptors accelerate atherosclerosis","volume":"65","author":"Yamada","year":"2015","journal-title":"Pathol Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0125","first-page":"89","article-title":"Copper and cell-oxidized low-density lipoprotein induces activator protein 1 in fibroblasts","volume":"33","author":"Mazi\u00e8re","year":"2000","journal-title":"Endothelial Biol. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.025_bib0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4067\/S0716-97602000000200008","article-title":"Endothelial cell oxidative stress and signal transduction","volume":"33","author":"Foncea","year":"2000","journal-title":"Biol. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218328919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218328919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T19:33:31Z","timestamp":1750880011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218328919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":26,"alternative-id":["S0753332218328919"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.025","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histamine H1 type receptor antagonist loratadine ameliorates oxidized LDL induced endothelial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}