{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:54:02Z","timestamp":1787507642467,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.biopha.2018.07.045","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T12:34:47Z","timestamp":1531571687000},"page":"976-982","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-\u03baB and NLRP3 inflammasome pathways"],"prefix":"10.1016","volume":"106","author":[{"given":"Xiaoguang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huicong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.07.045_bib0005","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1056\/NEJMe1313104","article-title":"New therapies for diabetic kidney disease","volume":"369","author":"Himmelfarb","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"A7","key":"10.1016\/j.biopha.2018.07.045_bib0010","article-title":"Renal data system 2011 annual data report: atlas of chronic kidney disease & end-stage renal disease in the United States","volume":"59","author":"Collins","year":"2012","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.biopha.2018.07.045_bib0015","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.07.045_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914nc391_1","article-title":"Licorice and cancer","volume":"39","author":"Wang","year":"2001","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.biopha.2018.07.045_bib0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ptr.2362","article-title":"Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds","volume":"22","author":"Asl","year":"2008","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.07.045_bib0030","doi-asserted-by":"crossref","first-page":"800","DOI":"10.4014\/jmb.1112.12020","article-title":"Antimicrobial activity of licochalcone E against Staphylococcus aureus and its impact on the production of staphylococcal alpha-toxin","volume":"22","author":"Zhou","year":"2012","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0035","doi-asserted-by":"crossref","first-page":"13041","DOI":"10.3390\/molecules200713041","article-title":"Anti-inflammatory activities of licorice extract and its active compounds, glycyrrhizic acid, liquiritin and liquiritigenin, in BV2 cells and mice liver","volume":"20","author":"Yu","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.biopha.2018.07.045_bib0040","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbr.2010.01.041","article-title":"Effects of liquiritigenin treatment on the learning and memory deficits induced by amyloid beta-peptide (25-35) in rats","volume":"210","author":"Liu","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.biopha.2018.07.045_bib0045","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/ptr.5071","article-title":"Liquiritigenin restores osteoblast damage through regulating oxidative stress and mitochondrial dysfunction","volume":"28","author":"Choi","year":"2014","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.07.045_bib0050","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2006.03.008","article-title":"Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine","volume":"161","author":"Kim","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.07.045_bib0055","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.biopha.2016.12.066","article-title":"Liquiritigenin attenuates cardiac injury induced by high fructose-feeding through fibrosis and inflammation suppression","volume":"86","author":"Xie","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.07.045_bib0060","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2018.07.045_bib0065","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/ki.2014.322","article-title":"Revisiting inflammation in diabetic nephropathy: the role of the Nlrp3 inflammasome in glomerular resident cells","volume":"87","author":"Sakai","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.07.045_bib0070","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.amjms.2018.03.005","article-title":"Tetrahydroxy stilbene glucoside alleviates high glucose-induced MPC5 podocytes injury through suppression of NLRP3 inflammasome","volume":"355","author":"Li","year":"2018","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.biopha.2018.07.045_bib0075","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.biopha.2016.11.009","article-title":"Antihyperuricemic effect of liquiritigenin in potassium oxonate-induced hyperuricemic rats","volume":"84","author":"Hongyan","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.07.045_bib0080","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/sj.ki.5002517","article-title":"Effects of long-term elevated glucose on collagen formation by mesangial cells","volume":"72","author":"Baccora","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.07.045_bib0085","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3181\/0705-MR-134","article-title":"Diabetic nephropathy: mechanisms of renal disease progression","volume":"233","author":"Kanwar","year":"2008","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.biopha.2018.07.045_bib0090","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1242\/bio.015990","article-title":"Exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells to promote renal fibrosis","volume":"5","author":"Wu","year":"2016","journal-title":"Biol. Open"},{"key":"10.1016\/j.biopha.2018.07.045_bib0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.pathol.4.110807.092150","article-title":"A glimpse of various pathogenetic mechanisms of diabetic nephropathy","volume":"6","author":"Kanwar","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0100","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1124\/jpet.114.214205","article-title":"Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro","volume":"350","author":"Xu","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.07.045_bib0105","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1745-7254.2006.00360.x","article-title":"Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells","volume":"27","author":"Wang","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"issue":"Pt. 3","key":"10.1016\/j.biopha.2018.07.045_bib0110","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1042\/bj3160985","article-title":"Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia","volume":"316","author":"Wahab","year":"1996","journal-title":"Biochem. J"},{"key":"10.1016\/j.biopha.2018.07.045_bib0115","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1089\/ars.2007.1595","article-title":"Mechanisms for oxidative stress in diabetic cardiovascular disease","volume":"9","author":"Pennathur","year":"2007","journal-title":"Antioxid. Redox. Signal."},{"key":"10.1016\/j.biopha.2018.07.045_bib0120","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1113\/expphysiol.2012.068361","article-title":"The Akt-FoxO3a-manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy","volume":"98","author":"Lu","year":"2013","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0125","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1681\/ASN.2013070810","article-title":"Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy","volume":"25","author":"Jha","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0130","doi-asserted-by":"crossref","first-page":"14385","DOI":"10.1073\/pnas.0906805106","article-title":"Subcellular localization of Nox4 and regulation in diabetes","volume":"106","author":"Block","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biopha.2018.07.045_bib0135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.2007091048","article-title":"The role of inflammatory cytokines in diabetic nephropathy","volume":"19","author":"Navarro-Gonzalez","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.2057","article-title":"Urinary levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8), and renal injuries in patients with type 2 diabetic nephropathy","volume":"16","author":"Tashiro","year":"2002","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.biopha.2018.07.045_bib0145","first-page":"5099","article-title":"Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRalpha pathway in HK-2 cells","volume":"9","author":"Du","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.biopha.2018.07.045_bib0150","article-title":"CYLD deubiquitinase negatively regulates High glucose-induced NF-kappaB inflammatory signaling in mesangial cells","author":"Li","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.biopha.2018.07.045_bib0155","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-kappaB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.biopha.2018.07.045_bib0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2016.06.004","article-title":"miR-451 suppresses the NF-kappaB-mediated proinflammatory molecules expression through inhibiting LMP7 in diabetic nephropathy","volume":"433","author":"Sun","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0165","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2010020143","article-title":"The NLRP3 inflammasome promotes renal inflammation and contributes to CKD","volume":"21","author":"Vilaysane","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.07.045_bib0170","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.phrs.2016.11.004","article-title":"Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy","volume":"114","author":"Qiu","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2018.07.045_bib0175","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.bbamcr.2014.07.001","article-title":"Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy","volume":"1843","author":"Gao","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.07.045_bib0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.lfs.2016.06.002","article-title":"Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-kappaB and NLRP3 inflammasome","volume":"157","author":"Samra","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.07.045_bib0185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.451","article-title":"LincRNA-Gm4419 knockdown ameliorates NF-kappaB\/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy","volume":"8","author":"Yi","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218321000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218321000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T15:31:37Z","timestamp":1750865497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218321000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":37,"alternative-id":["S0753332218321000"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.045","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquiritigenin attenuates high glucose-induced mesangial matrix accumulation, oxidative stress, and inflammation by suppression of the NF-\u03baB and NLRP3 inflammasome pathways","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}