{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:03:01Z","timestamp":1782255781699,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.biopha.2018.07.047","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T02:41:48Z","timestamp":1532054508000},"page":"1210-1219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions"],"prefix":"10.1016","volume":"106","author":[{"given":"Yaoyue","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-5552","authenticated-orcid":false,"given":"Satomi","family":"Kagota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Oonishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shino","family":"Miyauchi-Wakuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumasa","family":"Shinozuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.07.047_bib0005","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3389\/fphar.2017.00412","article-title":"Therapeutic properties of bioactive compounds from different honeybee products","volume":"8","author":"Cornara","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2018.07.047_bib0010","first-page":"1","article-title":"New findings on biological actions and clinical applications of royal jelly: a review","author":"Khazaei","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.biopha.2018.07.047_bib0015","doi-asserted-by":"crossref","first-page":"1259510","DOI":"10.1155\/2017\/1259510","article-title":"Honey, Propolis, and royal jelly: a comprehensive review of their biological actions and health benefits","volume":"2017","author":"Pasupuleti","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.biopha.2018.07.047_bib0020","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/01.hjh.0000240041.43214.8a","article-title":"Is hypertension a tissue perfusion disorder? Implications for renal and myocardial perfusion","volume":"24","author":"Mourad","year":"2006","journal-title":"J. Hypertens. Suppl."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.047_bib0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/1534734609336768","article-title":"Peripheral arterial disease and diabetes: a clinical update","volume":"8","author":"Dinh","year":"2009","journal-title":"Int. J. Low. Extrem. Wounds"},{"issue":"2","key":"10.1016\/j.biopha.2018.07.047_bib0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1248\/bpb.27.189","article-title":"Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats","volume":"27","author":"Tokunaga","year":"2004","journal-title":"Biol. Pharm. Bull."},{"issue":"6","key":"10.1016\/j.biopha.2018.07.047_bib0035","first-page":"677","article-title":"A dipeptide YY derived from royal jelly proteins inhibits renin activity","volume":"21","author":"Sultana","year":"2008","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.047_bib0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0955-2863(01)00198-X","article-title":"Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR","volume":"13","author":"Matsui","year":"2002","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2018.07.047_bib0045","first-page":"57","article-title":"Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats","volume":"63","author":"Takaki-Doi","year":"2009","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.biopha.2018.07.047_bib0050","first-page":"229","article-title":"Antihypertensive effects and safety of drink containing protease-treated royal jelly in subjects with high-normal or mild hypertension","volume":"21","author":"Kajimoto","year":"2005","journal-title":"Health Sci."},{"key":"10.1016\/j.biopha.2018.07.047_bib0055","first-page":"9","article-title":"Studies on insulin-like substances and inhibitory substances toward angiotensin-converting enzyme in royal jelly","volume":"19","author":"Okuda","year":"1998","journal-title":"Mitsubachi Kagaku"},{"issue":"11","key":"10.1016\/j.biopha.2018.07.047_bib0060","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1248\/bpb.31.2103","article-title":"Royal jelly ameliorates insulin resistance in fructose-drinking rats","volume":"31","author":"Zamami","year":"2008","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.biopha.2018.07.047_bib0065","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1248\/yakushi.127.1877","article-title":"Effect of long-term treatment with royal jelly on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats","volume":"127","author":"Nomura","year":"2007","journal-title":"Yakugaku Zasshi"},{"issue":"2","key":"10.1016\/j.biopha.2018.07.047_bib0070","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1248\/yakushi1947.98.2_139","article-title":"Biochemical studies on vasodilative factor in royal jelly (author's transl)","volume":"98","author":"Shinoda","year":"1978","journal-title":"Yakugaku Zasshi"},{"issue":"3","key":"10.1016\/j.biopha.2018.07.047_bib0075","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1254\/jjp.53.331","article-title":"Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats","volume":"53","author":"Fujii","year":"1990","journal-title":"Jpn. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.047_bib0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/iwj.12063","article-title":"The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double-blind placebo-controlled clinical trial","volume":"12","author":"Siavash","year":"2015","journal-title":"Int. Wound J."},{"issue":"5-6","key":"10.1016\/j.biopha.2018.07.047_bib0085","first-page":"171","article-title":"Determinants of chilliness among young women and their application to psychopharmacological trials","volume":"29","author":"Yamada","year":"2009","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"issue":"5","key":"10.1016\/j.biopha.2018.07.047_bib0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1139\/y11-029","article-title":"Telmisartan provides protection against development of impaired vasodilation independently of metabolic effects in SHRSP.Z-Lepr(fa)\/IzmDmcr rats with metabolic syndrome","volume":"89","author":"Kagota","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.047_bib0095","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1291\/hypres.18.319","article-title":"Mechanism of hypertension induced by chronic inhibition of nitric oxide in rats","volume":"18","author":"Takahashi","year":"1995","journal-title":"Hypertens. Res."},{"issue":"3","key":"10.1016\/j.biopha.2018.07.047_bib0100","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1161\/01.HYP.21.3.359","article-title":"Sustained hypertension induced by orally administered nitro-L-arginine","volume":"21","author":"Dananberg","year":"1993","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.biopha.2018.07.047_bib0105","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12929-017-0366-4","article-title":"Age-dependent redox status in the brain stem of NO-deficient hypertensive rats","volume":"24","author":"Majzunova","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"8","key":"10.1016\/j.biopha.2018.07.047_bib0110","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1248\/bpb.29.1756","article-title":"Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats","volume":"29","author":"Kubota","year":"2006","journal-title":"Biol. Pharm. Bull."},{"issue":"11","key":"10.1016\/j.biopha.2018.07.047_bib0115","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/elps.200800721","article-title":"A novel method developed for acetylcholine detection in royal jelly by using capillary electrophoresis coupled with electrogenerated chemiluminescence based on a simple reaction","volume":"30","author":"Wei","year":"2009","journal-title":"Electrophoresis"},{"issue":"4","key":"10.1016\/j.biopha.2018.07.047_bib0120","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1159\/000025659","article-title":"Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: importance of processes mediating precontractions","volume":"36","author":"Tomioka","year":"1999","journal-title":"J. Vasc. Res."},{"issue":"5789","key":"10.1016\/j.biopha.2018.07.047_bib0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.biopha.2018.07.047_bib0130","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00005344-199611000-00014","article-title":"The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation","volume":"28","author":"Shimokawa","year":"1996","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.047_bib0135","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/hy1001.092651","article-title":"An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide","volume":"38","author":"Scotland","year":"2001","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.biopha.2018.07.047_bib0140","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1254\/jphs.10R30FM","article-title":"New molecular mechanisms for cardiovascular disease: contribution of endothelium-derived hyperpolarizing factor in the regulation of vasoconstriction in peripheral resistance arteries","volume":"116","author":"Jin","year":"2011","journal-title":"J. Pharmacol. Sci."},{"issue":"11","key":"10.1016\/j.biopha.2018.07.047_bib0145","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.07.047_bib0150","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/sj.bjp.0706639","article-title":"Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery","volume":"147","author":"Liu","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.07.047_bib0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.micres.2016.06.007","article-title":"Royal Jelly: an ancient remedy with remarkable antibacterial properties","volume":"192","author":"Fratini","year":"2016","journal-title":"Microbiol. Res."},{"issue":"1","key":"10.1016\/j.biopha.2018.07.047_bib0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jff.2011.12.007","article-title":"Bioactive compounds and health-promoting properties of royal jelly: a review","volume":"4","author":"Ramadan","year":"2012","journal-title":"J. Funct. Foods"},{"issue":"3","key":"10.1016\/j.biopha.2018.07.047_bib0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/BF03044353","article-title":"The physiology and pathophysiology of the nitric oxide\/superoxide system","volume":"22","author":"Munzel","year":"1997","journal-title":"Herz"},{"issue":"6","key":"10.1016\/j.biopha.2018.07.047_bib0170","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00005-017-0465-7","article-title":"Evaluation of endothelial function by flow-mediated dilation: a comprehensive review in rheumatic disease","volume":"65","author":"Moroni","year":"2017","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"issue":"11","key":"10.1016\/j.biopha.2018.07.047_bib0175","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11906-015-0596-3","article-title":"Clinical significance of endothelial dysfunction in essential hypertension","volume":"17","author":"Gkaliagkousi","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.047_bib0180","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10623320802228872","article-title":"Evaluation of endothelial dysfunction: flow-mediated dilation","volume":"15","author":"Korkmaz","year":"2008","journal-title":"Endothelium"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218331299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218331299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T19:34:08Z","timestamp":1750880048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218331299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":36,"alternative-id":["S0753332218331299"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.047","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Royal jelly increases peripheral circulation by inducing vasorelaxation through nitric oxide production under healthy conditions","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}