{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:14:21Z","timestamp":1770509661900,"version":"3.49.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.biopha.2018.07.173","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T13:28:45Z","timestamp":1533302925000},"page":"90-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats"],"prefix":"10.1016","volume":"107","author":[{"given":"Dawlat A.","family":"Sayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amel M.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohair R.","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biopha.2018.07.173_bib0005","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12906-015-0713-5","article-title":"Gastroprotective and ulcer healing effects of piptadeniastrum Africanum on experimentally induced gastric ulcers in rats","volume":"15","author":"Ateufack","year":"2015","journal-title":"BMC Complement. Altern. Med."},{"issue":"35","key":"10.1016\/j.biopha.2018.07.173_bib0010","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.2174\/1381612821666150915105738","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) induced dyspepsia","volume":"21","author":"Yap","year":"2015","journal-title":"Curr. Pharm. Des."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.07.173_bib0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpharm.2004.12.019","article-title":"Solid dispersion particles of amorphous indomethacin with fine porous silica particles by using spray-drying method","volume":"293","author":"Takeuchi","year":"2005","journal-title":"Int. J. Pharm."},{"issue":"19","key":"10.1016\/j.biopha.2018.07.173_bib0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00535-008-2267-5","article-title":"Mast cells are involved in the pathogenesis of indomethacin-induced rat enteritis","volume":"44","author":"Okayama","year":"2009","journal-title":"J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.173_bib0025","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4014\/jmb.1012.12019","article-title":"Curative effect of selenium against indomethacin-induced gastric ulcers in rats","volume":"21","author":"Kim","year":"2011","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.biopha.2018.07.173_bib0030","first-page":"244","volume":"5","year":"2003"},{"key":"10.1016\/j.biopha.2018.07.173_bib0035","first-page":"693","article-title":"Involvement of reactive oxygen species in gastric ulceration: protection by melatonin","volume":"40","author":"Bandyopadhyay","year":"2002","journal-title":"Ind J Exp Biol."},{"key":"10.1016\/j.biopha.2018.07.173_bib0040","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3390\/molecules14030979","article-title":"Flavonoids with gastro-protective activity","volume":"14","author":"Mota","year":"2009","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.biopha.2018.07.173_bib0045","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1021\/ml400158k","article-title":"Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors","volume":"4","author":"Ononye","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.biopha.2018.07.173_bib0050","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.lwt.2009.02.020","article-title":"Antioxidant property of polyhydroxylated naphthoquinone pigments from shells of purple sea urchin Anthocidaris crassispina","volume":"42","author":"Kuwahara","year":"2009","journal-title":"LWT. Food Sci. Technol."},{"key":"10.1016\/j.biopha.2018.07.173_bib0055","first-page":"178","article-title":"Antimicrobial and antioxidant activity of purple sea urchin shell (Salmacis virgulata L. Agassiz and Desor 1846)","volume":"6","author":"Shankarlal","year":"2011","journal-title":"Am.-Euras. J. Sci. Res."},{"issue":"1659","key":"10.1016\/j.biopha.2018.07.173_bib0060","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0269","article-title":"Global regime shift dynamics of catastrophic sea urchin overgrazing","volume":"370","author":"Ling","year":"2015","journal-title":"Philos. Trans. Biol. Sci."},{"key":"10.1016\/j.biopha.2018.07.173_bib0065","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.foodchem.2011.06.014","article-title":"Extraction and antioxidant property of polyhydroxylated naphthoquinone pigments from spines of purple sea urchin Strongylocentrotus nudus","volume":"129","author":"Zhou","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2018.07.173_bib0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.foodchem.2012.01.099","article-title":"Chemical composition of shells from red (Strongylocentrotus franciscanus) and green (Strongylocentrotus droebachiensis) sea urchin","volume":"133","author":"Amarowicz","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.biopha.2018.07.173_bib0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0010-406X(69)91347-4","article-title":"Distribution of spinochrome pigments inechinoids","volume":"28","author":"Anderson","year":"1969","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.biopha.2018.07.173_bib0080","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1016\/j.chroma.2011.10.045","volume":"1218","author":"Shikov","year":"2011","journal-title":"J. Chromatogr. A"},{"issue":"3","key":"10.1016\/j.biopha.2018.07.173_bib0085","doi-asserted-by":"crossref","first-page":"281","DOI":"10.18097\/pbmc20125803281","article-title":"Pharmacological activity echinochrome A singly and consisting of BAA\" Timarin\"","volume":"58","author":"Artiukov","year":"2012","journal-title":"Biomed. Khim."},{"issue":"7","key":"10.1016\/j.biopha.2018.07.173_bib0090","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.3390\/md12073874","article-title":"Pigment cell differentiation in sea urchin blastula-derived primary cell cultures","volume":"12","author":"Ageenko","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biopha.2018.07.173_bib0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jobaz.2015.03.001","article-title":"Ameliorative effect of the sea cucumber Holothuria arenicola extract against gastric ulcer in rats","volume":"72","author":"Fahmy","year":"2015","journal-title":"J. Basic Appl. Zool."},{"issue":"9","key":"10.1016\/j.biopha.2018.07.173_bib0100","doi-asserted-by":"crossref","first-page":"163","DOI":"10.22159\/ijpps.2016v8i9.12846","article-title":"Antiulcerogenic efficacy of ethanolic extract of vitis vinifera leaves in rats","volume":"8","author":"Sayed","year":"2016","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.biopha.2018.07.173_bib0105","first-page":"687","article-title":"Wound healing was improved in mice after myocardial infarction by nature naphthoquinone shikonin","volume":"31","author":"Cai","year":"2017","journal-title":"Faseb J."},{"key":"10.1016\/j.biopha.2018.07.173_bib0110","series-title":"Monograph of Shallow-water Indo-West Pacific Echinoderms","author":"Clark","year":"1971"},{"key":"10.1016\/j.biopha.2018.07.173_bib0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0308-8146(94)90262-3","article-title":"Separation of pigments from shells of red sea urchin (Strongylocentrotus franciscanus)","volume":"51","author":"Amarowicz","year":"1994","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.biopha.2018.07.173_bib0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0031-9384(90)90060-H","article-title":"Effect of an endogenous satiety substance, 2-buten-4-olide, on gastric acid secretion and experimental ulceration in rats","volume":"47","author":"Arai","year":"1990","journal-title":"Physiol. Behav."},{"issue":"13","key":"10.1016\/j.biopha.2018.07.173_bib0125","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3748\/wjg.v18.i13.1479","article-title":"Curcumin prevents indomethacin-induced gastropathy in rats","volume":"18","author":"Thong-Ngam","year":"2012","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"1","key":"10.1016\/j.biopha.2018.07.173_bib0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jep.2008.06.008","article-title":"Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz (Solanaceae) in rats","volume":"119","author":"Nguelefack","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.07.173_bib0135","first-page":"171","article-title":"Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats","volume":"20","author":"Lennikov","year":"2014","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biopha.2018.07.173_bib0140","series-title":"Hand Book of Experimental Pharmacology","first-page":"149","author":"Kulkarni","year":"2002"},{"key":"10.1016\/j.biopha.2018.07.173_bib0145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.25004\/IJPSDR.2011.030205","article-title":"Evaluation of anti-ulcer activity of methanolic extract of abutilon indicum linn leaves in experimental rats","volume":"3","author":"Dashputre","year":"2011","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"key":"10.1016\/j.biopha.2018.07.173_bib0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2018.07.173_bib0155","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"issue":"102","key":"10.1016\/j.biopha.2018.07.173_bib0160","first-page":"414","article-title":"Determination of nitrite in water","volume":"86","author":"Montgomery","year":"1961","journal-title":"Analyst"},{"key":"10.1016\/j.biopha.2018.07.173_bib0165","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione-S-transferase","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.07.173_bib0170","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of the superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.07.173_bib0175","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Meth. Enzymol."},{"issue":"3","key":"10.1016\/j.biopha.2018.07.173_bib0180","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10616-013-9594-y","article-title":"Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage","volume":"66","author":"Ozbayer","year":"2014","journal-title":"Cytotechnology"},{"key":"10.1016\/j.biopha.2018.07.173_bib0185","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.lfs.2016.03.007","article-title":"Mechanisms of echinochrome potency in modulating diabetic complications in liver","volume":"151","author":"Mohamed","year":"2016","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.biopha.2018.07.173_bib0190","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0895-3988(10)60006-2","article-title":"Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress\/antioxidant, IL-6 and enzyme activities","volume":"22","author":"Tuorkey","year":"2009","journal-title":"Biomed. Environ. Sci."},{"issue":"9","key":"10.1016\/j.biopha.2018.07.173_bib0195","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3109\/15376516.2010.508079","article-title":"Protective effects of Punica granatum in experimentally-induced gastric ulcers","volume":"20","author":"Alam","year":"2010","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biopha.2018.07.173_bib0200","first-page":"315","article-title":"The effects of acetyl shikonin isolated from Onosma armeniacum on oxidative stress in ethanol-induced ulcer model of rats","volume":"43","author":"Toker","year":"2013","journal-title":"Turk. J. Med. Sci."},{"issue":"6","key":"10.1016\/j.biopha.2018.07.173_bib0205","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/acs.jnatprod.6b01186","article-title":"Naphthoquinones of Sinningia reitzii and Anti-inflammatory\/Antinociceptive activities of 8-Hydroxydehydrodunnione","volume":"80","author":"Adson","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.biopha.2018.07.173_bib0210","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.phymed.2004.10.009","article-title":"Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha","volume":"13","author":"Kundakovic","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.biopha.2018.07.173_bib0215","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.fct.2013.07.075","article-title":"Zinc (II)\u2013curcumin accelerates the healing of acetic acid-induced chronic gastric ulcers in rats by decreasing oxidative stress and downregulation of matrix metalloproteinase-9","volume":"60","author":"Mei","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.biopha.2018.07.173_bib0220","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s13105-013-0241-z","article-title":"Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats","volume":"69","author":"Abbas","year":"2013","journal-title":"J. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2018.07.173_bib0225","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.biopha.2018.07.173_bib0230","doi-asserted-by":"crossref","first-page":"3","DOI":"10.33073\/pjm-2011-001","article-title":"New antibacterial therapeutics and strategies","volume":"60","author":"Kurek","year":"2011","journal-title":"Pol. J. Microbiol."},{"issue":"4","key":"10.1016\/j.biopha.2018.07.173_bib0235","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0016-5085(79)90235-X","article-title":"Cytoprotection by prostaglandins","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2018.07.173_bib0240","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1734-1140(11)70518-7","article-title":"Antiulcerative effect of dexmedetomidine on indomethacin-induced gastriculcer in rats","volume":"63","author":"Polat","year":"2011","journal-title":"Pharmacol. Rep."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218334589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218334589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:10:40Z","timestamp":1766023840000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218334589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":48,"alternative-id":["S0753332218334589"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.173","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echinochrome pigment as novel therapeutic agent against experimentally - induced gastric ulcer in rats","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.07.173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}