{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:47:15Z","timestamp":1790434035949,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2016A030310397"],"award-info":[{"award-number":["2016A030310397"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2014C006"],"award-info":[{"award-number":["2014C006"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010112","name":"Nanfang Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.biopha.2018.08.067","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T06:49:36Z","timestamp":1534920576000},"page":"785-792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["TXNIP mediated the oxidative stress response in glomerular mesangial cells partially through AMPK pathway"],"prefix":"10.1016","volume":"107","author":[{"given":"Wenwei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoming","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.08.067_bib0005","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1056\/NEJMoa0908292","article-title":"Prevalence of diabetes among men and women in China","volume":"362","author":"Yang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.08.067_bib0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diabres.2009.10.007","article-title":"Global estimates of the prevalence of diabetes for 2010 and 2030","volume":"87","author":"Shaw","year":"2010","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2018.08.067_bib0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.08.067_bib0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2018.08.067_bib0025","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2337\/db08-0057","article-title":"Oxidative stress as a major culprit in kidney disease in diabetes","volume":"57","author":"Forbes","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2018.08.067_bib0030","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/35008121","article-title":"Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage","volume":"404","author":"Nishikawa","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.08.067_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2017.12.040","article-title":"Diabetic nephropathy: is there a role for oxidative stress?","author":"Sagoo","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biopha.2018.08.067_bib0040","article-title":"Oxidative stress in kidney diseases: the cause or the consequence?","author":"Krata","year":"2017","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.biopha.2018.08.067_bib0045","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cbi.2017.10.031","article-title":"Antioxidant for treatment of diabetic nephropathy: a systematic review and meta-analysis","volume":"278","author":"Kandhare","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.08.067_bib0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fphys.2017.00211","article-title":"Mitochondrial reactive oxygen species and kidney hypoxia in the development of diabetic nephropathy","volume":"8","author":"Schiffer","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biopha.2018.08.067_bib0055","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.96","article-title":"Hydrogen peroxide: a Jekyll and Hyde signalling molecule","volume":"2","author":"Gough","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2018.08.067_bib0060","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8379327","article-title":"Diabetes-induced reactive oxygen species: mechanism of their generation and role in renal injury","volume":"2017","author":"Fakhruddin","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.08.067_bib0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101081","article-title":"Anti-inflammatory thioredoxin family proteins for medicare, healthcare and aging care","volume":"9","author":"Yodoi","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2018.08.067_bib0070","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1681\/ASN.2008020142","article-title":"Expression, localization, and function of the thioredoxin system in diabetic nephropathy","volume":"20","author":"Advani","year":"2009","journal-title":"J. Am. Soc. Nephrol. Jasn"},{"key":"10.1016\/j.biopha.2018.08.067_bib0075","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fimmu.2013.00514","article-title":"Thioredoxin\/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases","volume":"4","author":"Yoshihara","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biopha.2018.08.067_bib0080","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mito.2012.06.004","article-title":"Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer","volume":"13","author":"Zhou","year":"2013","journal-title":"Mitochondrion"},{"key":"10.1016\/j.biopha.2018.08.067_bib0085","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1016\/j.cellsig.2013.09.009","article-title":"Knockdown of thioredoxin-interacting protein ameliorates high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells","volume":"25","author":"Wei","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.biopha.2018.08.067_bib0090","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/labinvest.2014.2","article-title":"Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux","volume":"94","author":"Huang","year":"2014","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biopha.2018.08.067_bib0095","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1016\/j.febslet.2010.07.010","article-title":"p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells","volume":"584","author":"Ren","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biopha.2018.08.067_bib0100","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1074\/jbc.M112.419101","article-title":"Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells","volume":"288","author":"Shah","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.08.067_bib0105","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/sj.onc.1209218","article-title":"Thioredoxin-interacting protein (txnip) is a glucocorticoid-regulated primary response gene involved in mediating glucocorticoid-induced apoptosis","volume":"25","author":"Wang","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.biopha.2018.08.067_bib0110","doi-asserted-by":"crossref","first-page":"H64","DOI":"10.1152\/ajpheart.00151.2016","article-title":"TXNIP regulates myocardial fatty acid oxidation via miR-33a signaling","volume":"311","author":"Chen","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2018.08.067_bib0115","doi-asserted-by":"crossref","first-page":"29196","DOI":"10.1038\/srep29196","article-title":"Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.08.067_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2014.12.037","article-title":"Next generation sequencing of the hepatitis C virus NS5B gene reveals potential novel S282 drug resistance mutations","volume":"477","author":"Ji","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.biopha.2018.08.067_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2865912","article-title":"Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK\/SIRT1\/PGC-1alpha signaling in db\/db mice","volume":"2017","author":"Hou","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.08.067_bib0130","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1074\/jbc.M107895200","article-title":"Mechanism for fatty acid \"sparing\" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase","volume":"277","author":"Kawaguchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.08.067_bib0135","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3109\/0886022X.2012.668491","article-title":"The role of AMPKalpha in high-glucose-induced dysfunction of cultured rat mesangial cells","volume":"34","author":"Lv","year":"2012","journal-title":"Ren. Fail."},{"key":"10.1016\/j.biopha.2018.08.067_bib0140","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.molcel.2013.01.035","article-title":"AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1","volume":"49","author":"Wu","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biopha.2018.08.067_bib0145","doi-asserted-by":"crossref","first-page":"E225","DOI":"10.1152\/ajpendo.00391.2015","article-title":"A novel mechanism of action for salidroside to alleviate diabetic albuminuria: effects on albumin transcytosis across glomerular endothelial cells","volume":"310","author":"Wu","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.08.067_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028804","article-title":"AMP-activated protein kinase (AMPK) mediates nutrient regulation of thioredoxin-interacting protein (TXNIP) in pancreatic beta-cells","volume":"6","author":"Shaked","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.08.067_bib0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2015.05.012","article-title":"Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP\/NLRP3 inflammasome activation in an AMPK dependent manner","volume":"99","author":"Li","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biopha.2018.08.067_bib0160","doi-asserted-by":"crossref","first-page":"29196","DOI":"10.1038\/srep29196","article-title":"Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.08.067_bib0165","first-page":"6247","article-title":"Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-kappaB signaling pathways in alloxan-induced mice","volume":"9","author":"Yuan","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.biopha.2018.08.067_bib0170","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1074\/jbc.M112.419101","article-title":"Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells","volume":"288","author":"Shah","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.08.067_bib0175","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1097\/01.ASN.0000064500.89551.76","article-title":"Overview of glucose signaling in mesangial cells in diabetic nephropathy","volume":"14","author":"Haneda","year":"2003","journal-title":"J. Am. Soc. Nephrol. Jasn"},{"key":"10.1016\/j.biopha.2018.08.067_bib0180","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1021\/bi011953s","article-title":"Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation","volume":"41","author":"Fontayne","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2018.08.067_bib0185","doi-asserted-by":"crossref","first-page":"744","DOI":"10.2353\/ajpath.2007.060813","article-title":"High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1","volume":"171","author":"Gilbert","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biopha.2018.08.067_bib0190","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2014050528","article-title":"Thioredoxin-interacting protein deficiency protects against diabetic nephropathy","volume":"26","author":"Shah","year":"2015","journal-title":"J. Am. Soc. Nephrol. Jasn"},{"key":"10.1016\/j.biopha.2018.08.067_bib0195","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6973175","article-title":"High glucose and lipopolysaccharide prime NLRP3 inflammasome via ROS\/TXNIP pathway in mesangial cells","volume":"2016","author":"Feng","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.08.067_bib0200","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tcb.2007.07.009","article-title":"ROS, mitochondria and the regulation of autophagy","volume":"17","author":"Scherzshouval","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.biopha.2018.08.067_bib0205","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol. Cb"},{"key":"10.1016\/j.biopha.2018.08.067_bib0210","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","article-title":"Oxidative stress in diabetic nephropathy","volume":"17","author":"Kashihara","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2018.08.067_bib0215","article-title":"The role of 5\u2019-AMP-Activated protein kinase (AMPK) in diabetic nephropathy: a new direction?","volume":"5","author":"Prabhakar","year":"2009","journal-title":"Curr. Enzym. Inhib."},{"key":"10.1016\/j.biopha.2018.08.067_bib0220","article-title":"Extracellular superoxide dismutase attenuates renal oxidative stress through the activation of AMPK in diabetic nephropathy","author":"Hong","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biopha.2018.08.067_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2865912","article-title":"Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK\/SIRT1\/PGC-1\u03b1 signaling in db\/db mice","volume":"2017","author":"Hou","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.08.067_bib0230","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1124\/jpet.116.237925","article-title":"Selective activation of AMPK \u00ce\u00b21-Containing isoforms improves kidney function in a rat model of diabetic nephropathy","volume":"361","author":"Salatto","year":"2017","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.08.067_bib0235","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3390\/ijms18071408","article-title":"Identification of direct activator of Adenosine monophosphate-activated protein kinase (AMPK) by structure-based virtual screening and molecular docking approach","volume":"18","author":"Huang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2018.08.067_bib0240","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.bbrc.2018.03.020","article-title":"Downregulation of TXNIP leads to high proliferative activity and estrogen-dependent cell growth in breast cancer","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.08.067_bib0245","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.3892\/or.2017.5577","article-title":"TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation","volume":"37","author":"Li","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2018.08.067_bib0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cbi.2017.10.012","article-title":"Salidroside alleviates high glucose-induced oxidative stress and extracellular matrix accumulation in rat glomerular mesangial cells by the TXNIP-NLRP3 inflammasome pathway","volume":"278","author":"Wang","year":"2017","journal-title":"Chem. Biol. Interact."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218338940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218338940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:09:22Z","timestamp":1766023762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218338940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":50,"alternative-id":["S0753332218338940"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.08.067","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TXNIP mediated the oxidative stress response in glomerular mesangial cells partially through AMPK pathway","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.08.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}