{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:16:42Z","timestamp":1791303402312,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biopha.2018.08.131","type":"journal-article","created":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T20:33:04Z","timestamp":1537043584000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis"],"prefix":"10.1016","volume":"108","author":[{"given":"Huanguang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-0220","authenticated-orcid":false,"given":"Theasha","family":"Manicum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liaojun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2018.08.131_bib0005","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/jcb.21573","article-title":"Understanding the pathology and mechanisms of type I diabetic bone loss","volume":"102","author":"McCabe","year":"2007","journal-title":"J. Cell. Biochem."},{"issue":"21","key":"10.1016\/j.biopha.2018.08.131_bib0010","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1056\/NEJMoa0907845","article-title":"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease","volume":"361","author":"Pfeffer","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"14","key":"10.1016\/j.biopha.2018.08.131_bib0015","first-page":"1408","article-title":"Therapies for type 2 diabetes and coronary artery disease","volume":"361","author":"DeVries","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.biopha.2018.08.131_bib0020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1056\/NEJM197601292940502","article-title":"Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes","volume":"294","author":"Levin","year":"1976","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/dmr.5610110103","article-title":"Diabetic osteopenia: pathophysiology and clinical aspects","volume":"11","author":"Seino","year":"1995","journal-title":"Diabetes Metab. Rev."},{"issue":"4","key":"10.1016\/j.biopha.2018.08.131_bib0030","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mehy.2012.06.016","article-title":"Possible therapeutic potential of berberine in diabetic osteopathy","volume":"79","author":"Rahigude","year":"2012","journal-title":"Med. Hypotheses"},{"issue":"7","key":"10.1016\/j.biopha.2018.08.131_bib0035","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/jbmr.5650100709","article-title":"Influence of high glucose on 1,25-dihydroxyvitamin D3-induced effect on human osteoblast-like MG-63 cells","volume":"10","author":"Inaba","year":"1995","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.08.131_bib0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jdiacomp.2009.05.002","article-title":"Metformin reverses the deleterious effects of high glucose on osteoblast function","volume":"24","author":"Zhen","year":"2010","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.biopha.2018.08.131_bib0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0378-4274(95)03474-9","article-title":"Signalling mechanisms and oxidative stress in apoptosis","volume":"82\u201383","author":"Slater","year":"1995","journal-title":"Toxicol. Lett."},{"issue":"9","key":"10.1016\/j.biopha.2018.08.131_bib0050","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0891-5849(00)00224-0","article-title":"Oxidative stress and cell cycle checkpoint function","volume":"28","author":"Shackelford","year":"2000","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.biopha.2018.08.131_bib0055","doi-asserted-by":"crossref","first-page":"27087","DOI":"10.3390\/ijms161125998","article-title":"Berberine Sulfate attenuates osteoclast differentiation through RANKL induced NF-kappaB and NFAT pathways","volume":"16","author":"Zhou","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.biopha.2018.08.131_bib0060","first-page":"711","article-title":"Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research","volume":"8","author":"Ni","year":"1988","journal-title":"Zhong Xi Yi Jie He Za Zhi"},{"issue":"3","key":"10.1016\/j.biopha.2018.08.131_bib0065","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.bbrc.2010.05.153","article-title":"Berberine inhibits PTP1B activity and mimics insulin action","volume":"397","author":"Chen","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.biopha.2018.08.131_bib0070","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.biochi.2011.04.013","article-title":"Berberine acutely activates the glucose transport activity of GLUT1","volume":"93","author":"Cok","year":"2011","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.biopha.2018.08.131_bib0075","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3748\/wjg.14.876","article-title":"Berberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta","volume":"14","author":"Yi","year":"2008","journal-title":"World J. Gastroenterol."},{"issue":"1\u20132","key":"10.1016\/j.biopha.2018.08.131_bib0080","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2007.11.013","article-title":"Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways","volume":"580","author":"Hu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2018.08.131_bib0085","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1359\/jbmr.080325","article-title":"Berberine promotes osteoblast differentiation by Runx2 activation with p38 MAPK","volume":"23","author":"Lee","year":"2008","journal-title":"J. Bone Miner. Res."},{"issue":"16","key":"10.1016\/j.biopha.2018.08.131_bib0090","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1055\/s-0030-1250040","article-title":"Preventive effects of berberine on glucocorticoid-induced osteoporosis in rats","volume":"76","author":"Xu","year":"2010","journal-title":"Planta Med."},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0095","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1248\/bpb.26.110","article-title":"Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model","volume":"26","author":"Li","year":"2003","journal-title":"Biol. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0100","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.abb.2008.04.022","article-title":"Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose","volume":"475","author":"Liu","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.fitote.2010.08.019","article-title":"Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver","volume":"82","author":"Zhou","year":"2011","journal-title":"Fitoterapia"},{"issue":"4","key":"10.1016\/j.biopha.2018.08.131_bib0110","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.biopha.2018.08.131_bib0115","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bone.2006.12.057","article-title":"Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: a possible role of oxidative stress","volume":"40","author":"Hamada","year":"2007","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.biopha.2018.08.131_bib0120","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/ptr.5693","article-title":"Berberis vulgaris and berberine: an update review","volume":"30","author":"Imenshahidi","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.biopha.2018.08.131_bib0125","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biopha.2017.02.018","article-title":"The protective effects of silibinin in the treatment of streptozotocin-induced diabetic osteoporosis in rats","volume":"89","author":"Wang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.biopha.2018.08.131_bib0130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1139\/o76-051","article-title":"Acid phosphatases: androgen dependent markers of rat prostate","volume":"54","author":"Tenniswood","year":"1976","journal-title":"Can. J. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0135","first-page":"130","article-title":"A modified spectrophotometric assay of superoxide dismutase","volume":"21","author":"Kakkar","year":"1984","journal-title":"Indian J. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.biopha.2018.08.131_bib0140","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s001250051248","article-title":"Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trondelag Health Survey","volume":"42","author":"Forsen","year":"1999","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/j.biopha.2018.08.131_bib0145","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1002\/jcb.26089","article-title":"Berberine Alleviates oxidative stress in islets of diabetic mice by inhibiting miR-106b expression and up-regulating SIRT1","volume":"118","author":"Chen","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0150","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan- and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0155","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S8756-3282(03)00169-8","article-title":"Effects of combined treatment of insulin and human parathyroid hormone(1-34) on cancellous bone mass and structure in streptozotocin-induced diabetic rats","volume":"33","author":"Suzuki","year":"2003","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0160","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.phrs.2004.06.002","article-title":"Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas","volume":"51","author":"Coskun","year":"2005","journal-title":"Pharmacol. Res."},{"issue":"1\u20133","key":"10.1016\/j.biopha.2018.08.131_bib0165","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2008.12.056","article-title":"Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate\/high-fat diet-induced diabetic rats","volume":"606","author":"Zhou","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.biopha.2018.08.131_bib0170","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.2337\/db06-0006","article-title":"Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states","volume":"55","author":"Lee","year":"2006","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.biopha.2018.08.131_bib0175","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/1097-4644(20001101)79:2<301::AID-JCB130>3.0.CO;2-0","article-title":"Extracellular glucose influences osteoblast differentiation and c-Jun expression","volume":"79","author":"Zayzafoon","year":"2000","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0180","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S8756-3282(97)00220-2","article-title":"Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells","volume":"22","author":"Terada","year":"1998","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S8756-3282(00)00426-9","article-title":"Glucose-induced inhibition of in vitro bone mineralization","volume":"28","author":"Balint","year":"2001","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.biopha.2018.08.131_bib0190","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.08.131_bib0195","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.biopha.2017.08.001","article-title":"Pioglitazone-induced bone loss in diabetic rats and its amelioration by berberine: a portrait of molecular crosstalk","volume":"94","author":"Adil","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218330841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218330841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:52:10Z","timestamp":1777272730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218330841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":39,"alternative-id":["S0753332218330841"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.08.131","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.08.131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}