{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:32:23Z","timestamp":1777275143461,"version":"3.51.4"},"update-to":[{"DOI":"10.1016\/j.biopha.2018.09.007","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000}}],"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Kaifeng Science & Technology Bureau Foundation","award":["1803015"],"award-info":[{"award-number":["1803015"]}]},{"name":"Department of Education Science and Technology Research Project of Henan Province","award":["17A320022"],"award-info":[{"award-number":["17A320022"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biopha.2018.09.007","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T13:07:19Z","timestamp":1536584839000},"page":"7-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["RETRACTED: Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression"],"prefix":"10.1016","volume":"108","author":[{"given":"Xiaoping","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanwei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.09.007_bib0005","doi-asserted-by":"crossref","first-page":"811","DOI":"10.5301\/jn.5000262","article-title":"The pathogenesis of diabetic nephropathy: focus on microRNAs and proteomics","volume":"26","author":"Conserva","year":"2013","journal-title":"J. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000324942","article-title":"Pathology of human diabetic nephropathy","volume":"170","author":"Najafian","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0015","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"SuSTZak","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.biopha.2018.09.007_bib0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrneph.2011.51","article-title":"Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy","volume":"7","author":"Navarro-Gonzalez","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0025","doi-asserted-by":"crossref","first-page":"F716","DOI":"10.1152\/ajprenal.00314.2016","article-title":"Immunity and inflammation in diabetic kidney disease: translating mechanisms to biomarkers and treatment targets","volume":"312","author":"Pichler","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0030","doi-asserted-by":"crossref","first-page":"12200","DOI":"10.1021\/bi035358x","article-title":"Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3","volume":"42","author":"Wei","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.biopha.2018.09.007_bib0035","doi-asserted-by":"crossref","first-page":"F1341","DOI":"10.1152\/ajprenal.00349.2012","article-title":"Loss of TIMP3 selectively exacerbates diabetic nephropathy","volume":"303","author":"Basu","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ki.2013.225","article-title":"TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury","volume":"85","author":"Wang","year":"2014","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.biopha.2018.09.007_bib0045","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.ejca.2010.01.009","article-title":"Loss of expression of TIMP3 in clear cell renal cell carcinoma","volume":"46","author":"Masson","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.biopha.2018.09.007_bib0050","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2008050492","article-title":"Loss of TIMP3 enhances interstitial nephritis and fibrosis","volume":"20","author":"Kassiri","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/emmm.201201475","article-title":"Loss of TIMP3 underlies diabetic nephropathy via FoxO1\/STAT1 interplay","volume":"5","author":"Fiorentino","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.biopha.2018.09.007_bib0060","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in stress signaling and human disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biopha.2018.09.007_bib0065","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3390\/cells3030702","article-title":"MicroRNAs control macrophage formation and activation: the inflammatory link between obesity and cardiovascular diseases","volume":"3","author":"Chang","year":"2014","journal-title":"Cells"},{"key":"10.1016\/j.biopha.2018.09.007_bib0070","doi-asserted-by":"crossref","first-page":"F109","DOI":"10.1152\/ajprenal.00387.2015","article-title":"Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases","volume":"310","author":"Bhatt","year":"2016","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0075","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/593956","article-title":"MicroRNAs in diabetic kidney disease","volume":"2014","author":"Li","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0080","first-page":"1","article-title":"MicroRNAs in diabetic nephropathy: from biomarkers to therapy","volume":"16","author":"Kate","year":"2016","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.biopha.2018.09.007_bib0085","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1038\/s41598-017-01027-5","article-title":"MiRNA-29c regulates the expression of inflammatory cytokines in diabetic nephropathy by targeting tristetraprolin","volume":"7","author":"Guo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.09.007_bib0090","first-page":"4055","article-title":"microRNA-125b contributes to high glucose-induced reactive oxygen species generation and apoptosis in HK-2 renal tubular epithelial cells by targeting angiotensin-converting enzyme 2","volume":"20","author":"Huang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.biopha.2018.09.007_bib0095","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1139\/cjpp-2016-0066","article-title":"Hyperoside ameliorates glomerulosclerosis in diabetic nephropathy by downregulating miR-21","volume":"94","author":"Zhang","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0100","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1042\/CS20150427","article-title":"miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7","volume":"129","author":"McClelland","year":"2015","journal-title":"Clin. Sci."},{"key":"10.1016\/j.biopha.2018.09.007_bib0105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1681\/ASN.2013121274","article-title":"MicroRNA-21 in glomerular injury","volume":"26","author":"Lai","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0110","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00592-013-0492-8","article-title":"Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs","volume":"50","author":"Fiorentino","year":"2013","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0115","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabet. Med."},{"key":"10.1016\/j.biopha.2018.09.007_bib0120","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrendo.2013.184","article-title":"Diabetic nephropathy: diagnosis and treatment","volume":"9","author":"Fineberg","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ki.2013.113","article-title":"NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy","volume":"84","author":"Du","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.09.007_bib0130","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1440-1797.2007.00796.x","article-title":"Rodent models of streptozotocin-induced diabetic nephropathy","volume":"12","author":"Tesch","year":"2007","journal-title":"Nephrology"},{"key":"10.1016\/j.biopha.2018.09.007_bib0135","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2015.1049799","article-title":"Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis","volume":"11","author":"Lenoir","year":"2015","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.biopha.2018.09.007_bib0140","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1159\/000480654","article-title":"Knockdown of angiopoietin-like protein 2 ameliorates diabetic nephropathy by inhibiting TLR4","volume":"43","author":"Yang","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biopha.2018.09.007_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2017.04.006","article-title":"Naringin ameliorates diabetic nephropathy by inhibiting NADPH oxidase 4","volume":"804","author":"Zhang","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"53","key":"10.1016\/j.biopha.2018.09.007_bib0150","doi-asserted-by":"crossref","first-page":"91185","DOI":"10.18632\/oncotarget.20434","article-title":"SOCS2 overexpression alleviates diabetic nephropathy in rats by inhibiting the TLR4\/NF-\u03baB pathway","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget."},{"issue":"8","key":"10.1016\/j.biopha.2018.09.007_bib0155","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1161\/ATVBAHA.111.228924","article-title":"Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy","volume":"31","author":"Devaraj","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"19","key":"10.1016\/j.biopha.2018.09.007_bib0160","doi-asserted-by":"crossref","first-page":"31915","DOI":"10.18632\/oncotarget.16651","article-title":"Tanshinone IIA attenuates renal damage in STZ-induced diabetic rats via inhibiting oxidative stress and inflammation","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.biopha.2018.09.007_bib0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4103\/ijn.IJN_264_16","article-title":"MicroRNAs involvement in renal pathophysiology: a bird\u2019s eye view","volume":"27","author":"Jaswani","year":"2017","journal-title":"Indian J. Nephrol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0170","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/nyas.12758","article-title":"MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets","volume":"1353","author":"Kato","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biopha.2018.09.007_bib0175","article-title":"Epigenetic regulations in diabetic nephropathy","volume":"2017","author":"Zeyuan","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.09.007_bib0180","doi-asserted-by":"crossref","first-page":"26072","DOI":"10.1038\/srep26072","article-title":"MicroRNA-27a induces mesangial cell injury by targeting of PPARgamma, and its in vivo knockdown prevents progression of diabetic nephropathy","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biopha.2018.09.007_bib0185","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.3892\/mmr.2017.7224","article-title":"microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7","volume":"16","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2018.09.007_bib0190","doi-asserted-by":"crossref","first-page":"C430","DOI":"10.1152\/ajpcell.00081.2017","article-title":"Reciprocal regulation of miR-214 and PTEN by high glucose regulates renal glomerular mesangial and proximal tubular epithelial cell hypertrophy and matrix expansion","volume":"313","author":"Bera","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biopha.2018.09.007_bib0195","first-page":"417","article-title":"Serum miR-21 may be a potential diagnostic biomarker for diabetic nephropathy","volume":"124","author":"Wang","year":"2016","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.biopha.2018.09.007_bib0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ymthe.2016.08.001","article-title":"Therapeutic miR-21 silencing ameliorates diabetic kidney disease in mice","volume":"25","author":"Kolling","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biopha.2018.09.007_bib0205","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexcr.2014.04.014","article-title":"High glucose increases Cdk5 activity in podocytes via transforming growth factor-\u03b21 signaling pathway","volume":"326","author":"Zhang","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biopha.2018.09.007_bib0210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/emmm.201201475","article-title":"Loss of TIMP3 underlies diabetic nephropathy via FoxO1\/STAT1 interplay","volume":"5","author":"Fiorentino","year":"2013","journal-title":"EMBO Mol. Med."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2023.114725","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"record-id":"44007"},{"DOI":"10.1016\/j.biopha.2018.09.007","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000}},{"DOI":"10.1016\/j.biopha.2023.114725","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000}}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218319176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218319176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:33:06Z","timestamp":1777271586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218319176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":42,"alternative-id":["S0753332218319176"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.007","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}