{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:38:09Z","timestamp":1777275489191,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biopha.2018.09.040","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T05:14:54Z","timestamp":1536729294000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-0264","authenticated-orcid":false,"given":"Isabella","family":"Rimoldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Cocc\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Facchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7848-8099","authenticated-orcid":false,"given":"Anna Teresa","family":"Brini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sisto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Parati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Cavicchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Lucchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Petrella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Ciusani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Pessina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.09.040_bib0005","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejmech.2017.07.063","article-title":"Malignant Pleural Mesothelioma: state of the art and advanced cell therapy","volume":"142","author":"Facchetti","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.biopha.2018.09.040_bib0010","doi-asserted-by":"crossref","first-page":"e1208876","DOI":"10.1080\/2162402X.2016.1208876","article-title":"Repurposing platinum-based chemotherapies for multi-modal treatment of glioblastoma","volume":"5","author":"Roberts","year":"2016","journal-title":"OncoImmunology"},{"issue":"11","key":"10.1016\/j.biopha.2018.09.040_bib0015","first-page":"920","article-title":"Natural anti-cancer agents: implications in gemcitabine-resistant pancreatic Cancer treatment","volume":"17","author":"Bishal","year":"2017","journal-title":"Mini-Rev. Med. Chem."},{"issue":"8","key":"10.1016\/j.biopha.2018.09.040_bib0020","first-page":"851","article-title":"Epidemiology of malignant mesothelioma\u2014an outline","volume":"54","author":"McDonald","year":"2010","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.biopha.2018.09.040_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.critrevonc.2016.05.004","article-title":"The third italian consensus conference for malignant pleural mesothelioma: state of the art and recommendations","volume":"104","author":"Novello","year":"2016","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.09.040_bib0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ica.2012.06.005","article-title":"Metallo-drugs in the treatment of malignant pleural mesothelioma","volume":"393","author":"Zanellato","year":"2012","journal-title":"Inorg. Chim. Acta Rev."},{"issue":"Part A","key":"10.1016\/j.biopha.2018.09.040_bib0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biocel.2016.05.013","article-title":"PTEN-regulated AKT\/FoxO3a\/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate","volume":"77","author":"Aroui","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.biopha.2018.09.040_bib0040","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/acs.molpharmaceut.5b00531","article-title":"A novel platinum\u2013maurocalcine conjugate induces apoptosis of human glioblastoma cells by acting through the ROS-ERK\/AKT-p53 pathway","volume":"12","author":"Aroui","year":"2015","journal-title":"Mol. Pharm."},{"issue":"13","key":"10.1016\/j.biopha.2018.09.040_bib0045","first-page":"1321","article-title":"Targeting the Akt\/PI3K signaling pathway as a potential therapeutic strategy for the treatment of pancreatic cancer","volume":"24","author":"Safieh","year":"2017","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biopha.2018.09.040_bib0050","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1158\/0008-5472.CAN-08-2819","article-title":"Epithelial to mesenchymal transition contributes to drug resistance in pancreatic Cancer","volume":"69","author":"Arumugam","year":"2009","journal-title":"Cancer Res."},{"issue":"30","key":"10.1016\/j.biopha.2018.09.040_bib0055","doi-asserted-by":"crossref","first-page":"11987","DOI":"10.1073\/pnas.1207670109","article-title":"Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile","volume":"109","author":"Park","year":"2012","journal-title":"PNAS"},{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.09.040_bib0060","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jinorgbio.2014.10.003","article-title":"A monofunctional platinum(II)-based anticancer agent from a salicylanilide derivative: Synthesis, antiproliferative activity, and transcription inhibition","volume":"142","author":"Wang","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.09.040_bib0065","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jinorgbio.2016.06.017","article-title":"Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole \u201cclick\u201d ligands","volume":"165","author":"Pages","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.09.040_bib0070","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1016\/j.bmc.2015.03.044","article-title":"Promising antiproliferative platinum(II) complexes based on imidazole moiety: synthesis, evaluation in HCT-116 cancer cell line and interaction with Ctr-1 Met-rich domain","volume":"23","author":"Ferri","year":"2015","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.biopha.2018.09.040_bib0075","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.bmc.2017.02.010","article-title":"In vitro anticancer activity evaluation of new cationic platinum(II) complexes based on imidazole moiety","volume":"25","author":"Rimoldi","year":"2017","journal-title":"Bioorg. Med. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2018.09.040_bib0080","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.jcyt.2015.09.005","article-title":"Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells","volume":"17","author":"Bonomi","year":"2015","journal-title":"Cytotherapy"},{"issue":"suppl 1","key":"10.1016\/j.biopha.2018.09.040_bib0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/03946320130260S105","article-title":"Adipose tissue-derived stromal cells primed in vitro with paclitaxel acquire anti-tumor activity","volume":"26","author":"Bonomi","year":"2013","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.09.040_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1871520617666170327113932","article-title":"Fluorescent immortalized human adipose derived stromal cells (hASCs-TS\/GFP+) for studying cell drug delivery mediated by microvesicles","volume":"17","author":"Cocc\u00e8","year":"2017","journal-title":"Anti-Cancer Agents Med. Chem."},{"issue":"12","key":"10.1016\/j.biopha.2018.09.040_bib0095","doi-asserted-by":"crossref","first-page":"e28321","DOI":"10.1371\/journal.pone.0028321","article-title":"Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy","volume":"6","author":"Pessina","year":"2011","journal-title":"PLoS One"},{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.09.040_bib0100","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.biopha.2017.01.118","article-title":"Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells","volume":"87","author":"Petrella","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"Supplement C","key":"10.1016\/j.biopha.2018.09.040_bib0105","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.biopha.2018.09.040_bib0110","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13046-015-0200-3","article-title":"Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model","volume":"34","author":"Pessina","year":"2015","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.biopha.2018.09.040_bib0115","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/(SICI)1097-0142(19970501)79:9<1723::AID-CNCR13>3.0.CO;2-#","article-title":"Loss of in vitro cytotoxicity of cisplatin after storage as stock solution in cell culture medium at various temperatures","volume":"79","author":"Schuldes","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.biopha.2018.09.040_bib0120","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/jcb.240630505","article-title":"NCI-navy medical oncology branch cell line data base","volume":"24","author":"Phelps","year":"1996","journal-title":"J. Cell. Biochem. Suppl."},{"issue":"1","key":"10.1016\/j.biopha.2018.09.040_bib0125","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jnci\/59.1.221","article-title":"One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice","volume":"59","author":"Fogh","year":"1977","journal-title":"J. Natl. Cancer Inst."},{"issue":"10","key":"10.1016\/j.biopha.2018.09.040_bib0130","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1073\/pnas.87.10.4012","article-title":"A cystic fibrosis pancreatic adenocarcinoma cell line","volume":"87","author":"Schoumacher","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"10.1016\/j.biopha.2018.09.040_bib0135","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3727\/096368912X657855","article-title":"A New nonenzymatic method and device to obtain a fat tissue derivative highly enriched in pericyte-like elements by mild mechanical forces from human lipoaspirates","volume":"22","author":"Bianchi","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.biopha.2018.09.040_bib0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13221-016-0037-3","article-title":"Angiogenic and anti-inflammatory properties of micro-fragmented fat tissue and its derived mesenchymal stromal cells","volume":"8","author":"Ceserani","year":"2016","journal-title":"Vascular Cell"},{"issue":"12","key":"10.1016\/j.biopha.2018.09.040_bib0145","doi-asserted-by":"crossref","first-page":"e28321","DOI":"10.1371\/journal.pone.0028321","article-title":"Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy","volume":"6","author":"Pessina","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.09.040_bib0150","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mossman","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"3","key":"10.1016\/j.biopha.2018.09.040_bib0155","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.09.040_bib0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"8","key":"10.1016\/j.biopha.2018.09.040_bib0165","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.bmc.2013.01.063","article-title":"Cytotoxic effect of (1-methyl-1H-imidazol-2-yl)-methanamine and its derivatives in PtII complexes on human carcinoma cell lines: A comparative study with cisplatin","volume":"21","author":"Ferri","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biopha.2018.09.040_bib0170","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejmech.2017.03.017","article-title":"An in vivo active 1,2,5-oxadiazole Pt(II) complex: a promising anticancer agent endowed with STAT3 inhibitory properties","volume":"131","author":"Porta","year":"2017","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.biopha.2018.09.040_bib0175","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1023\/A:1006738901839","article-title":"Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells","volume":"17","author":"Alessandri","year":"1999","journal-title":"Clin. Exp. Metastasis"},{"issue":"5","key":"10.1016\/j.biopha.2018.09.040_bib0180","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.semcancer.2005.05.004","article-title":"Matrigel: Basement membrane matrix with biological activity","volume":"15","author":"Kleinman","year":"2005","journal-title":"Semin. Cancer Biol."},{"issue":"1","key":"10.1016\/j.biopha.2018.09.040_bib0185","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2613.2009.00684.x","article-title":"Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?","volume":"91","author":"Shen","year":"2010","journal-title":"Int. J. Exp. Pathol."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218351382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218351382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:41:38Z","timestamp":1777272098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218351382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":37,"alternative-id":["S0753332218351382"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.040","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}