{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:25:42Z","timestamp":1782552342052,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:00:00Z","timestamp":1542931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260022"],"award-info":[{"award-number":["81260022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biopha.2018.09.047","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:58:20Z","timestamp":1537405100000},"page":"508-514","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Co-expression of Akt1 and Wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia\/reoxygenation-induced cardiomyocyte apoptosis"],"prefix":"10.1016","volume":"108","author":[{"given":"Bangdang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-700X","authenticated-orcid":false,"given":"Ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.09.047_bib0005","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics-2017 update: a report from the american heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.09.047_bib0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra1112570","article-title":"A tale of coronary artery disease and myocardial infarction","volume":"366","author":"Nabel","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.09.047_bib0015","doi-asserted-by":"crossref","first-page":"H2726","DOI":"10.1152\/ajpheart.2001.280.6.H2726","article-title":"Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats","volume":"280","author":"Palojoki","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0020","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3727\/096368912X655109","article-title":"Stem cell-based therapy for ischemic heart disease","volume":"22","author":"Hsiao","year":"2013","journal-title":"Cell Transpl."},{"key":"10.1016\/j.biopha.2018.09.047_bib0025","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nature06800","article-title":"Stem-cell therapy for cardiac disease","volume":"451","author":"Segers","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.09.047_bib0030","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCRESAHA.116.303614","article-title":"Use of mesenchymal stem cells for therapy of cardiac disease","volume":"116","author":"Karantalis","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2018.09.047_bib0035","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcp.20959","article-title":"From the laboratory bench to the patient\u2019s bedside: an update on clinical trials with mesenchymal stem cells","volume":"211","author":"Giordano","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0040","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1016\/j.jacc.2009.06.055","article-title":"A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction","volume":"54","author":"Hare","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0045","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transpl."},{"key":"10.1016\/j.biopha.2018.09.047_bib0050","doi-asserted-by":"crossref","first-page":"017","DOI":"10.1186\/s13287-017-0722-z","article-title":"MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction","volume":"8","author":"Chen","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.biopha.2018.09.047_bib0055","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.yjmcc.2007.11.010","article-title":"Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium","volume":"44","author":"Zhang","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0060","first-page":"417","article-title":"Overexpression of protein kinase C varepsilon improves retention and survival of transplanted mesenchymal stem cells in rat acute myocardial infarction","volume":"21","author":"He","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biopha.2018.09.047_bib0065","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3892\/ijmm.2016.2509","article-title":"Exendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen\/glucose and serum deprivation-induced apoptosis through the activation of the cAMP\/PKA signaling pathway and the attenuation of ER stress","volume":"37","author":"He","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biopha.2018.09.047_bib0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10557-016-6704-z","article-title":"Mesenchymal stem cells with eNOS over-expression enhance cardiac repair in rats with myocardial infarction","volume":"31","author":"Chen","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.biopha.2018.09.047_bib0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/hc0102.101442","article-title":"Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart","volume":"105","author":"Toma","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.09.047_bib0080","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/S0003-4975(02)03517-8","article-title":"Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects","volume":"73","author":"Shake","year":"2002","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.biopha.2018.09.047_bib0085","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.ymthe.2006.05.016","article-title":"Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation","volume":"14","author":"Noiseux","year":"2006","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biopha.2018.09.047_bib0090","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/scd.2011.0071","article-title":"Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury","volume":"21","author":"Zuo","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.biopha.2018.09.047_bib0095","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1089\/hum.2010.055","article-title":"Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale","volume":"21","author":"Lock","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biopha.2018.09.047_bib0100","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1089\/scd.2010.0380","article-title":"Transduction of Wnt11 promotes mesenchymal stem cell transdifferentiation into cardiac phenotypes","volume":"20","author":"He","year":"2011","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.biopha.2018.09.047_bib0105","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/nm912","article-title":"Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts","volume":"9","author":"Mangi","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.biopha.2018.09.047_bib0110","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.05-5211com","article-title":"Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement","volume":"20","author":"Gnecchi","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.biopha.2018.09.047_bib0115","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.tcm.2008.12.001","article-title":"Noncanonical Wnt11 signaling and cardiomyogenic differentiation","volume":"18","author":"Flaherty","year":"2008","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.biopha.2018.09.047_bib0120","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nature00921","article-title":"Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis","volume":"418","author":"Pandur","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.09.047_bib0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/MCB.01539-09","article-title":"Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals","volume":"31","author":"Abdul-Ghani","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0130","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ydbio.2014.11.015","article-title":"Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the caspase-dependent degradation of AKT","volume":"398","author":"Bisson","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.biopha.2018.09.047_bib0135","doi-asserted-by":"crossref","first-page":"16838","DOI":"10.1074\/jbc.M500323200","article-title":"Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells","volume":"280","author":"Koyanagi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.09.047_bib0140","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1161\/CIRCULATIONAHA.107.741066","article-title":"Noncanonical Wnt11 signaling is sufficient to induce cardiomyogenic differentiation in unfractionated bone marrow mononuclear cells","volume":"117","author":"Flaherty","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.09.047_bib0145","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.bbrc.2004.10.103","article-title":"Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes","volume":"325","author":"Terami","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.09.047_bib0150","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/mt.2011.5","article-title":"Lentivirus-mediated Wnt11 gene transfer enhances Cardiomyogenic differentiation of skeletal muscle-derived stem cells","volume":"19","author":"Xiang","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biopha.2018.09.047_bib0155","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1258\/ebm.2012.011291","article-title":"Efficient cardiomyogenic differentiation of bone marrow mesenchymal stromal cells by combination of Wnt11 and bone morphogenetic protein 2","volume":"237","author":"Zhang","year":"2012","journal-title":"Exp. Biol. Med."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218342902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218342902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:47:33Z","timestamp":1777272453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218342902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":31,"alternative-id":["S0753332218342902"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.047","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Co-expression of Akt1 and Wnt11 promotes the proliferation and cardiac differentiation of mesenchymal stem cells and attenuates hypoxia\/reoxygenation-induced cardiomyocyte apoptosis","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.09.047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}