{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:41:51Z","timestamp":1780105311097,"version":"3.54.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.040","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:36:16Z","timestamp":1541165776000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice"],"prefix":"10.1016","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-1534","authenticated-orcid":false,"given":"Esben M.","family":"Bech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Voldum-Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren L.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Fabricius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise C.B.","family":"Rudkj\u00e6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik H.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-1022","authenticated-orcid":false,"given":"Jacob","family":"Jelsing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.10.040_bib0005","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/psc.2953","article-title":"Adrenomedullin - new perspectives of a potent peptide hormone","volume":"23","author":"Sch\u00f6nauer","year":"2017","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.biopha.2018.10.040_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bph.14075","article-title":"Update on the pharmacology of calcitonin\/CGRP family of peptides: IUPHAR review 25","volume":"175","author":"Hay","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0015","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/en.2016-1531","article-title":"Vasoprotective activities of the adrenomedullin-RAMP2 system in endothelial cells","volume":"158","author":"Xian","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0020","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejphar.2015.06.061","article-title":"Bench-to-bedside pharmacology of adrenomedullin","volume":"764","author":"Kato","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0025","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.1021\/acs.jmedchem.6b00126","article-title":"Adrenomedullin 2.0: adjusting key levers for metabolic stability","volume":"59","author":"Sch\u00f6nauer","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.10.040_bib0030","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0196-9781(99)00158-8","article-title":"Is adrenomedullin a causal agent in some cases of type 2 diabetes?","volume":"20","author":"Mart\u00ednez","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2018.10.040_bib0035","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1210\/endo.137.6.8641217","article-title":"Regulation of insulin secretion and blood glucose metabolism by adrenomedullin","volume":"137","author":"Mart\u00ednez","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0040","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1210\/endo.136.6.7750467","article-title":"The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat","volume":"136","author":"Murphy","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0045","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1210\/endo.138.2.4943","article-title":"Adrenomedullin inhibits salt appetite","volume":"138","author":"Samson","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0050","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1210\/endo.137.8.8754748","article-title":"Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors","volume":"137","author":"Taylor","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ygcen.2014.05.032","article-title":"Anorexigenic effects of central adrenomedullin are associated with hypothalamic changes in juvenile Gallus gallus","volume":"204","author":"Wang","year":"2014","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0060","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.peptides.2007.03.005","article-title":"Adrenomedullin is a novel adipokine: adrenomedullin in adipocytes and adipose tissues","volume":"28","author":"Li","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2018.10.040_bib0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1530\/EC-14-0131","article-title":"Gender-related alterations in plasma adrenomedullin level and its correlation with body weight gain","volume":"4","author":"Kawano","year":"2015","journal-title":"Endocr. Connect."},{"key":"10.1016\/j.biopha.2018.10.040_bib0070","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.1152\/ajpendo.00213.2005","article-title":"Adrenomedullin inhibits insulin exocytosis via pertussis toxin-sensitive G protein-coupled mechanism","volume":"291","author":"Sekine","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.10.040_bib0075","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0140-6736(05)64211-0","article-title":"Plasma adrenomedullin in diabetes","volume":"350","author":"Hayashi","year":"1997","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.biopha.2018.10.040_bib0080","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2337\/diacare.23.2.253","article-title":"Plasma adrenomedullin levels in patients with diabetes","volume":"23","author":"Kinoshita","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biopha.2018.10.040_bib0085","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/oby.2009.22","article-title":"Plasma MR-proADM correlates to BMI and decreases in relation to leptin after gastric bypass surgery","volume":"17","author":"Vila","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.biopha.2018.10.040_bib0090","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.regpep.2009.08.003","article-title":"Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity","volume":"158","author":"Nomura","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biopha.2018.10.040_bib0095","doi-asserted-by":"crossref","first-page":"R1395","DOI":"10.1152\/ajpregu.00597.2001","article-title":"Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats","volume":"282","author":"Reidelberger","year":"2002","journal-title":"Am. J. Physiol. - Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0100","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1210\/endo.138.9.5397","article-title":"Central action of adrenomedullin to inhibit gastric emptying in rats","volume":"138","author":"Mart\u00ednez","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0167-0115(03)00030-2","article-title":"Regulation of pancreatic physiology by adrenomedullin and its binding protein","volume":"112","author":"Zudaire","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biopha.2018.10.040_bib0110","first-page":"749","volume":"5","author":"Day","year":"2009","journal-title":"A new glucagon and GLP-1 co-agonist eliminates obesity in rodents"},{"key":"10.1016\/j.biopha.2018.10.040_bib0115","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00125-017-4354-8","article-title":"GLP-1\/glucagon receptor co-agonism for treatment of obesity","volume":"60","author":"S\u00e1nchez-Garrido","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.biopha.2018.10.040_bib0120","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin : pharmacology, physiology, and clinical potential","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmalog. Rev."},{"key":"10.1016\/j.biopha.2018.10.040_bib0125","doi-asserted-by":"crossref","first-page":"R945","DOI":"10.1152\/ajpregu.00275.2010","article-title":"Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates","volume":"299","author":"Bello","year":"2010","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ejphar.2014.08.010","article-title":"The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat","volume":"741","author":"Hansen","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0135","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","article-title":"The physiology of glucagon-like peptide 1","author":"Holst","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2018.10.040_bib0140","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/aps.2011.168","article-title":"Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats","volume":"33","author":"Hansen","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biopha.2018.10.040_bib0145","first-page":"R910","article-title":"GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans","volume":"277","author":"Naslund","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0150","first-page":"95","article-title":"Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans : a pharmacokinetic study","volume":"82","author":"Meeran","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.10.040_bib0155","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0167-0115(96)00005-5","article-title":"Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion","volume":"62","author":"Mulder","year":"1996","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biopha.2018.10.040_bib0160","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1053\/j.gastro.2012.08.044","article-title":"Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in \u03b2 cells and mice","volume":"143","author":"Aggarwal","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biopha.2018.10.040_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.peptides.2016.12.002","article-title":"Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice","volume":"88","author":"Pawlak","year":"2017","journal-title":"Peptides"},{"key":"10.1016\/j.biopha.2018.10.040_bib0170","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S2213-8587(14)70033-6","article-title":"Metabolic syndrome: a sympathetic disease?","volume":"3","author":"Schlaich","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.biopha.2018.10.040_bib0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2016.06.021","article-title":"Unimolecular polypharmacy for treatment of diabetes and obesity","volume":"24","author":"Tsch\u00f6p","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.biopha.2018.10.040_bib0180","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2016.1228439","article-title":"Regulation of endothelial and epithelial barrier functions by peptide hormones of the adrenomedullin family","volume":"4","author":"Garc\u00eda-Ponce","year":"2016","journal-title":"Tissue Barriers."},{"key":"10.1016\/j.biopha.2018.10.040_bib0185","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1074\/jbc.270.9.4412","article-title":"Adrenomedullin stimulates two signal transduction pathways, cAMP accumulation and Ca2+ mobilization, in bovine aortic endothelial cells","volume":"270","author":"Shimekake","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.10.040_bib0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/bbrc.1993.1451","article-title":"Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma","volume":"192","author":"Kitamura","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.10.040_bib0195","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1463-1326.2011.01357.x","article-title":"An overview of once-weekly glucagon-like peptide-1 receptor agonists-available efficacy and safety data and perspectives for the future","volume":"13","author":"Madsbad","year":"2011","journal-title":"Diabetes Obes. Metab."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218340137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218340137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:39:48Z","timestamp":1777876788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218340137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":39,"alternative-id":["S0753332218340137"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.040","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}