{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:52:58Z","timestamp":1793962378960,"version":"4.8.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.055","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T13:33:14Z","timestamp":1541251994000},"page":"536-546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice"],"prefix":"10.1016","volume":"109","author":[{"given":"Benneth","family":"Ben-Azu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekene Enekabokom","family":"Nwoke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adegbuyi Oladele","family":"Aderibigbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itivere Adrian","family":"Omogbiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-0421","authenticated-orcid":false,"given":"Abayomi Mayowa","family":"Ajayi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Toyin","family":"Olonode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Umukoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel O.","family":"Iwalewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.10.055_bib0005","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1021\/jf8006568","article-title":"Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity","volume":"56","author":"Benavente-Garc\u00efa","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1017\/S0007114512005405","article-title":"Drynaria fortunei-derived total flavonoid fraction and isolated compounds exert oestrogen like protective effects in bone","volume":"110","author":"Wong","year":"2013","journal-title":"Bri J. Nutr."},{"key":"10.1016\/j.biopha.2018.10.055_bib0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF03216747","article-title":"Intestinal bacterial metabolism of flavonoids and its relation to some biological activities","volume":"21","author":"Kim","year":"1998","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0020","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2012.07.060","article-title":"Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor erythroid 2-related factor-2 signalling pathway","volume":"227","author":"Gopinath","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.10.055_bib0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.biopha.2018.10.055_bib0030","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s12011-014-9948-0","article-title":"Protective effects of naringenin on iron-overload induced cerebral cortex neurotoxicity correlated with oxidative stress","volume":"158","author":"Fetoui","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1383-5718(02)00111-0","article-title":"The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study","volume":"519","author":"Jagetia","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.diabres.2012.02.011","article-title":"DPP-IV inhibitory potential of naringin: an in silico, in vitro and in vivo study","volume":"97","author":"Parmar","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.biopha.2018.10.055_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2013.07.019","article-title":"Acute and 13 weeks subchronic toxicological evaluation of naringin in Sprague-Dawley rats","volume":"60","author":"Li","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0050","first-page":"129","article-title":"Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor alpha levels in rats with walker 256 carcinosarcoma","volume":"32","author":"Camargo","year":"2012","journal-title":"Anticancer Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0055","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1142\/S0192415X07005156","article-title":"Anti-osteoporosis activity of naringin in the retinoic acid-induced osteoporosis model","volume":"35","author":"Wei","year":"2007","journal-title":"Am. J. Chin. Med"},{"key":"10.1016\/j.biopha.2018.10.055_bib0060","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.febslet.2011.07.046","article-title":"Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation","volume":"585","author":"Ang","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biopha.2018.10.055_bib0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/jor.21002","article-title":"Promotion of bone formation by naringin in a titanium particle-induced diabetic murine calvarial osteolysis model","volume":"28","author":"Zhou","year":"2010","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0070","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/j.1476-5381.2010.00664.x","article-title":"Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells","volume":"159","author":"Pang","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0075","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jat.1175","article-title":"Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin-induced genotoxicity and decline in survival","volume":"27","author":"Jagetia","year":"2007","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.intimp.2012.04.019","article-title":"Naringin attenuates enhanced cough, airway hyperresponsiveness and airway inflammation in a guinea pig model of chronic bronchitis induced by cigarette smoke","volume":"13","author":"Luo","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2015.06.036","article-title":"Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-kB and p53 signaling pathways","volume":"239","author":"Chtourou","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.10.055_bib0090","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1007\/s13277-015-4230-4","article-title":"Naringin inhibits the invasion and migration of human glioblastoma cell via downregulation of MMP-2 and MMP-9 expression and inactivation of p38 signaling pathway","volume":"37","author":"Aroui","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cbi.2015.12.011","article-title":"Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MM-9) via inhibition of ERK-P38-JNK signaling pathways in human glioblastoma","volume":"244","author":"Aroui","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.10.055_bib0100","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12031-015-0547-0","article-title":"Naringin abrogates cisplatin-induced cognitive deficits and cholinergic dysfunction through the down-regulation of AChE expression and iNOS signaling pathways in hippocampus of aged rats","volume":"56","author":"Chtourou","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0105","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/jat.1343","article-title":"Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats","volume":"28","author":"Punithavathi","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0110","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1089\/jmf.2012.2251","article-title":"Antiinflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats","volume":"15","author":"Nie","year":"2012","journal-title":"J. Med. Food"},{"key":"10.1016\/j.biopha.2018.10.055_bib0115","article-title":"Evaluation of the neurobehavioral properties of naringin in Swiss mice","volume":"67","author":"Ben-Azu","year":"2018","journal-title":"Drug Res. (Stuttg.)"},{"key":"10.1016\/j.biopha.2018.10.055_bib0120","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.3390\/ijms14035576","article-title":"Naringin enhances CaMKII activity and improves long-term memory in a mouse model of Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0125","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3109\/00207454.2013.785542","article-title":"Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats","volume":"123","author":"Prakash","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0130","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1007\/s11064-012-0844-8","article-title":"Memory enhancing activity of naringin in unstressed and stressed mice. Possible cholinergic and nitriergic modulation","volume":"37","author":"Maratha","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0135","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1177\/0269881113503506","article-title":"Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice: possible involvement of antioxidant and nitrergic pathway","volume":"27","author":"Monte","year":"2013","journal-title":"J. Psychopharmacol. (Oxf.)"},{"key":"10.1016\/j.biopha.2018.10.055_bib0140","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat. Protocols"},{"key":"10.1016\/j.biopha.2018.10.055_bib0145","first-page":"545","article-title":"Neurobehavioral and analgesic properties of Ethanol bark exctract of Terminalia ivorensis A. Chev. (Combrataceae) in mice","volume":"65","author":"Adeoluwa","year":"2015","journal-title":"Drug Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0150","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bbadis.2006.01.008","article-title":"Smith, Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice","volume":"1762","author":"Casadesus","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.10.055_bib0155","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.biopha.2018.10.055_bib0160","first-page":"151","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione an evidence for 3,4 bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.biopha.2018.10.055_bib0165","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0170","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1971","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0175","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Okhawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0180","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/oxfordjournals.schbul.a033430","article-title":"Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the \"right stuff\"?","volume":"26","author":"Green","year":"2000","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.biopha.2018.10.055_bib0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0190","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum protein by means of Biuret Reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0195","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-3057(91)90571-I","article-title":"Ketamine-induced hyperlocomotion associated with alteration of presynaptic component of dopamine neurons in the nucleus accumbens of mice","volume":"40","author":"Irifune","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2018.10.055_bib0200","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.neuropharm.2012.05.041","article-title":"Neurochemical and molecular characterization of ketamine-induced experimental psychosis model in mice","volume":"63","author":"Chatterjee","year":"2012","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0205","first-page":"33","article-title":"Evaluation of the antidepressant activity of Beta vulgaris alone and in combination with fluoxetine in mice","volume":"12","author":"Invally","year":"2017","journal-title":"Res. Articles"},{"key":"10.1016\/j.biopha.2018.10.055_bib0210","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.pnpbp.2009.12.010","article-title":"Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system","volume":"34","author":"Freitas","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2018.10.055_bib0215","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pnpbp.2009.11.023","article-title":"Evidence for the involvement of the serotonergic 5-HT2A\/C and 5-HT3 receptors in the antidepressant-like effect caused by oral administration of bis selenide in mice","volume":"34","author":"Jesse","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2018.10.055_bib0220","first-page":"36","article-title":"Antidepressant-like activity of methyl jasmonate involves modulation of monoaminergic pathways in mice","volume":"67","author":"Umukoro","year":"2017","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0225","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00432120","article-title":"The effect of chronic treatment with antidepressant drugs on salbutamol-induced hypoactivity in rats","volume":"80","author":"Przegali\u0144ski","year":"1983","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.biopha.2018.10.055_bib0230","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0149-7634(86)90022-9","article-title":"The effects of tricyclic and \u201catypical\u201d antidepressants on spontaneous locomotor activity in rodents","volume":"10","author":"Tucker","year":"1986","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.biopha.2018.10.055_bib0235","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.06.016","article-title":"Naringenin attenuates behavioral derangements induced by social defeat stress in mice via inhibition of acetylcholinesterase activity, oxidative stress and release of pro-inflammatory cytokines","volume":"105","author":"Umukoro","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.10.055_bib0240","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/15622970802465807","article-title":"World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders\u2014first revision","volume":"9","author":"Bandelow","year":"2008","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.biopha.2018.10.055_bib0245","first-page":"8","article-title":"Anxiety syndromes and their relationship to depressive illness","volume":"44","author":"FawcettJ","year":"1983","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.biopha.2018.10.055_bib0250","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s11064-009-9969-9","article-title":"The flavonoid glycosides, Myricitrin, Gossypin and naringin exert anxiolytic action in mice","volume":"34","author":"Fernandez","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biopha.2018.10.055_bib0255","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrd1825","article-title":"The ascent of mouse: advances in modeling human depression and anxiety","volume":"4","author":"Cryan","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biopha.2018.10.055_bib0260","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF00470579","article-title":"Benzodiazepine antagonist RO 15\u20131788: neurological and behavioral effects","volume":"78","author":"Bonetti","year":"1982","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.biopha.2018.10.055_bib0265","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The cholinergic hypothesis of age and Alzheimer\u2019s disease-related cognitive deficits: recent challenges and their implications fornovel drug development","volume":"306","author":"Terry","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biopha.2018.10.055_bib0270","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/alzrt7","article-title":"Persistent treatment with cholinesterase inhibitors and\/or memantine slows clinical progression of Alzheimer disease","volume":"1","author":"Rountree","year":"2009","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.biopha.2018.10.055_bib0275","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.nlm.2003.07.003","article-title":"Gold acetylcholine modulation of neural systems involved in learning and memory","volume":"80","author":"Paul","year":"2003","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0280","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2015.04.007","article-title":"Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice","volume":"132","author":"Eduviere","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0285","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbb.2014.11.002","article-title":"Naringin ameliorates memory deficits in experimental paradigm of Alzheimer\u2019s disease by attenuating mitochondrial dysfunction","volume":"127","author":"Sachdeva","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2018.10.055_bib0290","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1021\/jf020603p","article-title":"Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a P-Glycoprotein modulator","volume":"50","author":"Tsai","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0295","series-title":"Three Pharmacological Studies on Nicotinic Acetylcholine Receptors: b-Amyloid Peptides, Flavonoids and Aconotoxins","author":"Chu","year":"2006"},{"key":"10.1016\/j.biopha.2018.10.055_bib0300","first-page":"1097","article-title":"Effect of nicotine and nicotinic receptors on anxiety and depression","volume":"13","author":"Picciotto","year":"2002","journal-title":"Prim. Sens. Neuron"},{"key":"10.1016\/j.biopha.2018.10.055_bib0305","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0091-3057(91)90594-R","article-title":"The effect of imipramine and lithium on \"learned helplessness\" and acetylcholinesterase in rat brain","volume":"38","author":"Geoffroy","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2018.10.055_bib0310","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00004714-198906000-00003","article-title":"Cholinergic hypothesis of depression: a reappraisal","volume":"9","author":"Dilsaver","year":"1989","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0315","first-page":"229","article-title":"Cholinergic hypothesis of depression","volume":"11","author":"Leboyer","year":"1985","journal-title":"Encephale"},{"key":"10.1016\/j.biopha.2018.10.055_bib0320","first-page":"68","article-title":"Central cholinergic effects of tricyclic antidepressants in mouse","volume":"255","author":"Bohman","year":"1982","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.biopha.2018.10.055_bib0325","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0014-2999(74)90158-7","article-title":"Effect of diazepam on mouse whole brain and brain area acetylcholine and choline levels","volume":"27","author":"Consolo","year":"1974","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0330","first-page":"127","article-title":"Action of methaminodiazepoxide cardiac, smooth and skeletal muscles","volume":"143","author":"Madan","year":"1963","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.biopha.2018.10.055_bib0335","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yebeh.2014.09.058","article-title":"Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection","volume":"41","author":"Golechha","year":"2014","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.biopha.2018.10.055_bib0340","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/354326","article-title":"Naringin attenuates autophagic stress and neuroin\ufb02ammation in kainic acid-treated hippocampus in vivo","author":"Jeong","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2018.10.055_bib0345","doi-asserted-by":"crossref","first-page":"396","DOI":"10.47102\/annals-acadmedsg.V38N5p396","article-title":"Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress","volume":"38","author":"Wood","year":"2009","journal-title":"Ann. Acad. Med. Singap."},{"key":"10.1016\/j.biopha.2018.10.055_bib0350","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11427-010-0013-8","article-title":"A meta-analysis of oxidative stress markers in schizophrenia","volume":"53","author":"Zhang","year":"2010","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.biopha.2018.10.055_bib0355","unstructured":"R. Selva, G. Cesar, Oxidative Stress and Neurodegenerative Disease, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring, Dr Raymond Chuen-Chung Chang (Ed.), (2011) ISBN: 978 953-307-485-6."},{"key":"10.1016\/j.biopha.2018.10.055_bib0360","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1007007630118","article-title":"Pro and antioxidant responses to repeated administration of diazepam in rat brain","volume":"206","author":"Musavi","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biopha.2018.10.055_bib0365","doi-asserted-by":"crossref","DOI":"10.1007\/s00580-014-1907-9","article-title":"Effect of piracetam, vincamine, vinpocetine, and donepezil on oxidative stress and neurodegeneration induced by aluminum chloride in rat","author":"Abdel-Salam","year":"2015","journal-title":"Comp. Clin. Pathol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0370","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1742-7843.2011.00738.x","article-title":"Diazepam blocks striatal lipid peroxidation and improves stereotyped activity in a rat model of acute stress","volume":"109","author":"M\u00e9ndez-Cuesta","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0375","first-page":"236","article-title":"Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice","volume":"64","author":"Umukoro","year":"2014","journal-title":"Drug Res. (Stuttg.)"},{"key":"10.1016\/j.biopha.2018.10.055_bib0380","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4161\/oxim.3.5.13109","article-title":"Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus","volume":"3","author":"R\u00e9us","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biopha.2018.10.055_bib0385","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fct.2014.01.023","article-title":"Six months chronic toxicological evaluation of naringin in Sprague-Dawley rats","volume":"66","author":"Li","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.055_bib0390","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.brainresbull.2018.03.006","article-title":"Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice","volume":"139","author":"Ben-Azu","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biopha.2018.10.055_bib0395","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1161\/01.CIR.0000155617.54749.09","article-title":"QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids","volume":"111","author":"Zitron","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.biopha.2018.10.055_bib0400","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fncel.2014.00119","article-title":"Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives","volume":"8","author":"Deidda","year":"2014","journal-title":"Front. Cell. Neurosci."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218347668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218347668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:24:33Z","timestamp":1777875873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218347668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":80,"alternative-id":["S0753332218347668"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.055","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}