{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:44:35Z","timestamp":1780656275962,"version":"3.54.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["APQ-00330-14"],"award-info":[{"award-number":["APQ-00330-14"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.057","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:37:14Z","timestamp":1541165834000},"page":"157-166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex"],"prefix":"10.1016","volume":"109","author":[{"given":"Drielly A.","family":"Paix\u00e3o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla D.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zumira A.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana M.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia P.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto P.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Pivatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Darc S.","family":"Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro V.","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ellena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariete B.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelino V.G.","family":"Netto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo J.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Guilardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendell","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.10.057_bib0005","unstructured":"WHO - World Health Organization. http:\/\/www.who.int\/chagas\/disease\/en\/ (Accessed 30 May 2018)."},{"key":"10.1016\/j.biopha.2018.10.057_bib0010","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/465S3a","volume":"465","author":"Grayson","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.biopha.2018.10.057_bib0015","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pt.2005.08.026","volume":"21","author":"Croft","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.biopha.2018.10.057_bib0020","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.jinorgbio.2008.05.010","volume":"102","author":"Fricker","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0025","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10534-012-9565-3","volume":"25","author":"Martins","year":"2012","journal-title":"Biometals"},{"key":"10.1016\/j.biopha.2018.10.057_bib0030","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jinorgbio.2012.01.010","volume":"109","author":"Becco","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0035","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.poly.2011.04.001","volume":"16","author":"Batista","year":"2011","journal-title":"Polyhedron"},{"key":"10.1016\/j.biopha.2018.10.057_bib0040","author":"Paix\u00e3o","year":"2018","journal-title":"J. Saudi Chem. Soc."},{"key":"10.1016\/j.biopha.2018.10.057_bib0045","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1016\/j.ejmech.2010.08.039","volume":"45","author":"Manjunatha","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0050","first-page":"248","volume":"3","author":"Parikh","year":"2011","journal-title":"Int. J. Drug Dev. Res."},{"key":"10.1016\/j.biopha.2018.10.057_bib0055","first-page":"435","volume":"27","author":"Altomare","year":"1994","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.biopha.2018.10.057_bib0060","series-title":"SHELXL2014, Programs for the Refinement of Crystal Structures","author":"Sheldrick","year":"2014"},{"key":"10.1016\/j.biopha.2018.10.057_bib0065","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1107\/S0021889812029111","volume":"45","author":"Farrugia","year":"2012","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.biopha.2018.10.057_bib0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S002188980600731X","volume":"39","author":"Macrae","year":"2006","journal-title":"J. Appl. Cryst."},{"key":"10.1016\/j.biopha.2018.10.057_bib0075","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1128\/AAC.40.11.2592","volume":"40","author":"Buckner","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2018.10.057_bib0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.biopha.2018.10.057_bib0085","first-page":"119","volume":"4","author":"Brener","year":"1962","journal-title":"Rev. Inst. Med. Trop."},{"key":"10.1016\/j.biopha.2018.10.057_bib0090","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1073\/pnas.78.4.2179","volume":"78","author":"Drew","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.biopha.2018.10.057_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2015.07.049","volume":"152","author":"Mukherjee","year":"2016","journal-title":"Spectrochim. Acta A. Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.biopha.2018.10.057_bib0100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jlumin.2017.05.068","volume":"190","author":"Mukherjee","year":"2017","journal-title":"J. Lumin."},{"key":"10.1016\/j.biopha.2018.10.057_bib0105","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"Verdonk","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.biopha.2018.10.057_bib0110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ejmech.2017.10.013","volume":"141","author":"Gon\u00e7alves","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jinorgbio.2017.04.024","volume":"172","author":"Paix\u00e3o","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0120","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jinorgbio.2013.09.014","volume":"132","author":"Silva","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0125","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1021\/ic101791r","volume":"50","author":"Silva","year":"2011","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.poly.2014.12.026","volume":"89","author":"Almeida","year":"2015","journal-title":"Polyhedron"},{"key":"10.1016\/j.biopha.2018.10.057_bib0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF01202553","volume":"5","author":"Lewis","year":"1975","journal-title":"J. Cryst. Mol. Struct."},{"key":"10.1016\/j.biopha.2018.10.057_bib0140","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.ica.2009.06.003","volume":"362","author":"Singh","year":"2009","journal-title":"Inorg. Chim. Acta"},{"key":"10.1016\/j.biopha.2018.10.057_bib0145","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.poly.2009.01.023","volume":"28","author":"Lazarou","year":"2009","journal-title":"Polyhedron"},{"key":"10.1016\/j.biopha.2018.10.057_bib0150","volume":"E65","author":"Thiam","year":"2009","journal-title":"Acta Cryst."},{"key":"10.1016\/j.biopha.2018.10.057_bib0155","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1002\/aoc.3582","volume":"31","author":"Mohanraj","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0160","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11243-006-0039-8","volume":"31","author":"Huang","year":"2006","journal-title":"Trans. Met. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0165","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.poly.2011.11.020","volume":"33","author":"Caballero","year":"2012","journal-title":"Polyhedron"},{"key":"10.1016\/j.biopha.2018.10.057_bib0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jinorgbio.2017.11.027","volume":"180","author":"M\u00e9ndez-Arriaga","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2016\/5027404","volume":"2016","author":"Martins","year":"2016","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.biopha.2018.10.057_bib0180","first-page":"87","volume":"28","author":"Martins","year":"2017","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.biopha.2018.10.057_bib0185","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jinorgbio.2017.07.026","volume":"175","author":"M\u00e9ndez-Arriaga","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0190","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1087057114550585","volume":"20","author":"Chatelain","year":"2015","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.biopha.2018.10.057_bib0195","author":"Cevery","year":"2006","journal-title":"Int. J. Parasitol. Drugs Drugs Resist."},{"key":"10.1016\/j.biopha.2018.10.057_bib0200","author":"Cevery","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.biopha.2018.10.057_bib0205","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s00436-015-4488-x","volume":"114","author":"Novaes","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biopha.2018.10.057_bib0210","doi-asserted-by":"crossref","first-page":"e2847","DOI":"10.1371\/journal.pntd.0002847","volume":"8","author":"Carneiro","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2018.10.057_bib0215","doi-asserted-by":"crossref","first-page":"e3207","DOI":"10.1371\/journal.pntd.0003207","volume":"8","author":"Sesti-Costa","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.biopha.2018.10.057_bib0220","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/AAC.00514-18","volume":"62","author":"Providello","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biopha.2018.10.057_bib0225","series-title":"Bioinorganic Medicinal Chemistry","author":"Alessio","year":"2011"},{"key":"10.1016\/j.biopha.2018.10.057_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2013.03.013","volume":"124","author":"Sirajuddin","year":"2013","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.biopha.2018.10.057_bib0235","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molstruc.2015.04.033","volume":"1096","author":"Kazemi","year":"2015","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.biopha.2018.10.057_bib0240","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ica.2016.02.053","volume":"446","author":"Barra","year":"2016","journal-title":"Inorg. Chem. Acta"},{"key":"10.1016\/j.biopha.2018.10.057_bib0245","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.abb.2015.03.024","volume":"576","author":"Rehman","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biopha.2018.10.057_bib0250","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1021\/ic902176e","volume":"49","author":"Gao","year":"2010","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0255","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.inoche.2018.05.008","volume":"93","author":"Zehra","year":"2018","journal-title":"Inorg. Chem. Commun."},{"key":"10.1016\/j.biopha.2018.10.057_bib0260","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.3390\/ijms13033394","volume":"13","author":"Chang","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biopha.2018.10.057_bib0265","series-title":"Circular Dichroism and Linear Dichroism","author":"Rodger","year":"1997"},{"key":"10.1016\/j.biopha.2018.10.057_bib0270","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jinorgbio.2011.09.016","volume":"105","author":"da Silveira","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0275","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.saa.2014.04.158","volume":"132","author":"Zhao","year":"2014","journal-title":"Spectrochim. Acta Part A"},{"key":"10.1016\/j.biopha.2018.10.057_bib0280","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1021\/jm100488w","volume":"53","author":"Ferreira","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0285","doi-asserted-by":"crossref","first-page":"e4164","DOI":"10.1002\/aoc.4164","volume":"32","author":"Gao","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"10.1016\/j.biopha.2018.10.057_bib0290","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1039\/C4NJ00092G","volume":"38","author":"Zheng","year":"2014","journal-title":"New J. Chem."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218366757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218366757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:37:18Z","timestamp":1777876638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218366757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":58,"alternative-id":["S0753332218366757"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.057","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}