{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:39:42Z","timestamp":1781588382067,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012228","name":"Development and Reform Commission of Shenzhen Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013093","name":"Science and Technology Planning Project of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20140408152909279"],"award-info":[{"award-number":["JCYJ20140408152909279"]}],"id":[{"id":"10.13039\/501100013093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.060","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T13:36:18Z","timestamp":1541165778000},"page":"93-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1\/M2 phenotype macrophage"],"prefix":"10.1016","volume":"109","author":[{"given":"Lu","family":"Jiandong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinting","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongcai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0005","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.semnephrol.2010.03.006","article-title":"Targeting the recruitment of monocytes and macrophages in renal disease","volume":"30","author":"Vielhauer","year":"2010","journal-title":"Semin. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0010","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4239\/wjd.v5.i3.393","article-title":"Diabetic nephropathy and inflammation","volume":"5","author":"Duran-Salgado","year":"2014","journal-title":"World J. Diabetes"},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0015","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/QCO.0b013e328344b73e","article-title":"Macrophage polarization and bacterial infections","volume":"24","author":"Mege","year":"2011","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"9","key":"10.1016\/j.biopha.2018.10.060_bib0020","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ki.2011.217","article-title":"Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis","volume":"80","author":"Anders","year":"2011","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.10.060_bib0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J. Pathol."},{"issue":"2","key":"10.1016\/j.biopha.2018.10.060_bib0030","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0035","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI69778","article-title":"Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance","volume":"124","author":"Tian","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.biopha.2018.10.060_bib0040","doi-asserted-by":"crossref","first-page":"F398","DOI":"10.1152\/ajprenal.00136.2015","article-title":"Podocyte endocytosis in the regulation of the glomerular filtration barrier","volume":"309","author":"Inoue","year":"2015","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"1","key":"10.1016\/j.biopha.2018.10.060_bib0045","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/ki.2008.128","article-title":"Proteinuria in diabetic kidney disease: a mechanistic viewpoint","volume":"74","author":"Jefferson","year":"2008","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.biopha.2018.10.060_bib0050","doi-asserted-by":"crossref","first-page":"F3","DOI":"10.1152\/ajprenal.00122.2013","article-title":"Pathogenic and protective role of macrophages in kidney disease","volume":"305","author":"Cao","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0055","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.ki.5002275","article-title":"Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease","volume":"72","author":"Wang","year":"2007","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.biopha.2018.10.060_bib0060","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","article-title":"Macrophage diversity in renal injury and repair","volume":"118","author":"Ricardo","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.biopha.2018.10.060_bib0065","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1210\/en.2014-1020","article-title":"Vitamin D prevents podocyte injury via regulation of macrophage M1\/M2 phenotype in diabetic nephropathy rats","volume":"155","author":"Zhang","year":"2014","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.biopha.2018.10.060_bib0070","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1016\/j.fct.2012.05.022","article-title":"A triterpenoid sapoinin from Platycodon grandiflorum, ameliorates cisplatin-induced nephrotoxicity in mice","volume":"50","author":"Kim","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.biopha.2018.10.060_bib0075","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/14786419.2014.952229","article-title":"Trichosanthes kirilowii ameliorates cisplatin-induced nephrotoxicity in both in vitro and in vivo","volume":"29","author":"Seo","year":"2015","journal-title":"Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.biopha.2018.10.060_bib0080","first-page":"111","article-title":"The immunomodulatory and antitumor activities of trichosanthin-an abortifacient protein isolated from tian-hua-fen (Trichosanthes kirilowii)","volume":"4","author":"Leung","year":"1986","journal-title":"Asian Pac. J. Allergy Immunol."},{"issue":"5","key":"10.1016\/j.biopha.2018.10.060_bib0085","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.fitote.2012.02.011","article-title":"Trichosanthin down-regulates Notch signaling and inhibits proliferation of the nasopharyngeal carcinoma cell line CNE2 in vitro","volume":"83","author":"Liu","year":"2012","journal-title":"Fitoterapia"},{"issue":"12","key":"10.1016\/j.biopha.2018.10.060_bib0090","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1158\/0008-5472.CAN-10-0269","article-title":"Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses","volume":"70","author":"Wang","year":"2010","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.biopha.2018.10.060_bib0095","doi-asserted-by":"crossref","first-page":"e2341","DOI":"10.1038\/cddis.2016.244","article-title":"Notch-Hes-1 axis controls TLR7-mediated autophagic death of macrophage via induction of P62 in mice with lupus","volume":"7","author":"Li","year":"2016","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0100","first-page":"475","article-title":"[Study on the extraction technology and hypoglycemic activity of lectin from Trichosanthes kirilowi]","volume":"35","author":"Li","year":"2012","journal-title":"Zhong Yao Cai"},{"issue":"4","key":"10.1016\/j.biopha.2018.10.060_bib0105","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"2","key":"10.1016\/j.biopha.2018.10.060_bib0110","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1399-3011.1986.tb01812.x","article-title":"Chemical and biological characterization of the galactose binding lectins from Trichosanthes kirilowii root tubers","volume":"27","author":"Yeung","year":"1986","journal-title":"Int. J. Pept. Protein Res."},{"key":"10.1016\/j.biopha.2018.10.060_bib0115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000327337","article-title":"Unmet need in renal protection--do we need a more comprehensive approach?","volume":"171","author":"de Zeeuw","year":"2011","journal-title":"Contrib. Nephrol."},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0120","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1053\/j.ajkd.2015.04.013","article-title":"Recent advances in traditional Chinese medicine for kidney disease","volume":"66","author":"Zhong","year":"2015","journal-title":"Am. J. Kidney Dis."},{"issue":"16","key":"10.1016\/j.biopha.2018.10.060_bib0125","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1042\/CS20160636","article-title":"Diabetic nephropathy - is this an immune disorder?","volume":"131","author":"Tesch","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.biopha.2018.10.060_bib0130","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1440-1797.2006.00576.x","article-title":"Macrophage accumulation in human progressive diabetic nephropathy","volume":"11","author":"Nguyen","year":"2006","journal-title":"Nephrology (Carlton)"},{"issue":"1","key":"10.1016\/j.biopha.2018.10.060_bib0135","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1523-1755.2004.00367.x","article-title":"Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury","volume":"65","author":"Chow","year":"2004","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.biopha.2018.10.060_bib0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.ki.5000014","article-title":"Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice","volume":"69","author":"Chow","year":"2006","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biopha.2018.10.060_bib0145","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000431214","article-title":"Macrophage phenotype in kidney injury and repair","volume":"1","author":"Meng","year":"2015","journal-title":"Kidney Dis. (Basel)"},{"key":"10.1016\/j.biopha.2018.10.060_bib0150","first-page":"157834","article-title":"1,25-dihydroxyvitamin d(3) promotes high glucose-induced M1 macrophage switching to M2 via the VDR-PPARgamma signaling pathway","volume":"2015","author":"Zhang","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"7","key":"10.1016\/j.biopha.2018.10.060_bib0155","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/jbmr.3117","article-title":"Targeting notch-activated M1 macrophages attenuates joint tissue damage in a mouse model of inflammatory arthritis","volume":"32","author":"Sun","year":"2017","journal-title":"J. Bone Miner. Res."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218335200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218335200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:25:02Z","timestamp":1777875902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218335200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":31,"alternative-id":["S0753332218335200"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.060","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trichosanthes kirilowii lectin ameliorates streptozocin-induced kidney injury via modulation of the balance between M1\/M2 phenotype macrophage","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}