{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:49:30Z","timestamp":1790725770669,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600197"],"award-info":[{"award-number":["81600197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800142"],"award-info":[{"award-number":["81800142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.081","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T20:28:44Z","timestamp":1541449724000},"page":"1016-1023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro"],"prefix":"10.1016","volume":"109","author":[{"given":"Ningning","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbo","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.10.081_bib0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1161\/01.RES.10.3.250","article-title":"Compensatory hyperfunction of the heart and cardiac insufficiency","volume":"10","author":"Meerson","year":"1962","journal-title":"Circ. Res."},{"key":"10.1016\/j.biopha.2018.10.081_bib0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.10.081_bib0015","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.10.081_bib0020","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/eurheartj\/ehq166","article-title":"Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload","volume":"32","author":"Bjornstad","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2018.10.081_bib0025","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0195-668X(03)00316-6","article-title":"Regression of left ventricular hypertrophy during 10 years after valve replacement for aortic stenosis is related to the preoperative risk profile","volume":"24","author":"Lund","year":"2003","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biopha.2018.10.081_bib0030","doi-asserted-by":"crossref","first-page":"H994","DOI":"10.1152\/ajpheart.00245.2011","article-title":"A new model of congestive heart failure in rats","volume":"301","author":"Chen","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.00246.2006","article-title":"Gene profiling during regression of pressure overload-induced cardiac hypertrophy","volume":"30","author":"Yang","year":"2007","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.biopha.2018.10.081_bib0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5142\/jgr.2013.37.8","article-title":"A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system","volume":"37","author":"Kim","year":"2013","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.biopha.2018.10.081_bib0045","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1111\/j.1755-5922.2011.00271.x","article-title":"Ginsenoside Re: pharmacological effects on cardiovascular system","volume":"30","author":"Peng","year":"2012","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.biopha.2018.10.081_bib0050","doi-asserted-by":"crossref","first-page":"293","DOI":"10.5142\/jgr.2013.37.293","article-title":"20S-dihydroprotopanaxadiol, a ginsenoside derivative, boosts innate immune responses of monocytes and macrophages","volume":"37","author":"Kim","year":"2013","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.biopha.2018.10.081_bib0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pbb.2014.02.012","article-title":"Protective effects of ginsenoside Rg1 on chronic restraint stress induced learning and memory impairments in male mice","volume":"120","author":"Wang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biopha.2018.10.081_bib0060","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000044911","article-title":"A study of ginsenoside-Rd in a renal ischemia-reperfusion model","volume":"78","author":"Yokozawa","year":"1998","journal-title":"Nephron"},{"key":"10.1016\/j.biopha.2018.10.081_bib0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1211\/0022357022449","article-title":"Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice","volume":"56","author":"Yokozawa","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000045277","article-title":"Effect of ginsenoside-Rd in cephaloridine-induced renal disorder","volume":"81","author":"Yokozawa","year":"1999","journal-title":"Nephron"},{"key":"10.1016\/j.biopha.2018.10.081_bib0075","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.bbagen.2007.06.008","article-title":"Neuroprotective effect of individual ginsenosides on astrocytes primary culture","volume":"1770","author":"Lopez","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.10.081_bib0080","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1016\/j.fct.2008.06.011","article-title":"Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis","volume":"46","author":"Tamura","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1440-1681.2009.05286.x","article-title":"Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons","volume":"37","author":"Li","year":"2010","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0090","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-211-73574-9_13","article-title":"Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture","volume":"72","author":"Lin","year":"2007","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.biopha.2018.10.081_bib0095","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.intimp.2006.04.021","article-title":"Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia","volume":"7","author":"Wu","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0100","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1248\/bpb.31.1923","article-title":"Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide","volume":"31","author":"Ye","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.10.081_bib0105","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neures.2009.03.016","article-title":"Neuroprotective effects of ginsenoside Rd against oxygen-glucose deprivation in cultured hippocampal neurons","volume":"64","author":"Ye","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.biopha.2018.10.081_bib0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2011.01.007","article-title":"Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia","volume":"178","author":"Ye","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.biopha.2018.10.081_bib0115","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1056\/NEJMra021498","article-title":"Heart failure","volume":"348","author":"Jessup","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.10.081_bib0120","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00204-015-1477-x","article-title":"Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets","volume":"89","author":"Tham","year":"2015","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5152\/akd.2014.5731","article-title":"Mortality in heart failure patients","volume":"15","author":"Byty\u00e7i","year":"2015","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0135","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fphar.2017.00702","article-title":"Panax Notoginseng Saponins for treating coronary artery disease: a functional and mechanistic overview","volume":"8","author":"Duan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22091518","article-title":"State of Panax Ginseng research: a global analysis","volume":"22","author":"Xu","year":"2017","journal-title":"Molecules."},{"key":"10.1016\/j.biopha.2018.10.081_bib0145","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/FJC.0b013e31828f8d45","article-title":"The ginsenoside Rg1 prevents transverse aortic constriction-induced left ventricular hypertrophy and cardiac dysfunction by inhibiting fibrosis and enhancing angiogenesis","volume":"62","author":"Zhang","year":"2013","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0150","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejphar.2009.01.048","article-title":"Ginsenoside Rg(1) inhibits rat left ventricular hypertrophy induced by abdominal aorta coarctation: involvement of calcineurin and mitogen-activated protein kinase signalings","volume":"608","author":"Deng","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0155","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1248\/bpb.33.631","article-title":"Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats","volume":"33","author":"Deng","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biopha.2018.10.081_bib0160","article-title":"Ginsenoside Re Attenuates Isoproterenol-Induced Myocardial Injury in Rats","volume":"2018","author":"Wang","year":"2018","journal-title":"Evid. Complement. Alternat. Med."},{"key":"10.1016\/j.biopha.2018.10.081_bib0165","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jphp.12900","article-title":"Ginsenoside Rb1 inhibits autophagy through regulation of Rho\/ROCK and PI3K\/mTOR pathways in a pressure-overload heart failure rat model","volume":"70","author":"Yang","year":"2018","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.081_bib0170","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.bbadis.2013.05.018","article-title":"Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice","volume":"1832","author":"Dolinsky","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biopha.2018.10.081_bib0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092903","article-title":"A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes","volume":"9","author":"Cox","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.10.081_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064986","article-title":"Left and right ventricle late remodeling following myocardial infarction in rats","volume":"8","author":"Stefanon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.10.081_bib0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nrcardio.2009.229","article-title":"Hypertension: cardiac hypertrophy as a target of antihypertensive therapy","volume":"7","author":"Zanchetti","year":"2010","journal-title":"Nat. Rev. Cardiol."}],"updated-by":[{"DOI":"10.1016\/j.biopha.2020.110720","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000}}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218347814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218347814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:42:56Z","timestamp":1777876976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218347814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":37,"alternative-id":["S0753332218347814"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.081","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}