{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:52:36Z","timestamp":1783385556134,"version":"3.54.6"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471334"],"award-info":[{"award-number":["81471334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871002"],"award-info":[{"award-number":["81871002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine & Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.10.176","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T12:53:58Z","timestamp":1542113638000},"page":"1498-1505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["EETs\/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy"],"prefix":"10.1016","volume":"109","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biopha.2018.10.176_bib0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jchf.2017.12.018","article-title":"Comorbidities and cardiometabolic disease: relationship with longitudinal changes in diastolic function","volume":"6","author":"Nayor","year":"2018","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.biopha.2018.10.176_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/01635581.2015.976320","article-title":"Chemopreventive and therapeutic potential of \u201cnaringenina flavanone\u201d present in citrus fruits","volume":"67","author":"Mir","year":"2015","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.biopha.2018.10.176_bib0015","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.biopha.2018.10.176_bib0020","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.3892\/etm.2015.2816","article-title":"Naringenin attenuates pressure overload- induced cardiac hypertrophy","volume":"10","author":"Zhang","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.10.176_bib0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/JOE-16-0004","article-title":"Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo","volume":"230","author":"You","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.biopha.2018.10.176_bib0030","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11892-013-0375-y","article-title":"Diabetes mellitus and inflammation","volume":"13","author":"Lontchi-Yimagou","year":"2013","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.biopha.2018.10.176_bib0035","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tem.2012.05.001","article-title":"PPARs at the crossroads of lipid signaling and inflammation","volume":"23","author":"Wahli","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.biopha.2018.10.176_bib0040","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jff.2017.07.015","article-title":"Polydatin exhibits the hepatoprotective effects through PPAR-\u03b1\/-\u03b2 signaling pathway in Streptozocin-induced diabetic mice","volume":"36","author":"Xue","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.biopha.2018.10.176_bib0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.addr.2011.03.006","article-title":"The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diaeases","volume":"63","author":"Xu","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biopha.2018.10.176_bib0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2891-13-17","article-title":"Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review","volume":"13","author":"Grygiel-G\u00f3rniak","year":"2014","journal-title":"Nutr. J."},{"key":"10.1016\/j.biopha.2018.10.176_bib0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00021.2001","article-title":"P-450 metabolites of arachidonic acid in the control of cardiovascular function","volume":"82","author":"Roman","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biopha.2018.10.176_bib0060","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/1753-0407.12358","article-title":"Soluble epoxide hydrolase: a potential target for metabolic diseases","volume":"8","author":"He","year":"2016","journal-title":"J. Diabetes"},{"key":"10.1016\/j.biopha.2018.10.176_bib0065","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1538\/expanim.14-0084","article-title":"Contribution of hyperglycemia on diabetic complications in obese type 2 diabetic SDT fatty rats: effects of SGLT inhibitor phlorizin","volume":"64","author":"Katsuda","year":"2015","journal-title":"Exp. Anim."},{"key":"10.1016\/j.biopha.2018.10.176_bib0070","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.2174\/1381612822666160530150936","article-title":"Pharmacological properties and therapeutic potential of naringenin: a citrus flavonoid of pharmaceutical promise","volume":"22","author":"Rani","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biopha.2018.10.176_bib0075","doi-asserted-by":"crossref","first-page":"pii: E502","DOI":"10.3390\/nu9050502","article-title":"Nutraceutical value of citrus flavanones and their implications in cardiovascular disease","volume":"9","author":"Testai","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2018.10.176_bib0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cbi.2017.12.007","article-title":"Isolated mangiferin and naringenin exert antidiabetic effect via PPAR(\u03b3)\/GLUT4 dual agonistic action with strong metabolic regulation","volume":"280","author":"Singh","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biopha.2018.10.176_bib0085","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrendo.2016.135","article-title":"PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD","volume":"13","author":"Gross","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.biopha.2018.10.176_bib0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2017.03.042","article-title":"Metformin-like antidiabetic, cardio-protective and non-glycemic effects of naringenin: Molecular and pharmacological insights","volume":"803","author":"Nyane","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.176_bib0095","doi-asserted-by":"crossref","DOI":"10.3390\/nu9101161","article-title":"Flavonoid naringenin attenuates oxidative stress, apoptosis and improves nneurotrophic effects in the diabetic rat retina","volume":"9","author":"Al-Dosari","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.biopha.2018.10.176_bib0100","first-page":"8738760","article-title":"Naringenin ameliorated kidney injury through Let-7a\/TGFBR1 signaling in diabetic nephropathy","author":"Yan","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.biopha.2018.10.176_bib0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejphar.2016.01.002","article-title":"Apigenin andnaringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats","volume":"773","author":"Ren","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biopha.2018.10.176_bib0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/aiht-2016-67-2708","article-title":"Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study","volume":"67","author":"Sirovina","year":"2016","journal-title":"Arh. Hig. Rada Toksikol."},{"key":"10.1016\/j.biopha.2018.10.176_bib0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2018.05.119","article-title":"Naringenin exhibits the protective effect on cardiac hypertrophy via EETs-PPARs activation in streptozocin-induced diabetic mice","volume":"502","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.10.176_bib0120","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.3892\/mmr.2015.4232","article-title":"Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPAR\u03b3 signaling pathway in a type 2 diabetic rat model","volume":"12","author":"Qi","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biopha.2018.10.176_bib0125","doi-asserted-by":"crossref","first-page":"e12399","DOI":"10.1371\/journal.pone.0012399","article-title":"Transcriptional regulation ofhuman and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha","volume":"5","author":"Goldwasser","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.biopha.2018.10.176_bib0130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2017.06.007","article-title":"Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPAR\u03b1 in HUVECs","volume":"490","author":"Huang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biopha.2018.10.176_bib0135","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/FJC.0000000000000036","article-title":"Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy","volume":"63","author":"Althurwi","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."}],"container-title":["Biomedicine & Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218360839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218360839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:29:43Z","timestamp":1777876183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218360839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":27,"alternative-id":["S0753332218360839"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.176","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EETs\/PPARs activation together mediates the preventive effect of naringenin in high glucose-induced cardiomyocyte hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.10.176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}