{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:15:43Z","timestamp":1791299743875,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chinese National Scientific Foundation","award":["31371254"],"award-info":[{"award-number":["31371254"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.008","type":"journal-article","created":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T22:58:43Z","timestamp":1542149923000},"page":"1541-1546","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Triptolide interferes with XRCC1\/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin"],"prefix":"10.1016","volume":"109","author":[{"given":"Zhiwei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-9385","authenticated-orcid":false,"given":"Jiamei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Likun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-1942","authenticated-orcid":false,"given":"Weifeng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biopha.2018.11.008_bib0005","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.008_bib0010","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3802\/jgo.2018.29.e7","article-title":"Epidemiology of gynecologic cancers in China","volume":"29","author":"Jiang","year":"2018","journal-title":"J. Gynecol. Oncol."},{"issue":"3","key":"10.1016\/j.biopha.2018.11.008_bib0015","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.breast.2010.02.003","article-title":"Cisplatin-gemcitabine therapy in metastatic breast cancer: improved outcome in triple negative breast cancer patients compared to non-triple negative patients","volume":"19","author":"Koshy","year":"2010","journal-title":"Breast"},{"issue":"15 Pt 1","key":"10.1016\/j.biopha.2018.11.008_bib0020","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1158\/1078-0432.CCR-06-3045","article-title":"Triple-negative breast cancer: clinical features and patterns of recurrence","volume":"13","author":"Dent","year":"2007","journal-title":"Clin. Cancer Res."},{"issue":"17","key":"10.1016\/j.biopha.2018.11.008_bib0025","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1111\/bph.13211","article-title":"Therapeutic targets of triple-negative breast cancer: a review","volume":"172","author":"Jamdade","year":"2015","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.008_bib0030","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/cncr.28914","article-title":"Subtyping of triple-negative breast cancer: implications for therapy","volume":"121","author":"Abramson","year":"2015","journal-title":"Cancer"},{"issue":"20","key":"10.1016\/j.biopha.2018.11.008_bib0035","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biopha.2018.11.008_bib0040","doi-asserted-by":"crossref","first-page":"769","DOI":"10.2147\/OTT.S149788","article-title":"Anti-tumor effect of triptolide in T-cell lymphoblastic lymphoma by inhibiting cell viability, invasion, and epithelial-mesenchymal transition via regulating the PI3K\/AKT\/mTOR pathway","volume":"11","author":"Huang","year":"2018","journal-title":"Oncotargets Ther."},{"issue":"10","key":"10.1016\/j.biopha.2018.11.008_bib0045","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.7150\/ijbs.20485","article-title":"Triptolide suppresses glomerular mesangial cell proliferation in diabetic nephropathy is associated with inhibition of PDK1\/Akt\/mTOR pathway","volume":"13","author":"Han","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0050","first-page":"149","article-title":"Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: a mini review","volume":"6","author":"Ziaei","year":"2016","journal-title":"Avicenna J. Phytomed."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.008_bib0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jep.2014.06.006","article-title":"Triptolide: progress on research in pharmacodynamics and toxicology","volume":"155","author":"Li","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biopha.2018.11.008_bib0060","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jep.2015.01.004","article-title":"Investigation of the active components in Tripterygium wilfordii leading to its acute hepatotoxicty and nephrotoxicity","volume":"162","author":"Li","year":"2015","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0065","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3892\/or.2012.2170","article-title":"Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes","volume":"29","author":"Chueh","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biopha.2018.11.008_bib0070","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.biopha.2016.12.055","article-title":"AMD3100 combined with triptolide inhibit proliferation, invasion and metastasis and induce apoptosis of human U2OS osteosarcoma cells","volume":"86","author":"Jiang","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbrc.2018.01.052","article-title":"Anti-tumor effects of triptolide on angiogenesis and cell apoptosis in osteosarcoma cells by inducing autophagy via repressing Wnt\/beta-Catenin signaling","volume":"496","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.biopha.2018.11.008_bib0080","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.7150\/jca.16178","article-title":"Anti-cancer and sensibilisation effect of triptolide on human epithelial ovarian Cancer","volume":"7","author":"Hu","year":"2016","journal-title":"J. Cancer"},{"issue":"3","key":"10.1016\/j.biopha.2018.11.008_bib0085","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/0929867033368484","article-title":"Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways","volume":"10","author":"Fuertes","year":"2003","journal-title":"Curr. Med. Chem."},{"issue":"5","key":"10.1016\/j.biopha.2018.11.008_bib0090","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1349-7006.2010.01514.x","article-title":"BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin","volume":"101","author":"Shim","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.biopha.2018.11.008_bib0095","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.biocel.2017.08.001","article-title":"Inhibition of PARP1 activity enhances chemotherapeutic efficiency in cisplatin-resistant gastric cancer cells","volume":"92","author":"Wang","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.biopha.2018.11.008_bib0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.lungcan.2008.02.019","article-title":"XRCC1 polymorphisms and severe toxicity in lung cancer patients treated with cisplatin-based chemotherapy in Chinese population","volume":"62","author":"Wang","year":"2008","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.008_bib0105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1476-4598-4-18","article-title":"ABCC5, ERCC2, XPA and XRCC1 transcript abundance levels correlate with cisplatin chemoresistance in non-small cell lung cancer cell lines","volume":"4","author":"Weaver","year":"2005","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0110","first-page":"172","article-title":"Cisplatin resistance: preclinical findings and clinical implications","volume":"1806","author":"Koberle","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.008_bib0115","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/mc.22795","article-title":"Triptolide sensitizes breast cancer cells to Doxorubicin through the DNA damage response inhibition","volume":"57","author":"Deng","year":"2018","journal-title":"Mol. Carcinog."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.008_bib0120","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/emm.2002.64","article-title":"Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation","volume":"34","author":"Lee","year":"2002","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0125","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood-2005-09-3898","article-title":"Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells","volume":"108","author":"Carter","year":"2006","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.008_bib0130","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1142\/S0192415X14500323","article-title":"Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-kappaB signaling in glioma initiating cells","volume":"42","author":"Sai","year":"2014","journal-title":"Am. J. Chin. Med. (Gard City N Y)"},{"issue":"15","key":"10.1016\/j.biopha.2018.11.008_bib0135","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.1093\/nar\/gkt479","article-title":"Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity","volume":"41","author":"Kothandapani","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.biopha.2018.11.008_bib0140","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1124\/mol.111.074708","article-title":"Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage","volume":"80","author":"Lin","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.008_bib0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.dnarep.2015.02.005","article-title":"The structural basis of XRCC1-mediated DNA repair","volume":"30","author":"London","year":"2015","journal-title":"DNA Repair (Amst.)"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.008_bib0150","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1139\/bcb-2016-0012","article-title":"Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication","volume":"94","author":"Godin","year":"2016","journal-title":"Biochem. Cell Biol."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.008_bib0155","first-page":"293","article-title":"PARP inhibition: PARP1 and beyond, Nature reviews","volume":"10","author":"Rouleau","year":"2010","journal-title":"Cancer"},{"issue":"34","key":"10.1016\/j.biopha.2018.11.008_bib0160","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1021\/acs.biochem.8b00331","article-title":"Structural and kinetic studies of the effect of guanine N7 alkylation and metal cofactors on DNA replication","volume":"57","author":"Kou","year":"2018","journal-title":"Biochemistry"},{"issue":"44","key":"10.1016\/j.biopha.2018.11.008_bib0165","doi-asserted-by":"crossref","first-page":"14067","DOI":"10.1021\/jacs.5b10172","article-title":"N7 methylation alters hydrogen-bonding patterns of guanine in duplex DNA","volume":"137","author":"Kou","year":"2015","journal-title":"J. Am. Chem. Soc."}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218351539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218351539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:25:56Z","timestamp":1777875956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218351539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":33,"alternative-id":["S0753332218351539"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.008","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triptolide interferes with XRCC1\/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}