{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:05:29Z","timestamp":1777950329199,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T00:00:00Z","timestamp":1541548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202398"],"award-info":[{"award-number":["81202398"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703379"],"award-info":[{"award-number":["81703379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774216"],"award-info":[{"award-number":["81774216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201604016065"],"award-info":[{"award-number":["201604016065"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201607010338"],"award-info":[{"award-number":["201607010338"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["YN2014ZHR209"],"award-info":[{"award-number":["YN2014ZHR209"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["YN2015MS03"],"award-info":[{"award-number":["YN2015MS03"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biomedicine &amp; Pharmacotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.biopha.2018.11.031","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T12:42:23Z","timestamp":1543236143000},"page":"1932-1939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival"],"prefix":"10.1016","volume":"109","author":[{"given":"Yi-qi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-dong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-min","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu-sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5174-9079","authenticated-orcid":false,"given":"Hong-tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9539-2005","authenticated-orcid":false,"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biopha.2018.11.031_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/nu10060689","article-title":"Taurine Supplementation Alleviates Puromycin Aminonucleoside Damage by Modulaitochondrial-Related Apoptosis in Rat Kidney","volume":"10","author":"Stacchiotti","year":"2018","journal-title":"Nutrients"},{"issue":"10","key":"10.1016\/j.biopha.2018.11.031_bib0010","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.drudis.2015.06.003","article-title":"Targeting the podocyte to treat glomerular kidney disease","volume":"20","author":"Lal","year":"2015","journal-title":"Drug Discov Today"},{"issue":"Suppl 1","key":"10.1016\/j.biopha.2018.11.031_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000481633","article-title":"A Review of Podocyte Biology","volume":"47","author":"Garg","year":"2018","journal-title":"Am J Nephrol"},{"issue":"10","key":"10.1016\/j.biopha.2018.11.031_bib0020","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1681\/ASN.2017030247","article-title":"Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD","volume":"28","author":"Szeto","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.biopha.2018.11.031_bib0025","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1681\/ASN.2017010027","article-title":"New Insights into Podocyte Biology in Glomerular Health and Disease","volume":"28","author":"Assady","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"10141","key":"10.1016\/j.biopha.2018.11.031_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)30536-1","article-title":"Idiopathic nephrotic syndrome in children","volume":"392","author":"Noone","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.biopha.2018.11.031_bib0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00281-014-0423-y","article-title":"Immunopathogenesis of membranous nephropathy: an update","volume":"36","author":"Debiec","year":"2014","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.biopha.2018.11.031_bib0040","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-med-050311-163340","article-title":"Podocyte biology and pathogenesis of kidney disease","volume":"64","author":"Reiser","year":"2013","journal-title":"Annu Rev Med"},{"issue":"14","key":"10.1016\/j.biopha.2018.11.031_bib0045","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.addr.2010.08.012","article-title":"Targeting podocyte-associated diseases","volume":"62","author":"Leeuwis","year":"2010","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.031_bib0050","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/ndt\/gfn528","article-title":"Rosuvastatin protects against podocyte apoptosis in vitro","volume":"24","author":"Cormack-Aboud","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.biopha.2018.11.031_bib0055","doi-asserted-by":"crossref","DOI":"10.1172\/JCI97879","article-title":"Bowman\u2019s capsule provides a protective niche for podocytes from cytotoxic CD8+ T cells","author":"Chen","year":"2018","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.biopha.2018.11.031_bib0060","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1681\/ASN.2017020143","article-title":"The Evolving Complexity of the Podocyte Cytoskeleton","volume":"28","author":"Schell","year":"2017","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.031_bib0065","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1093\/ndt\/gfx049","article-title":"Seasonal variations in transition, mortality and kidney transplantation among patients with end-stage renal disease in the USA","volume":"32","author":"Obi","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.biopha.2018.11.031_bib0070","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12882-015-0034-4","article-title":"A vital role for Angptl3 in the PAN-induced podocyte loss by affecting detachment and apoptosis in vitro","volume":"16","author":"Dai","year":"2015","journal-title":"BMC Nephrol"},{"issue":"11","key":"10.1016\/j.biopha.2018.11.031_bib0075","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1681\/ASN.2016040490","article-title":"Homer W. Smith Award: The Podocyte from Periphery to Center Stage","volume":"27","author":"Kerjaschki","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.031_bib0080","first-page":"115","article-title":"Tripterygium glycoside protects against puromycin amino nucleosideinduced podocyte injury by upregulating autophagy","volume":"42","author":"Gong","year":"2018","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.biopha.2018.11.031_bib0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2018.06.012","article-title":"Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis","volume":"101","author":"Huang","year":"2018","journal-title":"Mol Immunol"},{"issue":"1","key":"10.1016\/j.biopha.2018.11.031_bib0090","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1038\/s41598-018-29203-1","article-title":"Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-kappaB\/GADD45B","volume":"8","author":"Wang","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.biopha.2018.11.031_bib0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ki.2008.203","article-title":"Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro","volume":"74","author":"Zheng","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.biopha.2018.11.031_bib0100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3892\/etm.2013.1226","article-title":"Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy","volume":"6","author":"Ma","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.11.031_bib0105","first-page":"2275","article-title":"Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy","author":"Liang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biopha.2018.11.031_bib0110","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1039\/c2np00088a","article-title":"Triptolide: structural modifications, structure\u2013activity relationships, bioactivities, clinical development and mechanisms","volume":"29","author":"Zhou","year":"2012","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.biopha.2018.11.031_bib0115","article-title":"Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-\u03baB Signaling Pathways","volume":"9","author":"Yi-Qi Yang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biopha.2018.11.031_bib0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11605-015-3000-3","article-title":"Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer","volume":"20","author":"Modi","year":"2016","journal-title":"J. Gastrointest. Surg."},{"key":"10.1016\/j.biopha.2018.11.031_bib0125","doi-asserted-by":"crossref","first-page":"10110","DOI":"10.1021\/jo501744j","article-title":"Divergent Total Synthesis of Triptolide, Triptonide, Tripdiolide, 16-Hydroxytriptolide, and Their Analogues","volume":"79","author":"Xu","year":"2014","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.biopha.2018.11.031_bib0130","first-page":"370","article-title":"Structural study of triptriolide isolated from Tripterygium wilfordii","volume":"33","author":"Ma","year":"1991","journal-title":"Acta Botanica Scnica."},{"key":"10.1016\/j.biopha.2018.11.031_bib0135","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.biopha.2017.06.041","article-title":"LLDT-288, a novel triptolide analogue exhibits potent antitumor activity in vitro and in vivo","volume":"93","author":"Xu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.11.031_bib0140","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.biopha.2014.05.002","article-title":"NF-\u03baB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro","volume":"68","author":"Li","year":"2014","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biopha.2018.11.031_bib0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejmech.2013.11.044","article-title":"Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide","volume":"73","author":"Xu","year":"2014","journal-title":"Eur. J. Med. Chem."},{"issue":"4","key":"10.1016\/j.biopha.2018.11.031_bib0150","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1159\/000492049","article-title":"RANK Deficiency Ameliorates Podocyte Injury by Suppressing Calcium\/Calcineurin\/ NFATc1 Signaling","volume":"43","author":"Liang","year":"2018","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.biopha.2018.11.031_bib0155","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.biopha.2018.06.054","article-title":"TGF-beta1 modulates podocyte migration by regulating the expression of integrin-beta1 and -beta3 through different signaling pathways","volume":"105","author":"Chen","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.biopha.2018.11.031_bib0160","doi-asserted-by":"crossref","DOI":"10.1681\/ASN.2018050490","article-title":"What Is the Glomerular Ultrafiltration Barrier?","author":"Fissell","year":"2018","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.biopha.2018.11.031_bib0165","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.canlet.2012.07.005","article-title":"FLIP: a flop for execution signals","volume":"332","author":"Subramaniam","year":"2013","journal-title":"Cancer Lett"},{"issue":"5","key":"10.1016\/j.biopha.2018.11.031_bib0170","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/ki.2008.203","article-title":"Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro","volume":"74","author":"Zheng","year":"2008","journal-title":"Kidney international"}],"container-title":["Biomedicine &amp; Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0753332218371269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:59:32Z","timestamp":1777877972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0753332218371269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":34,"alternative-id":["S0753332218371269"],"URL":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.031","relation":{},"ISSN":["0753-3322"],"issn-type":[{"value":"0753-3322","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival","name":"articletitle","label":"Article Title"},{"value":"Biomedicine & Pharmacotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biopha.2018.11.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}